Clinical trials: Central Line Infection, open to volunteers
Laboratory-confirmed Bloodstream Infection, Central Line-associated Bloodstream Infections
Using Microbial Genomics to Elucidate the Source of Central-line Associated Bloodstream Infections
Central line-associated bloodstream infections (CLABSIs) are the most common healthcare-associated infection in children and are associated with morbidity and mortality.
- Conditions
- Laboratory-confirmed Bloodstream Infection, Central Line-associated Bloodstream Infections, Mucosal Barrier Injury
- Trial name
- NCT02271243
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston Children's Hospital
CLABSI - Central Line Associated Bloodstream Infection, CRBSI - Catheter Related Bloodstream Infection
Neonatal Catheter Lock for Infection Prevention
For newborns admitted to Neonatal Intensive Care Units (NICUs), one of the main risk factors for late-onset sepsis is the presence of a central venous catheter (CVC), which is often essential for the administration of medications…
- Conditions
- CLABSI - Central Line Associated Bloodstream Infection, CRBSI - Catheter Related Bloodstream Infection, Neonatal Sepsis, Late-Onset
- Trial name
- Neo-CLIP (NCT07585188)
- Testing
- Taurolidine 2% lock, Normal saline lock
- Where
- Italy
- Volunteers
- 576 people
- Sponsor
- University of Turin, Italy
CRBSI - Catheter Related Bloodstream Infection, Evidence-based Nursing Practice
Multicenter Clinical Translational Study of "ICU-NO CRBSI" Based on Improvement Science
The goal of this type of study is to construct the continuous quality promotion project "ICU-NO CRBSI(Catheter-Related Bloodstream Infection , CRBSI)" based on improvement science, and to verify its effect in the prevention of…
- Conditions
- CRBSI - Catheter Related Bloodstream Infection, Evidence-based Nursing Practice, Central Venous Catheter Related Bloodstream Infection, Central Venous Catheter Associated Bloodstream Infection
- Trial name
- NCT06085690
- Testing
- evidence-based intervention Plan for the Prevention of CRBSI in ICU patients
- Where
- China
- Volunteers
- 8,050 people, healthy volunteers welcome
- Sponsor
- Fudan University
Critical Illness, Catheter-Related Infections
Efficacy and Safety of Peripherally Inserted Central Venous Catheters
Central venous access is critical for administering intravenous medications, parenteral nutrition, and fluid therapy in intensive care units (ICUs).
- Conditions
- Critical Illness, Catheter-Related Infections, Upper Extremity Deep Vein Thrombosis, Catheter Obstruction
- Trial name
- NCT07834996
- Volunteers
- 60 people
- Sponsor
- Assiut University
Peripherally Inserted Central Catheter, Umbilical Venous Catheter
Umbilical Venous Versus Peripherally Inserted Central Catheters in Neonates: A Prospective Cohort Study of Complications, Catheter Survival, and CLABSI"
This study aims to prospectively compare umbilical venous catheters (UVCs) and peripherally inserted central catheters (PICCs) in neonates, focusing on complications, catheter survival, and central line-associated bloodstream…
- Conditions
- Peripherally Inserted Central Catheter, Umbilical Venous Catheter, CLABSI - Central Line Associated Bloodstream Infection
- Trial name
- NCT07209670
- Testing
- peripherally inserted central catheter insertion, umbilical venous catheters insertion
- Volunteers
- 360 people
- Sponsor
- Assiut University
Helicobacter Infections
A Comparison of Four Different Treatment Regimens of Helicobacter Pylori in Chinese Children
With the resistance of Helicobacter pylori increasing, low and unsatisfactory eradication rate (64%) have been observed with standard triple therapy in European children.
