Clinical trials: Carotid Plaque
Atherosclerosis, Inflammatory Activity in Carotid Arteries
Effects of Crestor on Inflammation of Atherosclerotic Plaques
The primary aim of this study is to investigate the effect of 40 mg dose of rosuvastatin on carotid plaque inflammation measured with MRI and PET scanning, to evaluate whether these techniques are promising for future proof of…
- Trial name
- NCT00689416
- Testing
- rosuvastatin
- Where
- Sweden
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Cardiovascular Risk Stratification, Carotid Intima-media Thickness (CIMT)
CIMT and Plaque Assessment Findings in Subjects Undergoing Stress Echocardiography For Risk Stratification
The purpose of this research study is to determine if carotid artery ultrasound scanning can provide additional information for determining cardiovascular risk in patients.
- Conditions
- Cardiovascular Risk Stratification, Carotid Intima-media Thickness (CIMT), Stress Echocardiography (SE)
- Trial name
- NCT02245048
- Testing
- Carotid Intima-Media Thickness (CIMT)
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Mayo Clinic
Carotid Artery Diseases
The Changes in Carotid Plaque Neovascularization After Elovocumab Therapy
150 selected patients will be recruited, who have at least one atherosclerotic plaque in the carotid artery that is thicker than 2.0 mm and which is determined to be uniformly or predominantly echolucent by standard…
- Trial name
- NCT04423406
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Zibo Central Hospital
Cardiovascular Disease, Diabetes
The FLAVO Trial: Dietary Flavonoids and Cardiovascular Disease Risk Reduction in Postmenopausal Women With Type 2 Diabetes
The purpose of this placebo controlled trial is to determine whether a year long intervention with flavonoids (found in cocoa and soy) is more effective in reducing the risk of cardiovascular disease in postmenopausal women with…
- Trial name
- FLAVO (NCT00677599)
- Testing
- Flavonoid enrichment (cocoa / soy compounds)
- Where
- United Kingdom
- Volunteers
- 152 people
- Sponsor
- University of East Anglia
Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery
Oral Microbiome in Carotid Atherosclerosis
The goal of this observational study, called OMICA (Oral Microbiome in Carotid Atherosclerosis), is to learn how bacteria living in the mouth may influence the development and stability of plaques in the carotid arteries, which…
- Conditions
- Atherosclerosis Cardiovascular Disease, Atherosclerosis of Artery, Carotid Artery Plaque, Periodontitis
- Trial name
- OMICA (NCT07296965)
- Testing
- Sample Collection
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Carotid Artery Plaque, Carotid Stenosis
Carotid Artery Stent Implantation in the Treatment of Vulnerable Plaque
To investigate the efficacy and safety of carotid stenting for vulnerable carotid plaques. All patients with carotid artery stenosis underwent carotid arterial contrast-enhanced ultrasonography before operation.
- Conditions
- Carotid Artery Plaque, Carotid Stenosis, Stent Embolisation
- Trial name
- CASTLE (NCT05524207)
- Testing
- carotid artery stenting
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Atherosclerosis, Carotid Stenosis
Classification of Carotid Plaque With Computed Tomography With Fast kVp (Kilovolt Peak)-Switching Technique
Classification of carotid plaque vessel wall changes in carotid stenosis accordingly to AHA classification (American Heart Association)- comparison between histology and CT.
- Trial name
- NCT02436967
- Testing
- Carotid endarterectomy in clinical healthcare.
- Where
- Sweden
- Volunteers
- 31 people
- Sponsor
- Karolinska Institutet
Established Carotid Atherosclerosis
Carotid Atherosclerosis Regression at Magnetic Resonance Assessment.
The primary objective of this randomized, double blind, placebo controlled pilot study is to determine if therapies aimed at lowering LDL cholesterol (HMGCoA reductase inhibitor - simvastatin) or increasing HDL cholesterol…
- Trial name
- NCT00307307
- Testing
- Niacin/simvastatin compared to simvastatin alone at 2 doses
- Volunteers
- 69 people
- Sponsor
- University of Pennsylvania
Sleep Apnea Syndromes, Atherosclerosis
The Influence of Mandibular Advancement Device Treating OSAHS on Primary Prevention of Ischemic Stroke
1. The purpose of this study is to detect the differences of carotid atherosclerosis severity between patients with or without OSAHS(Obstructive Sleep Apnea and Hypopnea Syndrome) in a cross-sectional study in a large sample. 2.
- Conditions
- Sleep Apnea Syndromes, Atherosclerosis, Carotid Plaque
- Trial name
- NCT03665818
- Testing
- oral appliance treatment
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing
CAROTID STENOSIS
Plaque and Brain Inflammation in Symptomatic Carotid Stenosis: Role of the Ficolin-2
Carotid artery stenosis is observed in about 3% of ≥ 60 years subjects and accounts for around 10-20% of all ischemic strokes. Beyond the degree of stenosis, plaque composition affects the risk of ischemic stroke.
