Clinical trials: Cell Proliferation
Healthy
Cranberry Consumption Improves γδ T Cell Function
The purpose of this study is to determine the extent to which consuming a cranberry beverage modifies immune function, specifically related to γδ T cells and other innate immune cells.
- Trial name
- NCT01713829
- Testing
- Cranberry Beverage
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Florida
Multiple Myeloma
Effect of Eltrombopag Plus G-CSF on Human CD34+ Cell Mobilization in Multiple Myeloma Patients Undergoing ASCT
Eltrombopag may improve the cell collection available for Autologous Stem Cell Transplant(ASCT). The overall goal is to determine if adding Eltrombopag to the standard ASCT will increase the number of blood cells collected and…
- Trial name
- NCT01286675
- Testing
- Eltrombopag
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Dana-Farber Cancer Institute
Chronic Lymphocytic Leukemia
Characterization of Proliferating Compartment in B-Cell Patients and in Healthy Aging Subjects
By ingesting a non-radioactive and non-toxic compound "heavy water" for 6 weeks, the DNA of newly developed cells in the body of subjects with B-cell chronic lymphocytic leukemia can be labeled and followed by performing routine…
- Trial name
- NCT01110863
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Improvement in Immune Cell Function in Healthy Humans
The Effect of Aged Garlic Extract Supplementation on Immune System
The purpose of this study is to determine whether consuming capsules of aged garlic extract is effective in enhancing function of NK and/or γδ T cell resulting in fewer cold and flu symptoms.
- Trial name
- NCT01390116
- Testing
- Aged garlic extract, AGE
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Florida
Ovarian Cancer, Peritoneal Cavity Cancer
Topotecan, High-Dose Cyclophosphamide, Carboplatin, and an Autologous Peripheral Blood Cell Transplant in Treating Patients With Recurrent Ovarian Cancer or Primary Peritoneal Cancer
RATIONALE: Giving colony-stimulating factors, such as G-CSF help stem cells move from the patient's bone marrow to the blood so they can be collected and stored.
- Trial name
- NCT00652691
- Testing
- filgrastim, carboplatin, cyclophosphamide
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Adenomatous Polyps
Effect of 2 Doses of EPA on Apoptosis and Cell Proliferation on Colon Mucosa
The purpose of this study is to determine the effect of two doses purified EPA (an omega-3 fatty acid), on apoptosis (natural cell death) and cell proliferation (formation of new cells) in the lining of the colon for patients…
- Trial name
- NCT00432913
- Testing
- Eicosapentaenoic Acid (EPA), Endoscopy, Biopsies taken
- Where
- 2 sites in Italy, United Kingdom
- Volunteers
- 120 people
- Sponsor
- S.L.A. Pharma AG
IgA Nephropathy (IgAN)
To Evaluate the Effect and Safety of Telitacicept and Standard Treatment for 6months in IgA Nephropathy
The purpose of this clinical study is to evaluate the efficacy and safety of that test group was administered with Telitacicept in patients with IgA nephropathy.
- Trial name
- NCT07098897
- Testing
- Telitacicept 160mg, Corticosteroid, ACE Inhibitor or Angiotensin receptor antagonist
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Infertility
Effect of Low Level Laser Therapy on Endometrial Cells: An In Vitro Study
The human endometrium is an extremely sensitive target. LLLT can enhance the proliferation rate of various cell lines, it produces higher rates of ATP, RNA, and DNA synthesis in stem cells and other cell lines.
- Trial name
- LLLT (NCT02764034)
- Testing
- Low level Laser diode machine
- Where
- Egypt
- Sponsor
- Cairo University
IgA Nephropathy (IgAN), Membranous Nephropathy
A Clinical Study Evaluating the Safety and Efficacy of GT719 Universal Cell Injection in the Treatment of Immune-mediated Kidney Diseases
This study is a single-arm, open-label, dose-escalation and dose-expansion clinical trial, divided into two phases: the first phase is the dose-escalation phase, and the second phase is the dose-expansion phase.
- Conditions
- IgA Nephropathy (IgAN), Membranous Nephropathy, ANCA-associated Vasculitis (AAV)/ANCA-associated Glomerulonephritis (AAGN), Refractory Podocytopathy
- Trial name
- NCT07389499
- Testing
- CD19-targeted iNKT Cell Injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Grit Biotechnology
Oral Contraceptive
Oral Contraceptive (OC) Estrogen Dose and Breast Proliferation
The purpose of this research study is to gain a better understanding of the changes that may occur in the breast when a woman uses an oral contraceptive (birth control pill).
