Clinical trials: Cartilage Degeneration
Defect of Articular Cartilage, Articular Cartilage Disorder of Knee
the Safety and Efficacy Evaluation of Chondron Compared With Mircrofracture of Knee
The purpose of this study is to evaluate safety and efficacy of Chondron(autologous cultured Chondrocyte) by comparing between Chondron implantation and Microfracture.
- Conditions
- Defect of Articular Cartilage, Articular Cartilage Disorder of Knee, Degeneration; Articular Cartilage, Knee
- Trial name
- NCT02524509
- Where
- South Korea
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Unilateral Primary Osteoarthritis of Knee, Osteoarthritis Knee
Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid
This study seeks to evaluate a treatment for multiple full thickness chondral lesions in the knee. Eligible subjects will undergo a microdrilling surgery and up to 12 post operative intra-articular injections of bone marrow…
- Conditions
- Unilateral Primary Osteoarthritis of Knee, Osteoarthritis Knee, Degeneration; Articular Cartilage, Knee, Degenerative Lesion of Articular Cartilage of Knee
- Trial name
- NCT02285725
- Testing
- Microdrilling Surgery, Injections of BMAC + PRP + HA
- Volunteers
- 21 people
- Sponsor
- Joseph E. Broyles
Osteoarthritis
Effect of Methyl-Sulphonyl-Methane on Osteoarthritis and Cartilage
To delineate the effect of MSM on osteoarthritis
- Trial name
- msm (NCT01836757)
- Testing
- MethylSulfonylMethane (MSM)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- G.Papanikolaou Research Group
Degeneration; Articular Cartilage, Knee, Rheumatoid Arthritis
Comparison of Treatments Following Total Knee Replacement
Although total knee replacement (TKR) improves pain in numerous patients, it does not resolve many of the substantial functional limitations and physical inactivity that existed for a long time prior to the surgery.
- Conditions
- Degeneration; Articular Cartilage, Knee, Rheumatoid Arthritis, Osteoarthritis, Knee
- Trial name
- NCT02237911
- Testing
- Clinic-based outpatient exercise group, Community-based exercise group
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Pittsburgh
Degenerative Lesion of Articular Cartilage of Knee, Osteochondritis Dissecans
DeNovo NT Longitudinal Data Collection (LDC) Knee Study
The purpose of this study is to evaluate the long-term outcomes of DeNovo NT, a tissue product used for the repair of cartilage damage in the knee.
- Trial name
- NCT01329445
- Testing
- DeNovo NT, Natural Tissue Graft
- Where
- 15 sites in United States
- Volunteers
- 160 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Chondrofix Osteochondral Allograft Prospective Study
The overall study objective is to evaluate Chondrofix Osteochondral Allograft ("Chondrofix") for the repair of osteochondral lesions in the knee.
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01410136
- Testing
- Chondrofix Osteochondral Allograft
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Defect of Articular Cartilage, Degenerative Joint Disease of Ankle and/or Foot
Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in Their Ankle
The objective of this study is to evaluate the efficacy and safety of Chondron (Autologus Chondrocyte) in patients with cartilage defects in their ankle for 18 months
- Conditions
- Defect of Articular Cartilage, Degenerative Joint Disease of Ankle and/or Foot, Ankle (Ligaments); Instability, Familial
- Trial name
- NCT02537067
- Testing
- CHONDRON
- Where
- 2 sites in South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Degenerative Lesion of Articular Cartilage of Knee
Episealer® Knee System IDE Clinical Study
The study is a randomized, prospective, multicenter, controlled clinical trial of the Episealer Knee System. The Episealer Knee System is intended for subjects with up to two focal femoral knee chondral or osteochondral lesion…
- Trial name
- NCT04000659
- Testing
- Episealer Knee System, Microfracture
- Where
- 13 sites in United States, Canada and 2 more
- Volunteers
- 13 people
- Sponsor
- Episurf Medical Inc.
Articular Cartilage Defect, Articular Cartilage Degeneration
Phase 2 Clinical Trial of CartiLife® in the United States
To evaluate the safety and efficacy of implanting pellet-type extracellular matrix-associated autologous chondrocytes (CartiLife®) obtained by cultivating costal chondrocytes of the subject with articular cartilage defects of the…
- Trial name
- NCT04744402
- Testing
- Autologous Chondrocyte Implantation (CartiLife®)
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- Biosolution Co., Ltd.
