Clinical trials: Cartilage Degeneration
Degenerative Osteoarthritis, Defect of Articular Cartilage
Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect
This is a long term follow-up study to investigate the safety and efficacy of CARTISTEM®, human umbilical cord blood-derived mesenchymal stem cells, in repair of cartilage injury or defects, compared with microfracture.
- Trial name
- NCT01626677
- Testing
- CARTISTEM, Microfracture
- Where
- 10 sites in South Korea
- Volunteers
- 103 people
- Sponsor
- Medipost Co Ltd.
Cartilage Diseases
Molecular Biomarkers Associated With Degenerative Joint Disease in the Knee
This investigation describes a novel complex of structural degradation proteins that is associated with pain in individuals with meniscal pathology undergoing arthroscopic partial meniscectomy.
- Trial name
- NCT01006278
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scuderi, Gaetano J., M.D.
Meniscus Tear, Chondropathy/Degenerative Joint Disease (DJD)
Post-op Treatment With Hyaluronic Acid Injections
This study will look at patients with post-operative treatment of a meniscal tear or degenerative joint disease (degenerative arthritis).
- Trial name
- NCT01256788
- Testing
- Euflexxa, Saline
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The Hawkins Foundation
Osteoarthritis (OA), Knee Injury
Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis
This Phase I/II randomized clinical trial investigates the safety, feasibility, and early regenerative potential of intra-articular administration of mesenchymal stem cell (MSC)-derived secretome combined with Plasma Rich in…
- Conditions
- Osteoarthritis (OA), Knee Injury, Cartilage Degeneration
- Trial name
- PRGFSECKOA (NCT07157891)
- Testing
- MSC-Derived Secretome, MSC-Derived Secretome + Autologous PRGF
- Volunteers
- 25 people
- Sponsor
- University of the Punjab
Osteoarthritis, Knee
Use of Fresh Platelet Rich Plasma With Concentrated Leukocytes or Fresh Platelet Rich Plasma Without Concentrated Leukocytes in the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial
The aim of the study is to compare the triple infiltration of Fresh Platelet Rich Plasma with concentrated Leukocytes against triple infiltration of Fresh Platelet Rich Plasma Without Concentrated Leukocytes in the treatment of…
- Trial name
- PRP019 (NCT04187183)
- Testing
- Fresh Platelet Rich Plasma with leukocyte, Fresh Platelet Rich Plasma without leukocyte
- Where
- Italy
- Volunteers
- 132 people
- Sponsor
- Istituto Ortopedico Rizzoli
Articular Cartilage Lesion of Knee
Study to Assess the Safety of Treatment of Articular Cartilage Lesions With CartiLife®
The purpose of this study is to assess the safety and efficacy of implanting bead-type autologous chondrocytes (CartiLife®) obtained by culturing expanded costal chondrocytes of the patient with a chondral defect in the knee.
- Trial name
- NCT03517046
- Testing
- CartiLife
- Volunteers
- 6 people
- Sponsor
- Biosolution Co., Ltd.
Rheumatoid Arthritis, Knee Pain Chronic
The Cartilage and Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis
The knee pain status of the patients who are followed in the rheumatology special branch of the Physical Medicine and Rehabilitation Outpatient Clinic and who meet the inclusion criteria will be questioned.
- Conditions
- Rheumatoid Arthritis, Knee Pain Chronic, Muscle Loss, Cartilage Degeneration
- Trial name
- NCT05999266
- Testing
- Ultrasonographic Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries
Development of Computational Models to Predict the Short-, Medium- and Long-term Cartilage Degeneration and Pain for Patients With Early-stage Osteoarthritis or Anterior Cruciate Ligament Injury
Knee osteoarthritis is a complex condition, and selecting effective non-drug treatments like orthoses or exercise is often difficult and imprecise.
- Trial name
- MathKOA (NCT07134244)
- Where
- 2 sites in Denmark
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Osteoarthritis, Knee, Cartilage Degeneration
Analysis of the Pathophysiological and Functional State of the Knee Joint
Osteoarthritis is the most common degenerative condition affecting the knee joint globally, with an incidence of about 7% of the population.
