Clinical trials: Cartilage Lesion
Focal Cartilage Lesions of the Knee
Management of Focal Cartilage Lesions of the Knee: The Benefits of an Autograft Procedure
Cartilage is a tissue whose primary function is to transmit and distribute loads when joints are under stress. It acts as a buffer between bones at the joints.
- Trial name
- CART-MCI Knee (NCT07641868)
- Testing
- Management of focal cartilage lesions of the knee: micro-fracture, Minced Cartilage Implantation (MCI)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Louis Pasteur Santé Lorraine
Foreign-Body Reaction, Inflammation
IMPACT: Safety and Feasibility of a Single-stage Procedure for Focal Cartilage Lesions of the Knee.
Articular cartilage defects in the knee have a poor intrinsic healing capacity and may lead to functional disability and osteoarthritis.
- Conditions
- Foreign-Body Reaction, Inflammation, Effusion (L) Knee, Knee Pain Swelling
- Trial name
- IMPACT (NCT02037204)
- Testing
- Cartilage repair surgery
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- UMC Utrecht
Articular Cartilage Defects in the Knee Joint
Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects
Multicenter, open-label, controlled, non-randomized, double arm trial with a prospective treatment arm (GelrinC). This study compares the efficacy and safety of GelrinC to a historical control arm (microfracture) in the treatment…
- Trial name
- SAGE (NCT03262909)
- Testing
- GelrinC, Microfracture historical control arm
- Where
- 13 sites in United States
- Volunteers
- 181 people
- Sponsor
- Regentis Biomaterials
Osteoarthritis
Study of Safety, Tolerability, Preliminary Efficacy of Intra-articular LNA043 Injections in Patients With Articular Cartilage Lesions and Knee Osteoarthritis.
The purpose of this two-part study is to assess the efficacy, safety and tolerability of multiple intra-articular (i.a.) injections of LNA043, in regenerating the articular surface in patients with cartilage lesions of the knee…
- Trial name
- NCT03275064
- Testing
- LNA043
- Where
- 19 sites in United States, Czechia and 1 more
- Volunteers
- 142 people
- Sponsor
- Novartis Pharmaceuticals
Meniscal Tear, Chondromalacia
The ChAMP (Chondral Lesions And Meniscus Procedures) Trial
The purpose of this randomized controlled trial is to determine the effectiveness of treating cartilage lesions found during knee arthroscopy.
- Trial name
- NCT01527201
- Testing
- Arthroscopic debridement
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- State University of New York at Buffalo
Chondral Lesion of the Knee, Meniscal Injuries
Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy
This study will examine whether using bone marrow aspirate (BMA) during knee arthroscopy surgery can improve patient outcomes. The investigators will enroll 50 patients who need knee arthroscopy surgery for meniscus injuries or…
- Conditions
- Chondral Lesion of the Knee, Meniscal Injuries, Cartilage Defects of the Knee, Osteoarthritis (OA) of the Knee
- Trial name
- BMA (NCT06893302)
- Testing
- Bone Marrow Aspirate (BMA), Arthroscopic Debridement Surgery, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Articular Cartilage Injury
Evaluation of an Acellular Osteochondral Graft for Cartilage LEsions Pilot Trial
The Kensey Nash Corp. Cartilage Repair Device is a bioresorbable scaffold designed to promote repair of knee cartilage and subchondral bone.
- Trial name
- EAGLE Pilot (NCT01183637)
- Testing
- Kensey Nash Corp. Cartilage Repair Device, Microfracture
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Kensey Nash Corporation
Hallux Valgus, Cartilage Damage
Prospective Study: The Effect on Clinical Outcome After Treatment of MTP Cartilage Lesions in Hallux Valgus Surgery
The aim of this study is to investigate the point or nonsense of treating cartilage lesions at the level of the first metatarsophalane joint.
- Trial name
- NCT04716140
- Testing
- Debridement of the MTP1 cartillage lesion and microfracture
- Where
- Belgium
- Volunteers
- 99 people
- Sponsor
- Tom Lootens
Trachea Diseases, Tracheal Stenosis
Feasibility of Tracheobronchial Reconstruction Using Allogenic Aortic Patch in Children
Feasibility and safety of repairing tracheal and bronchial defects in infants and children using cryopreserved donor aortic patches.
- Conditions
- Trachea Diseases, Tracheal Stenosis, Tuberculosis; Tracheitis, Airway Disease
- Trial name
- NCT07240259
- Testing
- Cryopreserved aorta
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Tear; Knee, Cartilage, Articular
Autologous Chondrocyte Transplantation For Articular Cartilage Regeneration
The purpose of this study is to assess safety and efficacy of autologous chondrocyte implantation delivered arthroscopically into chondral lesions of the knee using clinical, biochemical, and MRI outcomes.
