Clinical trials: Carotid Arteriosclerosis
Coronary Artery Disease, Cerebrovascular Disease
RESTORE-IT-Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients With a History of Atherosclerotic Disease
The objective of this study is to evaluate an antibiotic therapy called Rifalazil to determine its effect on hardening of the carotid arteries.
- Conditions
- Coronary Artery Disease, Cerebrovascular Disease, Peripheral Vascular Disease
- Trial name
- NCT00385385
- Testing
- Rifalazil
- Where
- 6 sites in United States, Canada
- Volunteers
- 72 people
- Sponsor
- ActivBiotics
Coronary Artery Disease, Aortic Valve Disease
Robustness Check of Placement and Measurement Algorithms for Blood Flow Measurement on Common Carotid Artery
This study is set up to test the robustness of algorithms and models and to optimize them. Furthermore, data are used to investigate the influence of probe orientation on parameters of the common carotid artery.
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- RAdiUS (NCT05193760)
- Where
- Netherlands
- Volunteers
- 67 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Carotid Stenosis, Carotid Atherosclerosis
Comparison Between Different Techniques for Carotid Artery Endarterectomy
the goal of this interventional study is to compare between the conventional and the Eversion techniques in performing carotid endarterectomy in patients with carotid artery stenosis the main question it aim to answer is which…
- Conditions
- Carotid Stenosis, Carotid Atherosclerosis, Carotid Artery Plaque
- Trial name
- NCT06207643
- Testing
- carotid endarterectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Coronary Artery Disease
Fluid Responsiveness Through the Corrected Carotid Flow Time, Before and After Sternotomy
Perioperative fluid management is used to maintain the perfusion of vital organs, prevent hypovolemia, inadequate tissue perfusion, and tissue edema, and cardiovascular complications caused by the infusion of large amounts of…
- Trial name
- NCT06967142
- Testing
- Correcte Carotid flow measurement by USG Doppler
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Endstage Renal Disease, Diabetes
Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) Agonist in Diabetic End-Stage Renal Disease Patients
To test the hypothesis that PPAR-gamma agonist, rosiglitazone, induces carotid plaque regression in diabetic ESRD patients on maintenance PD via its anti-inflammatory property.
- Trial name
- NCT00745914
- Testing
- Pioglitazone
- Where
- 2 sites in Hong Kong
- Volunteers
- 22 people
- Sponsor
- The University of Hong Kong
Coronary Artery Disease, Carotid Plaque
Association Between Carotid Plaque Length and Cardiovascular Outcomes
This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No.
- Trial name
- NCT05843487
- Where
- 5 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Changhai Hospital
Atherosclerosis of Artery, Carotid Endarterectomy
Associations of Carotid Plaque Characteristics With Brain Perfusion and Cognitive Function in Patients Undergoing CEA
Stroke is one of the leading causes of death and disability-adjusted life-years worldwide. Carotid high-risk atherosclerotic plaques are considered to be one of the major sources of ischemic stroke.
- Trial name
- NCT04955015
- Testing
- carotid endarterectomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Atherosclerosis
Carotid Atherosclerotic Plaque Study
First, to establish a comparison of the pathophysiology of carotid atherosclerosis and the genetic and environmental variables that cause those plaques to become symptomatic.
- Trial name
- NCT00214006
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Wisconsin, Madison
Left Main Coronary Artery Disease, Left Anterior Descending Coronary Artery Stenosis
Prospective Evaluation for Hybrid Cardiac Procedures
Multidisciplinary team-approach in order to offer personalized treatments represents the emerging mainstream in cardiovascular medicine.
- Conditions
- Left Main Coronary Artery Disease, Left Anterior Descending Coronary Artery Stenosis, Valve Disease, Heart, Carotid Stenosis
- Trial name
- PERHAPS (NCT05143671)
- Testing
- Coronary artery bypass grafting, Percutaneous coronary intervention, Surgical valve replacement
- Where
- Italy
- Volunteers
- 134 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Choroid Disease, Carotid Stenosis
Ophthalmologic Outcomes in Patients With Carotid Artery Stenosis
The retinal vessels have been shown to reflect vascular changes inherent to systemic pathologies, even when no ocular disease is identified.
- Conditions
- Choroid Disease, Carotid Stenosis, Carotid Atherosclerosis, Retinal Disease
- Trial name
- NCT05623293
- Testing
- eye - Optcial coherence tomography
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Universidade do Porto
Coronary Artery Disease, Diabetes Mellitus, Type 2
Exercise Training in Patients With Coronary Heart Disease and Type 2 Diabetes
Diabetes mellitus (DM) is an important risk factor in the development of cardiovascular disease, and people with type 2 diabetes have a two- to four-fold increased risk for cardiovascular morbidity and mortality.