- Trial name
- Gait-MRI-Knee (NCT06490770)
- Testing
- Gait analysis, Magnetic Resonance Imaging
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Ortopedico Rizzoli
Degenerative Chondropathy, Early Osteoarthritis
Platelet Rich Plasma Injection for Knee Pain
Platelet-rich plasma (PRP) has been used as an alternative to non-operative treatments for increasing the rate of cure in bone and soft-tissue regeneration, although there are very few clinical studies regarding the treatment of…
- Trial name
- NCT01747018
- Testing
- Platelet-rich Plasma
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- The Catholic University of Korea
Knee Osteoarthritis, Cartilage Degeneration
Teriparatide as a Chondroregenerative Therapy in OA
The purpose of this study is to evaluate teriparatide (TP) as a chondroregenerative therapy for human knee osteoarthritis (OA). The central hypothesis to be tested is that TP supports structural modification of the joint and…
- Trial name
- NCT03072147
- Testing
- Teriparatide
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Christopher Ritchlin
Degeneration Articular Cartilage Knee
Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects
The purpose of this study is to determine whether CARTISTEM, a cell therapeutic product, is safe and effective in the treatment of articular cartilage defects of the knee as a result of ageing, trauma, or degenerative diseases.
- Trial name
- NCT01733186
- Testing
- CARTISTEM®
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Medipost, Inc.
Degenerative Disc Disease
A Study Comparing the Safety and Effectiveness of Cartilage Cell Injected Into the Lumbar Disc as Compared to a Placebo
This is a clinical study to collect safety and preliminary efficiency information on the use of NuQu chondrocytes (cartilage cells) delivered to the center of a lumbar spinal disc to treat low back pain.
- Trial name
- NCT01771471
- Testing
- NuQu
- Where
- 10 sites in United States
- Volunteers
- 44 people
- Sponsor
- ISTO Technologies, Inc.
Anterior Knee Pain Syndrome
Use of Hyaluronic Acid Injection in Lateral Patellar Compression With Femoral Condylar Degenerative Changes After Arthroscopic Release
Ninety patients are involved in this study, who underwent arthroscopic lateral patellar release for lateral patellar compression syndrome and they had patellofemoral degenerative lesion, which diagnoses by MRI preoperatively and…
- Trial name
- NCT04134611
- Testing
- Hyaluronic acid injection, No injection of Hyaluronic acid
- Where
- Iraq
- Volunteers
- 90 people
- Sponsor
- Hawler Medical University
Traumatic Amputation of Lower Extremity, Cartilage Degeneration
The Assessment of Talar Cartilage in Patients With Unilateral Traumatic Transtibial Amputation
Increased risk of osteoarthritis (OA) has been previously demonstrated in patients with lower limb amputation. Although there are many studies on knee joint of intact limb of amputees in the literature, the number of studies on…
- Trial name
- NCT04486534
- Testing
- Musculoskeletal ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Degenerative Arthritis, Knee Arthritis
Follow-up Study for Participants of Jointstem Investigator Initiated Trial by Arthroscopy
This clinical trial is conducted to assess the long-term safety of "jointstem" in patients with degenerative knee arthritis who participated in the previous BS-JS-IIT1 investigator initiated trial.
- Trial name
- NCT04825730
- Testing
- JOINTSTEM
- Volunteers
- 14 people
- Sponsor
- R-Bio
Musculoskeletal Pain, Knee Osteoarthritis
Impact of Mesenchymal Stem Cells in Knee Osteoarthritis
Many patients with osteoarthritis of the knee fail non-operative measures and elect to have knee arthroplasty to improve their quality of life.
- Conditions
- Musculoskeletal Pain, Knee Osteoarthritis, Cartilage Injury, Cartilage Degeneration
- Trial name
- NCT03477942
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Degenerative Arthritis, Chondral Defects
The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects
This study is conducted to assess whether implanting autologous, culture-expanded, mesenchymal stem cells obtained from the bone marrow of patients with early osteoarthritis, cartilage defects or cartilage and underlying bone and…
- Conditions
- Degenerative Arthritis, Chondral Defects, Osteochondral Defects
- Trial name
- NCT00891501
- Testing
- Bone Marrow Aspiration, Bone marrow mesenchymal stem cell implantation
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Cairo University
Cartilage Degeneration
Study of Platelet-rich Plasma in Treating Patients With Tibiofemoral Cartilage Degeneration
Recently an articular cartilage repair has been given much attention in the orthopaedic field. Cartilage regeneration capacity is very limited. Optimal approach seems to be a delivery of natural growth factors.
- Trial name
- NCT01418755
- Testing
- platelet rich plasma injection
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Komzak Martin, M.D.
Anterior Cruciate Ligament Injuries, Cartilage Degeneration
Effect of Early Gait Training on Knee Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction
A randomized controlled clinical study was conducted to elucidate the relationship between the lower extremity biomechanics of patients undergoing early gait training after ACLR surgery.The relationship between the biochemical…
- Trial name
- NCT06368544
- Testing
- lower-body positive-pressure
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital