Clinical trials: Cascade Testing, open to volunteers
Colon Adenocarcinoma, Colorectal Adenocarcinoma
Family Communications After Genetic Testing
This clinical trial compares patient (proband)-mediated communication to provider-mediated communication for improving genetic testing in first-degree relatives of patients with newly diagnosed colorectal cancer.
- Conditions
- Colon Adenocarcinoma, Colorectal Adenocarcinoma, Rectal Adenocarcinoma, Stage I Colon Cancer AJCC v8
- Trial name
- NCT07143487
- Testing
- Biospecimen Collection, Genetic Testing, Communication Intervention
- Where
- 360 sites in United States, Puerto Rico
- Volunteers
- 4,186 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer, Colorectal Cancer
Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics
To identify Black individuals who are eligible for genetic testing through trusted community organizations, and to connect Black individuals and their families to genetic testing and counseling so that they can know their cancer…
- Trial name
- NCT05694559
- Testing
- Genetic Testing and Counseling, Screening Form
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
BRCA1-Related Hereditary Breast and Ovarian Cancer Syndrome, BRCA2-Related Hereditary Breast and Ovarian Cancer Syndrome
A Web-Based Program (Kindred) to Improve the Understanding of Genetic Cancer Risk and Cancer Genetic Testing in African American Families
This clinical trial studies whether a web-based program, Kindred, works to improve the understanding of genetic cancer risk and cancer genetic testing in African American families.
- Conditions
- BRCA1-Related Hereditary Breast and Ovarian Cancer Syndrome, BRCA2-Related Hereditary Breast and Ovarian Cancer Syndrome, Hereditary Neoplastic Syndrome, Lynch Syndrome
- Trial name
- NCT07542405
- Testing
- Discussion, Internet-Based Intervention, Survey Administration
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Familial Hypercholesterolemia
Cascade Testing In Identifying At-risk Family Members Of Individuals With Familial Hypercholesterolemia (FH) In PCP
The purpose of this study is to evaluate the effectiveness of two models of cascade testing in identifying at-risk family members of individuals diagnosed with familial hypercholesterolemia (FH).
- Trial name
- NCT07653555
- Testing
- Cascade testing, Standard of Care
- Where
- United States
- Volunteers
- 480 people
- Sponsor
- Mayo Clinic
Hereditary Breast and Ovarian Cancer, Lynch Syndrome
Cascade Genetic Testing for Hereditary Breast/Ovarian Cancer and Lynch Syndrome in Switzerland
Breast, colorectal, ovarian, and endometrial cancers constitute approximately 30% of newly diagnosed cancer cases in Switzerland and affect more than 12,000 individuals annually.
- Trial name
- CASCADE (NCT03124212)
- Testing
- CASCADE genetic screening
- Where
- 9 sites in Switzerland
- Volunteers
- 700 people
- Sponsor
- University of Basel
Long QT Syndrome, Familial Hypercholesterolemia
Comparing Direct vs Indirect Methods for Cascade Screening
An important aspect of successful genomic medicine implementation is developing effective approaches for screening at-risk family members after probands are identified, also known as cascade screening.
- Conditions
- Long QT Syndrome, Familial Hypercholesterolemia, Ethics, Genetic Testing
- Trial name
- NCT05348564
- Testing
- Direct contact of family members for cascade screening of relevant variants
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Maryland, Baltimore
Dyslexia
Validating a Neurocognitive Remediation Model for Visual-Attentional Pathway in Chinese Developmental Dyslexia
Developmental dyslexia is a common and serious specific learning disability affecting up to one in eight children in Hong Kong, with profound consequences for academic success and personal well-being.
- Trial name
- NCT07707700
- Testing
- Action video game intervention group, Active Control (Non-Action Video Game) Group
- Where
- Hong Kong
- Volunteers
- 76 people
- Sponsor
- The Hong Kong Polytechnic University
Cascade Testing, Lynch Syndrome
Initial Testing of a Behavioral Intervention About Genetic Services for Families at Risk of Lynch Syndrome
The purpose of the study is to see if our education materials help people at risk for Lynch syndrome decide about seeking genetic services.
- Conditions
- Cascade Testing, Lynch Syndrome, Decision Making, Colorectal Cancer
- Trial name
- NCT07106359
- Testing
- Information Letter and Booklet, Information Letter
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Human Papillomavirus (HPV), HPV Associated Cancers
C2001P-CS3: Testing the Feasibility of Different HPV Screening and Care Strategies for Women Living With HIV
The overall goal of this study is to inform the design and establish feasibility for a future clinical trial to determine the optimal management of women living with HIV (WLWH) with high-risk human papillomavirus (hrHPV) detected…
- Conditions
- Human Papillomavirus (HPV), HPV Associated Cancers, Cervical Cancer, Human Immunodeficiency Virus (HIV)
- Trial name
- NCT07576842
- Testing
- HPV DNA Testing (Abbott Alinity m HPV Assay), Visual Inspection with Acetic Acid, Cervical Histology (Biopsy Procedures)
- Where
- Botswana
- Volunteers
- 750 people
- Sponsor
- University of California, San Diego
Hereditary Malignant Neoplasm, Hereditary Neoplastic Syndrome
Navigation Interventions to Improve Cascade Genetic Testing Among Relatives of Patients With Hereditary Cancer Syndromes
This clinical trial tests whether various web-based tools can help improve communication about hereditary cancer risk in families and decrease barriers to genetic testing for relatives of patients with hereditary cancer…
- Trial name
- NCT06927947
- Testing
- Communication Intervention, Health Promotion and Education, Informational Intervention
- Where
- United States
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- University of Michigan Rogel Cancer Center
Genetic Predisposition, Family Members
The Preventive Risk Outreach And Cascade Testing
The goal of this clinical trial is to learn whether a new online program developed by the research team is able to help families learn about family cancer risk and how to reduce this risk, as well as help interested family…
- Trial name
- PROACT (NCT07478237)
- Testing
- Minimally facilitated platform, AI-powered platform
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Stanford University