- Trial name
- OCP2 (NCT01318005)
- Testing
- Oral Contraceptive: Ortho-Novum® 1/35, Oral Contraceptive: Ovcon® 35, Oral Contraceptive: Microgestin Fe® 1/20
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Osteoarthritis
Mesenchymal Stromal Cells and Osteoarthritis
Osteoarthritis (OA) is one of the most frequent musculoskeletal disorders and represents the main indication for total joint arthroplasty.
- Trial name
- NCT01038596
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Human Immunodeficiency Virus I Infection
MMF for HIV Reservoir Reduction
This is an open label, randomized Phase II study to determine whether Mycophenolate mofetil (MMF) given over 22 months meaningfully decreases the size of participants' HIV reservoir.
- Trial name
- NCT03262441
- Testing
- Mycophenolate Mofetil 500Mg Tab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Fred Hutchinson Cancer Center
Hematopoietic Cell Proliferation, Myelodysplastic Syndromes
Development of an in Vitro Hematopoietic Culture System and Application to Myelodysplastic Syndromes.
Myelodysplastic syndromes (MDS) are myeloid hemopathies characterized by ineffective clonal haematopoiesis, peripheral cytopenias and a predisposition to the occurrence of acute myeloid leukemias.
- Trial name
- HEMASTEM (NCT03107273)
- Testing
- Dynamic cultures of in vitro hematopoietic stem cells
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chronic Myelogenous Leukemia
Study of Efficacy of CML-CP Patients Treated With ABL001 Versus Bosutinib, Previously Treated With 2 or More TKIs
The purpose of this pivotal study was to compare the efficacy of asciminib (ABL001) with that of bosutinib in the treatment of participants with chronic myeloid leukemia - chronic phase (CML-CP) having previously been treated…
- Trial name
- NCT03106779
- Testing
- Asciminib, Bosutinib
- Where
- 88 sites in United States, Argentina and 23 more
- Volunteers
- 233 people
- Sponsor
- Novartis Pharmaceuticals
Glioma
The Predictive Value of MRI for Adult-type Diffuse Gliomas
The goal of this observational study is to learn about the diagnostic value of preoperative MRI examination for adult-type diffuse gliomas.
- Trial name
- MRI; glioma; (NCT06572592)
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Type 1 Diabetes Mellitus
T Cell Validation Study Using Blood Samples From Subjects With Recent Onset Type 1 Diabetes Mellitus
Type 1 diabetes is a condition that is caused in part by an abnormality of the immune system which occurs when T cells, which are part of the immune system, damage the insulin secreting cells (islet cells) in the pancreas.
- Trial name
- NCT00212329
- Testing
- T Cell Proliferation and Autoreactivity Assays, Cellular Immunoblot Assays, Tetramer Studies
- Where
- 14 sites in United States, United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Lung Cancer
Clinical Application of 18F-3'-Fluoro-3'-Deoxy-L-thymidine (18F-FLT) Positron Emission Tomography (PET) in Lung Tumors
The ability of 18F-FDG PET for characterizing lung nodule remains a challenge, especially in Taiwan where tuberculosis is still prevalent.
- Trial name
- NCT01089894
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Von Hippel Lindau, Von Hippel Lindau Disease
Real-World Effectiveness and Pharmacogenetics of Belzutifan in VHL Syndrome: The BELIEVE-VHL Trial
The BELIEVE-VHL Trial is a prospective real-life study designed to evaluate the therapeutic effects, benefits, and adverse effects of belzutifan, as well as the timing of treatment response and disease progression in patients…
- Conditions
- Von Hippel Lindau, Von Hippel Lindau Disease, Von Hippel Lindau-Deficient Clear Cell Renal Cell Carcinoma, Hemangioblastoma (HB) of the Central Nervous System (CNS)
- Trial name
- BELIEVE-VHL (NCT07167329)
- Testing
- Belzutifan
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- José Claudio Casali da Rocha
Breast Cancer
Study to Evaluate the Effect of Sulforaphane in Broccoli Sprout Extract on Breast Tissue
The purpose of this research is to examine the effect of a broccoli sprout preparation on specific factors in breast tissue that are related to breast cancer risk and to assess whether sulforaphane a key component of broccoli…
- Trial name
- NCT00982319
- Testing
- Broccoli sprout extract, Mango juice
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Head and Neck Neoplasms
Validation of 18F-MISO-PET and 18F-FLT-PET
Hypoxia and tumor cell proliferation are important mechanisms contributing to resistance to radiotherapy in human head and neck tumor cells.
- Trial name
- NCT00159978
- Testing
- 18F-FLT and 18F-MISO-PET
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Radboud University Medical Center