Clinical trials: Caries
Dental Caries
In-situ Clinical Trial Assessing Ability to Detect and Monitor Active Caries and Their Remineralization
The goal of this clinical trial is to evaluate whether BlueCheck® can accurately detect and monitor early-stage dental caries (tooth decay) and their remineralization in adults.
- Trial name
- NCT07100626
- Testing
- BlueCheck
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Incisive Technologies Pty Ltd
Tooth Extraction, Tooth Fractures
Efficacy and Safety Evaluation Study of Implants With Periodontal Ligament
The goal of this clinical trial is to evaluate the efficacy and safety of periodontal ligament-integrated implants placed via residual periodontal ligament tissue in extraction sockets in adult patients (aged 18 and older)…
- Conditions
- Tooth Extraction, Tooth Fractures, Dental Caries, Tooth Dislocation
- Trial name
- NCT07302581
- Testing
- Periodontal Ligament-Integrated Implant
- Where
- 2 sites in Japan
- Volunteers
- 6 people
- Sponsor
- OrganTech, Inc.
Cavities of Teeth, Dental Decay
Scotchbond Universal Plus Compared to Scotchbond Universal for Posterior Class I & II Restorations With Filtek Universal
This research study is looking at a new bond-promoting substance (a dental adhesive called 3M™ Scotchbond™ Universal Plus Adhesive) used between the tooth and dental restoration (filling).
- Trial name
- NCT05248204
- Testing
- Scotchbond™ Universal Plus Adhesive, Scotchbond™ Universal Adhesive
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Solventum US LLC
Dental Caries, Unsatisfactory or Defective Restoration of Tooth
Clinical Evaluation of a Bulk Fill Resin Composite
The purpose of this clinical trial is to measure the clinical outcomes of Tetric PowerFill Class I and II restorations cured in 3 seconds with the Bluephase PowerCure curing unit.
- Trial name
- NCT04686422
- Testing
- Tetric PowerFill
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Ivoclar Vivadent AG
Caries, Defective Tooth Restorations
Prospective, Split-mouth, Comparative Study to Compare Clinical Outcomes of Two Different Posterior Composite
The objective of this 2-year split mouth comparative study, a randomized controlled study, is to determine whether the simplified placement procedure of the ultra-rapid polymerizing Tetric PowerFlow/ Tetric PowerFill with a…
- Trial name
- NCT04708223
- Testing
- Direct restorative treatment with fast-curing composites (Tetric PowerFill/ Tetric PowerFlow), Direct restorative treatment with conventionally applied composites (Tetric EvoCeram Bulk Fill/ Tetric EvoFlow Bulk Fill)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Ivoclar Vivadent AG
Caries, Dental Trauma
Lithium Disilicate Crowns Study
CAD-CAM crowns made of experimental lithium disilicate (shades A1, A2 and A3) are placed in patients by using either a dual-curing adhesive or a self-adhesive luting material in combination with total etch/universal bonding agent.
- Trial name
- NCT05070416
- Testing
- Lithium disilicate crowns
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Ivoclar Vivadent AG
Insufficient Dental Filling or Primary Caries (Class I or II Cavities in Premolars or Molars)
Clinical Evaluation of a New Flowable and a New Sculptable Universal Bulk-fill Composite for Direct Restorative Treatment
The overall objective of this clinical investigation is to evaluate the clinical safety and performance of the new flowable composite TM Flow and the new sculptable composite TM Fill for restoration of class I and class II…
- Trial name
- NCT06369779
- Testing
- TM Fill in combination with TM Flow
- Where
- Liechtenstein
- Volunteers
- 65 people
- Sponsor
- Ivoclar Vivadent AG
Class I Dental Restorations, Class II Dental Restorations
Clinical Evaluation of a New Dual-cure Universal Adhesive
The overall aim of this study is to evaluate the clinical performance and safety of the new dental dual-cure adhesive for luting indirect ceramic restorations (inlays and onlays).
- Conditions
- Class I Dental Restorations, Class II Dental Restorations, Insufficient Dental Restoration, Caries, Dental
- Trial name
- NCT06615544
- Testing
- Placement of indirect dental restoration
- Where
- Liechtenstein
- Volunteers
- 45 people
- Sponsor
- Ivoclar Vivadent AG
Dental Caries in Children
Efficacy and Safety Evaluation of Anti-Caries Varnish
The purpose of the study is to determine the efficacy \& safety of Advantage Anti-Caries Varnish for primary prevention. The objectives are: 1) To determine if Advantage Anti-Caries Varnish (test varnish) is superior to an active…
- Trial name
- NCT04947527
- Testing
- Test varnish
- Where
- United States Minor Outlying Islands
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Dental Caries
A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries
The aim of this study is to evaluate the relative efficacy of an experimental dentifrice containing 1150 parts per million (ppm) fluoride (as sodium fluoride [NaF]) to remineralize early stage caries type lesions in an in situ…
- Trial name
- NCT06949072
- Testing
- Test Dentifrice, Reference Dentifrice, Negative Control Dentifrice
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- HALEON
Enamel Lesions, Demineralization, Tooth
Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralization In-Situ Model
Clinical study to evaluate the anti-cavity efficacy of three dentifrices using an intra-oral enamel Demineralization - Remineralization In-Situ Model. This is a Phase III, single-center, triple-blind with a crossover design.
