Clinical trials: Catheter Thrombosis
Central Venous Catheter Thrombosis, Critical Illness
Daily Ultrasound-screening for CVC-related Thrombosis
The central venous catheters (CVC) related thrombosis is an issue of importance to ICU clinicians.This study conducts the daily ultrasound-screening for CVC-related thrombosis (DUCT).Its aim is to evaluate the characteristic and…
- Conditions
- Central Venous Catheter Thrombosis, Critical Illness, Ultrasonography
- Trial name
- DUCT (NCT03327376)
- Testing
- ultrasound-screening
- Where
- China
- Volunteers
- 1,262 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cancer, Thrombosis
Efficacy & Safety of Prophylaxis With Bemiparin in Cancer Patients With a Central Venous Catheter (BECAT)
The purpose of this study is to evaluate the efficacy and safety of the subcutaneous administration for 45 days of Bemiparin (3,500 UI/day) in cancer patients with a CVC, to prevent CVC-related deep venous thrombosis (CVC-DVT)
- Trial name
- NCT00311896
- Testing
- Bemiparin
- Where
- 19 sites in Romania, Spain
- Volunteers
- 402 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Mechanical Ventilation Complication, Arterial Thrombosis
Pragmatic Randomized Trial for Arterial Catheters in the Critical Care Environment
Investigators will conduct a pragmatic randomized trial to investigate the non-inferiority of restricted use of invasive arterial lines compared to standard arterial line use.
- Conditions
- Mechanical Ventilation Complication, Arterial Thrombosis, Limb Ischemia, Shock
- Trial name
- GRACE (NCT05411315)
- Testing
- Restricted-use of arterial catheter, Standard-use of arterial catheter
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Embolism, Thrombophlebitis
Treatment for Blood Clots in the Veins of the Legs
Acute deep venous thrombosis (ADVT) of the lower extremity is a common disorder. Traditional treatment with anticoagulation therapy is effective in reducing the associated risk of pulmonary embolism, but is ineffective in…
- Trial name
- NCT00001713
- Testing
- Recombinant Tissue Plasminogen Activator, Heparin, Warfarin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Deep Vein Thrombosis
Coagulation Changes in Trauma Patients
Hypothesis to be tested: placement of a central venous catheter will induce a systemic hypercoagulable state. To determine this, the investigators will measure thromboelastography (TEG), PT(prothrombin time), PTT (partial…
- Trial name
- NCT00795743
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Thrombosis
Heparin and the Reduction of Thrombosis (HART) Trial
Heparin is frequently used in central venous catheters (CVCs) in post-operative cardiac patients. It remains unclear if a heparin infusion, compared to a normal saline infusion, prevents thrombosis of CVCs after surgery.
- Trial name
- NCT00779558
- Testing
- Heparin sulfate infusion at 10 units/kg/hour
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Stanford University
Pulmonary Embolism, Deep Vein Thrombosis
Angel® Catheter Early Feasibility Clinical Study
The primary objective of this clinical trial is to obtain initial insights into the safety of the Angel® Catheter in critically ill subjects with high risk of venous thromboembolism (VTE) disease AND who are not receiving…
- Conditions
- Pulmonary Embolism, Deep Vein Thrombosis, Venous Thromboembolism
- Trial name
- NCT01847196
- Testing
- Angel® Catheter
- Where
- 4 sites in United States
- Volunteers
- 6 people
- Sponsor
- BiO2 Medical
Pulmonary Embolism, Acute Pulmonary Embolism
CLEANer Aspiration for Pulmonary Embolism
To evaluate the safety and efficacy of the Cleaner™ Pro Thrombectomy System for aspiration thrombectomy in patients with acute pulmonary embolism (PE).
- Conditions
- Pulmonary Embolism, Acute Pulmonary Embolism, Cardiovascular Diseases, Venous Thromboembolism
- Trial name
- CLEAN-PE (NCT06189313)
- Testing
- Cleaner Pro Thrombectomy System
- Where
- 14 sites in United States
- Volunteers
- 125 people
- Sponsor
- Argon Medical Devices
Upper Extremity Deep Vein Thrombosis, Central Venous Catheter Thrombosis
Thromboprophylaxis With Rivaroxaban In Patients With Malignancy and Central Venous Lines
Purpose of the Pilot Trial: To determine the feasibility of conducting a multicentre randomized open label controlled trial evaluating the use of prophylactic dose rivaroxaban to prevent central venous catheter (CVC) associated…
- Conditions
- Upper Extremity Deep Vein Thrombosis, Central Venous Catheter Thrombosis, Cancer
- Trial name
- TRIM-Line (NCT03506815)
- Testing
- Rivaroxaban 10 MG
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Ottawa Hospital Research Institute
Thrombosis
Safety and Efficacy of Tissue Plasminogen Activator (tPA) in Neonates and Infants
The purpose of this study is to determine if alteplase is effective in dissolving a clot in a catheter in a large vein (central venous line or PICC line) or artery in infants less than 6 months of age.
