Clinical trials: Cartilage Diseases
Osteoarthritis
Autologous Adipose-Derived Stromal Cells Delivered Intra-articularly in Patients With Osteoarthritis.
This will be an open-label, non-randomized, multi-center, patient sponsored study of Adipose-Derived Stromal Vascular Fraction (AD-SVF) implantation performed intra-articularly to affected joints.
- Trial name
- NCT01739504
- Testing
- Liposuction with Local Anesthesia, Intra articular infusion of AD-SVF
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ageless Regenerative Institute
Osteoarthritis, Knee
MRI Markers of Cartilage Damage in Knee With Osteoarthritis
The objectives of this study are: to identify and develop techniques to minimize precision errors in magnetic resonance imaging (MRI) evaluation of knee cartilage, and to determine if results from newly-identified MRI techniques…
- Trial name
- NCT00820430
- Testing
- Magnetic Resonance Imaging
- Where
- 5 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- American College of Radiology
Neurectomy
Graft Reinforcement for Posterior Nasal Nerve Neurectomy in Allergic Rhinitis Surgeries
Rhinitis is defined clinically as having two or more symptoms of anterior or posterior rhinorrhea, sneezing, nasal blockage and/or itching of the nose during two or more consecutive days for more than 1 h on most days.
- Trial name
- NCT05880134
- Testing
- conventional posterior nerve neurectomy, cartilage graft reinforcement after posterior nerve neurectomy
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Kafrelsheikh University
Osteoarthritis (OA)
Safety, Tolerability and Preliminary Efficacy of Multiple Intra-articular Injections of LRX712 in Patients With Knee OA
This study explored the preliminary efficacy of multiple intra-articular injections of LRX712 by evaluating the ability of the drug to restore structural integrity of articular cartilage.
- Trial name
- NCT04097379
- Testing
- LRX712
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Novartis Pharmaceuticals
Tracheomalacia
Dynamic Airway CT is Diagnostic for Tracheomalacia in Children
The purpose of this pilot interventional study is to evaluate the use of Dynamic Airway Computed Tomography (DA-CT) for diagnosis of tracheomalacia in children 0-18 years for whom flexible bronchoscopy has been performed.
- Trial name
- NCT06028646
- Testing
- Dynamic Airway CT scan (DA-CT)
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- NYU Langone Health
Laryngomalacia
Laryngomalacia Study
Noisy breathing is commonly caused by a floppy voicebox which is a condition called laryngomalacia. The cause of laryngomalacia is not fully understood, but some studies have suggested that it could be due to acid escaping from…
- Trial name
- NCT01782560
- Testing
- Omeprazole
- Where
- Canada
- Sponsor
- Children's & Women's Health Centre of British Columbia
Patellofemoral Pain Syndrome
Quadriceps Strengthening At Different Angles in Patellofemoral Pain
Introduction: Patellofemoral pain (PFP) is characterized by anterior, retropatellar and/or peripatellar pain during activities such as running, squatting, kneeling, or prolonged sitting.
- Trial name
- NCT06502795
- Testing
- Protected Range Quadriceps Strengthening group, Patient-Guided Range Quadriceps Strengthening group
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Universidade Federal do Ceara
Osteoarthritis, Pain
Efficacy of Exercise on Quality of Life and Physical Function in Patients With Knee Osteoarthritis
The overall contribution of this study is to increase the knowledge of the efficacy of strength and aerobic exercise on knee related quality of life, knee pain, and physical function in patients with knee osteoarthritis (OA).
- Trial name
- NCT01682980
- Testing
- Strength training, Aerobic exercise
- Where
- Norway
- Volunteers
- 207 people
- Sponsor
- Oslo University Hospital
Knee Injuries, Cartilage Injury
Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee
Multi-center, prospective, concurrently controlled, non-randomized, double-blind (patient and assessor). Treatment of large chondral lesions in the knee with microfracture plus the Chondro-Gide® ACC is non-inferior to treatment…
- Conditions
- Knee Injuries, Cartilage Injury, Cartilage Disease, Knee Discomfort
- Trial name
- SECURE (NCT04537013)
- Testing
- Microfracture, Microfracture plus placement of Chondro-Gide® ACC
- Where
- 15 sites in United States, Canada and 1 more
- Volunteers
- 82 people
- Sponsor
- Geistlich Pharma AG
Osteoarthritis, Knee
VItamin D Effect on Osteoarthritis Study
Observational evidence suggests that vitamin D deficiency may have a role in the causes of osteoarthritis (OA) and there are biologically plausible mechanisms to explain this.
- Trial name
- VIDEO (NCT01176344)
- Testing
- Vitamin D
- Where
- 2 sites in Australia
- Volunteers
- 413 people
- Sponsor
- Menzies Institute for Medical Research
Knee Osteoarthritis, Cartilage Degeneration
Impact of High Tibial Osteotomy in Preventing Degenerative Disease Progression in Medial Knee Osteoarthritis.
