Clinical trials: Carotid Artery Stenoses
Internal Carotid Artery, Atheromatous Stenosis
Assessment of Vulnerability to Carotid Stenosis by MultiModal Imaging and Cellular and Molecular Biology Analysis
Cerebrovascular accidents (CVA) are the second leading cause of death in France, and the most frequent cause of acquired physical and mental disability.
- Trial name
- EVA3M (NCT05190510)
- Testing
- Data collection, collection of the carotid plaque (surgical specimen), anatomopathological, histological, cellular and molecular biology examinations (metabolomics and transcriptomics) on surgical specimens
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Artery Stenosis, Carotid, Artery Stenosis
A Retrospective, Observational, Multicentre, Study to Evaluate the Safety and Performance of POLYPATCH ® Vascular Patch
POLYPATCH® study is RWE multicentre study which examine short and long-term outcomes of using POLYPATCH® when exposed to a larger and more varied population.
- Conditions
- Artery Stenosis, Carotid, Artery Stenosis, Occlusion of Artery, Stroke
- Trial name
- NCT04643743
- Testing
- Endarterectomy
- Where
- France
- Volunteers
- 198 people
- Sponsor
- Perouse Medical
Carotid Artery Stenosis, Glioma
Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)
Plastic particles are a ubiquitous pollutant in the living environment and food chain, so far, plenty of studies have reported the internal exposure of microplastics and nanoplastics in human tissues and enclosed body fluids.
- Conditions
- Carotid Artery Stenosis, Glioma, Intracranial Aneurysm, Intracranial Hemorrhages
- Trial name
- DT-MiNi (NCT05968053)
- Testing
- biological samples analysis
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Tiantan Hospital
TIA, Carotid Artery Plaque
The Effect of Low-dose Interleukin-2 on the Immune Landscape of Human Atherosclerotic Plaques at Single Cell Resolution.
The goal of this clinical trail is to compare the differences in carotid plaque Treg cells' gene signature for activation, proliferation, and suppressive function using scRNA-seq in patients treated with IL-2 compared to control.
- Conditions
- TIA, Carotid Artery Plaque, Carotid Atherosclerosis
- Trial name
- ELLIPSE (NCT05975554)
- Testing
- Interleukin-2 [IL-2], Standard care - Carotid Endarterectomy
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Carotid Stenosis, Carotid Artery Diseases
Carotid Stenosis Management During COVID-19 Era - Pilot Study
Carotid endarterectomy (CEA) and carotid stenting (CAS) are often performed for subgroups of patients for whom procedural benefit has not been established in randomised trials and despite evidence of serious procedural risk.
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Embolus
- Trial name
- CASCOM-Pilot (NCT04947046)
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Zealand University Hospital
Carotid Artery Diseases, Carotid Stenosis
The Management of Asymptomatic Carotid Stenosis
Carotid stenosis are asymptomatic if no hemispheric or retinal symptoms have appeared in the 6 months preceding the discovery of the stenosis. Asymptomatic carotid stenosis (ACS) accounts for about ¾ of all carotid lesions.
- Trial name
- NCT06882954
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Carotid Stenosis
Carotid Stenting in Patients With High Risk Carotid Stenosis ("Soft Plaque")
Stenting is an alternative to traditional surgery in the treatment of carotid stenosis.The intra and/or postprocedural cerebral embolization remains the most frequent complication.
- Trial name
- MOMA (NCT01274676)
- Testing
- carotid stenting with MOMA, Carotid stenting with filter wire EZ
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- Centro Cardiologico Monzino
Carotid Artery Stenosis
Smart Nitinol Stent System for the Treatment of Severe Atherosclerotic Carotid Stenosis
To validate the long-term effects of implantation of the self-expanding Smart nitinol stent system for the treatment of severe atherosclerotic carotid stenosis in a 2-year follow-up study of a large patient cohort
- Trial name
- NCT02800174
- Testing
- Smart nitinol stent implantation, antiplatelet drug
- Volunteers
- 103 people
- Sponsor
- Beijing Jishuitan Hospital
Cognitive Impairment, Carotid Artery Plaque
The Role of Large Artery Plaque Imaging Features in Predicting Inflammation and Cognition
The invesigators propose a clinical study on patients undergoing carotid surgery (endarterectomy). The invesigators will determine carotid artery imaging features associated with (1) vessel wall inflammation, (2) downstream brain…
- Conditions
- Cognitive Impairment, Carotid Artery Plaque, Inflammation
- Trial name
- NCT03068442
- Testing
- Imaging with flutemetamol F 18 PET/CT
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Scott Mcnally
Cardiovascular Diseases, Fatty Liver
Ultrasound Assessment of Atherosclerotic Plaque Burden and Cardiovascular Risk: A 10-Year Prospective Study
The P-SONAR study is a large, observational, prospective cohort study. The overall aim of the study is to investigate whether plaque burden estimation by 2D ultrasound of the carotid and femoral arteries may enhance…
