Clinical trials: Cataracts
Dry Eye Syndromes
Clinical Effects and Safety of 3% Diquafosol After Cataract Surgery
The purpose of this study is determine whether 3% diquafosol and 0.1% sodium hyaluronate are effective and safe in the treatment of patients with dry eye after cataract surgery.
- Trial name
- NCT02608489
- Testing
- Diquafosol (Diquas), Sodium Hyaluronate (Hyalein)
- Volunteers
- 86 people
- Sponsor
- Soonchunhyang University Hospital
Cataract
Three Intraocular Lenses Designed to Improve Distance, Intermediate and Near Vision Following Lens Extraction
The objective of this study is to compare the contrast sensitivity, high and low contrast visual acuity (VA), glare meter outcomes, and subject satisfaction with three different FDA-approved intraocular lenses (IOLs) designed to…
- Trial name
- NCT01225952
- Testing
- Crystalens AO, ReSTOR 3.0, AMO Tecnis Multifocal
- Where
- Philippines
- Volunteers
- 93 people
- Sponsor
- Bausch & Lomb Incorporated
Blepharitis, Dry Eye Syndrome
Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery
The purpose of this pilot feasibility study is to assess whether treating meibomian gland dysfunction (MGD) prior to cataract surgery helps promote meibomian gland function, visual quality and ocular comfort after cataract…
- Trial name
- NCT01808560
- Testing
- LipiFlow Pre-Treatment, LipiFlow Post-treatment
- Where
- 7 sites in United States
- Volunteers
- 34 people
- Sponsor
- TearScience, Inc.
Cataract
A Safety and Efficacy Study of a Dexamethasone Drug Delivery System for Postoperative Inflammation and Pain After Cataract Surgery
This is a safety and efficacy study of a Dexamethasone Drug Delivery System for anterior segment inflammation and pain following cataract extraction with lens implantation.
- Trial name
- NCT01605942
- Testing
- Dexamethasone Drug Delivery System
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Allergan
Glaucoma, Cataract
A Comparison of Three Different Formulations of Prednisolone Acetate 1%
Generic prednisolone acetate 1% is less effective than Pred Forte 1% or Econopred Plus 1%.
- Trial name
- NCT00345046
- Testing
- Pred Forte, EconoPred Plus, Prednisolone Acetate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Primary Open Angle Glaucoma (POAG), Cataract
Study of an Implantable Device for Lowering Intraocular Pressure in Glaucoma Patients Undergoing Cataract Surgery
The purpose of this study is to evaluate the safety and efficacy of the CyPass Implant for lowering intraocular pressure (IOP) in patients with glaucoma who undergo cataract surgery.
- Trial name
- COMPASS (NCT01085357)
- Testing
- Cataract Surgery, CyPass Micro-Stent
- Volunteers
- 897 people
- Sponsor
- Transcend Medical, Inc.
Post-Surgical Ocular Pain, Post-Surgical Ocular Inflammation
OTX-15:003: A Phase 3 Study Evaluating the Safety and Efficacy of OTX-DP for the Treatment of Ocular Inflammation and Pain After Cataract Surgery
The objective of the study was to evaluate the safety and efficacy of OTX-DP (dexamethasone insert) 0.4 mg for intracanalicular use when placed in the canaliculus of the eyelid for the treatment of post-surgical inflammation and…
- Trial name
- NCT02736175
- Testing
- Dexamethasone
- Volunteers
- 438 people
- Sponsor
- Ocular Therapeutix, Inc.
Non-Proliferative Diabetic Retinopathy, Cataract
Nepafenac Once Daily for Macular Edema - Study 1
The purpose of this study is to demonstrate superiority of Nepafenac Ophthalmic Suspension, 0.3% dosed once daily relative to Nepafenac Vehicle based upon clinical outcomes among diabetic subjects following cataract surgery.
- Trial name
- NCT01853072
- Testing
- Nepafenac Ophthalmic Suspension, 0.3%, Nepafenac vehicle, Prednisolone acetate
- Volunteers
- 881 people
- Sponsor
- Alcon Research
Cataract
Evaluation of Quality of Vision and Visual Outcomes With Bilateral Implantation of the Clareon PanOptix Intraocular Lens
To evaluate visual outcomes and quality of vision following bilateral implantation of the Clareon PanOptix intraocular lens (IOL) targeted for emmetropia.
- Trial name
- NCT05518539
- Testing
- The Clareon™ PanOptix™ Trifocal (toric and non-toric models)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Newsom Eye & Laser Center
Cataract
A Comparison of Visual Function After Bilateral Implantation of Presbyopia-correcting Intraocular Lenses (IOLs)
The purpose of this study is to prospectively evaluate postoperative visual and refractive parameters in a series of subjects bilaterally implanted with the AcrySof® IQ ReSTOR® +3 versus those bilaterally implanted with the…
- Trial name
- NCT01166971
- Testing
- ReSTOR +3, Tecnis MF
- Where
- 3 sites in United States
- Volunteers
- 65 people
- Sponsor
- Alcon Research
Aphakia, Cataract
A Clinical Study to Evaluate The Safety and Effectiveness of The RxSight Light Adjustable Lens (LAL) In Subjects Desiring an Extended Depth of Focus
The primary objective of this study is to evaluate, for the visual correction of aphakia and presbyopia, the safety and effectiveness of the RxSight Light Adjustable Lens (LAL) to provide an extended depth of focus (improve…
- Conditions
- Aphakia, Cataract, Presbyopia
- Trial name
- NCT04177771
- Testing
- Light Adjustable lens (LAL) and Light Delivery Device (LDD) - Pre-COVID Population, SofPort LI61AO IOL, Tecnis ZCB00 or ZTC150 IOL
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- RxSight, Inc.
