Clinical trials: Cell Function
Sickle Cell Disease
Voxelotor Brain Oxygenation and Neurocognitive Study
This is an open label, single arm multicenter trial to evaluate the effect of voxelotor treatment on cerebral blood flow (CBF) and neurocognitive function in adolescent and young adult participants (12-30 years of age) with…
- Trial name
- NCT05228821
- Testing
- Voxelotor Oral Tablet
- Where
- 2 sites in United States
- Sponsor
- Pfizer
Brachial Plexus Injury
Stem Cell Therapy to Improve the Muscle Function of Patients With Partly Denervated Muscles of the Arm
The purpose of this study is to assess muscle improvement after stem cell injection in the biceps muscle of patients with a brachial plexus injury.
- Trial name
- NCT00755586
- Testing
- Mononuclear cell injection: 4 * 10e8 cells, Mononuclear cell injection: 8 * 10e8 cells, No mononuclear cell injection
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Leiden University Medical Center
Kidney Cancer, Renal Cell Cancer Metastatic
Prospective Evaluation of AI R&D Tool for Patient Stratification: a Trial for Renal Immuno-oncology Model Experimental Evaluation 2
Pear Bio has developed a predictive biomarker technology that combines 3D cell culture, microscopy and computer vision to measure the response of an individual patient's tumor sample to different systemic therapy regimens that…
- Trial name
- PEAR-TREE2 (NCT06264479)
- Testing
- Biopsy
- Where
- 4 sites in United Kingdom
- Volunteers
- 7 people
- Sponsor
- Ourotech, Inc.
Hypoxia, Sleep Apnea
Intermittent Hypoxia 2: Cardiovascular and Metabolism
The purpose of this study is to compare cardiovascular physiological adaptation to intermittent hypoxia (IH) of nonobese healthy subjects. The exposure will be two periods of two weeks (IH versus exposure "placebo hypoxia").
- Conditions
- Hypoxia, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- IH2 (NCT02058823)
- Testing
- Valsartan, Amlodipine
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Organ Preservation
Ex Vivo Lung Perfusion : Effect of Cellular Perfusate on Mechanical Properties and Gas Exchange Function of Donor Lungs
The lungs retrieved from the brain dead multi organ donor will be placed in a lab . They will be connected to a ventilator and preservative solution will be circulated through it .
- Trial name
- NCT02953483
- Testing
- Red blood cells
- Where
- India
- Volunteers
- 6 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Intervention, Waitlist Control
Chiropractic T Cell Study
Some studies suggest that specific chiropractic care (techniques known as "spinal manipulation therapy") can have benefits to the immune system but studies are scarce, sample sizes small, and methodology and analyses often not of…
- Trial name
- NCT05412602
- Testing
- full spine corrective protocol
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Type 2 Diabetes Mellitus
Effects of Sequential Treatment Based on Lina/MET After Short-term Intensive Insulin in Newly Diagnosed Type 2 Diabetes
Short-term intensive insulin therapy(SIIT) is able to reverse β cell dysfunction and induce glycemic remission in patients with newly diagnosed type 2 diabetes.
- Trial name
- NCT03194945
- Testing
- CSII followed by Lina+MET, CSII followed by Lina, CSII followed by MET
- Where
- China
- Volunteers
- 412 people
- Sponsor
- Sun Yat-sen University
Metastatic Breast Cancer, Locally Advanced Breast Cancer
Impact of Endocrine Therapy and Abemaciclib on Host and Tumor Immune Cell Repertoire/Function in Advanced ER+/HER2- Breast Cancer
The purpose of this study is to perform an in depth analysis of changes in the tumor immune microenvironment in patients undergoing treatment with standard of care endocrine therapy and abemaciclib in the advanced setting via…
- Conditions
- Metastatic Breast Cancer, Locally Advanced Breast Cancer, Hormone Receptor Positive Tumor
- Trial name
- NCT04352777
- Testing
- Abemaciclib, Fulvestrant, Aromatase Inhibitors
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Somatoform Disorders, Fibromyalgia
Immune Patterns in Pain Patients DSM-IV
The purpose of this study is to define subgroups of patients with somatoform disorders due to DSM-IV by immunological, psychological and genetic characterization.
- Conditions
- Somatoform Disorders, Fibromyalgia, Myofascial Pain Syndrome, Diffuse, Depression
- Trial name
- IPPPDIV (NCT01106339)
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Transplant-Related Disorder
A Cohort Study on the Association Between the ANS Function and Acute GvHD
This is a prospective observational study. The investigators plan to utilize this model as a tool for early classification and interrogate ANS function of transplant recipients.
- Trial name
- NCT07374874
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Oropharyngeal Squamous Cell Carcinoma, Supraglottic Squamous Cell Carcinoma
Efficacy and Safety of TORS for SCCA
The purpose of this study is to learn more about the outcomes of treatment of throat and voice box cancers using transoral robotic surgery (TORS).
