Clinical trials: Cartilage Degeneration
Traumatic Amputation of Lower Extremity, Cartilage Degeneration
The Assessment of Talar Cartilage in Patients With Unilateral Traumatic Transtibial Amputation
Increased risk of osteoarthritis (OA) has been previously demonstrated in patients with lower limb amputation. Although there are many studies on knee joint of intact limb of amputees in the literature, the number of studies on…
- Trial name
- NCT04486534
- Testing
- Musculoskeletal ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Knee Osteoarthritis, Cartilage Degeneration
Effectiveness of Autologous Adipose-derived Stem Cells in the Treatment of Knee Cartilage Injury
This study was aimed to evaluate the efficacy and safety of Autologous Adipose-derived Mesenchymal Stem Cell Gel combine with High tibial osteotomy therapy in the treatment of cartilage damage in the knee.
- Trial name
- NCT03955497
- Testing
- Autologous Adipose-derived Mesenchymal Stem Cell Gel, Sodium Hyaluronate, Extraction of abdominal fat
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Qilu Hospital of Shandong University
Knee Osteoarthritis, Cartilage Degeneration
Platelet Rich Plasma Injection for Knee Osteoarthritis
The research questions of this study are; 1. Is platelet rich plasma (PRP) treatment effective in knee osteoarthritis (OA)? 2. What are the indications for PRP treatment? 3.
- Trial name
- NCT04454164
- Testing
- PRP, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 324 people
- Sponsor
- Ferhat Say
Knee Osteoarthritis, Cartilage Degeneration
Knee Osteoarthritis Treatment With Percutaneous Injections of Autologous Bone Marrow Concentrate
Recently there has been a growing interest in the role of subchondral bone in knee arthritis, both in its etiology and evolution and in its clinical significance.
- Trial name
- Bone-Gun (NCT04310852)
- Testing
- BioCue Concentration Kit
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Clinico Humanitas
Degeneration; Articular Cartilage, Knee, Rheumatoid Arthritis
Comparison of Treatments Following Total Knee Replacement
Although total knee replacement (TKR) improves pain in numerous patients, it does not resolve many of the substantial functional limitations and physical inactivity that existed for a long time prior to the surgery.
- Conditions
- Degeneration; Articular Cartilage, Knee, Rheumatoid Arthritis, Osteoarthritis, Knee
- Trial name
- NCT02237911
- Testing
- Clinic-based outpatient exercise group, Community-based exercise group
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Pittsburgh
Knee Osteoarthritis, Osteoarthritis, Knee
Autologous Conditioned Serum: Functional and Clinical Results
The purpose of this study was to investigate the potential ability of autologous conditioned serum (ACS) to decrease the pain and improve the joint functionality in patients affected by knee osteoarthritis (OA).
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Knee, Cartilage Degeneration
- Trial name
- NCT03850080
- Testing
- Autologous Conditioned Serum
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Ospedale San Raffaele
Osteoarthritis, Knee, Cartilage Degeneration
Subchondral and Intra-articular Application of Bone Marrow Concentrate for Knee Unicompartmental OA
Unicompartmental knee osteoarthritis (OA) is a common finding especially in patients with lower limb malalignment and previous meniscectomy.
- Trial name
- MarrowMule (NCT03790189)
- Testing
- Subchondral and intra-articular injection of BMC
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Clinico Humanitas
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Neocartilage Implant to Treat Cartilage Lesions of the Knee
ISTO Technologies, Inc. is proposing a clinical study with 225 subjects, to establish the safety and efficacy of the Neocartilage Implant for the treatment of ICRS Grade 3 and 4 articular cartilage lesions of the knee compared to…
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01400607
- Testing
- Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture
- Where
- 9 sites in United States
- Volunteers
- 14 people
- Sponsor
- ISTO Technologies, Inc.
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Chondrofix Osteochondral Allograft Prospective Study
The overall study objective is to evaluate Chondrofix Osteochondral Allograft ("Chondrofix") for the repair of osteochondral lesions in the knee.
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01410136
- Testing
- Chondrofix Osteochondral Allograft
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Cartilage Degeneration
Study of Platelet-rich Plasma in Treating Patients With Tibiofemoral Cartilage Degeneration
Recently an articular cartilage repair has been given much attention in the orthopaedic field. Cartilage regeneration capacity is very limited. Optimal approach seems to be a delivery of natural growth factors.
- Trial name
- NCT01418755
- Testing
- platelet rich plasma injection
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Komzak Martin, M.D.