Clinical trials: Caries,Dental
Dental Restoration, Caries
Cold Plasma for Dental Restoration and Caries Prevention
The main objective of this entire research project is to develop a miniature atmospheric cold plasma brush (m-ACPB) for dental clinical applications.
- Trial name
- NCT01529606
- Testing
- Composite restoration and tooth cleaning, Plasma treatment
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Nanova, Inc
Dental Caries
High-strength Glass-ionomer Dental Restorations
The purpose of this study is to extend our knowledge concerning the clinical performance of two dental filling materials in molars. The study will compare two high-strength glass-ionomer filling materials.
- Trial name
- ROCK (NCT01523613)
- Testing
- Chemfil ROCK Glassionomer restoration, Fuji IX GP Extra Glassionomer restoration
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Mathilde Peters, DMD, PhD
Dental Caries
Pharmacokinetics of Advantage Arrest in Children
The purpose of this study is to characterize basic PK parameters (Cmax, t1/2, AUC) in healthy children to contribute to evidence for the safety of Advantage Arrest, consistent with Guidance for Industry--Exposure--Response…
- Trial name
- NCT04186663
- Testing
- Silver Diamine Fluoride
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Dental Caries, Oral Bacterial Infection
Ecological Effect of Arginine Dentifrice on Oral Microbiota
caries-free (CF) individuals caries-active (CA) individuals (DMFT ≥ 6) will be recruited. Subjects will be instructed to brush their teeth twice daily for 3 min using Colgate® Sensitive Pro-Relief® toothpaste (containing 8%…
- Conditions
- Dental Caries, Oral Bacterial Infection, Microbiota
- Trial name
- NCT02988349
- Testing
- Colgate® Sensitive Pro-Relief® toothpaste
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sichuan University
Caries, Dental Trauma
Clinical Evaluation of a Dental Glass Ceramic
A clinical trial with an experimental glass ceramic (shades A1, A2 and A3) to ensure the safety and efficacy of the product. It is a study with single-arm in which inlays and onlays for molars and premolars are adhesively luted.
- Trial name
- NCT04933123
- Testing
- indirect restorative treatment with a glass ceramic
- Where
- Liechtenstein
- Volunteers
- 13 people
- Sponsor
- Ivoclar Vivadent AG
Cavity, Cavities of Teeth
In Vivo Assessment of the Tooth-Resin Composite Interface Using Optical Coherence Tomography
The aim of the study is to compare the short-term marginal integrity of two preparation techniques for Class I composite restoration using two visual assessment techniques, the FDI World Dental Federation and US Public Health…
- Trial name
- NCT05145322
- Testing
- Composite with 90 degree cavosurface angle, Composite with wide bevel
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Dental Caries
Older Adult Effectiveness of 2 Treatments
The study is a cluster randomized clinical trial (RCT) to be conducted in 40 (22 originally planned +16 additional) publicly subsidized housing facilities/sites (HUD Section 202) and other low-income housing voucher programs in…
- Trial name
- NCT03916926
- Testing
- A "simple medical strategy" consisting of silver diamine fluoride (SDF), B "typical dental strategy" consisting of atraumatic restorative treatment (ART) with glass ionomer cement + Fluoride varnish (FV)
- Where
- United States
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Dental Caries
Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults
This study is a randomized clinical trial lasting for 30 months. A total of 300 subjects will be recruited from social centres for elders located in different districts in Hong Kong.
- Trial name
- NCT02360124
- Testing
- silver diammine fluoride, saturated potassium iodide solution
- Where
- China
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dental Cements, Caries,Dental
Clinical Performance of Chairside CAD/CAM Restorations
This investigation will be a longitudinal clinical trial to study the long-term clinical performance of a resin cement for chairside CAD/CAM restorations.
- Trial name
- NCT04279574
- Testing
- Lithium disilicate onlays (IPS emaxCAD/Ivoclar), Chairside zirconia crowns (3M)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Solventum US LLC
Dental Caries
Pharmacokinetics of Advantage Arrest
The study aim is to characterize the kinetics of silver and fluoride after topical application of silver diamine fluoride.
- Trial name
- NCT04184271
- Testing
- 38% silver diamine fluoride
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Dental Caries
Enamel Remineralization Potential of Dentifrices in Situ
This study will use an oral in-situ caries model to study remineralization of enamel due to the action of different combinations of fluoride salts delivered from dentifrices.
- Trial name
- NCT01128946
- Testing
- NaF, SnF, NaMFP
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Preventive Oral Health
Oral Health Training Program for Pediatric Residents
The purpose of this study was to compare the effect of the addition of hands on training by a pediatric dentist on the pediatric residents skills, confidence, opinions and practice related to preventive oral health.
- Trial name
- NCT00846066
- Testing
- Hands on training, Web based training
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Dental Caries
A Phase 2 Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Varnish and Strip in Adolescent and Adult Subjects
An open-label and single-blind phase 2 study to evaluate the oral microbiology, safety and tolerability of multiple C16G2 Varnish and Strip applications in male and female dental subjects 12-75 years of age.
- Trial name
- C3J17-206-00 (NCT03196219)
- Testing
- C16G2
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Dental Caries in Children, Dental Caries Class II
Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective…
- Conditions
- Dental Caries in Children, Dental Caries Class II, Dental Caries
- Trial name
- NCT03770286
- Testing
- 5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Dental Caries
Family-centered Oral Health Promotion for New Parents
Early childhood caries (ECC) is a global health problem that causes pain and infection to the children affected. It is a common disease among preschool children in Hong Kong.
- Trial name
- NCT02937194
- Testing
- Personal oral health instruction + pamphlets distribution, Pamphlets distribution
- Where
- China
- Volunteers
- 580 people
- Sponsor
- The University of Hong Kong
Cavities of Teeth, Dental Decay
Scotchbond Universal Plus Compared to Scotchbond Universal for Posterior Class I & II Restorations With Filtek Universal
This research study is looking at a new bond-promoting substance (a dental adhesive called 3M™ Scotchbond™ Universal Plus Adhesive) used between the tooth and dental restoration (filling).
- Trial name
- NCT05248204
- Testing
- Scotchbond™ Universal Plus Adhesive, Scotchbond™ Universal Adhesive
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Solventum US LLC
Dental Caries, Dental Plaque
Orthodontic Varnish Microbiology Study
Orthodontic treatment is common in teenagers, which typically involve the attachment of metal brackets to the teeth. These brackets often impede proper oral hygiene, leading to plaque accumulation and the development of white…
- Conditions
- Dental Caries, Dental Plaque, Dental White Spot
- Trial name
- NCT04528134
- Testing
- Extended Contact RMGI (Resin-modified Glass Ionomer) Varnish, 5% Sodium Fluoride Varnish
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Dental Caries, Denture, Partial, Removable
Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite
Nobio has developed dental restorative materials with long term antibacterial properties in order to fight recurrent decay/caries around restorations.
- Trial name
- Nobio (NCT04059250)
- Testing
- Nobio composite, traditional composite
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Dental Caries
A Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Dental Strip Application
Single-blind study to evaluate whether C16G2 Strip administered in multiple doses can effectively kill the bacteria in the oral cavity that cause dental caries..
- Trial name
- NCT03052842
- Testing
- C16G2 Strip
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Cavities of Teeth
An Evaluation of Protective Effects of OpalSeal™ Against Early Dental Decay in Orthodontic Patients
Fluoride is very effective in preventing dental decay (cavities) when applied in the form of a varnish on tooth surfaces. The purpose of this study is to verify if fluoride-releasing primer (OpalSeal) offers more protection…
- Trial name
- NCT03722264
- Testing
- OpalSeal, TransbondXT
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University