Clinical trials: Cell Function
Lung Neoplasm, Cell Hypoxia
Pilot Study of 18F-FAZA in Assessing Early Functional Response in Patients With Inoperable Non Small Cell Lung Cancer Undergoing Radiotherapy or Chemo-radiotherapy
Non-small cell lung cancer (NSCLC) has a poor prognosis if not caught early enough. One of the factors that may impact the ability to control NSCLC is low oxygen levels (hypoxia) inside the tumour.
- Trial name
- NCT00765986
- Testing
- 18F-FAZA, 18F-Fluorodeoxyglucose (18F-FDG)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- AHS Cancer Control Alberta
Type 2 Diabetes Mellitus
Role of Canagliflozin on CD34+ Cells in Patients With Type 2 Diabetes
The investigators hypothesize that Cana may be able to improve number and function of CD34+ endothelial progenitor cells. The investigators also propose that this expected cardiovascular benefit is independent of HbA1C reduction.
- Trial name
- NCT02964585
- Testing
- Canagliflozin
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- George Washington University
RCC, Metastatic Renal Cell Carcinoma
Nivolumab in mRCC Patients: Treg Function, T-cell Access and NK Interactions to Predict and Improve Efficacy
The project aims to identify Nivolumab predictive biomarkers in metastatic renal cancer patients through functional evaluation of peripheral Tregs and NKs.
- Trial name
- REVOLUTION (NCT03891485)
- Testing
- Immunological and tumour characterization
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- National Cancer Institute, Naples
Cardiovascular Diseases
Red Blood Cell ATP Release and Vascular Function in Humans
Previous work demonstrates that the red blood cells of older adults do not release a potent vasodilator (ATP) as well as the red blood cells of younger adults.
- Trial name
- NCT03404843
- Testing
- Fasudil Hydrochloride, Saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Chronic Periodontitis, Aggressive Periodontitis
B Cell Functions in Periodontitis
The inflammatory response involves many players from the immune response, including B lymphocytes. These cells are responsible for the synthesis of immunoglobulins in response to the presence of an antigen.
- Trial name
- LBPARO (NCT02833285)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Diabetic Macular Edema
Retinal Ganglion Cell Function After Intravitreous Ranibizumab in Patients With Diabetic Macular Edema
To evaluate the safety of intravitreal ranibizumab repeated injections in patients with diabetic macular edema regarding maintenance of retinal ganglion cell function.
- Trial name
- NCT02055911
- Testing
- Ranibizumab
- Where
- Brazil
- Sponsor
- Federal University of São Paulo
Heart Rate Variability (ANS Function)
Autonomic Nervous System and Sickle Cell Disease
Sickle cell disease (SCD) children and adults with asthma have an increased rate of vaso-occlusive crisis, acute chest syndrome episodes, and premature mortality when compared to those without asthma.
- Trial name
- DrepaSympa (NCT04062409)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Glanzmann Thrombasthenia
The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.
Blood contains red blood cells, white blood cells, and platelets, as well as a fluid portion termed plasma. We primarily study blood platelets, but sometimes we also analyze the blood of patients with red blood cell disorders…
- Trial name
- NCT00230165
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Type 2 Diabetes
The Importance of GLP-1 in Post RYGB Improvement in Glycaemic Control Type 2 Diabetic Subjects
After Roux-en-Y gastric bypass (RYGB) meal induced GLP-1 secretion is dramatically increased, while beta-cell function is increased in type 2 diabetic (T2D) subjects.
- Trial name
- NCT01579981
- Testing
- Roux-en-Y Gastric Bypass
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Hvidovre University Hospital
Cell Physiology Education
RGE-Based Cell Physiology Education for International Medical Students
This study evaluated an integrated active-learning approach for teaching cell physiology to international medical students at Tehran University of Medical Sciences.
- Trial name
- NCT07885553
- Testing
- RGE-Based Cell Physiology Education
- Where
- Iran
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Achilles Tendinopathy (AT), Achilles Tendon
Achilles Tendinopathy; the Effect of Shockwave Treatment
BACKGROUND Achilles tendinopathy-pain in the Achilles tendon-is a common and often long-lasting condition that limits physical activity and performance, and also affects work capacity and quality of life.
