Clinical trials: Carotid Disease
Dialysis Patients, Hypertension
Carotid Intima-media Thickness in Dialysis Patients and Traditional Risk Factors
Cardiovascular disease (CVD) is the leading cause of mortality in hemodialysis (HD) patients. Carotid intima-media thickness (CIMT) is a validated surrogate marker for atherosclerosis.
- Conditions
- Dialysis Patients, Hypertension, Atherosclerosis
- Trial name
- NCT07558239
- Testing
- Ultrasound measurements of carotid intima- media thickness
- Volunteers
- 100 people
- Sponsor
- Minia University
Acute Ischemic Stroke
An EFS to Evaluate the CGuard Prime™ Carotid Stent in Acute Ischemic Stroke
The Jacobs Institute is conducting a Sponsor Investigator study of patients ≥ 18 years to establish safety and preliminary effectiveness in treating extracranial stenosis with the CGuard Prime™ Carotid Stent in the setting as an…
- Trial name
- NCT06447116
- Testing
- CGuard Prime™ Carotid Stent System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Jacobs institute
Carotid Atherosclerosis, Cerebrovascular Accident
Potential Risk Factors for Stroke
Early studies have shown that the immune system may play a role in the development of strokes. Conditions such as high blood pressure, high cholesterol, diabetes, and old age can activate the immune system and increase the risk…
- Conditions
- Carotid Atherosclerosis, Cerebrovascular Accident, Diabetes Mellitus, Hypercholesterolemia
- Trial name
- NCT00001368
- Testing
- cytokine and leukocyte activation profile
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
SLE, Atherosclerosis
Premature Atherosclerosis in Systemic Lupus Erythematosus
Patients with SLE have increased rates of atherosclerosis, while the risk factors for atherosclerosis in those patients were not fully revealed.
- Trial name
- PASLE (NCT04037293)
- Testing
- CIMT and baPWV measurement
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Peking Union Medical College Hospital
Carotid Atherosclerotic Disease
Supplementation of Lycopene in Carotid Atheroma
Stroke is the second leading cause of death worldwide. One of the causes of stroke which can be treated is narrowing of the carotid artery. Currently the only definite treatment option is surgery or endovascular treatment.
- Trial name
- SOLANUM (NCT01102504)
- Testing
- Ateronon
- Where
- United Kingdom
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Carotid Stenosis, Surgery
Revascularization of Extracranial Carotid Artery Stenosis
Investigate the current situation of carotid stenosis therapy in China. Establish the data bank of carotid stenosis revascularization (CAS and CEA) in China ,in order to get best quality control of the therapy, as well as confirm…
- Conditions
- Carotid Stenosis, Surgery, Stroke
- Trial name
- RECAS (NCT01994187)
- Testing
- Carotid endarterectomy, carotid angioplasty
- Where
- China
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Type II Diabetes Mellitus Without Mention of Complication
Carotid Atherosclerosis In Newly Diagnosed Type 2 Individuals
It has been hypothesized, based on recent trials, that only early intervention can reduce cardiovascular morbidity and mortality in individuals with type 2 diabetes (T2DM).
- Trial name
- DIABIMCAP (NCT01898572)
- Testing
- Standard care
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Clinic of Barcelona
Brain Tumor
Evaluation of Corrected Carotid Artery Flow Time as a Predictor of Fluid Responsiveness in Spontaneous Breathing Patients
It is still challenging to assess intravascular volume status in spontaneously breathing patients. Recently, the measurement of corrected flow time in carotid artery was introduced as quite useful, simple and noninvasive for the…
- Trial name
- NCT02843477
- Testing
- ultrasonographic measurement of corrected flow time in carotid artery
- Where
- South Korea
- Volunteers
- 54 people
- Sponsor
- Yonsei University
Atherosclerosis, Stroke
Metabolic Imaging in Carotid Atherosclerosis
Hardening of the arteries (atherosclerosis) is a common disorder that causes heart attacks and strokes. PET CT and contrast-enhanced MRI scans are two new ways of assessing atherosclerosis.
- Trial name
- MICA (NCT01674257)
- Testing
- USPIO (ferumoxytol)-enhanced MRI scan, 18f-Fluoride PET/CT scan, 18F-Flurodeoxyglucose PET/CT scan
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Edinburgh
Diabetes Mellitus, Type 2
Immune Profile and Complication Risk in Type 2 Diabetes
The aim of this study is to investigate the relation between individual differences in pattern recognition molecules (PRM's) in the innate immune system and the prevalence and development of vascular complications in patients…
- Trial name
- IMPACT (NCT00674271)
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Carotid Artery Stenosis
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Carotid Artery Stenosis Undergoing Carotid EndArterectomy
The purpose of this study is to explore the safety and efficacy of remote ischemic conditioning in patients with carotid artery stenosis undergoing carotid endarterectomy.
