Clinical trials: Cavity, Dental
Dental Caries
Stopping Cavities Study: Diammine Silver Fluoride
This study is being conducted to test whether the use of diammine silver fluoride (also called silver diamine fluoride) hardens the cavity sufficiently so that it arrests.
- Trial name
- NCT02536040
- Testing
- 38% diammine silver fluoride, Water
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Advantage Dental Services, LLC
Dental Caries
Providers Against Cavities in Children's Teeth
The study is a multi-site, multi-level, and multi-component cluster randomized clinical trial (RCT) to address poor dental utilization (attendance) and untreated caries among 3-6 year old Medicaid-enrolled children attending…
- Trial name
- PACT (NCT03385629)
- Testing
- CSM theory-based didactic education and skills training, AAP-based didactic education, Practice EMR changes
- Where
- United States
- Volunteers
- 2,108 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Dental Restoration, Caries
Cold Plasma for Dental Restoration and Caries Prevention
The main objective of this entire research project is to develop a miniature atmospheric cold plasma brush (m-ACPB) for dental clinical applications.
- Trial name
- NCT01529606
- Testing
- Composite restoration and tooth cleaning, Plasma treatment
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Nanova, Inc
Dental Caries
European Study on Three Different Approaches to Managing Class 2 Cavities in Primary Teeth
The purpose of this randomized clinical trial is to compare the clinical effectiveness of three treatments involving different caries management strategies (conventional restorations, Hall technique, and Non-Restorative Caries…
- Trial name
- NCT01797458
- Testing
- Hall Technique, Non-Restorative Caries Treatment, Conventional Restoration
- Where
- 3 sites in Germany, Lithuania and 1 more
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Caries,Dental, Apical Periodontitis
Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Pediatric
The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine…
- Trial name
- NCT03962634
- Testing
- Kovanaze Nasal Spray, Articaine Injection
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Virginia Commonwealth University
Insufficient Dental Filling or Primary Caries (Class I or II Cavities in Premolars or Molars)
Clinical Evaluation of a New Flowable and a New Sculptable Universal Bulk-fill Composite for Direct Restorative Treatment
The overall objective of this clinical investigation is to evaluate the clinical safety and performance of the new flowable composite TM Flow and the new sculptable composite TM Fill for restoration of class I and class II…
- Trial name
- NCT06369779
- Testing
- TM Fill in combination with TM Flow
- Where
- Liechtenstein
- Volunteers
- 65 people
- Sponsor
- Ivoclar Vivadent AG
Dental Caries in Children, Dental Caries Class II
Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective…
- Conditions
- Dental Caries in Children, Dental Caries Class II, Dental Caries
- Trial name
- NCT03770286
- Testing
- 5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Dental Plaque, Gingivitis
The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US
The objective of this clinical research study is to evaluate clinical efficacy of Colgate Total Toothpaste as compared to Crest Pro-Health Toothpaste and Crest Pro-Health Mouthwash, and Crest Cavity Protection Toothpaste and…
- Trial name
- NCT02360995
- Testing
- Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride toothpaste
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Deep Dental Caries
Clinical Comparison of Vital Pulp Capping Restorative Protocols
At present, dentistry aims for conservative treatments with the goal of maintaining as much tooth structure as possible. Dental caries remains the most prevalent chronic disease worldwide; these lesions can progress rapidly and…
- Trial name
- NCT02635867
- Testing
- Indirect Pulp capping-Resin-modified calcium silicate - TheraCal, Indirect Pulp capping-Calcium hydroxide - Dycal, Indirect Pulp capping-Resin-based dentin bonding agent
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Cavities of Teeth, Dental Decay
Scotchbond Universal Plus Compared to Scotchbond Universal for Posterior Class I & II Restorations With Filtek Universal
This research study is looking at a new bond-promoting substance (a dental adhesive called 3M™ Scotchbond™ Universal Plus Adhesive) used between the tooth and dental restoration (filling).
- Trial name
- NCT05248204
- Testing
- Scotchbond™ Universal Plus Adhesive, Scotchbond™ Universal Adhesive
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Solventum US LLC
Cavities of Teeth
Esthetics of Dental Composite and Adhesive System
To compare a newly developed filling composite to a current filling composite system. Two restorations will be placed in each subject, one using system A and one using system B.
- Trial name
- NCT03716349
- Testing
- Pulp vitality testing, Photos, local and/or topical anesthetic
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Erica Teixeira
Dental Prophylaxis and Implant Surgery
Antimicrobial Agent for Reducing Bacteria in Aerosols and Oral Cavity
The primary objective of this study will be to evaluate the effect of two week pre-surgical rinsing with an antimicrobial mouthrinse containing 0.2% w/v Chlorhexidine digluconate on the total number of plaque bacteria in the…
- Trial name
- NCT02319668
- Testing
- 0.2% w/v Chlorhexidine digluconate, Sodium fluoride toothpaste (Aquafresh Mild & Minty)
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cavities of Teeth
Effectiveness of Silver Diamine Fluoride (SDF) in Arresting Cavitated Caries Lesions
This trial is a Phase III, multisite, randomized, placebo-controlled trial, with two parallel groups. The groups are SDF or placebo and they are applied every 6 months.
- Trial name
- NCT03649659
- Testing
- Silver Diamine Fluoride
- Where
- 3 sites in United States
- Volunteers
- 830 people
- Sponsor
- University of Michigan
Cavity, Cavities of Teeth
In Vivo Assessment of the Tooth-Resin Composite Interface Using Optical Coherence Tomography
The aim of the study is to compare the short-term marginal integrity of two preparation techniques for Class I composite restoration using two visual assessment techniques, the FDI World Dental Federation and US Public Health…
- Trial name
- NCT05145322
- Testing
- Composite with 90 degree cavosurface angle, Composite with wide bevel
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Cavities of Teeth
An Evaluation of Protective Effects of OpalSeal™ Against Early Dental Decay in Orthodontic Patients
Fluoride is very effective in preventing dental decay (cavities) when applied in the form of a varnish on tooth surfaces. The purpose of this study is to verify if fluoride-releasing primer (OpalSeal) offers more protection…
- Trial name
- NCT03722264
- Testing
- OpalSeal, TransbondXT
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Dental Plaque, Gingivitis
Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste
The objective of this randomized, single center, parallel clinical research study is to evaluate the comparative efficacy performance of three dentifrices -Colgate Total Toothpaste, Parodontax Toothpaste and Colgate Cavity…
- Trial name
- NCT02080273
- Testing
- Colgate Cavity Protection toothpaste, Colgate Total toothpaste, Parodontax toothpaste
- Where
- Thailand
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive