Clinical trials: Carious Teeth
Remineralization Potential, Dentin Caries
Clinical Performance and Remineralization Potential of Self- Assembling Peptide P11-4 Containing Fluoride Versus Er, Cr: YSGG Laser Treatment and Micro Tensile Bond Strength of Giomer Restoration in Carious Lesions
This study will be performed in two parts, in vivo and in vitro to assess the effect of the remineralization potential of self-assembling peptide P11-4 containing Fluoride on caries-affected dentin compared to untreated…
- Trial name
- NCT07065305
- Testing
- Curodont Repair Fluoride Plus (Self-assembling peptide remineralization agent)P11-4 peptide, fluoride, mild acidic buffer (pH ~4.5) , Credentis AG, Switzerland, Beautifil II LS
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Dental Caries, Tooth Demineralization
Kissing as a Protective Factor Against Acidic pH in Saliva
The pH of saliva can be acidic or alkaline; When it is acidic, the tooth enamel is demineralized, that is, weakened. Additionally, bacteria in the mouth can increase and cause infections such as cavities.
- Conditions
- Dental Caries, Tooth Demineralization, Teeth Erosion Limited to the Enamel
- Trial name
- NCT06501729
- Testing
- Kiss
- Where
- Ecuador
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Universidad Catolica Santiago de Guayaquil
Dental Caries
2-year Caries Clinical Study: Arginine Fluoride-Free Toothpastes vs. NaF Toothpaste
The objective of this study is to evaluate the anticaries efficacy for three dentifrices (1.5% arginine in a calcium base, 8.0% arginine in a calcium base, and 0.32% sodium fluoride in a silica base) in a two-year caries clinical…
- Trial name
- NCT05560945
- Testing
- 0.32% Sodium Fluoride Dentifrice Toothpaste, 1.5% Arginine Dentifrice, 8.0% Arginine Dentifrice
- Where
- 3 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Caries, Dental
Role of Aloe Vera Versus Fluoride Toothpaste in Changing High to Low Salivary Bacterial Count
Patient's salivary bacterial count will be evaluated , then the patient will bbe instructed to follow oral hygiene measures including the use of aloe vera toothpaste or fluoride toothpaste , the after 15 days and 30 days the…
- Trial name
- NCT03108313
- Testing
- aloe vera toothpaste, fluoride toothpaste
- Where
- Egypt
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Cost-effectiveness of Four Methods in Preventing Fissure Caries in Permanent Teeth
The aim of this proposed study is to investigate the cost-effectiveness of four methods in preventing fissure caries in permanent teeth, which is the most prevalent dental disease in primary school children in China.
- Trial name
- NCT01829334
- Testing
- ART dental sealant, Resin dental sealant, Sodium fluoride varnish
- Where
- China
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Periodontal Diseases, Inflammation Gum
Evaluation of Oral Condition and the Effect of Dental Treatment on Physical Parameters of Athletes
It is essential that athletes have perfect general health. Oral health plays an important role in this healthy framework necessary so that the results that must be achieved by athletes are not influenced.
- Conditions
- Periodontal Diseases, Inflammation Gum, Caries,Dental
- Trial name
- NCT04251858
- Testing
- Dental Scaling, Oral hygiene instruction
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidade Metropolitana de Santos
Class II Dental Caries, Sensitivity, Tooth
Post-operative Sensitivity in Composite Restorations
Participants will be divided into groups. In group A, Composite restoration done using oblique incremental technique. In group B, Bulk-fill technique was used.
- Trial name
- NCT06092567
- Testing
- Group A ( Oblique Incremental Placement Technique), Group B (Bulk-fill Placement technique)
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Class V Dental Caries
Clinical Evaluation of Giomer Based Injectable Resin Composite Versus Resin Modified Glass Ionomer in Class V Carious Cavities Over 18-months.
Class V carious lesions will be restored using either Resin modified glass ionomer or Giomer based injectable resin composite.The restorations will be evaluated at baseline and regular recalls of 3 months, 6 months, 12 months and…
- Trial name
- NCT05389163
- Testing
- Giomer based injectable resin composite, Resin modified glass ionomer
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Pharmacokinetics of Advantage Arrest in Children
The purpose of this study is to characterize basic PK parameters (Cmax, t1/2, AUC) in healthy children to contribute to evidence for the safety of Advantage Arrest, consistent with Guidance for Industry--Exposure--Response…
- Trial name
- NCT04186663
- Testing
- Silver Diamine Fluoride
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Deep Dental Caries
Randomized Clinical Trial for Primary Molar Pulpotomy, Biodentine Vs Formocresol-ZOE
This is a RCT that will compare the clinical and radiographic success of pulpotomies on primary molars between the traditional technique (Formocresol/ZOE) and the new technique with Biodentine.
