Clinical trials: Carotid Artery Atheroma
Carotid Atherosclerosis
RLIP76 in Human Serum in Adults With Rheumatologic Diseases
It is the investigators aim to determine the feasibility of directly detecting anti-RLIP76 auto-antibodies in human serum using prepared RLIP76 antigen peptides in persons with rheumatologic disease and persons without…
- Trial name
- NCT00861159
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center
Carotid Atherosclerosis, Carotid Artery Disease
ACCULINK for Revascularization of Carotids in High Risk Patients "The ARCHeR Trial"
1. To evaluate the safety and efficacy of the over-the-wire (OTW) ACCULINK (tm) System in patients deemed to be either at high risk or unsuitable for carotid endarterectomy (CEA) 2.
- Trial name
- NCT00180518
- Testing
- Over-the-wire & Rapid Exchange ACCULINK (tm) Carotid Stent & ACCUNET (tm) embolic protection system
- Volunteers
- 581 people
- Sponsor
- Abbott Medical Devices
Carotid Atherosclerosis, Carotid Stenosis
Carotid Arteries Stenting Complications: Transradial Approach Versus Transfemoral
The aim is to compare the safety of using transfemoral and transradial approach in patient undergoing carotid arteries stenting.
- Conditions
- Carotid Atherosclerosis, Carotid Stenosis, Ischemic Attack, Stroke
- Trial name
- NCT02722720
- Testing
- Transradial carotid artery stenting, Transfemoral carotid artery stenting
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Atheroma; Carotid Artery, Atheromatosis
Assessment of Platelet-derived GARP in Atherosclerotic Disease
The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions.
- Trial name
- CAPGAD (NCT07364058)
- Testing
- Tissue sample and data collection
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Université Catholique de Louvain
Carotid Atherosclerosis
PET Detection of CCR2 in Human Atherosclerosis
: Use of novel radio-pharmaceutical 64CUDOTA-ECL1i to evaluate arterial atherosclrosis
- Trial name
- NCT04537403
- Testing
- Group 1-64CU-DOTA-ECL1i (radioactive imaging medicine), Group 2 64CU-DOTA-ECL1i (radioactive imaging medicine)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Coronary Artery Disease, Diabetes Mellitus, Type 2
Exercise Training in Patients With Coronary Heart Disease and Type 2 Diabetes
Diabetes mellitus (DM) is an important risk factor in the development of cardiovascular disease, and people with type 2 diabetes have a two- to four-fold increased risk for cardiovascular morbidity and mortality.
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Atherosclerosis
- Trial name
- EXCADI (NCT01232608)
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 137 people
- Sponsor
- Oslo University Hospital
HIV Infection, Carotid Atherosclerosis
Influence of Pravastatin on Carotid Artery Structure and Function in HIV-infected Patients Under Antiretroviral Therapy
The advent of new antiretroviral agents, in particular Highly Active Antiretroviral Therapy (HAART), spectacularly reduced HIV-associated morbidity and mortality.
- Conditions
- HIV Infection, Carotid Atherosclerosis, Dyslipidemia
- Trial name
- NCT00147797
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Saint Antoine University Hospital
Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases
Immunomodulatory Effects of PCSK9 Inhibition
Cardiovascular disease (CVD) represents the leading cause of death worldwide. While medications, such as statins, significantly reduce atherosclerotic CVD (ASCVD) risk by lowering low density lipoprotein levels, they may also…
- Conditions
- Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases, Atherosclerosis, Arterial Inflammation
- Trial name
- INSPIRAR (NCT05720156)
- Testing
- 99mTc-tilmanocept SPECT/CT scanning
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Subclinical Carotid Atherosclerosis
Autonomic Testing in Subclinical Carotid Atherosclerosis
Background: Atherosclerotic carotid intima-media thickness (IMT) may be associated with alterations in the sensitivity of carotid and subclavian baroreceptors.
- Trial name
- AtheroDetect (NCT02726321)
- Volunteers
- 101 people
- Sponsor
- Universidade Camilo Castelo Branco
Atherosclerosis
Carotid Atherosclerotic Disease Following Childhood Scalp Irradiation
Background: During the first half of the 20th century, scalp irradiation was a standard treatment for induction of epilation in children suffering from Tinea Capitis.