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Atherosclerosis
- Trial name
- EXCADI (NCT01232608)
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 137 people
- Sponsor
- Oslo University Hospital
Hypercholesterolemia, Hypercholesterolemia, Familial
PET Imaging of Inflammation and Lipid Lowering Study
While 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging has been used as an early marker of drug efficacy in numerous clinical cardiovascular drug trials, as a glucose analog, its signal in the vasculature…
- Conditions
- Hypercholesterolemia, Hypercholesterolemia, Familial, Atherosclerosis, Carotid Artery Plaque
- Trial name
- PIILL (NCT04073797)
- Testing
- Inclisiran, 68Ga-DOTATATE PET-MRI, Colchicine
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Cambridge
HIV, Menopause
The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women
Menopause is associated with the acceleration of many comorbidities, including cardiovascular disease. Whether HIV and menopause together increase cardiovascular disease risk is a key knowledge gap.
- Conditions
- HIV, Menopause, Cardiovascular (CV) Risk, Carotid Arteriosclerosis
- Trial name
- NCT07284082
- Testing
- Whole body MRI
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Francisco
Peripheral Artery Disease, Carotid Artery Stenosis
Study on PAD and CAS Based on Omics and Imaging
This study aims to investigate the pathogenesis of Peripheral Artery Disease (PAD) and Carotid Artery Stenosis (CAS) using a comprehensive multi-omics and multi-modal imaging approach.
- Conditions
- Peripheral Artery Disease, Carotid Artery Stenosis, Artery Stenosis
- Trial name
- NCT06917547
- Volunteers
- 100 people
- Sponsor
- Yijie Ning
Asymptomatic, Artery
Stenting Versus Best Medical Treatment of Asymptomatic High Grade Carotid Artery Stenosis
Background. Carotid artery stenting (CAS) recently has become an accepted method for treatment of patients with high-grade carotid artery stenosis, who are at an increased risk for surgical carotid endarterectomy (CEA).
- Trial name
- NCT00497094
- Testing
- carotid artery stenting
- Where
- Austria
- Volunteers
- 148 people
- Sponsor
- Vienna General Hospital
Dyslipidemia, Atherosclerosis
Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT)
Dyslipidaemia is characterized by low plasma levels of high-density lipoprotein cholesterol (HDL-c), elevated triglycerides and an increase in low density lipoprotein (LDL-c) particles, and has been unequivocally established as a…
- Trial name
- NASCIT (NCT00712049)
- Testing
- simvastatin, Nicotinic Acid
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
Carotid Artery Diseases, Stroke
The Role of Maintaining External Carotid Artery Flow in Graft Interposition After Carotid Endarterectomy
Analyzing results of carotid graft interposition with and without flow preservation through external carotid artery after endarterectomy.
- Conditions
- Carotid Artery Diseases, Stroke, Carotid Atherosclerosis
- Trial name
- AGICS (NCT06528717)
- Testing
- Carotid graft interposition
- Where
- Serbia
- Volunteers
- 250 people
- Sponsor
- Institute for Cardiovascular Diseases Dedinje
Coronary Artery Disease, Cardiomyopathy
Carotid Ultrasound in the Evaluation of Heart Failure
Coronary artery disease (CAD, cholesterol plaque buildup in the heart arteries) is the most common cause of left ventricular systolic dysfunction (weakening of the heart muscle).
- Conditions
- Coronary Artery Disease, Cardiomyopathy, Heart Failure
- Trial name
- CUE-HF (NCT00810550)
- Testing
- Carotid ultrasound
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Atherosclerosis
Subclinical Atherosclerosis in Juvenile Systemic Lupus Erythematosus
The aim of this study is to evaluate subclinical atherosclerosis in children and adolescents with juvenile SLE by measuring carotid intima-media thickness (CIMT), and to determine its associations with traditional cardiovascular…
- Trial name
- NCT07545408
- Volunteers
- 70 people
- Sponsor
- Assiut University
Carotid Artery Stenosis
Evaluation of a Novel Technique to Diagnose Carotid Artery Stenosis
The purpose of this study is to determine the accuracy of a new non-invasive device, the Carotid Stenotic Scan (CSS), to check for stenosis of the internal carotid artery (ICA) as compared to a carotid ultrasound study.
- Trial name
- NCT03464851
- Testing
- Carotid Stenotic Scan (CSS)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- The Cleveland Clinic