Clinical trials: Central Apnea
Stroke, Ischemic, Sleep Disorder
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)
The study is aimed at the investigation of the association of biomarkers of circadian rhythms with sleep characteristics and stroke outcome in acute stroke patients.
- Trial name
- NCT05242393
- Testing
- No intervention is planned
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Obese, Sleep Apnea, Obstructive
Eval EarlySense Bet Lowenstein Sleeplab
The study objective is to collect heart rate, respiration rate and motion data of patients admitted to sleep lab and to determine the accuracy level of the EarlySense system vs.
- Conditions
- Obese, Sleep Apnea, Obstructive, Central Apnea, Sleep Disorders
- Trial name
- NCT01978340
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- EarlySense Ltd.
Cardiac Diseases, Muscular Weakness
Biomarker for Pompe Disease (BioPompe)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Pompe disease from blood (plasma)
- Conditions
- Cardiac Diseases, Muscular Weakness, Hepato-splenomegaly, Lung Disease
- Trial name
- BioPompe (NCT01457443)
- Where
- 4 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Sleep Disordered Breathing, Able Bodied
Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment
Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive…
- Trial name
- CSA (NCT04118387)
- Testing
- Acetazolamide + supplemental oxygen + PAP therapy, Zolpidem + PAP therapy, Buspirone + PAP therapy
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Ondine Syndrome, Congenital Central Hypoventilation Syndrome (CCHS)
Relationship Between Breathing and Attention in Children With Ondine Syndrome
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic and respiratory regulation that alters oxygen delivery to the brain. CCHS patients are at risk for broad neurocognitive deficits.
- Trial name
- OndineCo (NCT06337149)
- Testing
- neuropsychological tests used usually in clinical practice (TEA-ch, NEPSY, BRIEF) and research (Conners 3, K-CPT II or CPT III, Flankers Task)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sleep Disorder, Body Fat Distribution
Relationship Between Normal-weight Central Obesity and Obstructive Sleep Apnea
Comparison of the prevalence of obstructive sleep apnea (OSA), measured by polysomnography in normal weight patients with central obesity by body mass index (BMI) and waist hip ratio (WHR), with normal weight patients without…
- Trial name
- NCT04061226
- Testing
- Overnight polysomnography
- Where
- Czechia
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Sleep Apnea, Obstructive
Obstructive Sleep Apnea (OSA) Treated With a Potassium Channel Inhibitor
The aim of this study in subjects with obstructive sleep apnea is to investigate pharmacodynamics, safety and tolerability after a single nasal administration of BAY2253651 and to evaluate first safety and tolerability of…
- Trial name
- SANDMAN (NCT03603678)
- Testing
- BAY2253651
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 34 people
- Sponsor
- Bayer
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Malocclusion
Multi-disciplinary Diagnosis and Treatment Process and Evaluation System for Children With Sleep Disordered Breathing and Malocclusion
The aim of this study is to compare the efficacy and safety of drug therapy, tonsillar adenoidectomy only, orthodontic treatment only and tonsillar adenoidectomy plus orthodontic treatment in children with obstructive sleep apnea…
- Trial name
- NCT03451318
- Testing
- Mometasone Furoate Nasal Spray, tonsillar adenoidectomy, Maxillary expander plus Twin-Block
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Stomotological Hospital
Obstructive Sleep Apnea
Long-term CPAP Effect with Obstructive Sleep Apnea: a Telemedicine-based
we hypothesize that long-term CPAP could results in increase weight and muscle composite by changing intake content and hormone and the effect was influenced by presence of CVD, social jet lag, and CPAP compliance.
- Trial name
- MSLS-LT (NCT06738940)
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Stroke
Stroke - Sleep Disorders, Dysfunction of the Autonomic Nervous System and Depression
The purpose of this study is to investigate sleep disordered breathing, autonomic dysfunction, and post stroke depression in acute and chronic stroke patients.
