Clinical trials: Carotid Disease
TIA, Stroke
Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease
The investigators hypothesize that inflammation in carotid plaque is predictive of the extent of ischemic lesion burden on the brain and will add to risk stratification for individuals with carotid disease.
- Conditions
- TIA, Stroke, Carotid Artery Stenosis
- Trial name
- NCT01236508
- Testing
- PET/CT imaging with F-18 fluorodeoxyglucose
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Carotid Artery Disease
Residual Platelet Reactivity in Patients on Antiplatelet Therapy After Carotid Angioplasty With Stenting
A carotid stenosis is treated with invasive procedures of revascularization when the lumen is reduced by more than 70% or when the lumen is reduced by more than 50% in patients who have had symptoms attributable to the affected…
- Trial name
- ARS (NCT01449617)
- Testing
- Aspirin plus clopidogrel
- Where
- Italy
- Volunteers
- 272 people
- Sponsor
- Azienda Ospedaliera di Perugia
Carotid Surgery
Trigeminus-evoked Somatosensory Potentials in Patients Undergoing Carotid Surgery
Hypothesis: Trigeminus-evoked somatosensory potentials (TRI-SEP) may be used as an alternative technique to medianus-evoked somatosensory potentials (MED-SEP) in patients undergoing elective carotid surgery.
- Trial name
- TRISEP (NCT00484796)
- Testing
- MED-SEP, TRI-SEP, neuropsychological tests
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Klinikum St. Georg gGmbH
Stroke, Acute, Carotid Artery Diseases
Platelet Function and Neurological Events
Several studies have shown an association between platelet function and stroke in patients undergoing carotid thromboendarterectomy (TEA).
- Trial name
- MULTINEUR (NCT05572320)
- Testing
- Platelet Aggregometry Testing
- Where
- Italy
- Volunteers
- 650 people
- Sponsor
- Scientific Institute San Raffaele
Coronary Artery Disease, Diabetes Mellitus, Type 2
Exercise Training in Patients With Coronary Heart Disease and Type 2 Diabetes
Diabetes mellitus (DM) is an important risk factor in the development of cardiovascular disease, and people with type 2 diabetes have a two- to four-fold increased risk for cardiovascular morbidity and mortality.
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Atherosclerosis
- Trial name
- EXCADI (NCT01232608)
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 137 people
- Sponsor
- Oslo University Hospital
Diabetic Nephropathy
Low-dose Colchicine in Patients With Type 2 Diabetes Mellitus and Microalbuminuria
1. The primary objective of this study was： in patients with type 2 diabetes and microalbuminuria who have been receiving stable treatment of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker (ACEI/ARB) for…
- Trial name
- NCT02035891
- Testing
- colchicine 0.5mg/d
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Chongqing Medical University
Atrial Fibrillation, Stroke
Carotid Artery Implant for Preventing Stroke in Atrial Fibrillation Patients Taking Oral Anticoagulants
This study will assess the safety and performance of the Vine™ Embolic Protection System (embolic filtering device) in atrial fibrillation (AF) patients on top of oral anticoagulants (OAC), and remain at high risk for stroke…
- Trial name
- CAPTURE2 (NCT03892824)
- Testing
- Vine™ Embolic Protection System
- Where
- 17 sites in Belgium, Czechia and 6 more
- Volunteers
- 100 people
- Sponsor
- Javelin Medical
Carotid Artery Stenosis
Sundt™ Carotid Shunt Retrospective Post Market Clinical Follow-up Study (PMCF)
The primary objective of this study is to retrospectively investigate the safety and efficacy of the Integra Sundt™ carotid shunt during endarterectomy procedures.
- Trial name
- NCT03816202
- Testing
- Sundt carotid shunt
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Integra LifeSciences Corporation
Carotid Stenosis, Constriction, Pathologic
GORE Flow Reversal System and GORE Embolic Filter Extension Study
The objective of this study is to provide an ongoing evaluation of clinical outcomes associated with the GORE Flow Reversal System and the GORE Embolic Filter when used for embolic protection during carotid artery stenting.
- Conditions
- Carotid Stenosis, Constriction, Pathologic, Carotid Artery Diseases, Cerebrovascular Disorders
- Trial name
- FREEDOM (NCT01343667)
- Testing
- Gore Flow Reversal System, Gore Embolic Filter
- Where
- 39 sites in United States
- Volunteers
- 1,397 people
- Sponsor
- W.L.Gore & Associates
Carotid Atherosclerosis, Coronary Atheroscleroses
Carotid Atherosclerosis in Predicting Coronary Artery Disease
Carotid plaque burden and composition features, particularly lipid necrotic core, are significantly associated with severity of CAD stenosis.
