Clinical trials: Carotid Atherosclerotic Plaques
Plaque, Atherosclerotic
Molecular Imaging of Plaque Vulnerability
Accumulating data in the literature suggests that radiolabeled-choline (18F-choline) is a sensitive molecular tracer for PET imaging that is taken up in activated cells and, as such, is able to identify active inflammatory sites.
- Trial name
- PARISK (NCT02640313)
- Testing
- 18F-choline PET-MR imaging
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Maastricht University Medical Center
Atherosclerosis, Inflammation
Silencing Inflammatory Activity by Injecting Nanocort in Patients at Risk for Atherosclerotic Disease
Cardiovascular disease(CVD) is the leading cause of morbidity and mortality in developed nations. CVD is primarily caused by atherosclerosis, a systemic disease characterized by lipid deposition in the subendothelial space with a…
- Trial name
- SILENCE (NCT01601106)
- Testing
- liposomal prednisolone
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Carotid Atherosclerosis, Stroke
Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque
The aim of the present study is to examine the atherosclerotic plaque stability using in vivo and in vitro techniques and to investigate the influence of exercise, anti-diabetic, lipid-lowering and cannabinoids receptor…
- Conditions
- Carotid Atherosclerosis, Stroke, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT00636766
- Testing
- atorvastatin, rimonabant, rosiglitazone
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Carotid Atherosclerosis
Imaging 61CuATSM Uptake in Atherosclerotic Plaque Using PET-CT
The build up of plaque in the wall of the artery supplying blood to the brain poses a risk of stroke when the plaques become unstable and fragile.
- Trial name
- NCT01000181
- Testing
- PET-CT with CuATSM
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- King's College London
Atherosclerosis
Study Effect of VIA-2291 on Atherosclerotic Vascular Inflammation in Patients Undergoing Elective Carotid Endarterectomy
This is a study to compare the effect of VIA-2291 vs. Placebo on various inflammatory biomarkers in patients with carotid stenosis scheduled for elective carotid endarterectomy
- Trial name
- NCT00352417
- Testing
- VIA-2291
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Tallikut Pharmaceuticals, Inc.
Atherosclerotic Disease, Plaque, Atherosclerotic
Natural History of Carotid Plaque as Determined by 3D Ultrasound
This proposed follow-up study aims to recruit participants from the original BioImage cohort for a one-time follow-up examination.
- Conditions
- Atherosclerotic Disease, Plaque, Atherosclerotic, Heart Diseases, Stroke
- Trial name
- BioImage2 (NCT03314818)
- Testing
- Ultrasound 3D Imaging
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Pieter Muntendam
Atherosclerosis, Aortic Aneurysm
Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques
Lipid-rich atherosclerotic plaques, or "vulnerable plaques" are prone to rupture, causing local intravascular thrombosis, with subsequent grave clinical consequences.
- Conditions
- Atherosclerosis, Aortic Aneurysm, Peripheral Vascular Diseases
- Trial name
- NCT00449306
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center
Carotid Artery Stenosis, Carotid Atherosclerosis
Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis
This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of…
- Conditions
- Carotid Artery Stenosis, Carotid Atherosclerosis, Carotid Atherosclerotic Plaque
- Trial name
- NCT07762664
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Carotid Atherosclerosis
A Study to Evaluate the Efficacy and Safety of Rosuvastatin in the Treatment of the Carotid Atherosclerotic Plaques
This is a 2-year, open-label, randomized study to evaluate the efficacy of Rosuvastatin dosing adjustment by LDL-C level compared to that of 5mg maintenance dose in chinese patients with Carotid Atherosclerosis.
