Clinical trials: Carotid Endarterectomy
Carotid Artery Disease
Protected Carotid Artery Stenting in Subjects at High Risk for Carotid Endarterectomy (CEA) (PROTECT)
The purpose of this study is to evaluate the long-term safety and efficacy of the Xact™ Rapid Exchange Carotid Stent System used in conjunction with the Emboshield® Pro Rapid Exchange Embolic Protection System (Generation 5) and…
- Trial name
- PROTECT (NCT00402740)
- Testing
- Xact Stent with either Emboshield Pro (Gen 5) or Emboshield (Gen 3)
- Where
- 38 sites in United States
- Volunteers
- 322 people
- Sponsor
- Abbott Medical Devices
Carotid Artery Diseases, Stroke
The Role of Maintaining External Carotid Artery Flow in Graft Interposition After Carotid Endarterectomy
Analyzing results of carotid graft interposition with and without flow preservation through external carotid artery after endarterectomy.
- Conditions
- Carotid Artery Diseases, Stroke, Carotid Atherosclerosis
- Trial name
- AGICS (NCT06528717)
- Testing
- Carotid graft interposition
- Where
- Serbia
- Volunteers
- 250 people
- Sponsor
- Institute for Cardiovascular Diseases Dedinje
Carotid Endarterectomy
Correlation Between New O3 Regional Oximetry, Electroencephalography and the Somatosensory Evoked Potential in Carotid Endarterectomy Surgery
Carotid endarterectomy (CEA) is one of the modalities to treat carotid artery disease. One of the perioperative complications of this surgery includes stroke, a condition that occurs when the blood supply to part of your brain is…
- Trial name
- NCT05267782
- Testing
- Masimo's O3 Regional Oximetry
- Where
- United Arab Emirates
- Volunteers
- 4 people
- Sponsor
- Cleveland Clinic Abu Dhabi
Carotid Stenosis, Carotid Artery Diseases
Early Warning and Optimization Strategy in Carotid Endarterectomy
Carotid endarterectomy has been proven effective in prevention of cerebral vascular events in patients with severe carotid artery stenosis (symptomatic,>50%;asymptomatic,60%).
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Stroke, Vascular Diseases
- Trial name
- NCT01210937
- Testing
- CEA and TCD monitoring
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Carotid Endarterectomy, Carotid Stenting
Carotid Endarterectomy and Stenting Timing
To compare the safety and efficacy of carotid revascularization performed within 48 hours versus after 14 days in patients with symptomatic carotid stenosis accompanied with MRI-confirmed acute infarction (high signal on…
- Trial name
- CEST (NCT06898151)
- Testing
- CEA/CAS plus best medical treatment
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Xuanwu Hospital, Beijing
Internal Carotid Artery Stenosis
EEG, Cerebral Oximetry, and Arterial to Jugular Venous Lactate to Assess Cerebral Ischemia During Carotid Endarterectomy
A highly desired result during carotid endarterectomy (CEA) is the ability to predict and warn the surgeon if the brain is at risk of damage during the period of time that the carotid artery is cross-clamped for surgical repair…
- Trial name
- NCT00737334
- Testing
- EEGo, BIS, FORE-SIGHT cerebral oximeter
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Carotid Artery Stenosis
Imaging of Unstable Carotid Plaque in Patient Referred to Endarterectomy
This study will assess unstable plaque imaging features by using high resolution MR imaging and Sodium Fluoride F-18 PET. This is a comparative study between symptomatic and asymptomatic patient referred to carotid…
- Trial name
- CAROTEP (NCT03353103)
- Testing
- Sodium fluoride F-18 PET imaging
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Stroke
Short- and Long-Term Hemodynamic Effects of Carotid Endarterectomy and Carotid Artery Stenting
Carotid artery stenting(CAS) and endarterectomy(CEA) are both important treatment strategy for patients with ICA (internal carotid artery) stenosis.
- Trial name
- NCT03216369
- Testing
- MRI
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese PLA General Hospital
Carotid Stenosis
Co-administration of Dexmedetomidine in Carotid Endarterectomy (CEA)
All neurosurgical patients at the Neurosurgery University Hospital Bern who will be operated for carotid endarterectomy (CEA) are routinely operated in deep anae¬sthesia with suppression of the electrical activity of the…
- Trial name
- NCT04662177
- Testing
- Dexmedetomidine
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Carotid Artery Diseases, Peripheral Artery Disease
Assessment of Carotid Artery Stenosis and Lower Limb Peripheral Ischemia Prior to CABG
From our experience among Egyptian population in our institution, there is an increased prevalence of hidden subclinical peripheral artery disease along with carotid artery affection.
