Clinical trials: Carotid Atherosclerosis, active
Carotid Artery Diseases, Peripheral Arterial Disease
Study to Image Inflammatory Activity of a Fluorescence Imaging Agent in Excised Human Artery Plaques
Active inflammation plays a key role in causing Coronary Artery Disease (CAD) and Peripheral Arterial Disease (PAD). Since inflammation is so important in how these diseases start, are diagnosed, and treated, being able to see it…
- Trial name
- NCT06957821
- Testing
- Pegulicianine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery
Oral Microbiome in Carotid Atherosclerosis
The goal of this observational study, called OMICA (Oral Microbiome in Carotid Atherosclerosis), is to learn how bacteria living in the mouth may influence the development and stability of plaques in the carotid arteries, which…
- Conditions
- Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery, Carotid Artery Plaque, Periodontitis
- Trial name
- OMICA (NCT07296965)
- Testing
- Sample Collection
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Acute Myocardial Infarction, Severe Periodontitis
Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)
Multicenter randomized clinical trial with two arms in patients hospitalized for an AMI nested in the Frenchie registry. Periodontal therapy is performed by periodontists in the intervention group versus treatment by dental…
- Conditions
- Acute Myocardial Infarction, Severe Periodontitis, Carotid Atherosclerosis
- Trial name
- PAROCARD (NCT04046237)
- Testing
- Periodontal treatment
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Type 2, Chronic Kidney Disease
Carotid Doppler Screening for Subclinical Atherosclerosis in Diabetic CKD Patients.
This study is being done at Assiut University to look for early signs of hardening of the arteries (atherosclerosis) in people who have both diabetes and chronic kidney disease (CKD).
- Conditions
- Diabetes Mellitus, Type 2, Chronic Kidney Disease, Atherosclerosis
- Trial name
- DiCKD-CAROTID (NCT07266220)
- Volunteers
- 96 people
- Sponsor
- Abdallah Ali Mohammed
Atherosclerosis, Inflammation
Atherosclerosis and Acute Ischemic Stroke Study
A significant proportion of strokes are thromboembolic in nature, arising from atherosclerotic plaque at the carotid bifurcation. It is now wellknown that inflammation plays a key role in atherogenesis and plaque destabilization.
- Conditions
- Atherosclerosis, Inflammation, Ischemic Stroke
- Trial name
- NCT03685006
- Where
- Norway
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Type 2 Diabetes, Atherosclerosis
Clopidogrel Versus Cilostazol on Vessels
Diabetes is an increasing cause of atherosclerotic and cardiovascular illnesses in South Korea. The clinical application of ultrasound for measuring carotid intima-media thickness, which helps in early detection and surveillance…
- Trial name
- NCT06402747
- Testing
- Clopidogrel, Cilostazol
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Seoul National University Bundang Hospital
Peripheral Arterial Disease, Venous Thormboembolism
VTE Incidence After Rivaroxaban + Aspirin or SAPT After Lower-limb Revascularization
Venous thromboembolism (VTE) has a high prevalence in patients with multiple comorbidities undergoing complex surgical procedures.
- Conditions
- Peripheral Arterial Disease, Venous Thormboembolism, Cardiovascular Diseases, Vascular Surgery Patient with PAD / Carotid Stenosis
- Trial name
- RESOLUTION (NCT06873321)
- Testing
- rivaroxaban 2.5 mg bid + aspirin 100 mg, clopidogrel 75 mg od for 3 months followed by aspirin 100 mg od for endovascular procedures or aspirin for open procedures
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Science Valley Research Institute
Carotid Atherosclerosis
Atherosclerosis in Juvenile Mixed Connective Tissue Disease (ACTID)
This Study investigates presence of preclinical atherosclerosis in patients with Juvenile Mixed Connective Tissue Disease in Norway.
- Trial name
- ACTID (NCT03581162)
- Testing
- Carotid Ultrasound and venous blood sampling
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Atherosclerosis Cerebral, Carotid Plaque
RESCUE: PCSK9 Inhibitors for Carotid Vulnerable Plaque Remodeling
Carotid artery stenosis is a major cause of ischemic stroke. However, many strokes occur in patients with only mild-to-moderate stenosis.
- Conditions
- Atherosclerosis Cerebral, Carotid Plaque, Vulnerable Plaque, Carotid Stenosis
- Trial name
- RESCUE (NCT07819643)
- Testing
- Intervention 1, Intervention 3, Intervention 2
- Volunteers
- 120 people
- Sponsor
- Keqiang Zhao
Carotid Arteriosclerosis, Carotid Stenosis
Residual Stenosis and Restenosis Following Carotid Endarterectomy With Primary Closure, A Prospective Tracking Study
This prospective, multicenter observational study aims to evaluate the incidence, timing, and characteristics of residual and recurrent (restenosis) carotid artery stenosis following carotid endarterectomy (CEA) with primary…
- Conditions
- Carotid Arteriosclerosis, Carotid Stenosis, Brain Stroke
- Trial name
- RECEPT (NCT07057297)
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Charles University, Czech Republic
Carotid Artery Plaques, Atherosclerosis
Effects of Rosa Roxburghii Tratt Freeze-Dried Powder on Carotid Atherosclerotic Plaques: A Real-World Study
This study aims to evaluate the effectiveness and safety of Rosa roxburghii freeze-dried powder in reducing carotid atherosclerotic plaques.
