Clinical trials: Caries
Caries, Salivary Function
Lesion Progression After Icon Treatment in Young Adults
This is a three year single site clinical evaluation of a FDA approved (510(k):K100062) lesion penetrating resin used to infiltrate and hamper progression of proximal carious lesions.
- Conditions
- Caries, Salivary Function, Tooth Sensitivity
- Trial name
- NCT01988337
- Testing
- Resin infiltration, Mock treatment
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH
Cavities of Teeth
An Evaluation of Protective Effects of OpalSeal™ Against Early Dental Decay in Orthodontic Patients
Fluoride is very effective in preventing dental decay (cavities) when applied in the form of a varnish on tooth surfaces. The purpose of this study is to verify if fluoride-releasing primer (OpalSeal) offers more protection…
- Trial name
- NCT03722264
- Testing
- OpalSeal, TransbondXT
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Dental Caries, Quality of Life
Comparative Effectiveness of School-based Caries Prevention
Dental caries (tooth decay) is the most prevalent childhood disease in the world. Multiple interventions are available to treat and prevent caries.
- Trial name
- NCT03442309
- Testing
- Silver Diamine Fluoride, Fluoride Varnishes, Glass Ionomer
- Where
- United States
- Volunteers
- 7,418 people, healthy volunteers welcome
- Sponsor
- NYU College of Dentistry
Dental Caries
Efficacy of Three Toothpastes Using an in Situ Caries Model
This will be a single-centre, randomized, blinded, placebo-controlled, 6-treatment, 4-period crossover, incomplete block design, in situ caries study in healthy adults who wear a removable bilateral mandibular partial denture.
- Trial name
- NCT02751320
- Testing
- 0.425 % w/w phytate,1150ppm F, 0.85 % w/w phytate,1150ppm F, 0.85 % w/w phytate,0.3%ZnCl2 0.5% sodium citrate, 1150ppm F
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
Fissure Caries Inhibition Study With Solea CO2-9.3μm Short-pulsed Laser
The objective of this clinical study is to evaluate whether the use of the new CO2 - 9.3μm short-pulsed laser increases the caries resistance of occlusal pit and fissure surfaces in patients in addition to fluoride therapy.
- Trial name
- LaserFissure (NCT02357979)
- Testing
- Laser, Fluoride
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hydration, Dental Caries
Healthy Hydration Pilot in Elementary Schools
This study will pilot a school-based stakeholder-informed hydration intervention and examine its feasibility and preliminary efficacy.
- Conditions
- Hydration, Dental Caries, Body Mass Index
- Trial name
- NCT06132763
- Testing
- Hydration Intervention, Control - Assessments Only
- Where
- United States
- Volunteers
- 563 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Caries,Dental
Clinical Trial Proximal Caries Infiltration and Detection
The purpose of this study is to investigate the clinical efficacy of resin infiltration (Icon, DMG, Germany) compared to fluoride varnish (Duraphat Fluoride Varnish, Colgate, USA) in the management of proximal early caries…
- Trial name
- NCT01796106
- Testing
- Resin infiltration, Fluoride varnish & Oral hygiene instruction
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Caries
In Situ Caries Model of Fluoride Toothpastes
This study is to evaluate the effect of fluoride dentrifrices on enamel with artificial caries lesions in an in situ model
- Trial name
- NCT01005966
- Testing
- Sodium Fluoride Toothpaste, Amine Fluoride Toothpaste, Sodium monofluorophosphate/Sodium Fluoride Toothpaste
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
Efficacy Of A PVP-I Fluoride Varnish
The purpose of the study is to determine the efficacy of Advantage Anti-Caries Varnish. Single-center, double-blind, controlled Phase 2 study with parallel groups of children.