- Trial name
- NCT03516929
- Testing
- carotid duplex, both LL arterial duplex
- Where
- Egypt
- Volunteers
- 360 people
- Sponsor
- Mr Ihab Ali
Cerebral Oxygen Saturation, Postoperative Delirium
Association Between Local Cerebral Oxygenation Monitoring and Postoperative Delirium in Carotid Endarterectomy
Postoperative delirium (POD) is a common perioperative complication, which can lead to adverse outcomes. Patients undergoing carotid endarterectomy (CEA) were elderly, complicated with vascular risk factors, cognitive…
- Conditions
- Cerebral Oxygen Saturation, Postoperative Delirium, Carotid Endarterectomy
- Trial name
- NCT05198635
- Testing
- local cerebral oxygen saturation
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Artery Disease, Carotid Artery Stenosis
The Gore SCAFFOLD Clinical Study
Evaluate the safety and efficacy of the GORE® Carotid Stent for the treatment of carotid artery stenosis in patients at increased risk for adverse events from carotid endarterectomy
- Trial name
- NCT01901874
- Testing
- Carotid Artery Stenting
- Where
- 2 sites in United States
- Volunteers
- 312 people
- Sponsor
- W.L.Gore & Associates
Stroke
Validation of a Purine Biosensor in Detecting Acute Cerebral Ischaemia: Carotid Endarterectomy Model in SMARTChip
This study will validate the sensitivity of a purine biosensor (SMARTChip) in detecting acute cerebral ischaemia in a group of patients undergoing elective carotid endarterectomy.
- Trial name
- CEMS (NCT02545166)
- Where
- 2 sites in United Kingdom
- Volunteers
- 198 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Carotid Stenoses
Additional Neurological Symptoms Before Surgery of the Carotid Arteries - A Prospective Study (ANSYSCAP)
A single center observational study. Observing the time between cerebrovascular symptoms and Carotid Endarterectomy (CEA) and patient outcome.
- Trial name
- ANSYSCAP (NCT00514592)
- Testing
- New Guidelines
- Where
- Sweden
- Volunteers
- 230 people
- Sponsor
- Umeå University
Carotid Stenosis, Carotid Artery Diseases
Modified Method of Eversion Carotid Endarterectomy in Patients With Extensive Atherosclerotic Disease of Carotid Bifurcation
A prospective comparative randomized single-centre non-inferiority trial. The purpose of this study is to compares of modified method of eversion carotid endarterectomy with standard eversion carotid endarterectomy for 3,6 and 12…
- Trial name
- NCT04255316
- Testing
- Modified method of eversion carotid endarterectomy, Standard method of eversion carotid endarterectomy
- Where
- Russia
- Volunteers
- 126 people
- Sponsor
- Pirogov Russian National Research Medical University
Carotid Atherosclerosis, Regional Anesthesia Morbidity
Anterior Ultrasound-guided Cervical Plexus Block for Carotid Endarterectomy
The aim of this study is to describe technique, efficiency, safety and satisfaction of ultrasound guided intermediate cervical plexus block for carotid endarterectomy.
- Trial name
- NCT01640613
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Hôpital Edouard Herriot
Surgery, Cholecystectomy, Laparoscopic
Benefits of 'Repeat Back' Protocols Within A Computer-Based Informed Consent Program
This is a VA Merit Review Study involving 7 VA medical centers participating in a parallel group randomized trial comparing "repeat back" versus standard electronic consent for 4 common elective surgical procedures (total hip…
- Conditions
- Surgery, Cholecystectomy, Laparoscopic, Prostatectomy, Arthroplasty, Replacement, Hip
- Trial name
- NCT00288899
- Testing
- Enhanced surgical iMedConsent process (with "repeat back"), standard surgical iMedConsent process
- Where
- 7 sites in United States
- Volunteers
- 575 people
- Sponsor
- VA Office of Research and Development
Carotid Stenosis, Surgery
Revascularization of Extracranial Carotid Artery Stenosis
Investigate the current situation of carotid stenosis therapy in China. Establish the data bank of carotid stenosis revascularization (CAS and CEA) in China ,in order to get best quality control of the therapy, as well as confirm…
- Conditions
- Carotid Stenosis, Surgery, Stroke
- Trial name
- RECAS (NCT01994187)
- Testing
- Carotid endarterectomy, carotid angioplasty
- Where
- China
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Carotid Atherosclerosis
Merck Carotid Atherosclerosis Trial (MK-0000-111)(COMPLETED)
This study will examine the effect of statin and niacin therapy on carotid plaque biomarkers
- Trial name
- MCAT (NCT00804843)
- Testing
- Atorvastatin/niacin extended-release, Atorvastatin, Simvastatin
- Volunteers
- 100 people
- Sponsor
- Merck Sharp & Dohme LLC
Carotid Artery Disease, Carotid Stenosis
Carotid Angioplasty and Stenting Versus Endarterectomy in Asymptomatic Subjects Who Are at Standard Risk for Carotid Endarterectomy With Significant Extracranial Carotid Stenotic Disease (ACT I)
The study is being conducted to demonstrate the non-inferiority of carotid artery stenting (CAS) using the Emboshield® Embolic Protection System with the Xact® Carotid Stent System to carotid endarterectomy (CEA) for the…
- Conditions
- Carotid Artery Disease, Carotid Stenosis, Stroke, Atherosclerosis
- Trial name
- ACT I (NCT00106938)
- Testing
- Carotid artery stenting with filter (interventional), Carotid artery endarterectomy (surgical)
- Where
- 62 sites in United States
- Volunteers
- 1,663 people
- Sponsor
- Abbott Medical Devices