- Trial name
- CACA (NCT06253962)
- Testing
- coronary agiongraphy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Death, Carotid Artery Disease
NOR-SYS: The Norwegian Stroke in the Young Study
NOR-SYS is a clinical research program about young ischemic stroke patients from 15 to 60 years. Patients, partners and the couple´s adult children who are at least 18 years old, are all invited to ultrasound examinations due to…
- Conditions
- Death, Carotid Artery Disease, Cardiovascular Disease, Peripheral Artery Disease
- Trial name
- NOR-SYS (NCT01597453)
- Testing
- Lifestyle counseling
- Where
- Norway
- Volunteers
- 1,062 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Stenosis, Carotid, Stroke
Deoxyhemoglobin Concentration Changes and Cerebral Perfusion Imaging
To investigate a new method to rapidly modulate pulmonary venous hemoglobin oxygen saturation to enable the use of deoxyhemoglobin concentration in arterial blood as an intra-arterial MRI contrast agent for cerebral tissue…
- Conditions
- Stenosis, Carotid, Stroke, Neurovascular Disorder
- Trial name
- NCT04537611
- Testing
- dHb contrast and gadolinium contrast imaging
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto
Dysbetalipoproteinemia
DARK STUDY "DysbetalipoproteinemiA and atheRoma Risk"
Dysbetalipoproteinemia (type III, Fredrickson's classification) is a rare metabolic disorder. It results from a defect in the clearance of VLDL and chylomicron remnants due to homozygous APOE2 variants or heterozygous APOE…
- Trial name
- DARK (NCT01760265)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Carotid Stenosis
Cardiac Output and Duplex Sonography in Carotid Endarterectomy
The aim of this study is to investigate the differences between the cardiac output and the cerebral blood-flow between a regional anesthesia (RA) and a general anesthesia (GA) in a randomized, controlled, single center study at…
- Trial name
- NCT02230358
- Testing
- Regional anesthesia, General anesthesia, Transcranial Doppler ultrasonography
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University Innsbruck
Stroke, Transient Ischemic Attack
"Carotid Web Incidence and Radiological Classification, Determination of Its Relationship With Ischemic Stroke"
In our research, we aim to increase awareness on this issue by classifying the frequency of carotid webs and their radiological classification; Evaluating the clinical data and vascular risk factors of carotid web cases and…
- Conditions
- Stroke, Transient Ischemic Attack, Carotid Artery Diseases
- Trial name
- NCT06058507
- Testing
- CT angiography
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Suleyman Demirel University
Carotid Artery Plaque
The Evaluation of Tomographic 3D Ultrasound for the Assessment of Vascular Pathology
This study concentrates on providing more ultrasound image details when scanning vascular system including arterial and venous systems. A new sensor which provides 3D images is newly designed.
- Trial name
- NCT04318171
- Testing
- 3D Imaging.
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Inflammation, Atheromatous Plaques
Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque
The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET/CT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET/CT, MRI and US and to determine the contribution of…
- Conditions
- Inflammation, Atheromatous Plaques, Carotid Artery Diseases
- Trial name
- NCT01608516
- Testing
- 68Ga-NODAGA-RGD PET/CT
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Lausanne Hospitals
Other Endothelial Dystrophy
The Effect of Plant-based Diets (Vegetarian and Vegan) on Endothelial Function and Atherogenic Parameters
The investigators' hypothesis is that a plant-based diet may be beneficial if nutritional deficiencies will be corrected. The aims of the present proposal are to 1) study endothelial functions of subjects on well-defined…
- Trial name
- NCT02153138
- Testing
- Endo-pat 2000, carotid intima media thickness Ultrasound, Dexa- Bone densitometer & Bone ultrasonometer System
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Carotid Atherosclerosis
Study of Anti-atherosclerotic Activity of Inflaminat in Asymptomatic Participants With Subclinical Atherosclerosis
The purpose of this study is to investigate the anti-atherosclerotic effect of long-term anti-inflammatory therapy (Inflaminat) in asymptomatic participants with subclinical atherosclerosis of carotid arteries.
- Trial name
- NCT01743404
- Testing
- Inflaminat
- Where
- Russia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Institute for Atherosclerosis Research, Russia
Obstructive Sleep Apnea
Effects of CPAP on Visceral Fat Thickness
We hypothesize that patients with untreated OSAS will have more visceral fat, fatty liver and increased carotid artery thickness whereas treatment with CPAP may reduce the mesenteric and liver fat, plasma lipids, carotid artery…
- Trial name
- NCT01828281
- Testing
- CPAP
- Where
- China
- Volunteers
- 141 people
- Sponsor
- Chinese University of Hong Kong
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