Clinical trials: Cathartics
Constipation
A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adolescent Subjects
The objective of this study is to evaluate the safety and efficacy of BLI400 laxative in constipated adolescent subjects.
- Trial name
- NCT02665728
- Testing
- BLI400 Laxative
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Braintree Laboratories
Chronic Constipation
To Determine the Effect of Forlax® Treatment in Children With Chronic Constipation Who May Also Suffer From Soiling/ Faecal Incontinence.
The purpose of this study is to determine whether Forlax® is more effective than placebo in relieving chronic constipation in children who may also suffer from soiling or faecal incontinence.
- Trial name
- NCT00255372
- Testing
- PEG 4000 (Forlax®)
- Where
- 2 sites in Thailand
- Volunteers
- 88 people
- Sponsor
- Ipsen
Bowel Preparation Solutions, Colonoscopy
Efficacy, Tolerance and Safety of Split Dose Bowel Preparation for Colonoscopy: 4L Polyethylene Glycol (PEG) Versus 1L Polyethylene Glycol Plus Sodium Picosulfate-magnesium Citrate (SPMC)
4L split dose PEG is the gold standard for bowel preparation, however it comes with poor tolerability and poor compliance. Combination of PEG with different agent is useful in reducing total volume, improving compliance and…
- Trial name
- NCT04474002
- Testing
- 4L Klean Prep®, 1L Klean prep® and 2 sachets Picoprep®
- Where
- Hong Kong
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Irritable Bowel Syndrome
The Effects of Laxative-probiotic Sequential Treatment in the Irritable Bowel Syndrome Patients
the laxative-probiotic sequential treatment might reduce the symptoms of IBS and alter the fecal microbiota of the patients in a more robust manner .
- Trial name
- NCT02254629
- Testing
- Probiotic Clostridium Butyricum, Laxative Polyethylene Glycol
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Shandong University
Constipation, Chronic Idiopathic Constipation
An Open Label Study of Chronic Use of BLI400 Laxative in Constipated Adults
The objective of this study is to evaluate the safety of chronic use of BLI400 laxative in constipated adults.
- Conditions
- Constipation, Chronic Idiopathic Constipation, CIC
- Trial name
- NCT02819310
- Testing
- BLI400 Laxative
- Where
- 24 sites in United States
- Volunteers
- 330 people
- Sponsor
- Braintree Laboratories
Laxative Compatibility
Sodium Picosulfate Plus Magnesium Citrate Versus Macrogol 4000 in the Bowel Cleansing Procedure: a Comparison of Efficiency and Compatibility
For effective cleansing of the bowel prior to colonoscopy polyethylene glycol (e.g. macrogol) has widely been used in Germany. Usually patients have to drink between 4 an 6 liter of macrogol in a split dose (3 liter on the day…
- Trial name
- NCT01607099
- Testing
- Compatibility
- Where
- Germany
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Chronic Constipation
Comparison of TCM and Laxatives for Adults With Chronic Constipation
The purpose of the study is to compare the therapeutic efficacy, safety, cost-effectiveness and maintenance effect between Chinese herbal formula and lactulose on chronic constipation in long-term care.
- Trial name
- NCT00745147
- Testing
- Chinese herbal formula (CCH1), Duphalac
- Where
- Taiwan
- Volunteers
- 93 people
- Sponsor
- National Taiwan University Hospital
Constipation - Functional, Constipation
A Trial of Actazin Versus PEG 3350 for Maintenance Therapy in Children With Constipation
The goal of this pilot feasibility randomized controlled trial is to determine whether Actazin (kiwifruit extract) is a feasible and effective alternative to polyethylene glycol 3350 (PEG 3350) for maintenance therapy in children…
- Conditions
- Constipation - Functional, Constipation, Constipation Aggravated
- Trial name
- NCT06836024
- Testing
- Actazin chewable tablet, PEG 3350, Chewable Tablet
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Hamilton Health Sciences Corporation
Cathartic Colon
Comparing Bowel Preparation Regimens for Flexible Sigmoidoscopy
Objective and Hypothesis: The investigators objective is to help determine the efficacy of oral and rectal bowel preparation regimens for sigmoidoscopy.
- Trial name
- NCT01554111
- Testing
- Picosulfate sodium,, phosphosoda rectal enema, Pico-Salax and Sodium phosphate enema
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Queen's University
Colorectal Neoplasia
Non-cathartic Computed Tomographic Colonography to Screen Subjects With a Family History of Colorectal Cancer
Background: Although subjects with first-degree relatives (FDR) with a history of colorectal cancer (CRC) are at increased risk for CRC, compliance to screening colonoscopy is suboptimal.