Cartilage Lesion, Degenerative Lesion of Articular Cartilage of Knee
Tissue Engineered Nasal Cartilage for Regeneration of Articular Cartilage
The purpose of this study is to investigate the safety and feasibility of implanting an engineered cartilage graft obtained by culturing expanded autologous nasal chondrocytes within a collagen type I/III membrane into the…
- Trial name
- Nose2Knee (NCT01605201)
- Testing
- Tissue engineered cartilage graft
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- University Hospital, Basel, Switzerland
Cartilage Degeneration, Rotator Cuff Tear
Use of MRI Labeling Technique to Track Mesenchymal Stem Cell Survival in Orthopaedic Conditions
The primary objective is to determine whether a surgical intervention involving removing of the calcified cartilage cap in patients with Grade II Kellgren-Lawrence osteoarthritis influences the incorporation of labeled bone…
- Conditions
- Cartilage Degeneration, Rotator Cuff Tear, Osteoarthritis, Knee
- Trial name
- NCT03648463
- Testing
- arthroscopy of the affected knee/ Bone Marrow Concentrate Injection
- Sponsor
- Stanford University
Osteoarthritis, Knee, Knee Degenerative Disease
Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells
In this prospective study we aim to evaluate the feasibility and safety of the implantation of 40 millions MSV in knees with osteoarthritis of grade II-IV (Kellgren and Lawrence).
- Conditions
- Osteoarthritis, Knee, Knee Degenerative Disease, Knee Osteoarthritis
- Trial name
- KDD&MSV (NCT01183728)
- Testing
- Autologous bone marrow mesenchymal stem cells (MSV)
- Where
- 2 sites in Spain
- Volunteers
- 12 people
- Sponsor
- Red de Terapia Celular
Osteoarthritis, Knee
Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial
Phase I/II randomized, double-blind, placebo-controlled clinical trial to test the safety and efficacy of Fisetin for treating mild to moderate osteoarthritis
- Trial name
- NCT04210986
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Steadman Philippon Research Institute
Knee Osteoarthritis, Knee Injuries
The Relationship Between Disease Severity and Various Lower Extremity Parameters in Individuals With Knee Osteoarthritis
This study perform to investigate the relationship between quadriceps femoris (QF) strength, QF thickness, femoral cartilage thickness, knee function, balance, kinesiophobia and gait of the patients with knee osteoarthritis.
- Trial name
- NCT05294224
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dilara Özen Oruk
Articular Cartilage Degeneration
MechSens - Dose-response Relationship of in Vivo Ambulatory Load and Mechanosensitive Cartilage Biomarkers
This study is to investigate the effects of age, tissue status and the presence of inflammation on the in vivo dose-response relationship of ambulatory load and mechanosensitive blood markers of articular cartilage.
- Trial name
- MechSens (NCT04128566)
- Testing
- walking stress test
- Where
- Switzerland
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Knee Osteoarthritis
Hydrolyzed Collagen Formulation vs Placebo in Knee Osteoarthritis
The aim of the study is to compare the 6 months clinical outcome of the treatment with a single intra-articular collagen injection versus a single placebo (saline solution) infiltration in the infiltrative treatment of knee…
- Trial name
- NCT04998188
- Testing
- Collagen
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- Istituto Ortopedico Rizzoli
Primary Osteoarthritis, Cartilage Degeneration
DEXA Bone Density Analysis of the CoreHip® Prosthesis System
The goal of this interventional post-market follow-up study is to evaluate radiological changes in the diaphyseal bone density (Gruen Zones 3 and 4) within 24 months postoperative in patients treated with CoreHip® primary…
- Conditions
- Primary Osteoarthritis, Cartilage Degeneration, Osteoarthritis, Hip, Inflammatory Arthritis
- Trial name
- CODEX (NCT06632301)
- Testing
- Primary hip replacement with cementless stem
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Aesculap AG
Degenerative Arthritis, Knee Arthritis
Investigator Initiated Trial to Evaluate Cartilage Regeneration by Arthroscopy After JOINTSTEM Administration
The purpose of this study is to confirm cartilage regeneration through arthroscopy after a single administration of autologous Adipose Tissue derived Mesenchymal stem cells(JOINTSTEM) in patients with degenerative arthritis of…
- Trial name
- NCT04821102
- Testing
- JOINTSTEM, Saline
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- R-Bio