- Trial name
- NCT01819480
- Testing
- Transoral robotic surgery
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Katherine L Fedder
Diabetes Mellitus, Type 2, Bariatric Surgery Candidate
Restoration of Beta Cell Function and Cardiovascular Parameters in Relation to Adipoinsular and Enteroinsular Axes After Gastric Bypass Surgery
Bariatric operations such as the gastric bypass procedure provide a unique in vivo model of improvement of pathological beta cell function.
- Trial name
- NCT01271062
- Testing
- gastric bypass surgery, abdominal surgery, very low caloric diet
- Where
- 2 sites in Austria, Switzerland
- Volunteers
- 55 people
- Sponsor
- Cantonal Hospital of St. Gallen
Muscle Loss, Protein
PRotein Optimization With eXercise to Improve MUscle Mass and Functional outcomeS
The investigators have designed a 2-center, pilot feasibility, randomized controlled trial (PROXIMUS) to determine the feasibility and safety of a larger multi center, randomized open-label trial comparing high protein combined…
- Conditions
- Muscle Loss, Protein, Mobility, Pediatric ALL
- Trial name
- PROXIMUS (NCT05296096)
- Testing
- Protein dosage and rehabilitation team delivered exercise prescription
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Boston Children's Hospital
Allogeneic Haematopoietic Stem Cell Transplantation, Malignant Hematologic Disease
Clinical Study on the Preservation of Ovarian Function Following Hematopoietic Stem Cell Transplantation in Patients With Malignant Hematologic Diseases Using Goserelin
This study is a prospective, multicenter, randomized controlled clinical trial planned to enroll 64 female patients with malignant hematologic diseases aged 14-50 years who are scheduled to undergo allogeneic hematopoietic stem…
- Conditions
- Allogeneic Haematopoietic Stem Cell Transplantation, Malignant Hematologic Disease, Ovarian Insufficiency
- Trial name
- NCT07552480
- Testing
- Goserelin
- Where
- 5 sites in China
- Volunteers
- 64 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Diabetes Mellitus, Type 2
Exercise Training and Type 2 Diabetes
The purpose of this study is to assess whether 4-months of interval-walking exercise training improves glycemic control in individuals with type 2 diabetes mellitus.
- Trial name
- NCT01234155
- Testing
- Exercise Training - Interval Walking, Exercise - Continuous Walking
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Oligodendroglioma
A Clinical Study to Improve Brain Function and Quality of Life of Patients With Newly Diagnosed Brain Tumors (Gliomas).
Oligodendrogliomas in the novel edition of the Central Nervous System (CNS) World Health Organization (WHO) classification are now molecularly defined by isocitrate dehydrogenase (IDH)1 or IDH2 mutations and 1p/19q co-deletion.
- Trial name
- ImproveCodel (NCT05331521)
- Testing
- CETEG, PCV, RT
- Where
- 19 sites in Germany
- Volunteers
- 406 people
- Sponsor
- University Hospital Heidelberg
Diabetes
Treatment of Latent Autoimmune Diabetes of the Adult
The purpose of the study is to clarify whether patients classified as Latent autoimmune diabetes of the adult (LADA) benefit from early treatment with insulin added to per oral treatment and lifestyle measures.
- Trial name
- LADA (NCT01140438)
- Testing
- metformin+ NPH insulin, metformin + sitagliptin +/- repaglinide
- Where
- Norway
- Volunteers
- 64 people
- Sponsor
- Norwegian University of Science and Technology
Non-Small Cell Lung Cancer
Single-Center Intelligent Pulmonary Rehabilitation After Lung Cancer Surgery
This study will compare an intelligent pulmonary function exercise device with usual care and natural recovery in patients recovering from lung cancer surgery.
- Trial name
- NCT07631533
- Testing
- Intelligent Pulmonary Function Exercise Device, Usual Care and Natural Recovery
- Volunteers
- 200 people
- Sponsor
- Jianxing He
Functional Iron Deficiency, Trauma
RCT of Goal-directed Iron Supplementation of Anemic, Critically Ill Trauma Patients, With and Without Oxandrolone
The purpose of this trial is to determine if the combination of goal directed iron supplementation and hepcidin mitigation can safely eliminate both the serum and bone marrow iron debt of anemic, critically ill trauma patients…
- Conditions
- Functional Iron Deficiency, Trauma, Anemia
- Trial name
- NCT02047552
- Testing
- Iron sucrose, Oxandrolone
- Where
- United States
- Sponsor
- Denver Health and Hospital Authority
Graves Disease
Characteristics of Islet β-cell Functions in Chinese Patients With Graves' Disease
Patients with GD often present with glucose dysregulation, which, according to most studies, is associated with islet β-cell dysfunctions, enhanced gluconeogenesis and insulin resistance (IR).
- Trial name
- NCT02376088
- Testing
- Methimazole
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Weikai Hou
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