- Trial name
- NCT01503970
- Testing
- Arthroscopic matrix encapsulated chondrocyte implantation
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Osteochondral Lesions of Knee, Osteo Arthritis
3D-Printed Grafts for Knee Cartilage Repair
Research Title:A study on 3D printing-assisted platelet-rich plasma combined with autologous periosteum-bone grafting in the treatment of knee cartilage injury Objectives:(1) To evaluate the accuracy of cartilage damage repair by…
- Trial name
- 3D-PR-PBG (NCT07312175)
- Testing
- 3D-Printed Scaffold-Assisted PRP Combined with Autologous Periosteal-Bone Grafting, 3D Printing-Assisted Autologous Periosteal-Bone Grafting
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Cartilage Lesion, Osteochondral Lesion
Cone Beam CT (CBCT) Arthrogram of the Ankle in Assessement of Osteochondral or Cartilage Lesions
This study aims to compare weight-bearing Cone Beam CT arthrogram and conventional CT arthrogram in assessement of patients with ankle osteo-chondral or cartilage lesions.
- Trial name
- Arthro-CBCT (NCT05203757)
- Testing
- ArthroCT scan, CBCT
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Laryngotracheal Lesions, Tracheostomy Complications
Laryngotracheal Lesions in Adults With Long-Term Tracheostomy
This multicenter prospective observational cohort study will enroll 224 adults with a tracheostomy tube in place for at least 14 days.
- Conditions
- Laryngotracheal Lesions, Tracheostomy Complications, Tracheal Stenosis, Tracheomalacia
- Trial name
- NCT07901946
- Testing
- Standardized Three-Station Bronchoscopy
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Hongying Jiang, MD
Meniscus Tear, Tibial
Diagnostic Value of Weight Bearing CT for Detecting Meniscal Tears
This observational study will compare the clinical value of weight-bearing CT arthrography (WBCTa) with that for MRI in evaluating meniscal and cartilage lesions of the knee joint.
- Trial name
- NCT04430829
- Testing
- Weight-Bearing CT arthrography, Knee MRI
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Kansas Medical Center
Chondral Defect, Articular Cartilage Defect
A Comparison of JointRep® and Microfracture in Repair of Cartilage Lesions on the Femoral Condyle or Trochlea,
The aim of the study is to compare whether JointRep® plus microfracture is more effective than microfracture alone when treating symptomatic focal articular cartilage lesions in the knee (femoral condyles or trochlea).
- Conditions
- Chondral Defect, Articular Cartilage Defect, Articular Cartilage Disorder of Knee
- Trial name
- JMAC (NCT04840147)
- Testing
- JointRep®, Microfracture
- Where
- 8 sites in Australia, Canada
- Volunteers
- 185 people
- Sponsor
- Oligo Medic Pty Ltd
Cartilage Lesion
A Talus Implant in Patients Between 20-60 Years of Age Followed up for a Minimum of 2 Years After Surgery
The project will investigate safety, feasibility and efficiency when using Episurf Episeal talus implant in patients with osteochondral ankle injuries.
- Trial name
- NCT06932380
- Testing
- Talus prosthesis
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Vestre Viken Hospital Trust
Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
Agili-C™ Implant Performance Evaluation
The current study compares the efficacy and safety of the Agili-C implant to Surgical Standard of Care treatment in patients suffering from joint surface lesions of the knee.
- Trial name
- NCT03299959
- Testing
- Agili-C implant, SSOC
- Where
- 26 sites in United States, Belgium and 6 more
- Volunteers
- 251 people
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthritis
Multimodal Evaluation of Cartilage Lesions of Patellofemoral Joint
Evaluation and comparison of histological analysis, 9,4 tesla MRI, Full-Field Optical Coherence Tomography (FFOCT) and ultrasound-based navigation system for cartilage degeneration analysis of patellofemoral joint.
- Trial name
- MULTICART (NCT03210584)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Grenoble
Degenerative Lesion of Articular Cartilage of Knee
Episealer® Knee System IDE Clinical Study
The study is a randomized, prospective, multicenter, controlled clinical trial of the Episealer Knee System. The Episealer Knee System is intended for subjects with up to two focal femoral knee chondral or osteochondral lesion…
- Trial name
- NCT04000659
- Testing
- Episealer Knee System, Microfracture
- Where
- 13 sites in United States, Canada and 2 more
- Volunteers
- 13 people
- Sponsor
- Episurf Medical Inc.
Articular Cartilage Lesion of the Femoral Condyle
Efficacy and Safety Study of co.Don Chondrosphere to Treat Cartilage Defects
This is a prospective, phase III, multicenter, open label, randomised clinical trial of co.don chondrosphere®, a three-dimensional autologous chondrocyte transplantation product (ACT3D-CS)compared to the procedure of…
- Trial name
- NCT01222559
- Testing
- co.don chondrosphere®, Microfracture
- Where
- 12 sites in Germany, Poland
- Volunteers
- 102 people
- Sponsor
- co.don AG