Clinical trials: Carotid Disease
Type 2 Diabetes, A1C Variability
Is Carotid Intima-media Thickness Affected by A1C Variability?
This study was conducted to evaluate the effect of A1C variability on the progression of carotid artery intima-media thickness in type 2 diabetic patients.
- Trial name
- NCT00842972
- Sponsor
- Yonsei University
Ischaemic Stroke, Carotid Endarterectomy
Carotid Endarterectomy Versus Stenting in Patients With Acute Stage of Ischemic Stroke.
The objective of this clinical trial is to compare immediate and long-term results of carotid endarterectomy and carotid stenting in acute period of ischemic stroke.
- Conditions
- Ischaemic Stroke, Carotid Endarterectomy, Carotid Stenting
- Trial name
- NCT07083986
- Testing
- Carotid Artery Stent Placement, carotid endarterectomy
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Pirogov Russian National Research Medical University
Moyamoya Disease
Study on the Mechanism of Cognitive Impairment in Patients with Moyamoya Disease
The purpose of this study is to comprehensively evaluate the risk factors for cognitive decline in patients with moyamoya disease, identify imaging target areas associated with cognitive damage in the brain, and explore the…
- Trial name
- NCT06832839
- Testing
- Revascularization
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Diabetes Mellitus, Type 2, Atherosclerosis of Artery
Molecular Mechanisms and Carotid Atherosclerosis
The role of methylase system and Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the accelerated atherosclerotic progression of diabetic patients is unclear.
- Conditions
- Diabetes Mellitus, Type 2, Atherosclerosis of Artery, Atherosclerotic Plaque
- Trial name
- NCT03962686
- Testing
- statin Oral Tablet plus PCSK9i
- Where
- Italy
- Volunteers
- 76 people
- Sponsor
- University of Campania Luigi Vanvitelli
Atherosclerosis
PET Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis (Volunteer - BioD and Safety Study)
This study is designed to assess the safety, biodistribution and dosimetry of the novel atherosclerotic imaging PET radiotracer, Cu[64]-25%-CANF-Comb.
- Trial name
- NCT02498379
- Testing
- Cu[64]-25%CANF-Comb
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Carotid Artery Stenosis, Cerebral Small Vessel Diseases
Revascularization Effect on CSVD Burden in Carotid Artery Stenosis
RECAS is a prospective cohort of 1,000 patients with carotid artery stenosis (CAS) and undergoing revascularization therapy or standard medication treatment alone.
- Trial name
- RECAS (NCT06031610)
- Testing
- carotid artery stenting, drug therapy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhejiang Provincial People's Hospital
Atherosclerosis, Cardiovascular Diseases
Investigating the Lowest Threshold of Vascular Benefits From LDL Cholesterol Lowering in Patients With Stable CV Disease
The INTENSITY-HIGH study aims to answer if there are any limits to LDL reduction in relation to benefiting vascular health, exploring the mechanisms by which secondary prevention in patients with established heart disease may…
- Trial name
- INTENSITY-HIGH (NCT03355027)
- Testing
- Alirocumab 150 MG/ML, Ezetimibe 10Mg Tablet, Atorvastatin 40Mg Tablet
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Cardiovascular Diseases, Carotid Stenosis
Recurrent Carotid Stenosis
To determine whether recurrent stenosis following carotid endarterectomy could be reduced by pre- and post-operative oral administration of platelet-inhibiting drugs.
- Conditions
- Cardiovascular Diseases, Carotid Stenosis, Cerebrovascular Disorders, Heart Diseases
- Trial name
- NCT00000527
- Testing
- aspirin, dipyridamole
- Sponsor
- Emory University
Carotid Artery Disease
Safety and Efficacy Study for Reverse Flow Used During Carotid Artery Stenting Procedure
The purpose of this study is to obtain and establish the safety and efficacy of The MICHI™ Neuroprotection System with Filter (MICHI™ NPS+f) for providing cerebral embolic protection during angioplasty and stenting procedures in…
- Trial name
- ROADSTER (NCT01685567)
- Testing
- MICHI NPS+f
- Where
- 21 sites in United States, Spain
- Volunteers
- 219 people
- Sponsor
- Silk Road Medical
Hypertension
Blood Pressure Follow-up Study in Two Chinese Cohorts(C-BPCS)
Essential hypertension is a complex trait which results from interaction between environmental factors and genetic factors. The aim of this study is to investigate the effects of interaction between environmental factors and…
- Trial name
- C-BPCS (NCT02734472)
- Testing
- Incidence and risk factors of hypertension
- Where
- China
- Volunteers
- 5,298 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Carotid Artery Stenosis, Ischemic Stroke
Platelet Reactivity and MES During CEA
The purpose of this study is to analyze the association between aspirin efficacy and general platelet reactivity in relation to microembolic signals (MES) during carotid endarterectomy (CEA).
