Clinical trials: Carious Teeth
Dental Caries
Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations
This study will examine the clinical performance of Class II restorations over a three year period with 3 composite resins - a conventional composite resin, a flowable composite resin and a bulk placed and cured composite resin.
- Trial name
- NCT02889835
- Testing
- Supreme Universal Restorative, Supreme Flowable Restorative, Bulk Fill Flowable Restorative
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Dental Caries
Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride
This study will evaluate and compare the effect of the amount of toothpaste used and brushing time on enamel strengthening (percent of surface microhardness recovery, % SMHR) and enamel fluoride uptake (EFU).
- Trial name
- NCT01563172
- Testing
- Sodium fluoride / silica and carbopol, 0.5g, Sodium fluoride / silica and carbopol, 1.5g, Fluoride free dentifrice
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Caries, Dental, Tooth Decay
Efficacy of Solventum™ Vitrebond™ Pulp Protect Liner/Base Used as a Liner/Base Under Dental Restorations
This is a clinical study evaluating a new dental product called Solventum™ Vitrebond™ Pulp Protect Liner/Base. This new product is designed to be used as a liner or base between the tooth and the dental filling, as well as for a…
- Conditions
- Caries, Dental, Tooth Decay, Dental Decay, Tooth Sensitivity
- Trial name
- NCT07261137
- Testing
- Vitrebond™ Pulp Protect Liner/Base, Vitrebond™ Plus (comparator)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Solventum US LLC
Dental Caries
Research on the Characteristics and Application of Lactobacillus Rhamnosus X253 as Oral Probiotics
The aim of the study is to study the application of Lactobacillus rhamnosus X253 as oral probiotics by the way of a randomised, double blinded, parallel, placebo-controlled clinical trial, and to eto detect the changes in oral…
- Trial name
- NCT05123651
- Testing
- Lactobacillus rhamnosus X253
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Junlebao Dairy Group Co., Ltd.
Dental Caries
Effect of 12 Months Supplementation With a Symbiotic Lozenge on Caries Increment in Healthy Children
The primary objective of this trial is to investigate the effect of a symbiotic lozenge on dental caries in young children.
- Trial name
- PiP-C (NCT03928587)
- Testing
- 2 billion CFU in total of the two strains Lactobacillus paracasei subsp. paracasei and Lactobacillus rhamnosus and arginine.
- Where
- Denmark
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Dental Caries
Clinical Study on a New Flowable Composite as a Restorative in Adult Teeth
Study hypothesis: a new, low polymerization stress flowable composite performs no differently to a conventional, highly filled composite filling material when used as a restorative in small cavities in back teeth.
- Trial name
- NCT01369108
- Testing
- Flowable composite, Conventional composite restorative
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Solventum US LLC
Dental Caries Class I, Dental Caries Class II
Clinical Study of Filtek™ Bulk Fill Posterior Restorative in Class I and II Restorations
Purpose of the Study:This study was to evaluate the 1 week, 1 year safety and effectiveness of dental composite resin (Filtek™ Bulk Fill Posterior Restorative) in restoring Class I and II dental cavities in posterior teeth.
- Trial name
- NCT03764059
- Testing
- Filtek™ Bulk Fill Posterior Restorative, Filtek™ Z350XT Universal Restorative
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- 3M
Dental Caries
Oral-Spray Bacillus Spore Probiotic in Preventing and Supporting Treatment of Dental Caries in Children
Despite advances in oral health care, cavities remain highly prevalent worldwide, especially among children. Conventional treatment methods focus on removing damaged tooth tissue but fail to completely eliminate or control…
- Trial name
- NCT07241052
- Testing
- oral-spray 0.9% NaCl physiological saline solution, Smile Care
- Where
- Vietnam
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Anabio R&D
Elderly, Periodontal Disease
Oral Hygiene Assistance Training Program
This is an oral health study with a nursing home staff training program and product intervention.
