Clinical trials: Carotid Occlusion
Cardiovascular Diseases, Carotid Stenosis
Asymptomatic Carotid Artery Plaque Study (ACAPS)
To determine whether warfarin or lovastatin alone or in combination retarded the progression of atherosclerotic plaques in the carotid arteries of high risk individuals with asymptomatic carotid stenosis.
- Conditions
- Cardiovascular Diseases, Carotid Stenosis, Cerebral Arteriosclerosis, Cerebrovascular Disorders
- Trial name
- NCT00000469
- Testing
- aspirin, lovastatin
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Arteriosclerosis, Diabetes Mellitus
A High-Resolution Magnetic Resonance Imaging Study to Evaluate the Effect of Rosuvastatin on Carotid Atherosclerotic Plaques
The aim of this study is to assess whether high intensive statin therapy could regress carotid atherosclerotic plaques as determined by High-Resolution Contrast Enhanced Magnetic Resonance imaging (CE-MRI).
- Conditions
- Arteriosclerosis, Diabetes Mellitus, Lipid Disorder
- Trial name
- NCT02305862
- Testing
- Rosuvastatin 5mg, Rosuvastatin 20mg
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Capital Medical University
Ischemic Stroke, Carotid Stenosis
Research on Ultrasound Diagnostic Criteria for Intracranial and Extracranial Arterial Serial Stenosis
This study utilized different hemodynamic parameters of transcranial color-coded Doppler (TCCD) and transcranial Doppler (TCD) to conduct ultrasonic grading evaluation on middle cerebral artery (MCA) stenosis severity in patients…
- Trial name
- NCT06947720
- Testing
- stenting
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Xuanwu Hospital, Beijing
Carotid Occlusion
Endovascular Revascularization for Chronic Carotid Artery Occlusion Trial
Revascularization for carotid artery occlusion (CAO) remained controversial, there is no prospective randomized control trial (RCT) regarding carotid artery stenting (CAS) in CAO patients.
- Trial name
- ERCAO (NCT03179774)
- Testing
- Endovascular revascularization
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Carotid Stenosis
Rho Kinase (ROCK) Inhibition in Carotid Atherosclerosis
To evaluate the causal relationship between Rho/Rho kinase overactivity and mechanisms of vascular dysfunction in patients with atherosclerosis.
- Trial name
- NCT00670202
- Testing
- Fasudil Hydrochloride
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Moyamoya, Stroke
The Role of Cerebral Hemodynamics in Moyamoya Disease
The purpose of this study is to determine if people with moyamoya disease who have insufficient blood flow are at a higher risk for stroke.
- Trial name
- NCT00629915
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Washington University School of Medicine
Carotid Stenosis
Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis
Remote ischemic conditioning (RIC) has emerged as a promising non-invasive strategy to protect the brain, with evidence suggesting its benefit in patients with carotid artery stenting (CAS).
- Trial name
- RICSICAS (NCT07412249)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 300 people
- Sponsor
- General Hospital of Shenyang Military Region
Carotid Stenosis
Paraoxonase and LDL Oxidation in Carotid Artery Disease
Atherosclerosis of the carotid arteries is a common cause of stroke. The prevalence and progression of carotid atherosclerosis are believed to be influenced by genetically inherited variations in lipoprotein metabolism.
- Trial name
- NCT00011258
- Testing
- Paraoxonase
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- US Department of Veterans Affairs
Carotid Artery Stenosis
Impact of Aspiration Thrombectomy During Carotid Stenting
The purpose of this study is to determine whether aspiration thrombectomy following carotid stent deployment will reduce the number of procedure related signals as identified by diffusion weighted MRI of the brain.
- Trial name
- NCT01550835
- Testing
- Emboshield NAV6® embolic protection system (Abbott Vascular, Santa Clara, CA)
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Fogarty Clinical Research Inc.
Coronary Artery Disease, Cardiomyopathy
Carotid Ultrasound in the Evaluation of Heart Failure
Coronary artery disease (CAD, cholesterol plaque buildup in the heart arteries) is the most common cause of left ventricular systolic dysfunction (weakening of the heart muscle).
- Conditions
- Coronary Artery Disease, Cardiomyopathy, Heart Failure
- Trial name
- CUE-HF (NCT00810550)
- Testing
- Carotid ultrasound
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Carotid Stenosis
Evaluation of the TriActiv ProGuard System During Carotid Artery Stenting
The purpose of this study is to evaluate the safety and efficacy of the TriActiv® ProGuard™ System when used during a stent placement in a blockage within the carotid artery in patients considered to be at high risk for…
- Trial name
- NCT00395785
- Testing
- Carotid Stent Implantation, Embolic Protection
- Where
- 34 sites in United States, Germany
- Volunteers
- 400 people
- Sponsor
- Kensey Nash Corporation
Carotid Artery Stenosis
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Carotid Artery Stenosis Undergoing Carotid EndArterectomy
The purpose of this study is to explore the safety and efficacy of remote ischemic conditioning in patients with carotid artery stenosis undergoing carotid endarterectomy.