- Trial name
- STATEMENT (NCT05850247)
- Testing
- [18F]DPA-714 PET/MRI
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Stroke, Atheroscleroses
A Cohort Study on Cardiovascular and Cerebrovascular Outcomes
A standardized tool for grading carotid atherosclerotic plaques-dubbed Carotid Plaque-RADS (Reporting and Data System)-has recently been developed.
- Trial name
- NCT07178015
- Testing
- ultrasound scanning
- Where
- China
- Volunteers
- 855 people
- Sponsor
- Sun Yat-sen University
Hypertriglyceridemia, Carotid Atherosclerotic Plaques
A Trial to Evaluate the Efficacy and Safety of DR10624 in Patients With Hypertriglyceridemia and Carotid Atherosclerotic Plaque
This is a researcher-initiated study to evaluate the effect of DR10624 injection on carotid atherosclerotic plaques in patients with hypertriglyceridemia and carotid atherosclerotic plaques.
- Trial name
- NCT07050134
- Testing
- DR10624 Injection；
- Where
- 4 sites in China
- Volunteers
- 40 people
- Sponsor
- Junbo Ge
Stroke (CVA) or TIA, Carotid Artery Plaque
[18F]AlF-NOTA-octreotide PET/MRI in Carotid Artery Disease
This clinical trial aims to evaluate whether [¹⁸F]AlF-OC PET/MRI can characterize and quantify inflammation in carotid atherosclerotic plaques.
- Conditions
- Stroke (CVA) or TIA, Carotid Artery Plaque, Atherosclerosis Cardiovascular Disease, Carotid Arteriosclerosis
- Trial name
- NCT07104487
- Testing
- [18F]AlF-OC
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Carotid Atherosclerosis, Ultrasound
3D Contrast Enhanced Microvascular Ultrasound of Carotid Atherosclerosis for the Detection of Carotid Plaque Neo-Revascularisation.
Atherosclerotic plaques, the build-up of fatty materials within our arteries, can develop over a long period of time without causing any symptoms.
- Conditions
- Carotid Atherosclerosis, Ultrasound, Plaque Neovascularization
- Trial name
- Carotid Neo3D (NCT07298655)
- Testing
- 3D Contrast Enhanced Microvascular Carotid Ultrasound
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- London North West Healthcare NHS Trust
Carotid Atherosclerosis
Risk Assessment of Carotid Plaques Using 3D Contrast-Enhanced Ultrasound
This is an open-label, non-randomized study conducted at Thomas Jefferson University comparing pressure-gradient estimates (obtained between a carotid plaque and the carotid artery) to imaging and histology markers of plaque…
- Trial name
- NCT04643431
- Testing
- Perflutren
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Type II Diabetes Mellitus Without Mention of Complication
Carotid Atherosclerosis In Newly Diagnosed Type 2 Individuals
It has been hypothesized, based on recent trials, that only early intervention can reduce cardiovascular morbidity and mortality in individuals with type 2 diabetes (T2DM).
- Trial name
- DIABIMCAP (NCT01898572)
- Testing
- Standard care
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Clinic of Barcelona
miRNAs, Carotid Plaque
Study of microRNAs in the Evolution of Carotid Plaque. Physiopathological and Therapeutic Interest
Carotid stenosis of atherosclerotic origin may be responsible for stroke, which is one of the most important causes of morbidity and mortality in the Western world
- Trial name
- NCT03149406
- Testing
- Comparing the expression of miRNAs
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Atherosclerosis, Inflammation
Silencing Inflammatory Activity by Injecting Nanocort in Patients at Risk for Atherosclerotic Disease
Cardiovascular disease(CVD) is the leading cause of morbidity and mortality in developed nations. CVD is primarily caused by atherosclerosis, a systemic disease characterized by lipid deposition in the subendothelial space with a…
- Trial name
- SILENCE (NCT01601106)
- Testing
- liposomal prednisolone
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Carotid Stenosis, Carotid Artery Plaque
CARotid Mri of Atherosclerosis
In the entire world most people die from cardiovascular disease. Death is primarily from myocardial infarction (MI) and stroke which are most often caused by rupture of atherosclerotic plaques. Patients with high-grade, i.e.
- Conditions
- Carotid Stenosis, Carotid Artery Plaque, Carotid Atherosclerosis
- Trial name
- CARMA (NCT04835571)
- Testing
- Optimization of cardiovascular risk management
- Volunteers
- 52 people
- Sponsor
- Linkoeping University
Hypertension, Target Organ Damage
GlycOxiTOD: Multimodal Vascular and Target-Organ Damage Registry
The goal of the GlycOxiTOD observational registry is to improve the early detection and characterization of vascular and other target-organ damage in adults at increased cardiovascular risk.
- Conditions
- Hypertension, Target Organ Damage, Heart Disease Risk Factors, Vascular Stiffness
- Trial name
- GlycOxiTOD (NCT06325800)
- Testing
- Multimodal Cardiovascular Phenotyping
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Complejo Hospitalario Universitario de Santiago