- Trial name
- NCT02201498
- Testing
- Pulpotomies with Formocresol/OZE and Biodentine
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Caries, Dental
Comparing Hall vs Conventional Technique in Placing Preformed Metal Crowns From Sudan
Preformed metal crowns (PMCs) have high success rates in restoring primary molars in children but they were not generally used by dentists, especially in developing countries due to its demand of high clinical skills with the…
- Trial name
- NCT03640013
- Testing
- Hall Technique PMC
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Khartoum Centre for Research and Medical Training
Acute Otitis Media, URTI
Xylitol for the Prevention of Acute Otitis Media Episodes in Children
This is a randomized controlled trial of regular daily use of xylitol (or "birch sugar"), a natural sweetener that has antimicrobial properties, for the prevention of acute otitis media (AOM, primary outcome) as well as upper…
- Conditions
- Acute Otitis Media, URTI, Dental Caries in Children
- Trial name
- POME-Xylitol (NCT03055091)
- Testing
- Xylitol syrup
- Where
- 2 sites in Canada
- Volunteers
- 472 people
- Sponsor
- Unity Health Toronto
Dental Caries
Caries Transmission Prevention in Alaska Native Infants
The purpose of this study is to conduct a community based, randomized control trial to determine if the use of chlorhexidine mouth rinse and xylitol-sweetened chewing gum will reduce the vertical transmission of caries between…
- Trial name
- NCT00067340
- Testing
- Chlorhexidine mouth rinse, Xylitol chewing gum
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dental Caries
In Vivo Comparison of Salivary Fluoride Levels Following the Application of Different 5% NaF Varnishes
This study will be a cross-over single blinded clinical study to evaluate the in vitro fluoride release of three different brands of 5% NaF varnish.
- Trial name
- NCT01629290
- Testing
- Enamel Pro, Duraphat, Vanish
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Dental Caries in Children, Tooth Erosion
3D Scanning as an Advanced Tool for Identifying Tooth Lesions in Children
This study focuses on assessing dental caries, erosive tooth wear, and fluorosis in primary teeth using a 3D intraoral digital scanner.
- Conditions
- Dental Caries in Children, Tooth Erosion, Fluorosis, Dental, Dental Caries
- Trial name
- NCT06829550
- Testing
- indirect- 3D digital scanning
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Indiana University
Dental Caries
Performance of Glass-ionomer Cements: 2-year Follow-up
The purpose of this randomized clinical trial was evaluate the performance of two conventional glass-ionomer cements in the pit and fissure sealing and atraumatic restorative treatment in high caries risk children.
- Trial name
- NCT02659917
- Testing
- Glass ionomer, Glass ionomer cement, -Glass ionomer-
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Fernanda Miori Pascon
Caries Experience
Evaluation of Dental Caries Using Caries Assessment Spectrum and Treatment Need (CAST) Index, International Caries Detection and Assessment System (ICDAS) Index and World Health Organization (WHO) Index
This study goals is to compare the three indices in Egyptian children aged 4 to 6 years in caries detection and time needed for the assessments which will contribute to valuable data for pediatric oral health assessments both…
- Trial name
- CAST/ICDAS/WHO (NCT06858462)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Microbial Colonization
Er:YAG Laser Effects on Microbial Population in Conservative Dentistry
The aim of this study is to verify the quantitative and qualitative effect of Erbium dental laser therapy on microbial populations in carious lesions and to compare the laser therapy with traditional conservative therapies.
- Trial name
- NCT04769882
- Testing
- Er:YAG Laser
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Dental Restoration, Permanent, Dental Restorations
Clinical Investigation Measuring the Long Term Clinical Performance and Safety of Biodentine™ XP in Patients Treated for Coronal Restorative or Endodontic Dental Indications.
The aim of this present study is to collect additional data for the post-marketing follow-up of Biodentine™ XP and measure long-term (up to 10 years) performance and safety of the biomaterial in all its indications.
- Conditions
- Dental Restoration, Permanent, Dental Restorations, Endodontic Treatment
- Trial name
- BIOD XP (NCT06955429)
- Testing
- Dental restorative or endodontic treatment requiring Biodentine XP use
- Where
- 8 sites in Belgium, France
- Volunteers
- 275 people
- Sponsor
- Septodont
Class IV Dental Caries
Evaluate the Shade Matching of Polychromatic Versus Monochromatic Composite Layering Techniques in Fractured Class IV Maxillary Central Incisors Using Universal , Layering & One Shade Composite In-vivo on Patients
The goal of this clinical trial is to evaluate shade matching ability of different techniques of application and different materials of resin composite restorations in class IV carious lesions
- Trial name
- NCT06743984
- Testing
- Polychromatic resin composite, Monochromatic resin composite
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Badr University
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