Clinical trials: Case-control Study
Healthy Subjects
Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases: Case-control
Connective tissue diseases (CTD) or systemic autoimmune diseases (SADs) as they are known today are a group of chronic inflammatory conditions with autoimmune aetiology with few treatment options and difficult diagnosis.Brest…
- Trial name
- PRECISESADST (NCT02890147)
- Where
- 17 sites in Austria, Belgium and 7 more
- Volunteers
- 649 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Breast Cancer Detection, Dense Breast Parenchyma
Delphinus SoftVue™ ROC Reader Study (DMT SV RRS3)
The purpose of this multi-reader, multi-case (MRMC) reader study is to evaluate reader performance when SoftVue™ automated breast ultrasound and screening mammography are combined, compared to screening mammography alone, in…
- Conditions
- Breast Cancer Detection, Dense Breast Parenchyma, Benign Breast Findings, Normal Breast Screening
- Trial name
- DMT SV RRS3 (NCT04260620)
- Testing
- Reading of Automated Breast Ultrasound in conjunction with Screening Mammography
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Delphinus Medical Technologies, Inc.
Brain Injuries, Stroke
Effects of Prolonged and Chronic Critical Illness Induced by Brain Injury on Metabolic State
Brain injuries, including acute stroke (AS) and traumatic brain injury (TBI), are prevalent pathologies with severe consequences.
- Conditions
- Brain Injuries, Stroke, Malnutrition, Critical Illness
- Trial name
- NCT06545825
- Testing
- Standard enteral nutrition
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology
Placenta Previa, Placenta Accreta Spectrum
Syncytiotrophoblast-derived Extracellular Vesicles in Placenta Previa and Accreta Spectrum
The main goal of this case-control study is to quantify the levels of circulating syncytiotrophoblast-derived extracellular vesicles (STBEVs) in maternal blood in a population of women with placenta previa and placenta accreta…
- Trial name
- PAS (NCT06867874)
- Testing
- Blood sample
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Covid19
DNA Damage and Oxidative Stress in Hospitalized COVID-19 Patients
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic challenging health systems worldwide.
- Trial name
- ABCD (NCT04784468)
- Testing
- No intervention
- Where
- Austria
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Myocardial Infarction
The Risk of Myocardial Infarction in Users of Antipsychotic Agents
A number of studies have suggested an association between the use of antipsychotic agents and cardiovascular mortality. However, the relationship between cardiac events and the use of antipsychotic drugs is not clear.
- Trial name
- NCT01236274
- Where
- United Kingdom
- Volunteers
- 90,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Pneumonia, Aspiration
The Clinical Application Value of "Showering Cells" in the Diagnosis of Aspiration Pneumonia
Based on our team's previous discovery of a unique type of squamous epithelial cell in the bronchoalveolar lavage fluid (BALF) of patients with aspiration pneumonia (AP) using microbiological rapid on-site evaluation (M-ROSE)…
- Trial name
- NCT07395310
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Chinese PLA General Hospital
SARS-CoV-2 Infection
Burn Injuries During COVID-19 Pandemic and Its Influence on Length of Stay
Burn injuries were thought to be difficult to treat during the new corona virus epidemic. Our goal is to determine the risk factors that influence length of hospital stay (LOS) of burn injured patients during COVID -19 pandemic.
- Trial name
- NCT06330389
- Testing
- Burn Injuries Graft Surgery
- Where
- Qatar
- Volunteers
- 70 people
- Sponsor
- Hamad Medical Corporation
Hyperemesis Gravidarum, Pregnant With Complication
Pepsinogen-1 Serum Levels in Hyperemesis Gravidarum
In this study, the investigators planned to investigate maternal serum pepsinogen-1 (MSPG-1) levels in pregnant women with severe hyperemesis gravidarum (HG) and pregnant women without severe HG.
- Trial name
- NCT06581796
- Testing
- pepsinogen-1
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Retinal Detachment, Achilles Tendon
A Study of Fluoroquinolones Exposure and Collagen-Related Serious Adverse Events
The purpose of this study is to evaluate whether there is an increased risk of achilles tendon rupture (ATR), retinal detachment (RD) or aortic aneurysm and dissection (AAD) following exposure to fluoroquinolone (FQ) or other…
- Conditions
- Retinal Detachment, Achilles Tendon, Aneurysm, Dissecting
- Trial name
- NCT03479736
- Testing
- Oral Fluoroquinolones (FQ), Other Antibiotics, Febrile Illness Not Treated with Antibiotics Will be Analyzed as an Exposure
- Where
- United States
- Volunteers
- 117,911 people
- Sponsor
- Janssen Research & Development, LLC
Stillbirth
The Midlands and North of England Stillbirth Study
The United Kingdom has one of the highest rates of stillbirth in Europe, with more than 4,000 stillbirths every year; which equates to more than 11 deaths every day.