- Trial name
- NCT00590421
- Where
- Israel
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Myocardial Infarction, Atheroma
Identification of Asymptomatic Patients at Very High Cardiovascular Risk: Contribution of a Strategy Based on Carotid and Coronary Explorations, Compared to Simple Risk Calculation Using the European "SCORE 2" Algorithm. (IDEA-CVR)
To prevent myocardial infarction ( MI), coronary atheroma development by LDL-cholesterol deposition in the arterial wall is the basis.
- Conditions
- Myocardial Infarction, Atheroma, Cholesterol, Cardiovascular (CV) Risk
- Trial name
- IDEA-CVR (NCT07252830)
- Testing
- SCORE2
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Elsan
Diabetes Mellitus, Type 2, Atherosclerosis of Artery
Molecular Mechanisms and Carotid Atherosclerosis
The role of methylase system and Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the accelerated atherosclerotic progression of diabetic patients is unclear.
- Conditions
- Diabetes Mellitus, Type 2, Atherosclerosis of Artery, Atherosclerotic Plaque
- Trial name
- NCT03962686
- Testing
- statin Oral Tablet plus PCSK9i
- Where
- Italy
- Volunteers
- 76 people
- Sponsor
- University of Campania Luigi Vanvitelli
Plaque, Atherosclerotic
Molecular Imaging of Plaque Vulnerability
Accumulating data in the literature suggests that radiolabeled-choline (18F-choline) is a sensitive molecular tracer for PET imaging that is taken up in activated cells and, as such, is able to identify active inflammatory sites.
- Trial name
- PARISK (NCT02640313)
- Testing
- 18F-choline PET-MR imaging
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Maastricht University Medical Center
Cardiovascular Diseases
Effect of High Dose Vitamin E on Carotid Atherosclerosis
The primary aim of the present study is to test the effect of alpha-tocopherol supplementation on the progression of carotid atherosclerosis in patients with coronary artery disease
- Trial name
- NCT00010699
- Testing
- Vitamin E
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Atherosclerosis, Inflammation
Atherosclerosis and Acute Ischemic Stroke Study
A significant proportion of strokes are thromboembolic in nature, arising from atherosclerotic plaque at the carotid bifurcation. It is now wellknown that inflammation plays a key role in atherogenesis and plaque destabilization.
- Conditions
- Atherosclerosis, Inflammation, Ischemic Stroke
- Trial name
- NCT03685006
- Where
- Norway
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Carotid Atherosclerosis, Stroke
Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque
The aim of the present study is to examine the atherosclerotic plaque stability using in vivo and in vitro techniques and to investigate the influence of exercise, anti-diabetic, lipid-lowering and cannabinoids receptor…
- Conditions
- Carotid Atherosclerosis, Stroke, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT00636766
- Testing
- atorvastatin, rimonabant, rosiglitazone
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Cryptogenic Stroke
Cardiac Abnormalities in Stroke Prevention and Risk of Recurrence
This is a multi-center retrospective analysis of consecutive adult patients with cryptogenic stroke patients following a comprehensive workup for the underlying stroke etiology.
- Trial name
- CASPR (NCT06398366)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Cooper Norcross Health
Internal Carotid Artery, Atheromatous Stenosis
Assessment of Vulnerability to Carotid Stenosis by MultiModal Imaging and Cellular and Molecular Biology Analysis
Cerebrovascular accidents (CVA) are the second leading cause of death in France, and the most frequent cause of acquired physical and mental disability.
- Trial name
- EVA3M (NCT05190510)
- Testing
- Data collection, collection of the carotid plaque (surgical specimen), anatomopathological, histological, cellular and molecular biology examinations (metabolomics and transcriptomics) on surgical specimens
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Carotid Atherosclerosis
Imaging 61CuATSM Uptake in Atherosclerotic Plaque Using PET-CT
The build up of plaque in the wall of the artery supplying blood to the brain poses a risk of stroke when the plaques become unstable and fragile.
- Trial name
- NCT01000181
- Testing
- PET-CT with CuATSM
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- King's College London
Carotid Stenosis, Carotid Artery Diseases
Carotid Stenosis Management During COVID-19 Era - Pilot Study
Carotid endarterectomy (CEA) and carotid stenting (CAS) are often performed for subgroups of patients for whom procedural benefit has not been established in randomised trials and despite evidence of serious procedural risk.
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Embolus
- Trial name
- CASCOM-Pilot (NCT04947046)
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Zealand University Hospital