Clinical trials: Cartilage Defects of the Knee
Defect of Articular Cartilage, Knee Osteoarthritis
Clinical Trial to Compare ReJoinTM to Sodium Hyaluronate Injection for Knee Osteoarthritis Cartilage Defects
The purpose of this study is to evaluate the effectiveness of ReJoinTM for the Knee Osteoarthritis patients with Cartilage Defects comparing to Sodium Hyaluronate Injection.
- Trial name
- NCT02855073
- Testing
- ReJoinTM, Sodium Hyaluronate
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Shanghai AbelZeta Ltd.
Articular Cartilage Lesion of Knee
Study to Assess the Safety of Treatment of Articular Cartilage Lesions With CartiLife®
The purpose of this study is to assess the safety and efficacy of implanting bead-type autologous chondrocytes (CartiLife®) obtained by culturing expanded costal chondrocytes of the patient with a chondral defect in the knee.
- Trial name
- NCT03517046
- Testing
- CartiLife
- Volunteers
- 6 people
- Sponsor
- Biosolution Co., Ltd.
Articular Cartilage Lesion of the Femoral Condyle
Efficacy and Safety Study of co.Don Chondrosphere to Treat Cartilage Defects
This is a prospective, phase III, multicenter, open label, randomised clinical trial of co.don chondrosphere®, a three-dimensional autologous chondrocyte transplantation product (ACT3D-CS)compared to the procedure of…
- Trial name
- NCT01222559
- Testing
- co.don chondrosphere®, Microfracture
- Where
- 12 sites in Germany, Poland
- Volunteers
- 102 people
- Sponsor
- co.don AG
Other Articular Cartilage Disorders, Osteochondritis Dissecans
Knee Articular Cartilage Repair: Cartilage Autograft Implantation System Versus Conventional Microfracture
The Cartilage Autograft Implantation System (CAIS) is a single-stage procedure in which cartilage is harvested from non-critical regions of articular cartilage, but then immediately morcellated and loaded onto a polymer…
- Trial name
- CAIS (NCT01498029)
- Testing
- Microfracture, Cartilage Autograft Implantation System (CAIS)
- Where
- Singapore
- Volunteers
- 36 people
- Sponsor
- Singapore General Hospital
Articular Cartilage Defects in the Knee Joint
Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects
Multicenter, open-label, controlled, non-randomized, double arm trial with a prospective treatment arm (GelrinC). This study compares the efficacy and safety of GelrinC to a historical control arm (microfracture) in the treatment…
- Trial name
- SAGE (NCT03262909)
- Testing
- GelrinC, Microfracture historical control arm
- Where
- 13 sites in United States
- Volunteers
- 181 people
- Sponsor
- Regentis Biomaterials
Degeneration Articular Cartilage Knee
Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects
The purpose of this study is to determine whether CARTISTEM, a cell therapeutic product, is safe and effective in the treatment of articular cartilage defects of the knee as a result of ageing, trauma, or degenerative diseases.
- Trial name
- NCT01733186
- Testing
- CARTISTEM®
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Medipost, Inc.
Defect of Articular Cartilage
Comparison of BioCartilage Versus Marrow Stimulating Procedure for Cartilage Defects of the Knee
Subjects will be selected among the investigators' patient population who are already scheduled to receive a marrow stimulating procedure (MSP), with or without the addition of BioCartilage.
- Trial name
- NCT02203071
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Missouri-Columbia
Knee Pain Chronic, Knee Osteoarthritis
BioPoly® Partial Resurfacing Knee Implant IDE
The goal of this randomized controlled clinical trial is to demonstrate the safety and effectiveness of the BioPoly® Partial Resurfacing Knee Implant for the treatment of cartilage defects of the distal femur in adult patients…
- Conditions
- Knee Pain Chronic, Knee Osteoarthritis, Cartilage Damage, Cartilage Defects of the Knee
- Trial name
- NCT06915363
- Testing
- BioPoly, surgical standard of care (SSOC)
- Where
- 4 sites in United States
- Volunteers
- 152 people
- Sponsor
- BioPoly LLC
Chondral Lesion of the Knee, Meniscal Injuries
Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy
This study will examine whether using bone marrow aspirate (BMA) during knee arthroscopy surgery can improve patient outcomes. The investigators will enroll 50 patients who need knee arthroscopy surgery for meniscus injuries or…
- Conditions
- Chondral Lesion of the Knee, Meniscal Injuries, Cartilage Defects of the Knee, Osteoarthritis (OA) of the Knee
- Trial name
- BMA (NCT06893302)
- Testing
- Bone Marrow Aspirate (BMA), Arthroscopic Debridement Surgery, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Cartilage Damage, Cartilage Disease
All Autologous Cartilage Regeneration in the Treatment of the Knee Cartilage Defects
The cartilage articular defects of the knee are extremely disabling lesions and represent one of the predisposition causes to the development of articular arthrosis.
- Trial name
- NCT04785092
- Testing
- All Autologous Cartilage Regeneration
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
Cartilage Defects
Chondro-Gide® Bilayer Collagen Membrane in Knee Cartilage Defect Repair
A prospective, multicenter, randomized, parallel controlled study evaluating the safety and efficacy of Chondro-Gide® bilayer collagen membrane in knee cartilage defect repair.
