Clinical trials: Carotid Disease
Carotid Atherosclerosis, Carotid Artery Stenosis Asymptomatic
PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With 64Cu-NODAGA-CANF (Multisite)
The goal of this clinical trial is to evaluate the feasibility of imaging atherosclerosis by 64Cu-NODAGA-CANF PET-MR in a pilot study of patients with asymptomatic carotid artery stenosis (ACAS).
- Conditions
- Carotid Atherosclerosis, Carotid Artery Stenosis Asymptomatic, Asymptomatic Carotid Artery Stenosis
- Trial name
- NCT07916883
- Testing
- 64Cu-NODAGA-CANF
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Squamous Cell Carcinoma of the Skin
Preventing Squamous Cell Skin Cancer
This study is proposed based on our work showing that the diabetes drug Pioglitazone strongly inhibits growth of tissue cultured squamous cell carcinoma (SCC) of the skin.
- Trial name
- NCT02347813
- Testing
- Pioglitazone
- Volunteers
- 12 people
- Sponsor
- University of Rochester
Carotid Artery Stenosis, Aortic Calcification
Aortic Calcification - is it a Marker for Carotid Artery Stenosis?
Atherosclerosis is the major contributor for the morbidity and mortality for the variety of cardiovascular diseases. Aortic calcification on x-ray is a marker for arterial atherosclerosis and an independent prognostic factor for…
- Trial name
- NCT01458860
- Volunteers
- 200 people
- Sponsor
- Ziv Hospital
Atherosclerosis
68Ga-FAPI PET/MR for Atherosclerosis
A thin-cap fibroatheroma with a large necrotic core and macrophage infiltration marks the vulnerable plaque. Fibroblast activating protein (FAP) is an active serine protease, which can degrade type I collagen, potentially…
- Trial name
- NCT05036759
- Testing
- 68Ga-FAPI
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Carotid Artery Disease
SVS VQI TransCarotid Revascularization Surveillance Project
The VQI TCAR Surveillance Project is designed to monitor the safety and effectiveness of stents placed directly into the carotid artery while reversing blood flow within the carotid artery to reduce stroke risk.
- Trial name
- VQI-TCAR (NCT02850588)
- Testing
- Transcarotid artery revascularization, Carotid endarterectomy
- Where
- United States
- Volunteers
- 60,000 people
- Sponsor
- Society for Vascular Surgery Patient Safety Organization
Cerebrovascular Disease, Ischemic Stroke
Florida Cerebrovascular Disease Biorepository and Genomics Center
The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by…
- Conditions
- Cerebrovascular Disease, Ischemic Stroke, Transient Ischemic Attack, Intracerebral Hemorrhage
- Trial name
- NCT05491980
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Aging, Brain Metabolic Disorder
Monitoring of Brain Metabolites Using Proton and Deuterium MR Techniques
MR pulse for whole brain optimal Deuterium (2H) Metabolic Imaging and EPSI (echo planar spectroscopic imaging) based SLOW-edited 1H-MRSI will be developed and optimized for use at an UHF scanner at 7 Tesla.
- Conditions
- Aging, Brain Metabolic Disorder, Carotid Stenosis, Alzheimer Disease
- Trial name
- SIGNATURES2023 (NCT06705010)
- Testing
- Application of new pulse sequence package SIGNATURES2023 to healthy controls, Application of new pulse sequence package SIGNATURES2023 to 4 groups of patients (pilot)
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Carotid Atherosclerosis
RLIP76 in Human Serum in Adults With Rheumatologic Diseases
It is the investigators aim to determine the feasibility of directly detecting anti-RLIP76 auto-antibodies in human serum using prepared RLIP76 antigen peptides in persons with rheumatologic disease and persons without…
- Trial name
- NCT00861159
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center
Quadrantectomies, Spinal Fusion
Complementary and Alternative Medicine Interventions in Targeting Pain
This Controlled Randomized Clinical Trial aimed at determining the effectiveness of a modified RR intervention in reducing post-operative pain and psychological symptoms in patients undergoing surgery intervention.
- Conditions
- Quadrantectomies, Spinal Fusion, Carotid Stenosis, Abdominal Aortic Aneurysm
- Trial name
- CAMP (NCT04845334)
- Testing
- RR intervention
- Volunteers
- 128 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Ischemic Attack, Transient, Transient Ischemic Attack
Pocket-size Cardiovascular Ultrasound in Stroke
Among patients admitted with cerebral ischemia (stroke and transitory ischemic attack (TIA)) it is important to reveal the underlying cause of the disease.
- Conditions
- Ischemic Attack, Transient, Transient Ischemic Attack, Stroke, Cerebrovascular Accident
- Trial name
- NCT02141932
- Testing
- Bed-side pocket size ultrasound imaging, GE Ultrasound Vscan
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Helse Nord-Trøndelag HF
Internal Carotid Artery Stenosis
SONOlysis in Prevention of Brain Infarctions dUring Carotid Stenting and caroTid EndaRterectomy
The aim of the project is to demonstrate a fibrinolytic effect of sonothrombolysis (continual transcranial Doppler monitoring) using 2 MegaHertz (MHz) diagnostic probe on the reduction of risk of brain infarctions due to the…
- Trial name
- SONOBUSTER (NCT01591005)
- Testing
- sonolysis, endarterectomy, carotid stenting
- Where
- Czechia
- Volunteers
- 242 people
- Sponsor
- University Hospital Ostrava
Moyamoya Disease
Precision Bypass in Patients With Moyamoya Disease
Extracranial-intracranial arterial bypass, including anastomosis of the superficial temporal artery to the middle cerebral artery and indirect bypass, can help prevent further ischaemic attacks in patients with Moyamoya disease…
- Trial name
- PBM (NCT03516851)
- Testing
- Precision bypass group
- Where
- 2 sites in China
- Sponsor
- Peking University International Hospital
Hypercholesterolemia
Nutraceuticals and Vascular Remodelling
Aim of the study is to assess the effect of a long-term nutraceutical multitarget approach on lipid profile, inflammatory mediators and vascular remodeling in primary cardiovascular prevention in a setting of controlled dietary…
- Trial name
- MALTRO (NCT04433429)
- Testing
- Liposcudil Plus
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marcello Rattazzi
Carotid Stenosis
Diabetes and Risk of Ischemic Stroke.
Diabetes in an independent risk factor for ischemic stroke, whose associated mortality rate is higher and sequelae more serious than for nondiabetics.
- Trial name
- NCT06401902
- Testing
- carotid clamping
- Where
- France
- Volunteers
- 3,739 people
- Sponsor
- Institut Mutualiste Montsouris
Obesity, Adolescent
Insulin Resistance, Lipid Profile, CRP, IL-18 and Carotid Intima-Media Thickness (CIMT) Diameter in Obese Adolescents
Carotid intima-media thickness (CIMT) is a marker for detecting endothelium dysfunction, and has become a non-invasive method that is very useful in detecting and evaluating subclinical atherosclerosis in obese children and…
- Trial name
- CIMT (NCT06152068)
- Where
- Indonesia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitas Airlangga
Carotid Artery Stenosis
A Cohort Study Comparing PCSK9 Inhibitor Plus Statin With Statin Monotherapy for Carotid Artery Stenosis
A multicenter cohort study
- Trial name
- TRIP-CAS (NCT07036991)
- Testing
- PCSK9 inhibitor (biweekly injections) + Rosuvastatin/Atorvastatin ± Ezetimibe, Rosuvastatin/Atorvastatin ± Ezetimibe
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Changhai Hospital
Cerebral Arterial Diseases
Carotid and Vertebral Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF)
The study will evaluate the efficacy and safety of Dotarem enhanced MRA in patients suffering from carotid or vertebral arterial disease.
- Trial name
- NCT01012674
- Testing
- Dotarem, TOF MRA
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- Guerbet
HTN-Hypertension, Blood Pressure Management
Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects
Uncontrolled hypertension (HTN) is growing in incidence globally creating a critical need for alternative therapeutic strategies.
- Trial name
- NCT06969846
- Testing
- CSN electrode was implanted around tissue including CSN branches
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Louis Stokes VA Medical Center
Carotid-Cavernous Sinus Fistula
Endovascular Management of Direct Carotid-cavernous Fistula
Carotid-cavernous fistula (CCF) refers to an aberrant arteriovenous communication between the carotid arterial system and the venous compartments of the cavernous sinus (CS) Direct CCFs are when there is a direct fistulous…
- Trial name
- NCT06091150
- Testing
- Endovascular management of direct carotid-cavernous fistula
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Sohag University
Aneurysm, Intracranial, Carotid-Cavernous Sinus Fistula
New Covered Stent (Willis) for the Endovascular Reconstruction of Intracranial Vessel Wall Defects Registry
The purpose of this study is to evaluate the effectiveness, long-term safety and explore the safety and efficacy factors WILLIS™ intracranial stent graft system in clinical applications.
- Trial name
- COVER (NCT02820779)
- Testing
- WILLIS
- Where
- 11 sites in China
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing