Clinical trials: Catecholamines
Blood Pressure, Inflammation
Mental Stress & Diesel Exhaust on Cardiovascular Health
This study uses an experimental design to conduct a double-blind, randomized, crossover study where participants receive both diesel exhaust and a mental stress test in a controlled setting.
- Conditions
- Blood Pressure, Inflammation, Catecholamines
- Trial name
- DESTRESS (NCT03467997)
- Testing
- Trier social stress test, Diesel exhaust
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Washington
Parkinson Disease, Autonomic Nervous System Diseases
Biomarkers of Risk of Parkinson Disease
This study (https://pdrisk.ninds.nih.gov) will determine if people who have risk factors for Parkinson disease (PD) have biomarkers (objective ways to measure a disease process) that show that the disease process is actually…
- Conditions
- Parkinson Disease, Autonomic Nervous System Diseases, Pure Autonomic Failure
- Trial name
- NCT00775853
- Testing
- 6-[18F]Fluorodopamine, 6-[18F]Fluorodopa, 13N-Ammonia
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Autoimmune Diseases
Concentration/Meditation Limits Inflammation
Auto-immune diseases are characterized by an inappropriate inflammatory response against tissues in the body and represent a major health care burden.
- Trial name
- NCT01835457
- Testing
- Lipopolysaccharide, Concentration/meditation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Autonomic Nervous System Disease, Healthy
Study of Norepinephrine Levels and Sympathetic Nervous System Activity
Brain and nerve cells communicate with each other by releasing and picking up chemicals called neurotransmitters. Norepinephrine is a neurotransmitter used by part of the nervous system activated during stress called the…
- Conditions
- Autonomic Nervous System Disease, Healthy, Hypertension
- Trial name
- NCT00001329
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Obesity, Abdominal
Microcurrent and Aerobic Exercise Effects in Abdominal Fat
The purpose of this study was to analyze microcurrent short term effects used with aerobic exercise on abdominal fat.
- Trial name
- NCT02110927
- Testing
- Transcutaneous microcurrent, Aerobic exercise
- Where
- Portugal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Escola Superior de Tecnologia da Saúde do Porto
Glaucoma, Open-Angle, Chronic Wounds
Absorption and Safety of Topical Timolol to Treat Chronic Wounds
Topical timolol has been used primarily as eye drops to treat glaucoma for many years. Recent clinical experience has broadened its off-label use for a number of skin conditions, including slow-healing wounds.
- Trial name
- NCT04903366
- Testing
- Timolol Maleate
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VA Northern California Health Care System
Neonatal Sepsis, Shock, Septic
Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock
Preterm infants (born at less than 37 weeks of pregnancy) sometimes develop a serious blood infection leading to low blood pressure, which does not respond to saline or to the standard medicines for increasing blood pressure…
- Trial name
- NCT06306001
- Testing
- Methylene Blue
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Obesity, Fibromyalgia
Impact of WBC on Patients With Metabolic or Neurological Diseases or Fibromyalgia (WBC-MeNeFi)
The purpose of this clinical trial is to investigate on different types of patients the effects of 10 sessions of whole-body cryostimulation (WBC): 1) in patients with obesity (BMI > 30), we want to investigate whether WBC…
- Conditions
- Obesity, Fibromyalgia, Neurological Conditions
- Trial name
- WBC-MeNeFi (NCT05443100)
- Testing
- Whole-body cryostimulation (WBC), Rehabilitation program
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Auxologico Italiano
Cardiac Surgery
Catecholamine-O-Methyl-Transferase(COMT)-Polymorphism in Cardiac Surgery
Although clinical risk factors for postoperative development of vasodilatory shock and acute renal failure have been identified; there is a considerable proportion of patients undergoing cardiac surgery where this syndrome cannot…
- Trial name
- NCT00334009
- Where
- Australia
- Volunteers
- 250 people
- Sponsor
- Austin Health
EGCG Influence on Catecholamine Metabolism
Epigallocatechin Gallate Lowers Circulating Catecholamine Concentrations and Alters Lipid Metabolism.