High tibial osteotomy (HTO) surgical procedure can lead to clinically significant improvements in the cartilage and in subchondral bone quality, with a slow down of the osteoarthritis (OA) progression.
- Conditions
- Knee Osteoarthritis, Cartilage Degeneration, Malalignment, Bone
- Trial name
- HTO-IOR (NCT05865899)
- Testing
- valgus producing medial opening wedge high tibial osteotomy
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli
Tracheomalacia, Bronchopulmonary Dysplasia (BPD)
Enhancing Lung Health in Kids With Structural Lung Damage and Malformations: Azithromycin (AZI) for Airway Infection Prevention
Children with lung and airway malformations or early structural lung damage face significant challenges, often leading to recurrent respiratory infections, hospitalizations, and decreased quality of life.
- Conditions
- Tracheomalacia, Bronchopulmonary Dysplasia (BPD), Vascular Ring, Cystic Lung Disease
- Trial name
- TRALULALA-AZI (NCT06409299)
- Testing
- Azithromycin 40 MG/ML
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Tympanic Membrane Perforation, Tympanoplasty
Comparison of Results of Myringoplasty Using Biodesign - an Otologic Graft Made From Porcine Small Intestinal Submucosa, Temporalis Fascia, or Tragal Perichondrium - a Retrospective Cohort Analysis
The goal of this observational, retrospective study is to learn whether a ready-made graft patch (Biodesign, made from porcine small intestinal submucosa) works as well as a participant's own tissue graft (such as tragal…
- Conditions
- Tympanic Membrane Perforation, Tympanoplasty, Myringoplasty
- Trial name
- Biodesign (NCT07698171)
- Testing
- tympanoplasty using Biodesign, tympanoplasty using autologous tissue graft
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Wolfson Medical Center
Knee Osteoarthritis
Effect of Knee Bracing on Improving Pain & Disability
The overall purpose of the proposed pilot study is to establish the feasibility of conducting a clinical trial by evaluating the preliminary effects of 8 weeks of knee bracing on physiological measures of self-reported pain and…
- Trial name
- NCT04044612
- Testing
- Medial Unloader Brace
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of North Carolina, Chapel Hill
Knee Osteoarthritis, Cartilage Degeneration
Platelet Rich Plasma Injection for Knee Osteoarthritis
The research questions of this study are; 1. Is platelet rich plasma (PRP) treatment effective in knee osteoarthritis (OA)? 2. What are the indications for PRP treatment? 3.
- Trial name
- NCT04454164
- Testing
- PRP, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 324 people
- Sponsor
- Ferhat Say
Parkinson Disease, Articular Cartilage Disorder
Femoral Cartilage Thickness in Parkinson's Disease
Parkinson's Disease (PD) is a chronic, progressive, degenerative movement disorder characterized by motor and non-motor findings, and the incidence increases with age.There are different methods for the evaluation of articular…
- Conditions
- Parkinson Disease, Articular Cartilage Disorder, Ultrasonography
- Trial name
- NCT05424848
- Testing
- Ultasonographic measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Knee Osteoarthritis
Effects of Carbon Dioxide Infrared Laser Moxibustion on Pain and Function in Knee Osteoarthritis
Knee osteoarthritis is a prevalent degenerative joint disorder characterized by chronic knee pain, stiffness, reduced range of motion, and limitations in daily functional activities.
- Trial name
- CILM-KOA (NCT07423182)
- Testing
- Exercise Program for Knee Osteoarthritis, CO2 Infrared Laser Moxibustion (CILM)
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- University of Lahore
Osteoarthritis of Knee
Effect of Overdose Ultrasound on Osteoarthritic Knee in Adult Albino Rat: a Histological Study
The purpose of this study is to investigate the effect of overdose ultrasound on the articular cartilage of the osteoarthritic knee in adult albino rate.
- Trial name
- NCT06774469
- Testing
- assigned, Injection, Solution, ultrasound
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Developmental Bone Disease, Dwarfism
Study of Skeletal Disorders and Short Stature
This study will determine the genes responsible for skeletal dysplasias (disorders of the skeleton) and short stature and define the range and type of medical problems they cause over time.
- Conditions
- Developmental Bone Disease, Dwarfism, Skeletal Dysplasias
- Trial name
- NCT00001754
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Articular Cartilage, Cartilage Diseases
The Objectives of the Cartilage Repair Registry is to Report Long Term Efficacy and Safety of Cartilage Repair Procedures in Registry Patients
The objectives of the Cartilage Repair Registry is to report the long term efficacy and safety of cartilage repair procedures in Registry patients.
- Trial name
- NCT00140634
- Testing
- Carticel (autologous cultured chondrocyte) implantation
- Where
- United States
- Volunteers
- 2,233 people
- Sponsor
- Vericel Corporation