- Conditions
- Elderly, Periodontal Disease, Gingivitis, Caries,Dental
- Trial name
- NCT07807397
- Testing
- Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Decay
Clinical Evaluation of Lava Digital Veneer System (DVS) Crowns
Study aim is to compare Lava Computer Aided Design / Computer Aided Milling Computer Aided Machining (CAD/CAM)crowns that are veneered (covered) with porcelain that has been milled using CAD/CAM, with similar CAD/CAM Lava crowns…
- Trial name
- NCT01278862
- Testing
- DVS veneer, Conventional Veneer
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Solventum US LLC
Dental Caries
Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste
This single-center, randomized, double-blind, three-period crossover in situ study evaluated the enamel remineralization potential and fluoride bioavailability of three dentifrices: a fluoride-free negative control, a positive…
- Trial name
- NCT07419763
- Testing
- Negative Control Toothpaste, Active Comparator, Test toothpaste
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Disintegration, Healthy
Scintigraphy Study to Evaluate the Gastrointestinal Behavior of EDP1815 Oral Dosage Forms
This study is to find out how different types of capsules or tablets containing EDP1815 move through the GI tract and release the drug after being swallowed.
- Trial name
- NCT05066373
- Testing
- EDP1815 capsule A, EDP1815 capsule B, EDP1815 tablet
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Evelo Biosciences, Inc.
Enamel Lesions, Demineralization, Tooth
Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralization In-Situ Model
Clinical study to evaluate the anti-cavity efficacy of three dentifrices using an intra-oral enamel Demineralization - Remineralization In-Situ Model. This is a Phase III, single-center, triple-blind with a crossover design.
- Conditions
- Enamel Lesions, Demineralization, Tooth, Remineralization, Dental Cavity
- Trial name
- REPAIR (NCT06732518)
- Testing
- Fluoride Toothpaste, Fluoride free toothpaste in a chalk base, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Caries
Effect of a Novel Sweetener on the pH of Dental Plaque.
Bacteria that live in the mouth can digest fermentable carbohydrates such as sucrose, fructose, and glucose to make acid. This acid can cause demineralization of the tooth and lead to dental caries or decay.
- Trial name
- NCT00739778
- Testing
- food - novel sweetener, food vehicle blank, food - sweetener, positive control
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cargill
Dental Caries in Children
Multi-Media Parent-based Intervention to Promote Dental Hygiene Among Young Children: BeReady2Smile
This application, BeReady2Smile, will promote dental health behavioral parenting strategies among parents by incorporating a behavioral program for their children.
- Trial name
- BR2S (NCT03637309)
- Testing
- BeReady2Smile Video and App
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Demineralization, Remineralization
Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ Model
Clinical study to evaluate the anti-cavity effectiveness of three dentrifices using an intra-oral enamel Demineralization and Remineralization In-Situ Model.
- Conditions
- Demineralization, Remineralization, Dental Cavity, Enamel Lesions
- Trial name
- NCT07134231
- Testing
- Fluoride free toothpaste in a chalk base, Fluoride Toothpaste, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Cavity, Dental
Clinical Performance of Bulk-fill Restorations in Class II Cavities
Direct composite resin restorations are considered an essential treatment option in the dental clinic because of increasing the demands for esthetics.
- Trial name
- NCT06461364
- Testing
- Assessment of cuspal deflection of bulk-fill restorations
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Egymedicalpedia
Dental Caries
Pharmacokinetics of Advantage Arrest
The study aim is to characterize the kinetics of silver and fluoride after topical application of silver diamine fluoride.
- Trial name
- NCT04184271
- Testing
- 38% silver diamine fluoride
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Caries Active, Caries Root
Surface Caries Feature Study
Dental caries (dental cavity) is very common and can impact oral health and oral health-related quality of life. Dental caries is when the tooth surfaces break down, and if left untreated, can cause tooth pain.
- Conditions
- Caries Active, Caries Root, Caries,Dental, Caries; Initial
- Trial name
- NCT07048444
- Testing
- N/A as observational study
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- 3Shape A/S
Dental Caries
Effects of a Hydroxyapatite-based Mouth Gel on Calcium Content of Plaque
The aim of this pilot study is to analyze if a hydroxyapatite-containing mouth gel has an influence on the calcium content of plaque.
- Trial name
- NCT03956992
- Testing
- Mouth gel
- Where
- Indonesia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Dr. Joachim Enax