Clinical trials: Cell Proliferation
Gaucher Disease, Hepatitis C
Examining the Immune Response in Patients With Gaucher Disease and Hepatitis C
Study objectives: Investigate the anti-HCV response in patients with Gaucher disease(GD) Define the potential role of high levels of Glucocerebroside in the immune system Study hypothesis: High levels of Glucocerebroside can be…
- Trial name
- NCT01274208
- Where
- 2 sites in Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Oral Contraceptive
Oral Contraceptive (OC) Progestin Dose and Breast Proliferation
The purpose of this research study is to gain a better understanding of the changes that may occur in the breast when a woman uses an oral contraceptive (birth control pill).
- Trial name
- NCT00972439
- Testing
- Oral Contraceptive: Ortho-Novum® 1/35, Oral Contraceptive: Ovcon Fe®
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Larynx Cancer
Patient Selection for Hypoxia Modifying Treatments in Larynx Carcinomas
The purpose of this study is to identify in a prospective manner microregional profiles of oxygenation and proliferation based on exogenous and endogenous markers that are predictive for outcome of radiotherapy in squamous cell…
- Trial name
- NCT00160095
- Where
- 5 sites in Netherlands
- Volunteers
- 79 people
- Sponsor
- Radboud University Medical Center
Larynx Cancer, Larynx Carcinoma
An Investigation of Biomarker Candidate Molecules in Laryngeal Carcinoma
The aim of this study was to determine serum levels of VEGF, sVEGFR1, VEGFR2, IGFBP-3, angiogenin and endoglin in patients with larynx squamous cell carcinoma; investigate their association with clinical parameters and determine…
- Trial name
- NCT05217147
- Testing
- Obtaining blood samples
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Lymphoma, Mantle-cell, CLL (Chronic Lymphocytic Leukemia)
A Study of the Kinetics of Lymphoid Cells in Patients With Monoclonal B-cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL), Mantle Cell Lymphoma (MCL) and Healthy Volunteers
Background: Chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and mantle cell lymphoma (MCL) are types of cancers in which there are too many abnormal lymphocytes (a type of white blood cell).
- Conditions
- Lymphoma, Mantle-cell, CLL (Chronic Lymphocytic Leukemia), Monoclonal B-Cell Lymphocytosis, Healthy Volunteers
- Trial name
- NCT01117142
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Endometrial Hyperplasia Without Atypia, Endometrial Hyperplasia With Atypia
Endometrial Tissues and Mononuclear Cells Receptivity in Pathogenesis of Endometrial Proliferative Processes
A prospective observational study of endometrial tissue and peripheral blood mononuclear cells receptivity to sex steroid hormones in postmenopausal patients with endometrial proliferative processes
- Conditions
- Endometrial Hyperplasia Without Atypia, Endometrial Hyperplasia With Atypia, Endometrial Cancer, Peripheral Blood Mononuclear Cells
- Trial name
- NCT06115577
- Testing
- endometrial tissue and peripheral blood mononuclear cells receptivity
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Pirogov Russian National Research Medical University
Melanoma, Non-small Cell Lung Cancer
TiTAN-1: Safety, Proliferation and Persistence of GEN-011 Autologous Cell Therapy
TiTAN-1 is a first-in-human study of GEN-011, an experimental treatment being evaluated in adult patients with advanced cancer. GEN-011 is a T cell therapy made specific to each patient, using the patient's own circulating immune…
- Conditions
- Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck, Urothelial Carcinoma
- Trial name
- NCT04596033
- Testing
- GEN-011, IL-2, Fludarabine
- Where
- 8 sites in United States
- Volunteers
- 49 people
- Sponsor
- Genocea Biosciences, Inc.
Refractory Multiple Myeloma
Tivantinib in Treating Patients With Relapsed, or Relapsed and Refractory Multiple Myeloma
This phase II trial studies the side effects and how well tivantinib works in treating patients with relapsed, or relapsed and refractory multiple myeloma.
- Trial name
- NCT01447914
- Testing
- Tivantinib, Diagnostic laboratory biomarker analysis, Questionnaire administration
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Cancer, Endometrial Intraepithelial Neoplasia
Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer
The goal of this study is to determine the anti-proliferative effect of tirzepatide on the endometrium of patients with endometrial intra-epithelial neoplasia (EIN) and Grade 1 endometrial cancer (EC), by comparing archival…
- Conditions
- Endometrial Cancer, Endometrial Intraepithelial Neoplasia, Grade 1 Endometrial Endometrioid Carcinoma
- Trial name
- NCT07078838
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Neuroendocrine Tumors, Neuroendocrine Carcinoma
A Trial of Cabozantinib in Patients With Advanced, Low Proliferative NEN G3
The main objective of this clinical trial represents the evaluation of efficacy of the tyrosine kinase inhibitor Cabozantinib in patients with NEN G3 with a proliferation rate of Ki67 20 - 60%.
- Trial name
- CABONEN (NCT04524208)
- Testing
- Cabozantinib
- Where
- 15 sites in Austria, Germany
- Volunteers
- 45 people
- Sponsor
- Karsten Gavenis
Corneal Endothelial Cell Changes in Diabetic Patients
Specular Microscopy in Patients With Proliferative Diabetic Retinopathy
.1. corneal endothelial profile in patients with proliferative diabetic retinopathy compared to a healthy age-matched control group. 2. The effect of the age, and duration of Diabetes on the corneal endothelium .
- Trial name
- NCT05838898
- Testing
- Specular microscopy
- Volunteers
- 60 people
- Sponsor
- Assiut University
Melanoma
PRAME Immunohistochemistry as an Adjunct for Evaluating Ambiguous Melanocytic Proliferation
Skin melanoma is a common form of skin cancer. Its diagnosis is usually clinically suspected and then affirmed by histopathological examination.
- Trial name
- ANTIPRAME (NCT05089188)
- Testing
- Immunomarkers
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Strasbourg, France
Locally Advanced Breast Cancer, Ductal Histologic Type
Comparative Study of Neoadjuvant Chemotherapy With and Without Zometa for Management of Locally Advanced Breast Cancers
Breast cancer is the leading female cancer by a very wide margin in France. Despite widespread breast cancer screening, many cases of breast cancer are discovered at a locally advanced stage.
- Conditions
- Locally Advanced Breast Cancer, Ductal Histologic Type, Without Her 2 Overexpression
- Trial name
- NEOZOL (NCT01367288)
- Testing
- Zometa + Neoadjuvant therapy, Neoadjuvant therapy
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Hospices Civils de Lyon
Diabetic Retinopathy, Proliferative Vitreoretinopathy
Molecular Taxonomy of Surgically-harvested Ocular Tissues Defined by Single-cell Transcriptomics
The surgically-harvested eye tissue (ie. vitreous-retinal proliferative membrane, outflow pathway, retinas, and pterygium) is a complex tissue responsible for maintaining intraocular homeostasis or mediating ocular pathogenesis.
- Conditions
- Diabetic Retinopathy, Proliferative Vitreoretinopathy, Pterygium, Glaucoma
- Trial name
- Eyesinglecell (NCT04682054)
- Testing
- ocular surgery
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Endometrial Cancer, Colon Cancer
Evaluation of the Proliferative Activities of Insulin Analogues in Primary Human Tumor Cells
Recently the general medical literature has become aware that the use of certain long-acting insulin analogues could potentially increase cancer risk.During the last few years the investigators group generated information of both…
- Trial name
- NCT01267461
- Testing
- Tissue sample from tumor
- Sponsor
- Meir Medical Center