- Trial name
- SERIC-CASCEA (NCT06033963)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yi Yang
Carotid Artery Stenosis, Image
Evaluation of Brain Health and Surgical Efficacy in Patients With Carotid Artery Stenosis
The purpose of this study is to explore the relationship between the recovery of cerebrovascular morphology and cognitive function before and after surgical treatment in patients with carotid artery stenosis and their…
- Trial name
- NCT05848921
- Testing
- magnetic resonance image, Neuropsychological scale
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing University of Traditional Chinese Medicine
CADASIL, CADASIL (Diagnosis)
RAre, But Not aLone: a Large Italian Network to Empower the Impervious diaGNostic Pathway of Rare cerEbrovascular Diseases (ALIGNED)
Cerebrovascular diseases (CVDs) are one leading cause of morbidity and mortality worldwide. Despite intensive investigations, more than 30% of strokes remain of undetermined origin.
- Conditions
- CADASIL, CADASIL (Diagnosis), Moya Moya Disease, Moyamoya
- Trial name
- ALIGNED (NCT06935578)
- Where
- 17 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Carotid Endarterectomy
Predictors of Post-clamping Neurologic Deficits During Carotid Endarterectomy With Regional Anesthesia
Patients undergoing carotid endarterectomy may suffer from neurologic deficits (ND) during the carotid cross-clamping due to cerebral hypoperfusion. An associated risk of postoperative stroke incidence is also well established.
- Trial name
- NCT04347785
- Testing
- carotid endarterectomy
- Where
- Portugal
- Volunteers
- 206 people
- Sponsor
- Universidade do Porto
Carotid Artery Disease, Atherosclerosis
Telerobotic Ultrasound for Carotid Imaging - Feasibility Study
In this proposal, the investigators will demonstrate the feasibility and noninferiority of telerobotic ultrasonography as compared to traditional manual acquisition in performing a limited carotid Duplex examination and in…
- Conditions
- Carotid Artery Disease, Atherosclerosis, Atheromatous Plaques, Arteriosclerosis
- Trial name
- NCT05654935
- Testing
- Ultrasound for Carotid Arteries, Telerobotic Ultrasound for Carotid Arteries
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Hyperlipidemias, Atherosclerosis
Percentage of Secondary Prevention Patients Treated to Their LDL-C Targets
A cholesterol/lipid profile screening project of high risk patients with hyperlipidaemia (secondary prevention) who already receive cholesterol-lowering therapy.
- Conditions
- Hyperlipidemias, Atherosclerosis, Coronary Heart Disease, Carotid Stenosis
- Trial name
- NCT00536965
- Where
- Austria
- Volunteers
- 951 people
- Sponsor
- AstraZeneca
Shock, Aortic Valve Disease
Non-invasive Prediction of Fluid and Noradrenaline Responsiveness Using the Carotid Wave Intensity.
The goal of this observational study is to study a new method to compute ventricular-arterial coupling (VAC) in adult intensive care patients after cardiac surgery.
- Conditions
- Shock, Aortic Valve Disease, Coronary Artery Disease, Mitral Valve Disease
- Trial name
- VACC (NCT06197321)
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Weight Loss, Reduce the Risk of Cardiac Disease
the Change in Carotid Intima-media Thickness After Laparoscopic Sleeve Gastrectomy
The aim of this study was to compare carotid intima-media thicknesses in laparoscopic sleeve gastrectomy patients preoperatively and at the end of the first postoperative year.
- Conditions
- Weight Loss, Reduce the Risk of Cardiac Disease, Carotis Intima-media Thickness
- Trial name
- NCT06882616
- Testing
- surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Umraniye Education and Research Hospital
Myeloproliferative Neoplasm
Carotid Plaque Burden in Patients With Philadelphia Negative Myeloproliferative Neoplasms
In around 90% of the patients with MPNs, an acquired mutation that promotes JAK/STAT signaling is identified [3, 4]. The JAK/STAT pathway transduces signals from cytokines including erythropoietin, thrombopoietin, and granulocyte…
- Trial name
- NCT05993052
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Moya Moya Disease, Moyamoya Syndrome
Efficacy and Safety of Ischemic Preconditioning Therapy Versus Optimal Medical Therapy in Reducing the Recurrence of Ischemic Events in Symptomatic Moyamoya Disease
This clinical trial aims to investigate whether remote ischemic conditioning (RIC) can reduce the risk of cerebral ischemic events, delay clinical progression, and improve long-term outcomes in patients with symptomatic Moyamoya…
- Trial name
- NCT07889531
- Testing
- Standard Remote Ischemic Preconditioning
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Beijing Tiantan Hospital