Clinical trials: Carotid Artery Atheroma
Carotid Atherosclerosis
Carotid Risk Prediction (CRISP) Consortium
Develop adverse event prediction and plaque phenotype classification models for patients with known or suspected carotid artery disease.
- Trial name
- CRISP (NCT04448353)
- Testing
- vascuCAP
- Where
- 5 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Elucid Bioimaging Inc.
Vascular Disease
Correlation Between Coronary and Carotid Atherosclerotic Disease and Links With Clinical Outcomes
The relationship of the natural history of atherosclerosis between different vascular beds has not been well characterized. Determination and comparison of the relative rates of progression and extents of atherosclerosis in the…
- Trial name
- NCT02114541
- Where
- 69 sites in United States, Canada and 3 more
- Volunteers
- 1,339 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Atherosclerotic Disease, Plaque, Atherosclerotic
Natural History of Carotid Plaque as Determined by 3D Ultrasound
This proposed follow-up study aims to recruit participants from the original BioImage cohort for a one-time follow-up examination.
- Conditions
- Atherosclerotic Disease, Plaque, Atherosclerotic, Heart Diseases, Stroke
- Trial name
- BioImage2 (NCT03314818)
- Testing
- Ultrasound 3D Imaging
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Pieter Muntendam
Atherosclerosis, Heterozygous Familial Hypercholesterolemia
Efficacy and Safety of the ACAT Inhibitor CS-505 (Pactimibe) for Reducing the Progression of Carotid Artery Disease. This Study is Also Known as CAPTIVATE.
The effects of pactimibe versus placebo on the progression of atherosclerosis in the carotid arteries will be assessed using standard ultrasound techniques.
- Trial name
- NCT00151788
- Testing
- Pactimibe sulfate
- Where
- 37 sites in United States, Canada and 7 more
- Volunteers
- 796 people
- Sponsor
- Daiichi Sankyo
Carotid Artery Diseases, Carotid Atherosclerosis
The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Evaluation
The goal of this evaluation is to document the incidence of post procedure DW-MRI lesions (relative to baseline) in patients treated with the transcarotid artery revascularization (TCAR) procedure.
- Conditions
- Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Stenosis, Carotid Artery Plaque
- Trial name
- DW-MRI-US (NCT03982420)
- Testing
- Transcarotid Revascularization (TCAR)
- Where
- 6 sites in United States, Spain
- Volunteers
- 55 people
- Sponsor
- Silk Road Medical
Carotid Artery, Carotid Arteriosclerosis
Predicting High-Risk Carotid Plaque: Integrating radioMics and biomEchanics
Non-pharmacological interventional study for the development of a predictive model aimed at identifying unstable carotid plaques in asymptomatic patients at first diagnosis, with the use of biological material and…
- Trial name
- PRIME (NCT07877480)
- Testing
- Radiomic features analysis
- Where
- Italy
- Volunteers
- 420 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Atherosclerosis
Relation of Circulating Endothelium-derived Microparticle to Carotid Atherosclerosis
The investigators hypothesized that circulating endothelium-derived microparticle (EMP) may be a useful surrogate marker of atherosclerosis and future episode of cerebrovascular events.
- Trial name
- NCT00795067
- Where
- Japan
- Volunteers
- 154 people
- Sponsor
- Kurume University
Atherosclerosis, Aortic Aneurysm
Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques
Lipid-rich atherosclerotic plaques, or "vulnerable plaques" are prone to rupture, causing local intravascular thrombosis, with subsequent grave clinical consequences.
- Conditions
- Atherosclerosis, Aortic Aneurysm, Peripheral Vascular Diseases
- Trial name
- NCT00449306
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center
Carotid Artery Stenosis, Carotid Atherosclerosis
Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis
This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of…
- Conditions
- Carotid Artery Stenosis, Carotid Atherosclerosis, Carotid Atherosclerotic Plaque
- Trial name
- NCT07762664
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Carotid Atherosclerosis
Atherosclerosis Monitoring and Atherogenicity Reduction Study
This study was designed to estimate the effect of two-year treatment with time-released garlic-based drug Allicor on the progression of carotid atherosclerosis in double-blinded placebo-controlled randomized clinical trial.
