Clinical trials: Cell Proliferation
Breast Cancer
Examination of Breast Cancer Cells of Pre-menopausal and Post-menopausal Women Before and After Exposure to Tamoxifen or Fulvestrant.
The purpose of this study is to microscopically examine breast cancer cells of pre-menopausal and post-menopausal women before and after exposure to one of the two commonly used breast cancer drugs, tamoxifen or fulvestrant.
- Trial name
- NCT02936206
- Testing
- Fulvestrant, Tamoxifen
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Squamous Cell Carcinoma of the Head and Neck
Pharmacodynamic Study to Assess the Anti-proliferative Activity of the PARP Inhibitor Olaparib in Patients With HPV Positive and HPV Negative HNSCC
This is an open label pilot study evaluating the pharmacodynamics and safety of single agent olaparib administered at 300mg bid (twice a day) for 14 days orally in patients with human papillomavirus (HPV) -positive and human…
- Trial name
- NCT02686008
- Testing
- Olaparib
- Sponsor
- Yale University
Head and Neck Neoplasms
Value of FLT-PET Before and During Radiotherapy in Head and Neck Tumors
Tumor cell proliferation and repopulation contribute to resistance to radiotherapy in head and neck cancer. Up to now, this characteristic is mostly assessed using biopsies acquired during inspection under general anaesthesia…
- Trial name
- NCT00163176
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Oxidative Stress, Stem Cell Research
Enriched Oxygen Mixtures in Athletes
Currently, Hyperbaric Oxigen (HBO) is a widely used treatment for several conditions. There are 14 indications for HBO, officially recognized by the Undersea and Hyperbaric Medical Society (UHMS), but research is discovering…
- Trial name
- OXY-SPORT (NCT04366427)
- Testing
- L-HBO, HBO, 30% O2
- Where
- Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Padova
Klinefelter Syndrome, Hypergonadotropic Hypogonadism
Androgen for Leydig Cell Proliferation
Patients with infertility often presents alterations at ultrasonographic examination of the testis. These alterations include a much higher incidence of small, multiple, non-palpable hypoechoic micro-nodules that can show…
- Conditions
- Klinefelter Syndrome, Hypergonadotropic Hypogonadism, Hypergonadotropic Azospermia, Hypergonadotropic Cryptozoospermia
- Trial name
- ALCeP (NCT01206270)
- Testing
- Testosterone undecanoate, Castor Oil
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of Roma La Sapienza
Rhegmatogenous Retinal Detachment
Early Prevention Strategies of Severe Proliferative Vitreoretinopathy Base on Precision Diagnosis of Single Cell Sequencingvitreoretinopathy
Study of initiating proliferative vitreoretinopathy (PVR)cell subtype (PVR initiating cells (PVR-IC) in RPE cells of rhegmatogenous retinal detachment (RRD) patients; to prove the percentage of PVR-IC decides the risk of serious…
- Trial name
- NCT04520789
- Testing
- RPE cell collection and single cell heterogeneity study, Postoperative intervention, Conventional Surgery for Retinal Detachment
- Volunteers
- 60 people
- Sponsor
- Shanghai 10th People's Hospital
Periodontal Attachment Loss
ESWT on Human Gingival Fibroblasts
The idea of treating different deformities or diseases in the maxillofacial region with Extracorporeal Shockwave Therapy (ESWT) has recently become popular.
- Trial name
- ESWT (NCT05766293)
- Testing
- extracorporeal shockwave device, Fibroblast cell lines not subjected to shockwaves from extracorporeal shockwave device
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Dr Prabhuji MLV
Human Blood Cell Disorders, Lymphoid, Myeloid and Erythroid Proliferative Disease
Human Blood Cell Disorders Tissue Bank
The Human Blood Cell Disorder Tissue Bank will provide a convenient, comprehensive source of tissue containing populations of human blood cells from patients with various types of lymphoid, myeloid, and erythroid proliferative…
- Trial name
- NCT00902447
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Lung Cancer, Nonsmall Cell, Esophageal Carcinoma
Thalidomide Prevention or Treatment of Camrelizumab-induced Reactive Cutaneous Capillary Endothelial Proliferation (RCCEP)
To explore the dose and safety of thalidomide for the prevention and treatment of camrelizumab-induced reactive cutaneous capillary endothelial proliferation (RCCEP)
- Trial name
- NCT06231680
- Testing
- Camrelizumab, Thalidomide 50mg, Thalidomide 100mg
- Where
- 2 sites in China
- Volunteers
- 132 people
- Sponsor
- Henan Cancer Hospital
Healthy Volunteers Pharmacokinetic Study
Dose-escalation Study to Assess Selumetinib Safety, Tolerability and PK
The purpose of the study is to assess the safety, tolerability and PK of selumetinib (AZD6244; ARRY-142886) (Hyd-Sulfate) in healthy male Japanese and non-Japanese Asian volunteers following administration of a single dose.
