Clinical trials: Cathartics
Opioid Induced Constipation
A Single-arm, Study to Assess the Effect and Tolerability of Standardised Laxative Therapy (SLT) for the Reversal of Opioid-induced Constipation (OIC).
The main purpose of this study is to assess how effective and tolerable the country specific clinical practice guidelines of SLTs are for UK, France and Sweden are.
- Trial name
- NCT01957046
- Testing
- Laxative
- Where
- Sweden
- Volunteers
- 117 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Colonoscopy
Effect of Lactulose and/or Polyethylene Glycol Solution for Bowel Preparation for Colonscopy Procedures
Colonoscopy is the most useful exam used to evaluate colorectal diseases, like colorectal polyps and cancer. The appropriate bowel preparation is indispensable for colonoscopy procedures.
- Trial name
- NCT05076799
- Testing
- 100 ml lactulose combined with 1 L PEG, 100 ml lactulose combined with 2 L PEG, 200 ml lactulose
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sichuan University
Constipation
PolyethyleneGlycol3350 Laxative vs Placebo in Constipated Children
Assess the safety and efficacy of polyethyleneglycol3350 laxative as compared to placebo therapy in pediatric patients with a history of constipation.
- Trial name
- NCT00153114
- Testing
- polyethyleneglycol3350
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Braintree Laboratories
Cholecystectomy
PEG Laxatives for Intestinal Preparation and Gut Microbiota in Cholecystectomy
This observational study aims to investigate the impact of polyethylene glycol (PEG) laxatives used for bowel preparation on the gut microbiota of patients who have undergone cholecystectomy.
- Trial name
- NCT07439640
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Chronic Constipation
Effect to Linaclotide on Colonic Motility
This study aim was to evaluate the effect of Linaclotide, a pharmacological treatment normally used to treat functional constipation or irritable bowel syndrome with predominant constipation, on colonic motility as assessed by…
- Trial name
- NCT06989268
- Testing
- Linaclotide 290 micrograms
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cathartics, Mobile Applications
Improving Bowel Cleansing With a Smart Phone Application
Getting ready for a colonoscopy is difficult and involves a lot of steps. The information given to patients is very important to adherence to treatment.
- Trial name
- NCT02303743
- Testing
- Smart Phone Application, Written instructions with visual aids
- Volunteers
- 260 people
- Sponsor
- Vicente Lorenzo-Zúñiga García
Postoperative Nausea and Vomiting, Abdominal Pain
Bisacodyl Use in the Post-operative Care of Obstetrical/Gynecological (OB/GYN) Patients
The purpose of this study is to determine whether Bisacodyl, 5 mg usage decreases the incidence of nausea and abdominal pain after surgery, and also decreases the number of hospitalization days.
- Trial name
- NCT01011426
- Testing
- Bisacodyl
- Where
- United States
- Volunteers
- 285 people
- Sponsor
- The Cooper Health System
Constipation
Post-Operative Constipation Following Total Knee Arthroplasty
Postoperative constipation, defined as no fully satisfying bowel movement within the first three postoperative days, is a common occurrence with some researchers estimating that between 41 and 85% of postoperative patients…
- Trial name
- NCT04380090
- Testing
- Propylene Glycol, Docusate Sodium
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Prostate Cancer, Kidney Cancer
Preop Laxatives in Robotic Urologic Surgery
Minimally-invasive surgery, either laparoscopic or robotic, is commonly used in urology. Several urologic procedures including prostatectomy, radical nephrectomy, and partial nephrectomy are now commonly performed robotically.
- Conditions
- Prostate Cancer, Kidney Cancer, Constipation
- Trial name
- NCT05805436
- Testing
- Polyethylene Glycol 3350
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Chad R. Tracy
Colorectal Cancer
Comparison of Bowel Preparation in Virtual Colonoscopy (VC) - Patient Experience
The study will compare patient's experience between those taking a standard bowel cleansing regimen with minimal laxative tagging regimen of senna and gastrofin.
- Trial name
- NCT00460837
- Testing
- bowel preparation: senna & gastrofin versus picolax (standard)
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- London North West Healthcare NHS Trust
Constipation, Faecal Impaction
Efficacy and Tolerability of PEG-only Laxative for Fecal Impaction and Chronic Constipation in Children
The aim of this study is to compare the efficacy, tolerability, acceptance and compliance of a PEG-only formulation compared to a reference PEG-EL formulation in resolving faecal impaction and in the treatment of chronic…
- Trial name
- NCT01592734
- Testing
- Polyethylene glycol with electrolytes, Polyethylene glycol
- Volunteers
- 96 people
- Sponsor
- Azienda Policlinico Umberto I
Colonoscopy, Bowel Preparation
Improving Tolerability of Bowel Preparation Laxative for Colonoscopy
The purpose of this study is to determine whether the pattern of flavoring and drinking of laxatives for colonoscopy can improve the experience of patients when they are undergoing bowel preparation for the test.