- Trial name
- MiNESS (NCT02025530)
- Testing
- Questionnaire
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,030 people
- Sponsor
- University of Manchester
Mpox (Monkeypox)
Epidemiological and Clinical Characteristics of Mpox Outbreak in Equateur, the DR Congo (Part1)
The goal of this observational study is to characterize the clinical features of the 2024 mpox outbreak in Equateur Province of DRC and to identify associated risk factors.
- Trial name
- NCT07055867
- Where
- Democratic Republic of the Congo
- Volunteers
- 122 people
- Sponsor
- Osaka Metropolitan University
Acute Appendicitis
Laparoscopic Assisted or Total Laparoscopic Appendectomy
Acute appendicitis (AA), is a common intra-abdominal surgical pathology with the overall incidence of approximately 7% and mortality of 0.2-0.8%.
- Trial name
- NCT02673528
- Testing
- Laparoscopic appendectomy
- Volunteers
- 451 people
- Sponsor
- Medical Park Gaziantep Hospital
Abdominal Wall Hernia
Outcomes of Open Versus Robotic-assisted Laparoscopic Posterior Component Separation in Complex Abdominal Wall Repair
This is a retrospective European multicenter study evaluating surgical treatment of patients with a complex ventral incisional hernia using robotic-assisted laparoscopic transversus abdominis release (rTAR) or open transversus…
- Trial name
- EUROTAR (NCT05195957)
- Testing
- Robotic tranversus abdominis release operation, Open transversus abdominis release operation
- Where
- 2 sites in Belgium, Finland
- Volunteers
- 169 people
- Sponsor
- University of Oulu
SCAR
An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine Acetate
The reason for this study is to understand if people with certain genes are predisposed to develop severe skin reactions after they are administered Eslicarbazepine Acetate.
- Trial name
- NCT02520557
- Testing
- Blood or Saliva
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Sumitomo Pharma America, Inc.
Tuberculosis
Early Risk Assessment in Household Contacts (≥10 Years) of TB Patients by New Diagnostic Tests in 3 African Countries
The ERASE - TB study will be conducted in order to fill a critical unmet need for tuberculosis control. Persons who are in contact with an infectious TB case may become infected themselves.
- Trial name
- ERASE-TB (NCT04781257)
- Testing
- New test candidates
- Where
- 3 sites in Mozambique, Tanzania and 1 more
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Michael Hoelscher
Retinal Detachment Multiple Breaks
Redetachment Under Densiron for RD Multiple Breaks
Densiron is used as a tamponading agent for inferior retinal detachment with inferior retinal breaks However, data about the use of Densiron -68 for RRD with multiple retinal breaks; especially if involving both superior and…
- Trial name
- Densiron (NCT05716971)
- Testing
- Densiron-68 (heavy silicone oil) tamponade for retinal detachment
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Dar El Oyoun Hospital
COPD, Healthy
Pulmonary Diffusing Capacity During Incremental Exercise in COPD
Background: The combined measurement of pulmonary diffusing capacity for carbon monoxide (CO) and nitric oxide (NO) (DL,CO,NO) has recently been standardized and validated for clinical use.
- Conditions
- COPD, Healthy, Lung Diseases
- Trial name
- DiffLung3 (NCT06505902)
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Breast Cancer, Vitamin D Deficiency
Epidemiological Analysis of Vitamin D and Breast Cancer Risk in Saudi Arabian Women
This is an analysis of de-identified data collected from 240 Saudi Arabian women, 120 with breast cancer and 120 control women, to evalyate if vitamin D status is associated with breast cancer risk.
- Trial name
- NCT01817231
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Cerebrovascular Disease
Why Does Aspirin Fail in Secondary Cerebrovascular Prevention? A Multicenter Prospective Case - Control Study
Multicenter prospective observational case-control study aimed at characterizing the possible determinants of treatment failure in patients with cerebrovascular disease on secondary prevention with ASA, who are hospitalized in…
- Trial name
- ASTRO (NCT05247931)
- Testing
- TXB2 assay of serum , and 11-dehydro-TXB2 assay of urine
- Where
- 16 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Fadoi Foundation, Italy
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