- Trial name
- NCT05785949
- Testing
- Microfracture, Chondro-Gide bilayer collagen membrane
- Where
- 18 sites in China
- Volunteers
- 75 people
- Sponsor
- Geistlich Pharma AG
Osteochondritis Dissecans, Osteoarthritis
ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee
ACI-C versus AMIC: A controlled randomized trial comparing Autologous Chondrocyte Implantation ( ACI) and Autologous Matrix Induced Chondrogenesis (AMIC) for repair of cartilage defects in the knee.
- Conditions
- Osteochondritis Dissecans, Osteoarthritis, Cartilage Injury, Osteonecrosis
- Trial name
- NCT01458782
- Testing
- Treatment of cartilage defects in the knee
- Where
- Norway
- Volunteers
- 41 people
- Sponsor
- University Hospital of North Norway
Cartilage Defects of the Knee
Study to Evaluate a New Cartilage Regeneration Platform for Knee Cartilage Repair
The goal of this clinical trial is to learn if a new treatment works to help regrow knee cartilage in people with knee cartilage damage.
- Trial name
- TCW (NCT07639424)
- Testing
- MAECM transplantation, Micronfracture
- Where
- 13 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- ROKIT Healthcare
Osteoarthritis, Knee, Articular Cartilage Defects of the Knee
Subchondral Drilling Diameter During CARTISTEM Implantation for Knee Cartilage Defects
This prospective, randomized study at Severance Hospital compares two subchondral drilling techniques during CARTISTEM implantation for symptomatic medial-compartment knee articular cartilage defects.
- Trial name
- NCT07881445
- Testing
- 2-mm subchondral drilling, Sequential 4-mm and 2-mm subchondral drilling
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Musculoskeletal Pain, Knee Osteoarthritis
Impact of Mesenchymal Stem Cells in Knee Osteoarthritis
Many patients with osteoarthritis of the knee fail non-operative measures and elect to have knee arthroplasty to improve their quality of life.
- Conditions
- Musculoskeletal Pain, Knee Osteoarthritis, Cartilage Injury, Cartilage Degeneration
- Trial name
- NCT03477942
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Cartilage Defects of the Knee
NOVOCART® Inject Plus for Cartilage Defects of the Knee
Prospective, Multicenter, Single-arm Phase III Clinical Trial to Evaluate the Efficacy and Safety of NOVOCART® Inject plus in the Treatment of Cartilage Defects of the Knee.
- Trial name
- NCT03319797
- Testing
- NOVOCART® Inject plus
- Where
- 20 sites in Czechia, Germany and 3 more
- Volunteers
- 100 people
- Sponsor
- Tetec AG
Chondral Defect, Osteochondritis Dissecans (OCD)
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
The objective of this study is to compare the efficacy and safety of MACI® vs arthroscopic microfracture in the treatment of participants aged 10 to 17 years with symptomatic articular chondral or osteochondral defects of the…
- Conditions
- Chondral Defect, Osteochondritis Dissecans (OCD), Articular Cartilage Defect, Articular Cartilage Disorder of Knee
- Trial name
- PEAK (NCT03588975)
- Testing
- MACI, microfracture
- Where
- 14 sites in United States
- Volunteers
- 45 people
- Sponsor
- Vericel Corporation
Defect of Articular Cartilage, Articular Cartilage Disorder of Knee
the Safety and Efficacy Evaluation of Chondron Compared With Mircrofracture of Knee
The purpose of this study is to evaluate safety and efficacy of Chondron(autologous cultured Chondrocyte) by comparing between Chondron implantation and Microfracture.
- Conditions
- Defect of Articular Cartilage, Articular Cartilage Disorder of Knee, Degeneration; Articular Cartilage, Knee
- Trial name
- NCT02524509
- Where
- South Korea
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Articular Cartilage Lesion of the Femoral Condyle
RCT of ChondroCelect® (in an ACI Procedure) vs Microfracture in the Repair of Cartilage Defects of the Knee
This is a phase III, multicenter, open-label, randomized controlled trial of ChondroCelect® in an Autologous Chondrocyte Implantation (ACI) procedure compared to the procedure of microfracture (MF) in the repair of symptomatic…
- Trial name
- TIGACT01 (NCT00414700)
- Testing
- ChondroCelect implantation, Microfracture
- Where
- 12 sites in Belgium, Croatia and 2 more
- Volunteers
- 118 people
- Sponsor
- TiGenix n.v.
Degenerative Lesion of Articular Cartilage of Knee, Osteochondritis Dissecans
DeNovo NT Longitudinal Data Collection (LDC) Knee Study
The purpose of this study is to evaluate the long-term outcomes of DeNovo NT, a tissue product used for the repair of cartilage damage in the knee.
- Trial name
- NCT01329445
- Testing
- DeNovo NT, Natural Tissue Graft
- Where
- 15 sites in United States
- Volunteers
- 160 people
- Sponsor
- Zimmer Orthobiologics, Inc.