- Trial name
- NCT02532309
- Testing
- Rosuvastatin (5mg，10mg，20mg), Rosuvastatin 5mg
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Wei Liu
Inflammation, Atheromatous Plaques
Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque
The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET/CT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET/CT, MRI and US and to determine the contribution of…
- Conditions
- Inflammation, Atheromatous Plaques, Carotid Artery Diseases
- Trial name
- NCT01608516
- Testing
- 68Ga-NODAGA-RGD PET/CT
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Lausanne Hospitals
Atherosclerosis
Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions
Atherosclerosis is a disease in which the blood vessels become blocked by plaques (consisting of fat, calcification, and fibrous tissue), reducing blood flow to vital organs and tissues.Blockage of the carotid arteries in the…
- Trial name
- DCAT (NCT00640744)
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Baylor College of Medicine
Plaque, Atherosclerotic, Carotid Artery Plaque
Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque With High Stroke Risk
Stroke is a leading cause of death and disability in the United States and around the world. The goal of this work is to develop and test a noninvasive ultrasound-based imaging technology to better identify patients at high risk…
- Conditions
- Plaque, Atherosclerotic, Carotid Artery Plaque, Carotid Stenosis
- Trial name
- NCT04063709
- Testing
- Acoustic Radiation Force Impulse (ARFI) ultrasound
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of North Carolina, Chapel Hill
Carotid Atherosclerosis
Carotid Plaque Regression With Statin Treatment Assessed by High Field Magnetic Resonance Imaging (MRI)
The purpose of the study is to determine if short term (6 months) treatment with statins to lower low-density lipoprotein (LDL) in vascular disease patients with carotid plaque will be associated with a measurable reduction in…
- Trial name
- NCT00388843
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Atherosclerosis, Carotid Stenosis
Investigation of Plaque Instability Using Bevacizumab-800CW and MSOT
Determining whether we could visualize uptake of the fluorescent tracer Bevacizumab-800CW, targeting VEGF-A in atherosclerotic plaques by using the new imaging technique Multispectral Optoacoustic Tomography both in- and ex vivo.
- Conditions
- Atherosclerosis, Carotid Stenosis, Fluorescence
- Trial name
- Carotid (NCT03757507)
- Testing
- MultiSpectral Optoacoustic Tomography
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- G.M. van Dam
Carotid Artery Stenosis
The Correlation Between the Enzyme Paraoxigenase 1 (PON1) to Carotid Artery Atheromatous Plaque
The objective of the research, is to examine the hypothesis, that the enzyme paraoxygenase 1 ( PON1) can influence carotid artery's atherosclerotic plaque content and stability, and its relation to plasma's enzyme concentration.
- Trial name
- NCT01440036
- Testing
- Carotid endarterectomy
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Ziv Hospital
Carotid Artery Stenosis, Asymptomatic Carotid Artery Stenosis
A Study of Evolocumab on Carotid Artery Atherosclerotic Plaque Morphology Prior to Carotid EndArterectomy
This is a multicenter, randomized, open label study with blinded outcome assessment to evaluate the impact of additional/intensive LDL-cholesterol reduction with evolocumab on carotid artery atherosclerotic plaques in higher risk…
- Trial name
- SLICE-CEA (NCT04539223)
- Testing
- Evolocumab
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Severe Periodontitis, Ischemic Stroke
Effectiveness of Periodontitis Treatment on the Metabolic Activity of Symptomatic Carotid Atherosclerotic Plaque Responsible for Ischemic Stroke
Cardiovascular disease is the world's leading cause of death. Atherothrombosis is a common cause of ischemic stroke. A strong epidemiological link has been established between periodontitis and the risk of stroke.
- Trial name
- PerioStroke (NCT06484036)
- Testing
- periodontal treatment strategy
- Volunteers
- 157 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carotid Atherosclerotic Disease
Supplementation of Lycopene in Carotid Atheroma
Stroke is the second leading cause of death worldwide. One of the causes of stroke which can be treated is narrowing of the carotid artery. Currently the only definite treatment option is surgery or endovascular treatment.
- Trial name
- SOLANUM (NCT01102504)
- Testing
- Ateronon
- Where
- United Kingdom
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Atherosclerotic Carotid Disease, Atheroma
Effects Of Atorvastatin On Macrophage Activity And Plaque Inflammation Using Magnetic Resonance Imaging
A new way of scanning narrowing in the arteries (main blood vessels) caused by fatty deposits known as plaques has been developed. Heart attacks and strokes occur when plaques become inflamed, depending on the artery affected.
- Conditions
- Atherosclerotic Carotid Disease, Atheroma, Atherosclerosis
- Trial name
- NCT00368589
- Testing
- atorvastatin
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline
Ultrasound
Evaluation of the Vulnerable Carotid Atherosclerotic Plaque: A Clinical Multicenter Study
Evaluation of carotid plaque vulnerability based on ultrasound imaging features， proteomics and metabolomics: a clinical multicenter study
- Trial name
- NCT05849909
- Where
- China
- Volunteers
- 57 people
- Sponsor
- huang pintong