The aim of this study was to explore the impact of acute ingestion of the polyphenol epigallocatechin galate (EGCG) on catecholamine, catecholamine metabolite, systemic metabolic and cardio-vascular variables across a range of…
- Trial name
- NCT03199430
- Testing
- Epigallocatechin gallate
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Swansea University
Burns
Catecholamine Blockade Post-burn
Severe burn is associated with a wide array of stress, metabolic, and physiologic processes in an attempt to restore homeostasis.
- Trial name
- NCT01299753
- Testing
- propranolol
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pheochromocytoma, Obstructive Sleep Apnea
Metanephrines in Obstructive Sleep Apnoea
Although most patients have essential (unexplained) hypertension, some patients have a treatable underlying condition. One such condition is phaeochromocytoma, a tumour that produces excessive stress hormones.
- Conditions
- Pheochromocytoma, Obstructive Sleep Apnea, Catecholamine; Secretion
- Trial name
- NCT05053685
- Testing
- Measurement of Urine and plasma metanephrines
- Where
- Singapore
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Schizophrenia, Schizoaffective Disorder
Effects of Modafinil on Brain Function in Patients With Schizophrenia
This study will evaluate whether modafinil improves cognition in patients with schizophrenia and healthy volunteers. Modafinil is a drug that has been FDA approved for day-time sleepiness and allegedly increase the amount of the…
- Trial name
- NCT00057707
- Testing
- Modafinil, Functional MRI, Neuropsychological Testing
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy Volunteers, Normal Physiology
Reference Values for Plasma Catechols
Objectives: Plasma levels of catechols have distinct meanings in terms of indicating functions of endogenous catecholamine systems.
- Trial name
- NCT00267904
- Testing
- Coffee, Banana, Olives
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
COPD, Sympathetic Nervous System Diseases
Sympathetic Nerve Activity Predictors in Patients With Chronic Obstructive Pulmonary Disease
The project will be pursued in our respiratory, autonomic nervous system physiology laboratory (Respiratory, autonomic nervous system physiology laboratory, Department of Pneumology and Intensive Care Medicine, RWTH Aachen…
- Conditions
- COPD, Sympathetic Nervous System Diseases, Catecholamine; Overproduction
- Trial name
- SNAP-COPD (NCT04849806)
- Testing
- Assessments of the sympathetic nerve activity axis, OSA severity, Determination of PH and right HF severity
- Where
- Germany
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Pheochromocytoma, Adrenal Incidentaloma
Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue
To investigate the effect of catecholamine excess on brown fat. To evaluate the effect of brown fat on energy expenditure and lipid and glucose metabolism
- Trial name
- NCT01949714
- Testing
- Removal of adrenal tumor
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Septic Shock
Phenylephrine in Septic Shock
The present study was conducted as a prospective, randomized, controlled study to compare: the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic…
- Trial name
- NCT00639015
- Testing
- Phenylephrine, Norepinephrine
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Roma La Sapienza
Catecholamine-resistant Hypotension (CRH), Distributive Shock
A Study of LJPC-501 in Paediatric Patients With Hypotension Associated With Distributive or Vasodilatory Shock
The objective of this study is to evaluate the effect of LJPC-501 infusion on mean arterial pressure (MAP) as assessed by standard of care vasopressor dose reduction in pediatric patients with catecholamine-resistant hypotension…
- Conditions
- Catecholamine-resistant Hypotension (CRH), Distributive Shock, High Output Shock, Septic Shock
- Trial name
- NCT03623529
- Testing
- LJPC-501 (angiotensin II)
- Where
- 2 sites in Belgium, Lithuania
- Volunteers
- 100 people
- Sponsor
- La Jolla Pharmaceutical Company
Brain Injuries, Traumatic
Beta Blockade in in Traumatic Brain Injury
The purpose of this study is test the effect of beta-adrenergic blockade on mortality in patients with traumatic brain injury with the hypothesis being that the addition of beta blockade to the treatment regime of this patient…
- Trial name
- NCT02957331
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Tennessee
Congenital Adrenal Hyperplasia, Healthy
Catecholamine Reserve and Exercise Tolerance in Healthy Volunteers and Patients With Congenital Adrenal Hyperplasia
This study will examine and compare the effects of intense exercise on the release of catecholamines in patients with congenital adrenal hyperplasia (CAH) and in healthy persons.
- Trial name
- NCT00011791
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)