- Trial name
- NCT01766479
- Testing
- CT colonography
- Where
- Italy
- Volunteers
- 844 people
- Sponsor
- Istituto Clinico Humanitas
Chronic Constipation
Laxative Effectiveness of a Phytotherapeutic Tea
The aim of this study is to evaluate the efficacy and safety of a phytotherapeutic laxative tea, composed by Pimpinella anisum, Foeniculum vulgare, Sambucus nigra and Cassia angustifolia, in a randomized crossover…
- Trial name
- NCT00872430
- Testing
- Klein Laxative Tea
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Colonic Polyps
Evaluation of Computer-assisted, Non-cathartic CT Colonography
The purpose of this study is to evaluate the performance of a non-cathartic, computer-assisted form of CT Colonography (Virtual Colonoscopy) for detection of pre-cancerous colon polyps in a group of asymptomatic screening…
- Trial name
- ncCTC (NCT01200303)
- Testing
- non-cathartic CTC
- Where
- 3 sites in United States
- Volunteers
- 605 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Intestinal Recovery After Cesarean Section
The Efficacy of Chewing Gums Versus Laxative in Early Return of Bowel Function After CS
540 consented women for being enrolled in this clinical trial and candidates for elective cesarean section will be divided into 3 groups: Group A, 180 women will receive sugarless gum after their operating room discharge by 3…
- Trial name
- NCT02765971
- Testing
- gums, picolax drops, normal saline
- Where
- Egypt
- Volunteers
- 540 people
- Sponsor
- Ahmed M Maged, MD
Constipation
Study Comparing PEG 3350 Laxative to Placebo in the Treatment of Occasional Constipation (Study CL2007-12)(P08216)
Randomized, placebo-controlled, double blind study. 203 subjects entered the study to compare the effect on occasional constipation of polyethylene glycol 3350 to placebo. Subjects took one of study treatments up to 7 days.
- Trial name
- NCT00770432
- Testing
- Polyethylene glycol 3350
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Bayer
Postoperative Ileus
Randomized Clinical Trial of Bisacodyl Versus Placebo on Postoperative Bowel Motility in Elective Colorectal Surgery
Postoperative bowel dysmotility is a frequent condition after colorectal surgery. The influence of colon stimulating laxatives have not been studied.
- Trial name
- NCT00509327
- Testing
- bisacodyl, glucosemonohydricum
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Constipation
A Pilot Efficacy Evaluation of BLI-801 as a Laxative in Constipated Adults
To compare the safety and efficacy of BLI-801 administered at 4 dose levels in constipated adults.
- Trial name
- NCT00583154
- Testing
- BLI-801
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Braintree Laboratories
Colonic Cancer
Effect of Postoperative Laxative on Bowel Function After Colonic Surgery
Randomised doublet blinded study of the effect of tablet Magnesia (laxative) on post operative bowel ileus after open colonic resection. Material: 56 patients in two equal groups. Primary endpoint: Bowel function.
- Trial name
- NCT00427492
- Testing
- Magnesia
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- Hvidovre University Hospital
Colonoscopy
Comparing Two Different Ways to Take MoviPrep® Before Colonoscopy
This study will evaluate whether morning-only dosing of MoviPrep® (2L) for afternoon colonoscopy is as effective as a standard dosing regimen of half of the volume of MoviPrep® (1L) solution the evening prior, and half (1L) the…
- Trial name
- NCT00929916
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Thomas Jefferson University
Hyponatremia
Incidence of Hyponatremia in PEG-SD Compared to PEG-ELS
Objective: To compare the incidence of peri-colonoscopy hyponatremia associated with PEG 3350 + sports drink (PEG-SD) versus PEG 3350-electrolyte solution + sodium sulfate + sodium ascorbate and ascorbic acid (PEG-ELS).
- Trial name
- NCT01299779
- Testing
- PEG-SD, PEG-ELS
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Thomas Jefferson University
Constipation
Impact of Laxative Therapy With Lactulose in the Evolution of Organ Dysfunction in Critically Ill Patients.
MAIN FEATURES OF THE STUDY: therapeutic intervention. Constipation is a frequent complication in critical ill patients. The disaccharide lactulose has a laxative osmotic activity.
- Trial name
- NCT01607060
- Testing
- Lactulone
- Where
- Brazil
- Volunteers
- 88 people
- Sponsor
- Federal University of São Paulo