- Trial name
- NCT01960374
- Testing
- Selumetinib
- Where
- United Kingdom
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Brain and Central Nervous System Tumors
Positron Emission Tomography Using Fluorothymidine F 18 in Finding Recurrent Disease in Patients With Gliomas
RATIONALE: Diagnostic procedures, such as positron emission tomography using fluorothymidine F 18, may be effective in finding recurrent disease in patients with gliomas.
- Trial name
- NCT00276770
- Testing
- fluorine F 18 fluorothymidine, positron emission tomography
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Washington
Cancer of the Prostate, Prostate Cancer
Study of Antioxidants on MRI Detectable Early Stage Prostate Cancer Among Men on Active Surveillance
The purpose of this study is to determine whether antioxidants (vitamin E, selenium and lycopene)can change(reduce)prostate tumor size or blood flow to the prostate as determined by MRI imaging among men on Active Surveillance.
- Conditions
- Cancer of the Prostate, Prostate Cancer, Prostatic Neoplasms
- Trial name
- NCT00744549
- Testing
- Lycopene, Vitamin D3, Selenium, Green Tea Extract, Vitamin E
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University Health Network, Toronto
Diabetic Foot Ulcer
Ultrasound Assisted Wound Debridement (UAW) Versus Standard Wound Treatment in Complicated Diabetic Foot Ulcers (DFU)
The investigators aimed to elucidate the effects of UAW debridement on cellular proliferation and dermal repair in complicated diabetic foot ulcers as compared to diabetic foot ulcers receiving surgical/sharp wound debridement.
- Trial name
- NCT04633642
- Testing
- Ultrasound group, Surgical group
- Where
- 2 sites in Spain
- Volunteers
- 51 people
- Sponsor
- Universidad Complutense de Madrid
Unspecified Adult Solid Tumor, Protocol Specific
Measuring Biomarker Response to AMP-514 in Blood Samples From Patients With Solid Tumors Undergoing Radiotherapy
This pilot research trial studies the response in blood cells to AMP-514, a drug shown to increase immune response (capacity to fight against infections and cancer) against cancer in patients with solid tumors undergoing…
- Trial name
- NCT02153151
- Testing
- Cytology specimen, Laboratory biomarker analysis
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Melanoma (Skin)
Vaccine Therapy and GM-CSF in Treating Patients With Recurrent or Metastatic Melanoma
RATIONALE: Vaccines made from a person's tumor cells and white blood cells may help the body build an effective immune response to kill tumor cells.
- Trial name
- NCT00436930
- Testing
- autologous tumor cell vaccine, sargramostim, therapeutic autologous dendritic cells
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Hoag Memorial Hospital Presbyterian
Endometriosis
Proliferation of Endometrial Stromal Cells in Adenomyosis
Adenomyosis refers to the presence of endometrial glands and stroma that is haphazardly deep within the myometrium. However, the etiology and pathologic mechanism responsible for adenomyosis are not yet very well known.
- Trial name
- NCT00173212
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Acute Myeloblastic Leukemia, Lymphoblastic Leukemia
Thymoglobuline Versus Alemtuzumab in Patients Undergoing Allogeneic Transplant
The purpose of this study is to compare Reduced Intensity Conditioning protocols containing either Thymoglobuline or Alemtuzumab in patients undergoing allogeneic transplant from voluntary unrelated donors.
- Conditions
- Acute Myeloblastic Leukemia, Lymphoblastic Leukemia, Myelodysplasia, Chronic Myeloid Leukemia
- Trial name
- GLOBAL (NCT00354120)
- Testing
- Alentuzumab, Globulina antilinfocitaria
- Where
- 22 sites in Italy
- Volunteers
- 121 people
- Sponsor
- Gruppo Italiano Trapianto di Midollo Osseo
Breast Cancer, Head and Neck Cancer
Assessment of Cellular Proliferation in Tumors by Positron Emission Tomography (PET) Using [18F]ISO-1
The main purpose of this study is to see if Positron Emission Tomography (PET) imaging with a radioactive tracer called 18F-ISO-1 can accurately identify how quickly cancer cells are growing or dividing.
- Conditions
- Breast Cancer, Head and Neck Cancer, Diffuse Large B-cell Lymphoma
- Trial name
- FISO PET/CT (NCT00968656)
- Testing
- PET/CT, Laboratory Testing, Safety Testing
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Chronic Obstructive Pulmonary Disease
Establishment of Human Lung Stem Cell Proliferation System and Organoid Construction in COPD
The goal of this study is to proliferate human lung stem cell in vitro in order to establish a lung organoid derived from patients with COPD. The main question it aims to answer are: Can human lung stem cell proliferate in vitro.
- Trial name
- NCT06275230
- Where
- China
- Volunteers
- 30 people
- Sponsor
- China-Japan Friendship Hospital
Healthy Humans
Immune Benefits From Mushroom Consumption
The purpose of this study is to determine whether consuming mushrooms is effective in enhancing the function of γδ T cells.
- Trial name
- NCT01398176
- Testing
- 3 ounces of mushrooms, 6 ounces of mushrooms
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Florida