- Trial name
- NCT02062112
- Testing
- Pattern of flavoring of bowel laxative
- Where
- United States
- Volunteers
- 313 people
- Sponsor
- Howard University
Polyethylene Glycol, Cathartics
Development and Validation for Predicting Inadequate Bowel Preparation
High-quality colonoscopy is considered the gold standard for the detection and prevention of colorectal cancer, and its efficacy is predicated on optimal colon cleansing.However, about 18%-35% of patients were still reported to…
- Conditions
- Polyethylene Glycol, Cathartics, Colonoscopy
- Trial name
- NCT04290715
- Testing
- no intervention
- Where
- China
- Volunteers
- 1,644 people
- Sponsor
- Ningbo No. 1 Hospital
Bowel Preparation, Efficacy, Tolerability, Safety, Colon Cancer Screening
Assessment of Safety, Quality, and Acceptance of a Bowel Preparation Using a Food Kit With Laxatives
The main purpose of this research study is to learn if an alternative bowel preparation (bowel prep) for colonoscopy is safe, tolerable and effective as compared to the standard bowel prep.
- Conditions
- Bowel Preparation, Efficacy, Tolerability, Safety, Colon Cancer Screening, Bowel Preparation for Colonoscopy
- Trial name
- NCT07605897
- Testing
- Use of a standardized meal content (food-kit) the day prior to colonoscopy, Polyethylene glycol 3350 - electrolyte solution (GoLYTELY)
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Joseph Spataro
Cathartic Colon
Oral Sulfate Solution (SUPREP) Versus Polyethylene Glycol (PEG) Plus Ascorbic Acid
The aims of the present study is to compare oral sulfate solution (OSS) with low-dose polyethylene glycol plus ascorbic acid (2-L PEG/Asc) for bowel cleansing efficacy.
- Trial name
- NCT02761213
- Testing
- Oral sulfate solution (OSS), 2-L PEG/Asc
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bo-In Lee
Bowel Evacuant Prior to Colonoscopy
Kristalose as Bowel Evacuant Prior to Colonoscopy
To determine whether Kristalose causes a significant increase in hydrogen and/or methane gas levels in patients requiring bowel evacuation, and also to determine the safety, efficacy, and patient preference of Kristalose as a…
- Trial name
- NCT01256541
- Testing
- Kristalose
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Benaroya Research Institute
Pain, Opioid Induced Constipation
Non-interventional Study Comparing Targiniq and Oxycodone/Laxatives
The objective of the non-interventional study is to compare the quality of life, health care resource use and costs between the use of a combination of oxycodone and naloxone (Targiniq) versus oxycodone and laxatives for patients…
- Trial name
- NCT01812733
- Where
- Sweden
- Volunteers
- 37 people
- Sponsor
- Mundipharma AB
Constipation
Acupressure for Constipation in the Elderly
This study will carried out to determine the effect of acupressure applied to Tianshu (ST25), Guanyuan (CV4) and Hegu (LI4) acupuncture points for a total of 6 minutes, two to each point, on the symptoms of constipation in the…
- Trial name
- NCT05805787
- Testing
- Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Constipation
Study to Gather Information on the Acceptability of a New Flavor System With Increasing Levels of 2, 4, 6 g or Higher of Mannitol for PEG 3350 in Subjects Having Infrequent Bowel Movements.
Study to gather information on the acceptability of a new flavor system with increasing levels of 2, 4, 6 g or higher of the sugar alcohol Mannitol for Polyethylene glycol (PEG) 3350 a drug stimulating bowel movement to pass…
- Trial name
- NCT04534465
- Testing
- Polyethylene glycol (MiraLAX, BAY81-8430), Mannitol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Bayer
Laxative Bowel Cleansing Solutions
Sensory Properties of Bowel Cleansing Solutions
Samples of 4 commercially available bowel cleansing solutions, namely PEG-electrolyte + ascorbic acid (PEG-Asc, Moviprep®, Norgine, UK), PEG-electrolyte (PEG, Fortrans® Ibsen, France), sodium picosulfate/magnesium citrate (SPS…
- Trial name
- NCT02642783
- Testing
- Descriptive analysis, acceptability test
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center