- Conditions
- Carotid Artery Plaques, Atherosclerosis, Ischemic Stroke
- Trial name
- RRC-AS (NCT07840950)
- Testing
- Rosa Roxburghii Freeze-Dried Powder, Conventional Anti-Atherosclerosis Therapy
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Stroke, Transient Ischemic Attack
Angiogenic Markers in Cerebrovascular Disease (ANFIS)
Intracranial atherosclerosis (ICAS) is the most common cause of stroke worldwide. It carries a worse prognosis than other stroke etiologies, with an annual rate of recurrent stroke and death of 15% despite intensive medical…
- Conditions
- Stroke, Transient Ischemic Attack, Atherosclerosis, Intracranial Arterial Stenosis
- Trial name
- ANFIS (NCT04240119)
- Testing
- According to current clinical care standards
- Volunteers
- 300 people
- Sponsor
- Cedars-Sinai Medical Center
Atherosclerosis, Atheroscleroses, Coronary
SIALIDASE INHIBITION AS ANTIATHEROSCLEROTIC THERAPY
The aim of this double-blind, randomized, placebo-controlled, multicenter study is to evaluate the pathogenetic effects of the dietary supplement "Tertinat" on a fundamental mechanism of atherosclerosis development: its ability…
- Conditions
- Atherosclerosis, Atheroscleroses, Coronary, Carotid Atherosclerosis
- Trial name
- SIAT (NCT06590012)
- Testing
- Tertinat
- Where
- 10 sites in Russia
- Volunteers
- 1,228 people
- Sponsor
- Institute for Atherosclerosis Research, Russia
Acute Coronary Syndrome, Stroke
Florbetaben for Imaging of Vascular Amyloid
The Primary Objective is to determine if a new nuclear tracer (named 18F-Florbetaben) used with nuclear imaging (PET imaging) can detect inflamed plaque in patients with recent ACS or stroke/TIA.
- Conditions
- Acute Coronary Syndrome, Stroke, Transient Ischemic Attack, Atherosclerosis of Artery
- Trial name
- FERMATA (NCT06091319)
- Testing
- [18F]-Florbetaben PET and CT imaging
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Cardiorenal Metabolic Syndrome, Atherosclerotic Cardiovascular Disease
Effect of Secukinumab on Cardiorenal Outcomes in Patients With Cardiorenal Metabolic Syndrome and Atherosclerotic Cardiovascular Disease
This is a prospective, randomized, open-label, parallel-controlled clinical trial to evaluate the efficacy and safety of targeted IL-17A inhibition with secukinumab on cardiovascular and renal endpoints in 100 patients with…
- Conditions
- Cardiorenal Metabolic Syndrome, Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease, Coronary Artery Disease
- Trial name
- NCT07704190
- Testing
- Secukinumab (75 mg), Standard Medical Therapy
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
HIV, Menopause
The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women
Menopause is associated with the acceleration of many comorbidities, including cardiovascular disease. Whether HIV and menopause together increase cardiovascular disease risk is a key knowledge gap.
- Conditions
- HIV, Menopause, Cardiovascular (CV) Risk, Carotid Arteriosclerosis
- Trial name
- NCT07284082
- Testing
- Whole body MRI
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Francisco
Carotid Artery, Carotid Arteriosclerosis
Predicting High-Risk Carotid Plaque: Integrating radioMics and biomEchanics
Non-pharmacological interventional study for the development of a predictive model aimed at identifying unstable carotid plaques in asymptomatic patients at first diagnosis, with the use of biological material and…
- Trial name
- PRIME (NCT07877480)
- Testing
- Radiomic features analysis
- Where
- Italy
- Volunteers
- 420 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Carotid Artery Diseases, Carotid Atherosclerosis
Prediction of Cerebral Hyperperfusion Syndrome After Carotid Revascularization Using Deep Learning
Cerebral hyperperfusion syndrome (CHS) was initially described as a clinical complication following carotid endarterectomy (CEA), but it may occur after both CEA and carotid artery stenting.
- Conditions
- Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Artery Stenosis, Cerebral Hyperperfusion Syndrome
- Trial name
- NCT05800821
- Testing
- Carotid revascularization
- Where
- Belarus
- Volunteers
- 500 people
- Sponsor
- State Institution "Republican Scientific and Practical Center" Cardiology, Belarus
Dyslipidemia, Atherosclerosis
Choline Fenofibrate and Carotid Atherosclerosis in Patients With Type 2 Diabetes and Combined Dyslipidemia
This is a randomized controlled study to assess the effect of choline fenofibrate compared with policosanol in Korean T2DM patients with asymptomatic atherosclerosis.
- Conditions
- Dyslipidemia, Atherosclerosis, Diabetes Mellitus, Type 2
- Trial name
- NCT05365425
- Testing
- Choline fenofibrate, Policosanol
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Seoul National University Bundang Hospital
Cardiovascular Diseases, Metabolic Disease
Vascular Lab Resource (VLR) Biorepository
This is a study of biomarkers obtained from prospectively collected subject samples and their correlation with cardiovascular and metabolic diseases.
- Conditions
- Cardiovascular Diseases, Metabolic Disease, Peripheral Artery Disease, Carotid Disease
- Trial name
- NCT05628948
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- The Cleveland Clinic