- Conditions
- Enamel Lesions, Demineralization, Tooth, Remineralization, Dental Cavity
- Trial name
- REPAIR (NCT06732518)
- Testing
- Fluoride Toothpaste, Fluoride free toothpaste in a chalk base, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Caries Active, Caries Root
Surface Caries Feature Study
Dental caries (dental cavity) is very common and can impact oral health and oral health-related quality of life. Dental caries is when the tooth surfaces break down, and if left untreated, can cause tooth pain.
- Conditions
- Caries Active, Caries Root, Caries,Dental, Caries; Initial
- Trial name
- NCT07048444
- Testing
- N/A as observational study
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- 3Shape A/S
Caries, Dental Trauma
Clinical Evaluation of a Dental Glass Ceramic
A clinical trial with an experimental glass ceramic (shades A1, A2 and A3) to ensure the safety and efficacy of the product. It is a study with single-arm in which inlays and onlays for molars and premolars are adhesively luted.
- Trial name
- NCT04933123
- Testing
- indirect restorative treatment with a glass ceramic
- Where
- Liechtenstein
- Volunteers
- 13 people
- Sponsor
- Ivoclar Vivadent AG
Dental Caries, Unsatisfactory or Defective Restoration of Tooth
Clinical Investigation of the F-Composite 2 System in Direct Filling Therapy
The objective of this study is to evaluate the clinical performance of F-Composite 2 system in Class I and Class II cavities in permanent teeth.
- Trial name
- NCT03221660
- Testing
- F-Composite 2 system
- Where
- Liechtenstein
- Volunteers
- 50 people
- Sponsor
- Ivoclar Vivadent AG
Caries Pit and Fissure Limited to Enamel
Clinical Performance of Two Fissure Sealants
Comparison of the retention of a new fissure sealant (Helioseal F Plus) and a fissure sealant that has been on the market for years in children
- Trial name
- NCT03470129
- Testing
- fissure sealing
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Ivoclar Vivadent AG
Dental Cements, Caries,Dental
Clinical Performance of Chairside CAD/CAM Restorations
This investigation will be a longitudinal clinical trial to study the long-term clinical performance of a resin cement for chairside CAD/CAM restorations.
- Trial name
- NCT04279574
- Testing
- Lithium disilicate onlays (IPS emaxCAD/Ivoclar), Chairside zirconia crowns (3M)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Solventum US LLC
Dental Caries, Defective Tooth Restorations
Clinical Evaluation of Adhese Universal DC in the Indirect Restorative Therapy
A post market clinical follow up study (PMCF) with Adhese Universal DC is planned to ensure the safety and efficacy of the product. It is a study with two arms.
- Trial name
- NCT04475679
- Testing
- Adhese Universal DC, Adhese Universal
- Where
- Liechtenstein
- Volunteers
- 80 people
- Sponsor
- Ivoclar Vivadent AG
Caries
Salivary Fluoride Clearance
This is a single-center, four-treatment, four-period crossover study. Over the course of the study, up to thirty qualified subjects will use four (4) study treatment products, one time each according to the randomization.
- Trial name
- NCT06735235
- Testing
- 0 ppm F, 250 ppm F as MFP, 1100 ppm as MFP
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Decay
Clinical Evaluation of Lava Digital Veneer System (DVS) Crowns
Study aim is to compare Lava Computer Aided Design / Computer Aided Milling Computer Aided Machining (CAD/CAM)crowns that are veneered (covered) with porcelain that has been milled using CAD/CAM, with similar CAD/CAM Lava crowns…
- Trial name
- NCT01278862
- Testing
- DVS veneer, Conventional Veneer
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Solventum US LLC
Caries, Unsatisfactory or Defective Restoration of Tooth
Comparison of 2 Different Resin Based Filling Materials in Posterior Teeth - a Multicenter Study
The purpose of this study is to compare the clinical performance of a new resin based filling material to an established resin-based filling material in posterior teeth at 2 different study centers.
- Trial name
- NCT01925040
- Testing
- Placement of restoration
- Where
- 2 sites in United States, Germany
- Volunteers
- 130 people
- Sponsor
- Heraeus Kulzer GmbH