- Trial name
- NCT03082196
- Testing
- Test varnish, Standard varnish
- Where
- Micronesia
- Volunteers
- 284 people
- Sponsor
- Advantage Dental Services, LLC
Dental Caries
Xylitol for Caries Prevention in Inner-City Children
The purposes of this study is to determine whether xylitol use in kindergarten school children in addition to oral health education, provision of tooth brush and fluoride paste, fluoride varnish and sealant treatment will reduce…
- Trial name
- NCT01901250
- Testing
- Xylitol gummy bears, Sugar free fiber gummy bears, Oral health education
- Where
- United States
- Volunteers
- 562 people
- Sponsor
- Case Western Reserve University
Caries
In Situ Caries Efficacy of Fluoride Toothpastes
This study is to evaluate the effect of fluoride dentifrices on enamel with artificial caries lesions in an in situ model
- Trial name
- NCT00708097
- Testing
- NaF, NaMFP
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
Self Assembling Peptide P11-4 in Patients With Early Occlusal Carious Lesions
Objectives: Occlusal surfaces of erupting permanent molars are highly prone to caries. Self-assembling peptide (P11-4) has proven to enhance biomimetic mineralization of early carious lesions.
- Trial name
- NCT02724592
- Testing
- self assembling peptide P11-4 (Curodont™ Repair), fluoride varnish (Duraphat®)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Dental Caries
Comparative Study of Experimental Dental Adhesive With and Without Phosphoric Acid Pretreatment
The intent of this study is to evaluate the clinical performance of an experimental dental bonding agent for use with dental restorative composites with and without pretreatment of the tooth dentin and enamel using phosphoric…
- Trial name
- NCT02071953
- Testing
- Experimental adhesive w/out phosphoric acid in post. rest., Experimental adhesive with phosphoric acid in post. rest.
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Dentsply International
Dental Caries
Assessment of Caries Diagnosis and Caries Treatment in Dental PBRN Japan
The objective of this study is to examine what methods Dental PBRN Japan dentists adopt for diagnosis, treatment, and prevention of dental caries.
- Trial name
- NCT01680848
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Dental PBRN Japan
Dental Fluorosis, Dental Caries
Effect of pH and Fluoride Concentration of Dentifrices on Caries Control
This study aims to assess the overall effect of pH and fluoride concentration of liquid dentifrices in the control of children dental caries of a fluoridated area, through visual inspection and the quantitative light-induced…
- Trial name
- EPHFCDCC (NCT01049503)
- Testing
- Low fluoride and conventional dentifrices with different pH
- Where
- Brazil
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy Subjects, Partial Denture Wearers
In Situ Caries of Fluoride Toothpastes
This study is to evaluate the effect of fluoride dentifrices on enamel with artificial caries lesions in an in situ model.
- Conditions
- Healthy Subjects, Partial Denture Wearers, Caries
- Trial name
- NCT00708123
- Testing
- Sodium fluoride toothpaste
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Primary Dental Caries, Multisurface Origin (Diagnosis)
Clinical Trial NuSmile Crowns
A clinical trial comparing two types of NuSmile anterior crowns to composite strip crowns on anterior dental restorations.
- Trial name
- NCT04975321
- Testing
- Nu Smile Zirconia crown, Nu Smile Pre Veneered crown, Composite strip crown
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dental Caries
Clinical Evaluation of Kerr SonicFill™ 2 vs 3M ESPE Filtek™ Supreme Ultra Universal Restorative
The purpose of this study is to compare esthetic, functional and biological properties of two restoration materials used to fill cavities.
- Trial name
- NCT03032705
- Testing
- SonicFill™ 2, Filtek™ Supreme
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Tufts University
Dental White Spots, Dental Caries
MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study
The objective of this clinical study is to evaluate the efficacy of multiple applications of MI Varnish in combination with MI Paste Plus in caries protection and remineralization in comparison to the use of a control (Crest…
- Trial name
- GC-WS (NCT02424097)
- Testing
- CPP-ACP 5% sodium fluoride varnish & 900ppm fluoride paste, 1,100pm F-toothpaste and 0.5%NaF rinse
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Caries Infiltration, Fluorosis
Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains
Dental fluorosis is a clinical manifestation of chronic exposure to high intakes of fluoride during the tooth development. The present study is planned to evaluate the efficacy of Resin Infiltration technique in improving the…
- Conditions
- Caries Infiltration, Fluorosis, Dental Care
- Trial name
- NCT01733888
- Testing
- Office Bleaching, Resin Infiltration, Resin Infiltration twice
- Where
- 2 sites in India
- Volunteers
- 80 people
- Sponsor
- DMG Dental Material Gesellschaft mbH