- Conditions
- Achilles Tendinopathy (AT), Achilles Tendon, Achilles Tendon Pain
- Trial name
- NCT07685509
- Testing
- individually tailored exercises and Radial Shockwave, Individually tailored exercises
- Volunteers
- 200 people
- Sponsor
- Vastra Gotaland Region
Pulmonary Hypertension
Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension
This study will evaluate new treatments for people who have pulmonary hypertension, or high blood pressure in the lungs, caused by sickle cell anemia or thalassemia.
- Trial name
- NCT00352430
- Testing
- Nitric Oxide/INP Pulse Delivery, Nitric Oxide/INO Pulse Delivery
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lymphoma, Solid Tumor
Analysis of Dendritic Phenotype and Function of Patients Receiving VEGF-Trap on VGFT-ST-0202
RATIONALE: Studying the dendritic cells in samples of blood from patients with cancer receiving aflibercept may help doctors learn about the effect of aflibercept on dendritic cells.
- Trial name
- NCT00896662
- Testing
- immunologic technique, laboratory biomarker analysis, pharmacological study
- Volunteers
- 9 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
B-Cell Non-Hodgkin Lymphoma, Multiple Myeloma
Geriatric Assessment Guided Interventions to Accelerate Functional Recovery After CAR-T Therapy for Patients 60 Years and Older With B-cell Non-Hodgkin Lymphoma or Multiple Myeloma, GOCART Study
This clinical trial compares the effectiveness of geriatric assessment (GA) guided interventions to accelerate functional recovery after chimeric antigen receptor T-cell (CAR-T) therapy compared to standard of care (SOC) in…
- Trial name
- NCT06052826
- Testing
- Best Practice, Cognitive Intervention, Comprehensive Geriatric Assessment
- Where
- 4 sites in United States
- Volunteers
- 164 people
- Sponsor
- City of Hope Medical Center
Diabetes Mellitus, Type 2, Obesity
Role of Interleukin-6 in Exercise
The purpose of the study is to understand the role of interleukin-6 during physical activity in patients with type 2 diabetes.
- Trial name
- Exil-6 (NCT01073826)
- Testing
- Sport, Tocilizumab, Sitagliptin
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- University of Zurich
Diabetes Mellitus, Type 1, Diabetes Mellitus
Urine Extracellular Vesicles: Non-invasive Biomarkers of Β-cell Function and Novel Therapeutic Agents in Diabetes
Diabetes mellitus is a common chronic disease with a huge socioeconomic burden worldwide. Type 1 Diabetes(T1D) accounts for nearly 95% of diabetes in pediatric age and a lifelong dependence on exogenous insulin.
- Trial name
- EvsBioDiabetes (NCT06832215)
- Testing
- Blood and urine samples collection
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Vestibular Schwannoma
Vestibular Outcomes in Vestibular Schwannoma
Previous studies have shown that vertigo is the symptoms that mostly affect quality of life in patients with vestibular schwannoma.
- Trial name
- VOVS (NCT03346889)
- Where
- Norway
- Volunteers
- 155 people
- Sponsor
- Haukeland University Hospital
Type 2 Diabetes
Outpatient Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Type 2 Diabetes Mellitus
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT02346344
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Foundation for the National Institutes of Health
Chronic Urticaria
T Cell Function in Chronic Idiopathic Urticaria
Chronic idiopathic urticaria (CIU) is a common form of chronic urticaria in which the cause is not detected after intensive clinical and laboratory investigation.In view of the current data, it was suggested that at least part of…
- Trial name
- NCT01425593
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Meir Medical Center
Diabetes Mellitus, Type 1
A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)
The purpose of this study is to find out if baricitinib can preserve beta-cell function in participants newly diagnosed with type 1 diabetes. Participation in the study will last about 60 weeks.
- Trial name
- NCT07222332
- Testing
- Baricitinib
- Where
- 130 sites in United States, Australia and 18 more
- Volunteers
- 300 people
- Sponsor
- Eli Lilly and Company
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