Clinical trials: Central Nervous Injury
Traumatic Brain Injury, Stroke
Remote Neuropsychological Assessment of Patients With Neurological Disorders and Injuries
For the last decades, many aspects of human life have been altered by digital technology. For health care, this have opened a possibility for patients who have difficulties travelling a long distance to a hospital to meet with…
- Conditions
- Traumatic Brain Injury, Stroke, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT05819008
- Testing
- Neuropsychological Assessment
- Where
- Sweden
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Umeå University
Traumatic Brain Injury
Therapeutic Normothermia in TBI
This feasibility trial is the first step in testing the hypothesis that maintenance of normal body temperature, called therapeutic normothermia (TN), for 72 continuous hours in traumatic brain injury (TBI) patients can improve…
- Trial name
- MAMBA-FT (NCT06540768)
- Testing
- Therapeutic Normothermia Group
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre
Spinal Cord Injuries
Treating Cognitive Deficits in Traumatic Spinal Cord Injury (SCI)
The purpose of this research study is to investigate the effectiveness of a memory retraining program and a processing speed program in a spinal cord injured (SCI) population.
- Trial name
- NCT03985540
- Testing
- Behavorial; memory exercise, Behavioral: speed exercises
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Kessler Foundation
Spasticity
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
The purpose of the study is to assess the safety and efficacy of increasing doses of Corabotase (also known as IPN10200) with the aim to evaluate the Pharmacodynamics (PD) profile of Corabotase and to establish the total…
- Trial name
- LANTIMA (NCT04752774)
- Testing
- Corabotase, Dysport
- Where
- 81 sites in United States, Austria and 12 more
- Volunteers
- 240 people
- Sponsor
- Ipsen
Insomnia, Traumatic Brain Injury
Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury
The purpose of this clinical trial is to assess the relative efficacy of two non-pharmacological interventions for insomnia in Veterans suffering from chronic mild traumatic brain injury (mTBI).
- Trial name
- NCT03261674
- Testing
- CBT-I, ABT-I
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries, Stroke
Evaluation of an Advanced Lower Extremity Neuroprostheses
The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate exercise, standing, stepping and/or balance in people with various degrees of paralysis.
- Conditions
- Spinal Cord Injuries, Stroke, Paralysis, Tetraplegia
- Trial name
- LE-IST (NCT00623389)
- Testing
- IST (Implanted Stimulator-Telemeter)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Case Western Reserve University
Spinal Cord Injuries (SCI), Muscle Spasticity as a Result of Spinal Cord Injury
Powered Exoskeleton-Assisted Walking in Persons With Spinal Cord Injury
Spinal Cord Injury (SCI) represents a significant health challenge, particularly when it comes to the ability to walk. Among its many consequences, mobility impairment can not only directly impact quality of life but also cause a…
- Conditions
- Spinal Cord Injuries (SCI), Muscle Spasticity as a Result of Spinal Cord Injury, Rehabilitation, Exoskeleton Device
- Trial name
- EKSO-SCI (NCT07884591)
- Testing
- Wearable Powered Exoskeleton
- Where
- Italy
- Volunteers
- 74 people
- Sponsor
- IRCCS San Raffaele Roma
Spinal Cord Injuries
UPnRIDE Power Standing Wheelchair for SCI
People with higher level of spinal cord injury have limitations to using exoskeletal-assisted walking devices due to restrictions of trunk stability, functional use of the upper extremities and hand grip.
- Trial name
- NCT04163796
- Testing
- UPnRIDE power wheelchair
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Bronx Veterans Medical Research Foundation, Inc
Quadriplegia
Visuomotor Prosthetic for Paralysis
The investigators objective is to run human clinical trials in which brain activity recorded through a "brain-chip" implanted in the human brain can be used to provide novel communication capabilities to severely paralyzed…
- Trial name
- NCT01958086
- Testing
- Neural Communication System
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Richard A. Andersen, PhD
Brain Injuries
Manual-Based Vocational Rehabilitation Program for Patients With Acquired Brain Injury
An acquired brain injury (ABI) is a complex injury often followed by a broad range of cognitive, physical, emotional, and behavioral disabilities.
- Trial name
- NCT03086031
- Testing
- Program -based vocational rehabilitation intervention, Conventional vocational rehabilitation (controls)
- Volunteers
- 84 people
- Sponsor
- Brain Injury Center BOMI, Roskilde, Denmark
Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
MicroRNA Diagnostics in Subarachnoid Hemorrhage 2
The purpose of this study is to validate results from a related trial (NCT01791257) and to compare the profile of microRNA in blood from patients suffering subarachnoid hemorrhage with and without systemic complications.
- Conditions
- Subarachnoid Hemorrhage, Delayed Cerebral Ischemia, Acute Lung Injury, Cardiac Dysfunction
- Trial name
- NCT02320539
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Traumatic Brain Injury
Advanced MRI In Acute Military TBI
Traumatic brain injury can cause permanent problems with thinking, memory, control of emotions, organization and planning. Thousands of soldiers, marines, and other military personnel have had injuries to the brain due the wars…
- Trial name
- NCT01313130
- Where
- 2 sites in United States, Germany
- Volunteers
- 400 people
- Sponsor
- Washington University School of Medicine
Traumatic Brain Injuries
Anti-inflammatory Effect of MgSO₄ in Patients With Moderate Traumatic Brain Injury by Measurming Nucleotide-binding Oligomerization Domain-Like Receptor Pyrin Domain-containing 3 (NLRP3) Inflammasome-a Multiprotein Complex
The primary objective of this study is to evaluate the biochemical efficacy of Magnesium Sulfate (MgSO₄) as an anti-inflammatory therapeutic agent in patients suffering from moderate traumatic brain injury (TBI) at Assiut…
- Trial name
- NCT07763665
- Testing
- Magnesium sulfate (MgSO4), Normal Saline
- Volunteers
- 64 people
- Sponsor
- Assiut University
Stroke, Vascular Severe Brain Injury
Blood Extracellular Vesicles as Predictive Recovery Biomarker After Stroke and Brain Injury
The rehabilitation outcome and recovery, in people after stroke or with vascular severe brain injury(vSBI), are difficult to predict.
- Conditions
- Stroke, Vascular Severe Brain Injury, Rehabilitation
- Trial name
- PRISMA (NCT06871800)
- Testing
- blood withdrawal
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Traumatic Brain Injury, Cerebral Hemorrhage
TCD Detection of Ophthalmic Artery Blood Flow Velocity Prediction Feasibility Study of Intracranial Pressure
Increased intracranial pressure is a cause of disease progression in patients with brain disease, a common cause of poor prognosis.
- Conditions
- Traumatic Brain Injury, Cerebral Hemorrhage, Increased Intracranial Pressure
- Trial name
- NCT02240394
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
TBI Traumatic Brain Injury
ESWT as a Treatment for Chronic NHO in TBI Patients
Effect of Extracorporeal Shock Wave Therapy on Chronic Neurogenic Heterotopic Ossification in Traumatic Brain Injured (TBI) patients Chronic Neurogenic Heterotopic Ossification (NHO) - Heterotopic ossification is a well known…
- Trial name
- NCT02331628
- Testing
- ESWT - Extracorporeal Shockwave Therapy
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Loewenstein Hospital
Brain Concussion, Neck Pain
Cervical Spine Focused Treatment for Patients With Persistent Concussion Symptoms and Neck Pain
Assess the feasibility of recruiting, enrolling and randomizing patients with concussion symptoms and neck pain to receive manual therapy and cervical rehabilitative exercises in addition to standard concussion treatment.
- Trial name
- ConCerv (NCT06616272)
- Testing
- Cervical rehabilitation, Standard Concussion Care
- Where
- 4 sites in United States, Ireland and 1 more
- Volunteers
- 2 people
- Sponsor
- University of Pittsburgh
Spinal Cord Injuries (SCI)
Exploring the Feasibility and Benefits of Implementing Pelvic Floor Muscle Training During Inpatient Rehabilitation for People With Spinal Cord Injury
The goal of this clinical study is to determine the feasibility and explore the potential benefits of pelvic floor muscle training during inpatient SCI rehabilitation on urinary, bowel, and sexual function and quality of life in…
- Trial name
- NCT07519928
- Testing
- Pelvic Floor Muscle Physiotherapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Spinal Cord Injuries
Study to Determine if a Reduction in Pain Can be Measured in Spinal Cord Injured Patients Using a New Study Design
The study is designed to assess if spinal cord injury patients have reduced pain after taking either pregabalin or placebo in a cross over design.
- Trial name
- NCT00978341
- Testing
- Pregabalin
- Where
- 4 sites in Australia
- Volunteers
- 15 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Mild Traumatic Brain Injury
BLOOD BIOMARKERS in PAEDIATRIC MTBI
The goal of this observational study is to identify blood biomarkers that could help in the management of paediatric patients with mild TBI. The main questions it aims to answer are: 1.
- Trial name
- t-BIOMAP (NCT06233851)
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Pediatric Clinical Research Platform
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