- Trial name
- SERIC-CASCEA (NCT06033963)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yi Yang
Atherosclerosis, Impaired Glucose Tolerance
The Study of Atherosclerosis With Ramipril and Rosiglitazone
The purpose of this study is to determine if ramipril and/or rosiglitazone retard the progression of atherosclerosis as evaluated by serial carotid intermedial thickness measurements.
- Conditions
- Atherosclerosis, Impaired Glucose Tolerance, Isolated Impaired Fasting Glucose, Cardiovascular Disease
- Trial name
- NCT00140647
- Testing
- Ramipril, Rosiglitazone
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Gerstein, Hertzel, MD
Carotid Stenosis
Alternative Sensory Presentation Formats in Asymptomatic Carotid Stenosis
Background: In a previous study, information verbally presented as relative risk (e.g. "50% less likely") or qualitative risk (e.g.
- Trial name
- NCT01531868
- Testing
- Video
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Carotid Artery Disease, Atherosclerosis
Telerobotic Ultrasound for Carotid Imaging - Feasibility Study
In this proposal, the investigators will demonstrate the feasibility and noninferiority of telerobotic ultrasonography as compared to traditional manual acquisition in performing a limited carotid Duplex examination and in…
- Conditions
- Carotid Artery Disease, Atherosclerosis, Atheromatous Plaques, Arteriosclerosis
- Trial name
- NCT05654935
- Testing
- Ultrasound for Carotid Arteries, Telerobotic Ultrasound for Carotid Arteries
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Atherosclerotic Carotid Disease, Atheroma
Effects Of Atorvastatin On Macrophage Activity And Plaque Inflammation Using Magnetic Resonance Imaging
A new way of scanning narrowing in the arteries (main blood vessels) caused by fatty deposits known as plaques has been developed. Heart attacks and strokes occur when plaques become inflamed, depending on the artery affected.
- Conditions
- Atherosclerotic Carotid Disease, Atheroma, Atherosclerosis
- Trial name
- NCT00368589
- Testing
- atorvastatin
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline
Atherosclerosis, Hypercholesterolemia
Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578)
The purpose of the study is to determine whether ezetimibe plus simvastatin will be more effective than simvastatin alone in preventing progression of atherosclerosis of the inner layer of the carotid artery.
- Conditions
- Atherosclerosis, Hypercholesterolemia, Hyperlipoproteinemia Type II
- Trial name
- ENHANCE (NCT00552097)
- Testing
- ezetimibe (plus simvastatin)
- Volunteers
- 720 people
- Sponsor
- Organon and Co
Hypercholesterolemia, Hypercholesterolemia, Familial
PET Imaging of Inflammation and Lipid Lowering Study
While 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging has been used as an early marker of drug efficacy in numerous clinical cardiovascular drug trials, as a glucose analog, its signal in the vasculature…
- Conditions
- Hypercholesterolemia, Hypercholesterolemia, Familial, Atherosclerosis, Carotid Artery Plaque
- Trial name
- PIILL (NCT04073797)
- Testing
- Inclisiran, 68Ga-DOTATATE PET-MRI, Colchicine
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Cambridge
Fibromuscular Dysplasia
Cohort Follow-up of Patients With Renal or Craniocervical Fibromuscular Dysplasia
PROFILE is a cohort study evaluating the progression of fibromuscular dysplasia lesions. This study is the prospective dimension of ARCADIA registry (ClinicalTrials.gov Identifier: NCT02884141), which aims to document phenotypic…
- Trial name
- PROFILE (NCT02961868)
- Testing
- Abdominal and supra-aortic trunks vascular imaging, Blood sampling (genetic), Blood sampling (biomarkers)
- Where
- 17 sites in Belgium, France
- Volunteers
- 340 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carotid Stenosis, Stroke
Structural Stability of Carotid Plaque and Symptomatology
The purpose of the research is to understand structural plaque abnormalities that make a carotid plaque unstable and brake off (embolize) which would help to predict and treat individuals who are likely to suffer not only classic…
- Conditions
- Carotid Stenosis, Stroke, Carotid Artery Plaque, Transient Ischemic Attack
- Trial name
- NCT02476396
- Testing
- Carotid Endarterectomy or Stenting
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- University of Wisconsin, Madison