- Trial name
- NCT00265005
- Testing
- alteplase
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Louisville
Pulmonary Embolism
Mechanical Thrombectomy With the FlowTriever Device in Acute Pulmonary Embolism - a Retrospective Analysis
International guidelines recommend intravenous thrombolysis (IVT) for high-risk pulmonary embolism (PE). In high-risk PE where IVT is contraindicated or has failed, surgical embolectomy or catheter-directed intervention (CDI) is…
- Trial name
- NCT06187987
- Testing
- Mechanical thrombectomy, Intravenous thrombolysis
- Where
- Sweden
- Volunteers
- 132 people
- Sponsor
- Kristina Svennerholm
Thrombosis
Safety and Efficacy of a Single Dose of Gruticibart to Prevent CRT
This phase II trial studies how well gruticibart works in reducing the incidence of catheter-related thrombosis (CRT) blood clots in patients with a central venous catheter (CVC) inserted.
- Trial name
- NCT07498517
- Testing
- Gruticibart, Ultrasound, Biopspecimen collection
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- OHSU Knight Cancer Institute
Pulmonary Embolism
Standard vs. Ultrasound-assisted Catheter Thrombolysis for Submassive Pulmonary Embolism
The study will compare standard catheter directed thrombolysis to ultrasound accelerated thrombolysis for the treatment of acute submassive pulmonary embolism (PE).
- Trial name
- SUNSET sPE (NCT02758574)
- Testing
- CDT without ultrasound acceleration, CDT with ultrasound acceleration
- Where
- 4 sites in United States
- Volunteers
- 77 people
- Sponsor
- University of Pittsburgh
Diabetes Mellitus, Type 2, Catheterization, Peripheral
Incidence of Complications of Peripheral Venous Access in the Type 2 Diabetic Population
Diabetes Mellitus type 2 (T2DM) is one of the most frequent metabolic diseases worldwide. It is expected that in 2035 around 600 million people will suffer from the disease.
- Conditions
- Diabetes Mellitus, Type 2, Catheterization, Peripheral, Upper Extremity Deep Vein Thrombosis, Catheter-Related Infections
- Trial name
- NCT04499638
- Testing
- Peripheral vascular catheters
- Where
- Spain
- Volunteers
- 350 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Venous Thrombosis Due to Central Venous Access Device (Disorder), Prophylactic Anticoagulation
Prophylactic Anticoagulation for Catheter-related Thrombosis
The main objective of this study is to compare the efficacy and safety of aspirin, low molecule heparin and rivaroxaban for preventing catheter-related thrombosis in middle-to-high-risk ambulatory patients with cancer and…
- Conditions
- Venous Thrombosis Due to Central Venous Access Device (Disorder), Prophylactic Anticoagulation, Patients With Tumor
- Trial name
- NCT04256525
- Testing
- Rivaroxaban 10mg, Aspirin 100mg, low molecule heparin
- Where
- 28 sites in China
- Volunteers
- 1,640 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Thromboses, Venous, Infection
Peripherally Inserted Versus Centrally Inserted Central Venous Catheters in the Neurosurgical Intensive Care Unit
This study aim to compare the cost-effectiveness and safety between centrally and peripherally inserted central venous catheters in neurosurgical intensive care unit patients.
- Conditions
- Thromboses, Venous, Infection, Economic Problems
- Trial name
- PICINI (NCT03908866)
- Testing
- PICC(Peripherally inserted central catheter), CVC(Central venous catheter )
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Coagulation; Intravascular
Randomized Comparison of Continuous and Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation
Optimal anticoagulation using heparin with close attention to maintain therapeutic dosing during the procedure is important. Randomized comparison of continuous and intermittent heparin infusion during catheter ablation of Atrial…
- Trial name
- COHERE (NCT01935557)
- Testing
- Continuous heparin infusion, Intermittent heparin infusion
- Where
- South Korea
- Volunteers
- 296 people
- Sponsor
- Yong Seog Oh
Thrombosis, Infection
PIcc Cost EffectiveneSS and Safety of Infusional Therapy
Infusion therapy comprises the parenteral administration of solutions, through peripheral or central vascular access. Some solutions and drugs are highly irritating to the vascular endothelium and therefore cannot be administered…
- Trial name
- PrInCESS (NCT03392831)
- Testing
- Peripherally inserted central catheter (PICC), Central venous catheter
- Volunteers
- 624 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Ischemic Stroke, Large Vessel Occlusion
Proximal TEmporary oCclusion Using Balloon Guide Catheter for Mechanical Thrombectomy
A multi-center, prospective, randomized, open-label, blinded endpoint assessment (PROBE) clinical trial of endovascular treatment among selected AIS.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Thrombectomy, Thrombosis
- Trial name
- PROTECT-MT (NCT05592054)
- Testing
- Balloon guide catheters (BGCs), Standard guide catheter
- Where
- China
- Volunteers
- 329 people
- Sponsor
- Changhai Hospital
Upper Extremity Deep Vein Thrombosis, Secondary
A Study to Investigate the Possible Causes of Secondary Effects During Use of Peripheral Midline Type Catheter in Patients Hospitalized in Different Care Settings
Although the use of peripheral venous catheters (CVP) with brachial insertion with echo-guide (Midline) has increased significantly over the last 5-10 years, there are no sensitive data concerning complications in the literature…
- Trial name
- MIDES (NCT04391205)
- Where
- Italy
- Volunteers
- 211 people
- Sponsor
- A.O.U. Città della Salute e della Scienza