- Trial name
- NCT02111408
- Where
- Denmark
- Volunteers
- 114 people
- Sponsor
- Helle Klingenberg Iversen, MD, DmSc
Ondine Syndrome
Assessment of Desogestrel in Ondine Syndrome
The congenital central hypoventilation syndrome (CCHS), also known as the Ondine syndrome, is a very rare genetic disorder. In contrast with healthy people, patients do not increase breathing in response to an excess of carbon…
- Trial name
- RESPIRONDINE (NCT01243697)
- Testing
- desogestrel
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cluster Headache, Chronic Disease
Continuous Positive Airway Pressure as a Potential New Treatment for Cluster Headache
Cluster headache is also called suicide headache due to excruciating nocturnal attacks. There are few treatment options available. Inhalation of oxygen has shown to abort the attacks.
- Trial name
- CPAP (NCT03397563)
- Testing
- Continuous Positive Airway Pressure
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Cardiovascular Diseases, Cardiovascular Diseases Risk
Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways
Cor360 is an observational study evaluating whether extended wearable electrocardiogram (ECG) data can support broad-spectrum cardiac phenotyping and risk assessment beyond conventional single-purpose ambulatory rhythm…
- Conditions
- Cardiovascular Diseases, Cardiovascular Diseases Risk, Cardiac Conduction System Disease, Bundle/Fascicular Abnormalities
- Trial name
- Cor360 (NCT07775976)
- Testing
- COR Wearable ECG Monitoring, Cor360 Clinician-Facing Decision-Aid Reporting
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Acromegaly
Acromegaly & Sleep Apnoea
Estimates of the prevalence of acromegaly, a condition resulting from excess growth hormone secretion, are as high as 1:1000. If detected late acromegaly increases the risk of joint destruction, heart disease, sleep apnoea, high…
- Trial name
- NCT02371057
- Where
- United Kingdom
- Volunteers
- 653 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Sleep Apnea, Central, Sleep Apnea, Obstructive
Evaluation of ApneaLink Plus Scoring Capabilities
The purpose of this study is to investigate the following topics: Determine the accuracy of ApneaLink Plus in separating Apneas into Obstructive Apneas, Mixed Apneas and Central Apneas.
- Trial name
- NCT00823134
- Testing
- ApneaLink Plus
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- ResMed
Stroke, Sleep Apnea
Telemedicine Monitoring of Sleep Apnea in Stroke
Study Objectives: Meta-analyses report a high prevalence of moderate to severe sleep apnea of more than 50% in stroke patients, with adherence rates for CPAP therapy of only 30%.
- Trial name
- HOPES (NCT02748681)
- Testing
- Auto CPAP AirSense™ 10(Resmed)
- Where
- Austria
- Volunteers
- 34 people
- Sponsor
- Neurologisches Rehabiliationszentrum Rosenhügel
Ischemic Stroke, Obstructive Sleep Apnea
Nasal EPAP for Stroke Patients With Sleep Apnea: a Pilot Trial.
Specific aim: To test the effects of nasal expiratory positive airway pressure (EPAP) therapy on sleep apnea severity among patients with recent ischemic stroke.
- Trial name
- NCT01703663
- Testing
- EPAP
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Sleep-disordered Breathing
Sleep and Breathing in the General Population - Chemical Stimuli
Central sleep apnea (CSA) is a common condition and its treatment remains elusive. The focus of this proposal is to identify the role of the physiologic path involving cortical arousals in CSA by decreasing arousal frequency…
- Trial name
- NCT04720547
- Testing
- Zolpidem, No Treatment
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Sleep Apnea, Stroke
Positional Therapy After Stroke
Stroke is the leading cause of adult disability and the third leading cause of death in the United States. Unfortunately, there are few therapies that have been proven to improve stroke outcome.
- Trial name
- NCT01047709
- Testing
- Positional therapy including the use of a special pillow
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Michigan
Sleep Apnea, Obstructive, Sleep Apnea, Central
Early Sleep Apnea Treatment in Stroke
Investigating the interrelation of stroke and sleep-disordered breathing (SDB) is of major importance. First because of the high occurrence rate of stroke and the fact that it is a frequent cause of long-term disability in…
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea, Central, Stroke
- Trial name
- eSATIS (NCT02554487)
- Testing
- AirCurveTM10 CS PACEWAVE Adaptive-Servo-Ventilator (ResMed Ldt., Australia)
- Where
- 6 sites in France, Germany and 2 more
- Volunteers
- 201 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern