Clinical trials: Cartilage Defects of the Knee
Osteoarthritis, Knee Osteoarthritis
Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage of the Knee
The purpose of this pilot study is to investigate the efficacy and safety of autologous transplantation, under arthroscopy, of Bone Marrow Mesenchymal stem cells, using, with a cell separator, a fresh non-culture expanded…
- Conditions
- Osteoarthritis, Knee Osteoarthritis, Osteochondritis Dissecans, Osteonecrosis
- Trial name
- NCT01159899
- Testing
- Transplantation of Bone Marrow Stem Cells Activated in Knee Arthrosis
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Michel Assor, MD
Knee Osteoarthritis
Autologous Transplantation of Mesenchymal Stem Cells (MSCs) and Scaffold in Full-thickness Articular Cartilage
The purpose of this study is to investigate the efficacy and safety of autologous transplantation of Bone Marrow Mesenchymal stem cells (MSCs) mixed with collagen I scaffold in patient with Knee cartilage defects and…
- Trial name
- NCT00850187
- Testing
- Bone marrow derived mesenchymal stem cells
- Where
- 2 sites in Iran
- Volunteers
- 6 people
- Sponsor
- Royan Institute
Cartilage Defect
REcycled CartiLage Auto/Allo IMplantation
This is an FDA phase I study to evaluate the safety of allogeneic culture-expanded adipose-derived mesenchymal stem cells (AMSCs) combined with autologous cartilage cells to treat focal knee cartilage defects in one stage surgery.
- Trial name
- NCT03672825
- Testing
- REcycled CartiLage Auto/Allo IMplantation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Chondrofix Osteochondral Allograft Prospective Study
The overall study objective is to evaluate Chondrofix Osteochondral Allograft ("Chondrofix") for the repair of osteochondral lesions in the knee.
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01410136
- Testing
- Chondrofix Osteochondral Allograft
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Articular Cartilage of the Femoral Condyle Between 2-6cm2
NOVOCART®3D for Treatment of Articular Cartilage of the Knee
This study is to compare NOVOCART 3D relative to Microfracture for the treatment of knee cartilage defects. Efficacy will be evaluated by both pain and function. Safety will also be evaluated.
- Trial name
- N3D (NCT01957722)
- Testing
- Microfracture, NOVOCART 3D
- Where
- 35 sites in United States, Canada
- Volunteers
- 233 people
- Sponsor
- Aesculap Biologics, LLC
Articular Cartilage Defect, Chondral Defect
Study Comparing Two Methods for the Treatment of Large Chondral and Osteochondral Defects of the Knee
The major objective of this study is to evaluate the efficacy of the MACT versus the AMT for the treatment of large cartilage defects in patellofemoral and femorotibial injuries.
- Conditions
- Articular Cartilage Defect, Chondral Defect, Osteochondritis
- Trial name
- NCT05651997
- Testing
- MACT, AMT
- Where
- 2 sites in Switzerland
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Articular Cartilage Defect, Articular Cartilage Degeneration
Phase 2 Clinical Trial of CartiLife® in the United States
To evaluate the safety and efficacy of implanting pellet-type extracellular matrix-associated autologous chondrocytes (CartiLife®) obtained by cultivating costal chondrocytes of the subject with articular cartilage defects of the…
- Trial name
- NCT04744402
- Testing
- Autologous Chondrocyte Implantation (CartiLife®)
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- Biosolution Co., Ltd.
Osteoarthritis, Traumatic Arthritis
The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy
A clinical trial to evaluate the long-term efficacy and safety of Chondron (Autologous cultured Chondrocyte) administered through arthroscopy from the drug's 48 weeks efficacy and safety evaluation with 96 weeks follow-up in…
- Trial name
- NCT02539069
- Testing
- Chondron Implantation
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Cartilage Diseases
Non-Interventional Study to Evaluate Safety and Efficacy of NOVOCART 3D in Patients With Cartilage Defects
Non-interventional study to evaluate safety and efficacy of NOVOCART 3D in adult and adolescent patients with full thickness cartilage defects after the treatment with NOVOCART 3D.
- Trial name
- NISANIK (NCT02348697)
- Testing
- NOVOCART 3D
- Where
- 9 sites in Germany
- Volunteers
- 81 people
- Sponsor
- Tetec AG
Cartilage Defects
Study on Efficacy and Safety of CaReSR-1S to Repair Cartilage Defects of the Knee
The purpose of this trial is to investigate the safety and effect of CaReS-1S to repair knee cartilage defects.
- Trial name
- NCT03307668
- Testing
- CaReSR-1S, Microfracture
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Arthro-Anda Tianjin Biologic Technology Co., Ltd.
Cartilage Injury, Knee Injuries
7T MRI to Evaluate Cartilage Defects in the Knee
The investigators propose to prospectively evaluate the accuracy of a novel 7-Tesla (7T) knee MRI protocol for the detection and grading of cartilage lesions in the knee, which is a significant limitation of current MRI…
- Conditions
- Cartilage Injury, Knee Injuries, Arthropathy of Knee, Cartilage Damage
- Trial name
- NCT04118023
- Testing
- 7 Tesla Magnetic Resonance Imaging Test
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- The Methodist Hospital Research Institute
Articular Cartilage Defects
Extension Study for Participants of MACI00206 Study of MACI® for the Treatment of Symptomatic Articular Cartilage Defects of the Knee
To examine the 5-year efficacy and safety of MACI implant, compared with arthroscopic microfracture, in participants who received study treatment in the SUMMIT study for treatment of symptomatic articular cartilage defects of the…
- Trial name
- Extension (NCT01251588)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Microfracture
- Where
- 14 sites in Czechia, France and 5 more
- Volunteers
- 128 people
- Sponsor
- Vericel Corporation
Articular Cartilage Defect
Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee
The objective of this trial is to demonstrate superior efficacy and safety of MACI compared with arthroscopic microfracture in the treatment of patients (aged 18 to 55 years) with symptomatic articular cartilage defects of the…
- Trial name
- SUMMIT (NCT00719576)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Microfracture
- Where
- 20 sites in Czechia, France and 5 more
- Volunteers
- 144 people
- Sponsor
- Vericel Corporation
Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
Agili-C™ Implant Performance Evaluation
The current study compares the efficacy and safety of the Agili-C implant to Surgical Standard of Care treatment in patients suffering from joint surface lesions of the knee.
- Trial name
- NCT03299959
- Testing
- Agili-C implant, SSOC
- Where
- 26 sites in United States, Belgium and 6 more
- Volunteers
- 251 people
- Sponsor
- Smith & Nephew, Inc.
Defect of Articular Cartilage
A Study to Evaluate the Safety of Augment™ Bone Graft
Is Augment Bone Graft plus Allograft safe to use for the treatment of osteochondral defects of the knee?
- Trial name
- NCT01290991
- Testing
- Augment Bone Graft
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Nova Scotia Health Authority