- Trial name
- NCT01734707
- Testing
- Allicor
- Where
- Russia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Institute for Atherosclerosis Research, Russia
Carotid Atherosclerosis
A Study to Evaluate the Efficacy and Safety of Rosuvastatin in the Treatment of the Carotid Atherosclerotic Plaques
This is a 2-year, open-label, randomized study to evaluate the efficacy of Rosuvastatin dosing adjustment by LDL-C level compared to that of 5mg maintenance dose in chinese patients with Carotid Atherosclerosis.
- Trial name
- NCT02532309
- Testing
- Rosuvastatin (5mg，10mg，20mg), Rosuvastatin 5mg
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Wei Liu
Atherosclerosis, Aortic Coarctation
Carotid Atherosclerosis in Patients With Aortic Coarctation
Despite aortic coarctation (CoA) repair these patients have cardiovascular complications and coronary artery disease is the most common cause of death.
- Trial name
- CoA (NCT03999073)
- Testing
- Ultrasound measurement
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Carotid Atherosclerosis, Regional Anesthesia Morbidity
Anterior Ultrasound-guided Cervical Plexus Block for Carotid Endarterectomy
The aim of this study is to describe technique, efficiency, safety and satisfaction of ultrasound guided intermediate cervical plexus block for carotid endarterectomy.
- Trial name
- NCT01640613
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Hôpital Edouard Herriot
ST-segment Elevation Myocardial Infarction, Subclinical Carotid Atherosclerosis
Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima-media Thickness (CIMT)
The aim of this study was to measure the effect of moderate and intensive lipid-lowering treatment with rosuvastatin on the carotid intima-media thickness (CIMT) as a surrogate marker of cardiovascular risk.
- Trial name
- NCT01203982
- Testing
- Rosuvastatin
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Odense University Hospital
Inflammation, Atheromatous Plaques
Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque
The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET/CT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET/CT, MRI and US and to determine the contribution of…
- Conditions
- Inflammation, Atheromatous Plaques, Carotid Artery Diseases
- Trial name
- NCT01608516
- Testing
- 68Ga-NODAGA-RGD PET/CT
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Lausanne Hospitals
Atherosclerosis
Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions
Atherosclerosis is a disease in which the blood vessels become blocked by plaques (consisting of fat, calcification, and fibrous tissue), reducing blood flow to vital organs and tissues.Blockage of the carotid arteries in the…
- Trial name
- DCAT (NCT00640744)
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Baylor College of Medicine
Aorta Aneurysm, Carotid Arteriosclerosis
The Role Oral Microbiome in the Development and Progression of Aorta Aneurysm and Carotid Atherosclerosis
The goal of this observational study is to compare the microbiome (bacterial al community) of the diseased vascular site and the oral cavity with specific attention to chronic inflammatory periodontitis in patients who have aorta…
- Trial name
- OMB (NCT07824921)
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University
Carotid Atherosclerosis
Carotid Plaque Regression With Statin Treatment Assessed by High Field Magnetic Resonance Imaging (MRI)
The purpose of the study is to determine if short term (6 months) treatment with statins to lower low-density lipoprotein (LDL) in vascular disease patients with carotid plaque will be associated with a measurable reduction in…
- Trial name
- NCT00388843
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Dyslipidemias, Atherosclerosis
Atmeg (Atorvastatin and Omega-3 Combination) and Carotid Atherosclerosis in Patients With Type 2 Diabetes and Combined Dyslipidemia
This is a randomized controlled study to assess the effect of atorvastatin and omega 3 combination therapy compared with atorvastatin and ezetimibe combination therapy in Korean T2DM patients with asymptomatic atherosclerosis.
- Conditions
- Dyslipidemias, Atherosclerosis, Diabetes Mellitus, Type 2
- Trial name
- NCT05365438
- Testing
- Omega 3-Atorvastatin, Atorvastatin-Ezetimibe
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Seoul National University Bundang Hospital
Carotid Arteriosclerosis, Carotid Stenosis
Residual Stenosis and Restenosis Following Carotid Endarterectomy With Primary Closure, A Prospective Tracking Study
This prospective, multicenter observational study aims to evaluate the incidence, timing, and characteristics of residual and recurrent (restenosis) carotid artery stenosis following carotid endarterectomy (CEA) with primary…
- Conditions
- Carotid Arteriosclerosis, Carotid Stenosis, Brain Stroke
- Trial name
- RECEPT (NCT07057297)
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Charles University, Czech Republic