- Conditions
- Cardiovascular Diseases, Fatty Liver, Atherosclerosis of Femoral Artery, Carotid Artery Plaque
- Trial name
- P-SONAR (NCT06933745)
- Where
- Norway
- Volunteers
- 21,029 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Carotid Stenosis
Evaluation of the Carotid Plaque Stability by Ultrafast-ultrasound Imaging (UF)
Unstable plaques are characterized by lower segmental stiffness and intimal neovascularization compared to stable plaques. Our objective is to determine the capacity of the elastographic parameters obtained by the UF to…
- Trial name
- UF-Plaques (NCT03234257)
- Testing
- UF-ultrasound
- Where
- France
- Volunteers
- 69 people
- Sponsor
- French Cardiology Society
Carotid Artery Stenoses
SPI-guided Analgesia During CEA Under RA
The aim of this randomized prospective trial is to assess the utility of Adequacy of Anaesthesia technique (Response Entropy and Surgical Pleth Index) for monitoring pain perception intraoperatively, maintainance of hemodynamic…
- Trial name
- CEA (NCT04500249)
- Testing
- infiltration rescue intraoperative analgesia, rescue IA, rescue antyhypertensive medication
- Where
- Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Silesia
Carotid Stenosis, Carotid Artery Diseases
Embolic Signals Detection Study (Esds) in Candidates for Surgical Carotid Revascularisation
About 20% of strokes are caused by emboli deriving from a carotid plaque. In symptomatic patients with carotid stenosis grater than 70% the Carotid Endarterectomy (CEA) reduces stroke risk by about 75% and is generally accepted…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Artery Plaque
- Trial name
- NCT05134493
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Carotid Artery Stenosis
GORE Embolic Protection With Reverse Flow
To compare the 30-day safety and efficacy of the GORE Flow Reversal System when used with approved carotid stents to an Objective Performance Criterion derived from distal embolic protection studies.
- Trial name
- EMPiRE (NCT00594100)
- Testing
- GORE Flow Reversal System (GFRS)
- Where
- 2 sites in United States
- Volunteers
- 245 people
- Sponsor
- W.L.Gore & Associates
Carotid Artery Stenosis
Safety and Efficacy of Low Dosage of Terazosin in Subjects Undergoing Carotid Artery Stenting
The purpose of this study is to assess the safety and efficacy of low dosage of Terazosin in Carotid Artery Stenting
- Trial name
- TZ-CAS (NCT03195673)
- Testing
- Terazosin, Carotid artery stenting
- Where
- 2 sites in China
- Volunteers
- 160 people
- Sponsor
- Capital Medical University
Carotid Artery Stenosis
A Cohort Study Comparing PCSK9 Inhibitor Plus Statin With Statin Monotherapy for Carotid Artery Stenosis
A multicenter cohort study
- Trial name
- TRIP-CAS (NCT07036991)
- Testing
- PCSK9 inhibitor (biweekly injections) + Rosuvastatin/Atorvastatin ± Ezetimibe, Rosuvastatin/Atorvastatin ± Ezetimibe
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Changhai Hospital
Carotid Artery Stenosis
Carotid Artery Stenting With Protection Registry
The purpose of this study is to evaluate ischemic events and neuropsychological changes after carotid artery angioplasty and stenting with a neuroprotection device.
- Trial name
- NCT00318851
- Testing
- Carotid Stent with Distal Protection Device
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Providence Health & Services
Carotid Artery Stenosis
Progression Assessment of Carotid Artery Stenosis by Ultrafast Ultrasound Flow Imaging
Rationale: Approximately 15-20% of strokes originates from an atherosclerotic plaque rupture in the carotid artery. To reduce the risk of stroke, patients should be evaluated for possible carotid endarterectomy (CEA), which is…
- Trial name
- CAS-PRO (NCT05270005)
- Testing
- Ultrasound-based flow imaging, Ultrasound-based strain imaging, Conventional duplex
- Where
- 2 sites in Netherlands
- Volunteers
- 85 people
- Sponsor
- Rijnstate Hospital
Carotid Stenosis, Cardiovascular Disease
Oxidative Stress and Oxysterols Profiling in Patients With Carotid Revascularization
The combination of aspirin and dipyridamole, two antiplatelet drugs, is approved in Italy for the secondary prevention of cerebral embolism in patients with carotid atherosclerosis.
- Conditions
- Carotid Stenosis, Cardiovascular Disease, Atherosclerosis, Stroke
- Trial name
- ICAR (NCT02630862)
- Testing
- Aspirin, aspirin plus dipyridamole
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- University of Roma La Sapienza
Carotid Artery Stenosis
Neuroimaging Correlates of Memory Decline Following Carotid Interventions
Carotid revascularization can significantly reduce the risk of stroke in patients with severe carotid stenosis; however, it has been associated with cognitive decline in 25% of the older adults who undergo the procedure.
- Trial name
- NCT02006095
- Testing
- Magnetic resonance imaging, Neuropsychological testing
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Stanford University