Cataract
Comparison of Functional Vision Provided by AMO Tecnis Z9000 and Alcon SA60AT Acrysof
This study is to compare intraindividually the functional vision provided by two different posterior chamber intraocular lenses: AMO Tecnis Z9000 and Alcon SA60AT Acrysoft.
- Trial name
- NCT00459303
- Testing
- aspherical intraocular lens, spherical intraocular lens
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cystoid Macular Edema
Effect of Nepafenac on Post-operative Macular Swelling Following Uncomplicated Cataract Surgery
Purpose: Study the effect of nepafenac ophthalmic suspension 0.1% to prevent post-operative cystoid macular edema following uncomplicated cataract surgery Participants: Patients having cataract surgery at UNC who meet eligibility…
- Trial name
- NCT00494494
- Testing
- Standard Care, nepafenac
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of North Carolina, Chapel Hill
Pseudophakia, Inflammation
Clinical Outcomes and Evaluation of Lotemax 0.5% in Treatment of Ocular Inflammation Associated With Cataract Surgery
Investigate the intraocular pressure(pressure inside the eye) of patients who are treated with Lotemax after undergoing cataract surgery.
- Trial name
- NCT01344226
- Testing
- loteprednol 0.5% ophthalmic solution
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Toyos Clinic
Cataract
A Comparison of Aspheric Toric Intraocular Lens (IOL) Implantation Versus Aspheric Non-Toric Lens Implantation
The purpose of this study was to evaluate and compare uncorrected distance visual acuity measurement in pseudophakic subjects with bilateral implantation of an AcrySof IQ Toric Intraocular Lens (IOL) versus bilateral implantation…
- Trial name
- NCT01225926
- Testing
- Toric T3 - T9, IQ SN60WF
- Volunteers
- 24 people
- Sponsor
- Alcon Research
Cataract
Phaco Versus Small Incision Cataract Surgery (SICS) Health Economic Study
To compare the health economic parameter and clinical outcome of Phacoemulsification with small incision cataract surgery (SICS)
- Trial name
- NCT00762606
- Testing
- Phacoemulsification cataract extraction surgery, Small incision cataract surgery
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Alcon Research
Cataract, Aphakia
Post-Market Clinical Investigation of the Clareon® IOL
The primary purpose of this study is to evaluate the long-term (3 years) visual acuity and adverse event outcomes for the Clareon® Intraocular Lens (IOL).
- Trial name
- NCT03316885
- Testing
- Clareon® IOL, Cataract Surgery
- Where
- 19 sites in Australia, France and 5 more
- Volunteers
- 245 people
- Sponsor
- Alcon Research
Aphakia, Cataract
Clinical Study to Evaluate the Safety and Effectiveness of the RxSight Light Adjustable Lens (LAL) in Subjects With Prior Corneal Refractive Surgery
The primary objective of this study is to evaluate, for the visual correction of aphakia, the safety and effectiveness of the RxSight Light Adjustable Lens (LAL) and Light Delivery Device (LDD) to reduce postoperative refractive…
- Trial name
- NCT03660865
- Testing
- Light Adjustable lens (LAL) and Light Delivery Device (LDD), Control IOL
- Where
- 6 sites in United States
- Volunteers
- 105 people
- Sponsor
- RxSight, Inc.
Cataract
Clobetasol Propionate Ophthalmic Nanoemulsion 0.05% for the Treatment of Inflammation and Pain Associated With Cataract Surgery (CLOSE-1)
Cataract surgery is one of the most common surgical procedures performed worldwide. In fact, in 2017, 3.8 million cataracts procedures were performed in the US.
- Trial name
- CLOSE-1 (NCT04246801)
- Testing
- Clobetasol propionate, Vehicle
- Where
- 22 sites in United States
- Volunteers
- 250 people
- Sponsor
- Salvat
Cataract
Nepafenac 0.3% Two Study
The purpose of this study was to assess the safety and efficacy of Nepafenac Ophthalmic Suspension, 0.3% for the prevention and treatment of inflammation (swelling and redness) and pain in the eye after cataract extraction.
- Trial name
- NCT01318499
- Testing
- Nepafenac Ophthalmic Suspension, 0.3%, Nepafenac Ophthalmic Suspension, 0.1%, Nepafenac Vehicle 0.3%
- Where
- United States
- Volunteers
- 1,342 people
- Sponsor
- Alcon Research