- Trial name
- NCT03365609
- Testing
- triple therapy, sequential therapy, bismuth quadruple therapy
- Where
- China
- Volunteers
- 1,440 people
- Sponsor
- Ying HUANG
Central Line Associated Blood Stream Infections (CLABSI)
Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults And Adolescent Participants Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)
This is a Phase 3, randomized, double-blind, controlled, adaptive, 2-arm, multicenter study to demonstrate the efficacy and safety of DefenCath in adult and adolescent participants receiving home Total Parenteral Nutrition (TPN)…
- Trial name
- NCT06822426
- Testing
- (taurolidine and heparin) catheter lock solution, Heparin
- Where
- 24 sites in United States, Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- CorMedix Therapeutics
Central Line-associated Bloodstream Infection (CLABSI)
Central Line-Associated Bloodstream Infection QI Project
This study evaluates a daily electronic health record (EHR) alert designed to reduce unnecessary central venous catheter (CVC) use among hospitalized adults.
- Trial name
- CLABSI (NCT07746674)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Ventilator Acquired Pneumonia, Central Line Associated Blood Stream Infections (CLABSI)
Evidence-Based Nursing to Reduce Adverse Events Regarding Ventilator Associated Pneumonia, Pressure Injuries and Central Line Bloodstream Infection in Intensive Care Unit in Bangladesh
Quality of care is crucial for preventing adverse events such as infection in the intensive care units (ICUs). The most common ICU-acquired infections include pneumonia such as Ventilator Associated Pneumonia (VAP), Pressure…
- Conditions
- Ventilator Acquired Pneumonia, Central Line Associated Blood Stream Infections (CLABSI), Pressure Ulcer (PU), Medical Device Related Pressure Ulcer (MDRPU)
- Trial name
- EBP in Nursing (NCT07299799)
- Testing
- Education with EBP, This is a pre- and post- quasi-experimental study.
- Where
- 2 sites in Bangladesh, Japan
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Intensive Care (ICU), Central Venous Catheter Related Infections
Impact of Infusion Line Change Frequency on Infectious Complications Related to Central Venous Catheters in the ICU - A Randomized Controlled Trial
In the intensive care unit, patients' care and secure drugs administration require a central venous catheter. These invasive devices can lead to complications, particularly infections.
- Conditions
- Intensive Care (ICU), Central Venous Catheter Related Infections, Critical Care Nursing, Catheter-associated Bloodstream Infections (CLABSI)
- Trial name
- TANDOORI (NCT07183592)
- Testing
- 7-day Infusion set replacement, 4-day infusion set replacement
- Where
- 27 sites in France
- Volunteers
- 2,830 people
- Sponsor
- University Hospital, Angers
Catheter-Related Infections, Biofilms
Biofilm-induced Antimicrobial Resistance RIsk ERadication in Critical Care Central Venous Catheters
Central venous catheter (CVC) infections are a frequent and serious nosocomial complication in critical care, leading to increased morbidity, mortality, and costs.
- Conditions
- Catheter-Related Infections, Biofilms, Infection Prevention
- Trial name
- BARRIER (NCT07546994)
- Testing
- Microbial analysis of catheter biofilm
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Helicobatcer Pylori, First-Line Eradication
Efficacy And Safety of Bismuth-Tetracycline-Rabeprazole Triple For First-Line Eradication of Helicobacter Pylori Infection
Most international treatment guidelines currently recommend a 14-day bismuth quadruple therapy as the first-line treatment for Helicobacter pylori infection, especially in areas with high clarithromycin resistance.
- Trial name
- NCT07788053
- Testing
- Bismuth, Bismuth quadruple therapy
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chih-An Shih, MD
Device Related Infection, Vascular Access Complication
The IVCare Adaptive Platform Trial
The IVCare trial is a multicentre adaptive platform study evaluating interventions to prevent infections and other complications associated with central venous access devices (CVADs) in patients with newly inserted or existing…
- Conditions
- Device Related Infection, Vascular Access Complication, Device Related Sepsis, Catheter Infection
- Trial name
- NCT07587593
- Testing
- Connectors/Caps Domain - Standard of Care, Curos™, ClearGuard™ HD
- Volunteers
- 2,500 people
- Sponsor
- The University of Queensland
Ventilator-Associated Pneumonia (VAP), Central Line-Associated Bloodstream Infection
Impact of Nurses' Behavior Change and Evidence-Based Practice Implementation on Quality Indicators in Intensive Care Units in Low- and Middle-Income Countries
Study title: Impact of nurses' behavior change and implementing evidence-based practice to improve quality indicators in intensive care units in low-and middle-income countries Background and Rationale: Quality care is crucial…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Central Line-Associated Bloodstream Infection, Pressure Ulcers (Hospital-acquired Pressure Injuries), Prolonged Intensive Care Unit Length of Stay
- Trial name
- NCT07397364
- Testing
- Evidence based practices bundles of care
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Central Line-Associated Bloodstream Infection (CLABSI), Bacteremia
Evaluation of an AI-Assisted Tool for CLABSI Surveillance at VA Medical Centers
Infection prevention and control programs at US hospitals perform surveillance to detect and publicly report hospital-onset central line-associated bloodstream infections (CLABSI) using standards set by CDC's National Healthcare…
- Conditions
- Central Line-Associated Bloodstream Infection (CLABSI), Bacteremia, Bloodstream Infections
- Trial name
- VA-AI-CLABSI (NCT07918352)
- Testing
- Generative AI tool for CLABSI surveillance
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
Acquired Immunodeficiency Syndrome, BK Virus Infection
Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus
This phase II trial studies how well donor cytotoxic T lymphocytes work in treating patients with malignancies with BK and/or JC virus.
- Conditions
- Acquired Immunodeficiency Syndrome, BK Virus Infection, Human Immunodeficiency Virus, JC Virus Infection
- Trial name
- NCT02479698
- Testing
- Allogeneic BK-specific Cytotoxic T-lymphocytes, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
CLABSI - Central Line Associated Bloodstream Infection
Epidemiological Investigation of Central Venous Catheter-related Bloodstream Infections in Icus in China
In recent years, with the rapid advancement of medical technology and the rapid development of critical care medicine, the use of various central venous catheters in icus has been increasing day by day.
- Trial name
- NCT07255105
- Where
- China
- Volunteers
- 1,846 people
- Sponsor
- Jianfeng Xie
Vascular Access Complication, Device Related Infection
Chlorhexidine Caps for CLABSI Prevention in Hemodialysis: a Pilot Randomized Controlled Trial
The goal of this clinical trial is to compare a chlorhexidine antimicrobial barrier cap in patients requiring hemodialysis treatment to the standard hemodialysis caps currently used within the Metro North Kidney Health Service.
- Conditions
- Vascular Access Complication, Device Related Infection, Device Related Sepsis, Catheter Infection
- Trial name
- ECHO-HD (NCT07019610)
- Testing
- ClearGuard HD, B Braun Combi-stopper
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- The University of Queensland
Neonatal Infection
Impact of a Multi-infusion Strategy in Neonatology on the Rate of Central Line-associated Bloodstream Infections
The management of premature infants hospitalized in neonatal units requires the simultaneous intravenous (IV) infusion of several drugs and parenteral nutrition solutions, when oral administration is impossible or unsuitable.
- Trial name
- EDELVAISS (NCT06656104)
- Testing
- Reference strategy, Experimental strategy
- Where
- 3 sites in France
- Volunteers
- 569 people
- Sponsor
- Hospices Civils de Lyon
Falls Injury, Readmission Rates
Duke Virtual IntEgrated Workflow
This quality improvement initiative aims to evaluate the implementation, utilization, and impact of virtual care technologies and workflows being implemented at Duke University Health System (DUHS).
- Conditions
- Falls Injury, Readmission Rates, CLABSI - Central Line Associated Bloodstream Infection, Catheter Associated Urinary Tract Infection
- Trial name
- Duke VIEW (NCT07406074)
- Testing
- Co-Care
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Duke University