- Conditions
- Carotid Artery Stenosis, Ischemic Stroke, Myocardial Infarction, Aspirin Resistance
- Trial name
- NCT01547039
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- UMC Utrecht
Carotid Atherosclerosis, Carotid Intimal Medial Thickness 1
Effects of Lutein Supplementation on Subclinical Atherosclerosis
This study is to investigate the possible positive effects of lutein and lycopene supplementation on early atherosclerosis in Beijing.
- Trial name
- NCT01534533
- Testing
- Lutein group, Combination group, Normal lutein control group
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Peking University
Atherosclerosis
Technical Innovation Protocol for MR & US Plaque Imaging: Reproducibility.
The aim of this study is to develop non-invasive MRI, and MRS approaches that will quantify the plaque composition and lipid content of plaques and will have the potential for repeated in vivo measurements.
- Trial name
- NCT01196221
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Stenosis, Internal Carotid Artery
Pilot Study of Autoarterial Remodeling of Bifurcation of the Common Carotid Artery
Comparison of two methods for revascularization of the bifurcation of common carotid artery: carotid endarterectomy with longitudinal incision carotid endarterectomy patch angioplasty compared with new technique of carotid…
- Trial name
- NCT03027752
- Testing
- Operation carotid endarterectomy with plastic of xenopericardial patch, New method of operation сarotid endarterectomy with autoarterial remodeling of bifurcation CCA
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Intracranial Aneurysm
French eCLIPs™ Efficacy and Safety Investigation
The objective of this study is to demonstrate the safety and efficacy of the eCLIPs™ products for the treatment of bifurcation aneurysms.
- Trial name
- EESIS-Fr (NCT05330897)
- Testing
- Implantation of an eCLIPs™ device, eCLIPs™ Electrolytic Bifurcation Systems
- Where
- 28 sites in France
- Volunteers
- 119 people
- Sponsor
- Evasc Medical Systems Corp.
Atherosclerosis, Coronary Disease
Specific Lp(a) Apheresis for Regression of Coronary and Carotid Atherosclerosis
To evaluate whether specific lipoprotein(a) apheresis on the top of optimal medical therapy could affect atherosclerotic disease burden in coronary and carotid arteries of coronary heart disease patients with elevated Lp(a)…
- Conditions
- Atherosclerosis, Coronary Disease, Carotid Artery Diseases
- Trial name
- LaRCA (NCT02133807)
- Testing
- Specific Lp(a) apheresis
- Where
- Russia
- Volunteers
- 32 people
- Sponsor
- Russian Cardiology Research and Production Center
Healthy Volunteers, Vascular Ehlers Danlos Syndrome
Non-Invasive Quantitative Imaging of Human Local Arterial Wall Elasticity Using Supersonic Shear Imaging
Arterial stiffness is associated with increased risk of cardiovascular events and death. Most of existing technique need dedicated device for arterial stiffness evaluation and indirect calculation of intra arterial pressure.
- Trial name
- ULTRAFASTECHO (NCT01096264)
- Testing
- SSI and SphygmoCor® evaluations
- Where
- France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Moya Moya Disease, Moyamoya Syndrome
Efficacy and Safety of Ischemic Preconditioning Therapy Versus Optimal Medical Therapy in Reducing the Recurrence of Ischemic Events in Symptomatic Moyamoya Disease
This clinical trial aims to investigate whether remote ischemic conditioning (RIC) can reduce the risk of cerebral ischemic events, delay clinical progression, and improve long-term outcomes in patients with symptomatic Moyamoya…
- Trial name
- NCT07889531
- Testing
- Standard Remote Ischemic Preconditioning
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Stenosis, Optical Coherence Tomography (OCT)
Endovascular Treatment of Cerebrovascular Diseases Guided by Optical Coherence Tomography (OCT) Technology（CVD-OCT）
OCT techniques have been used in the assessment of both intracranial and extracranial lesions.(1) Preprocedural evaluation: The morphologic characteristics of carotid atherosclerotic plaques can be evaluated by OCT before surgery…
- Conditions
- Carotid Stenosis, Optical Coherence Tomography (OCT), Endovascular Treatment
- Trial name
- （CVD-OCT) (NCT06986330)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Carotid Atherosclerosis
Imaging 61CuATSM Uptake in Atherosclerotic Plaque Using PET-CT
The build up of plaque in the wall of the artery supplying blood to the brain poses a risk of stroke when the plaques become unstable and fragile.
- Trial name
- NCT01000181
- Testing
- PET-CT with CuATSM
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- King's College London