Clinical trials: Central Nervous Injury
Neuropathic Pain
Acupuncture Treatment to Reduce Burning Pain in Spinal Cord Injury
Acupuncture has been used with good results for many years at Toronto Rehabilitation Institute Lyndhurst Centre (Toronto, ON, Canada), Parkwood Hospital (London, ON, Canada) and GF Strong Rehabilitation Institute (Vancouver, BC…
- Trial name
- APSCI (NCT00523016)
- Testing
- Lyndhurst Central Neuropathic Pain Acupuncture Protocol (LCCNPAP)
- Where
- 3 sites in Canada
- Volunteers
- 33 people
- Sponsor
- Toronto Rehabilitation Institute
Traumatic Brain Injury
Sovateltide for the Treatment of Acute Traumatic Brain Injury
Traumatic brain injury (TBI) remains a leading cause of global disability, yet current clinical management is limited to supportive care and pressure stabilization using hyperosmolar therapies like mannitol and hypertonic saline.
- Trial name
- RESTORE-TBI (NCT07861126)
- Testing
- Sovateltide
- Volunteers
- 214 people
- Sponsor
- Pharmazz, Inc.
Stroke
A Prospective Investigation of the VWF-ADAMTS 13 Axis in Acute Ischaemic Brain Injury (TIAs and Stroke).
In patients presenting with acute stroke or transient ischaemic attacks (TIA), von Willebrand factor related parameters, including VWF antigen, activity, FVIII:c and propeptides, ADAMTS13 levels and VWF multimers in cases where…
- Trial name
- NCT02219035
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College, London
Rehabilitation After Neurological or Orthopaedic Injuries
Feasibility of Unsupervised Therapy After Neurological or Orthopaedical Injury in the Home Setting With a Hand Rehabilitation Device (ReHandyBot) and an Assistive Smartphone Application (RehabCoach)
The goal of this clinical trial is to evaluate whether using the ReHandyBot hand rehabilitation device together with the RehabCoach smartphone app can support safe, independent, and effective home therapy in patients with stroke…
- Trial name
- NCT07182734
- Testing
- Supervised and minimally-supervised therapy with ReHandyBot and RehabCoach, Unsupervised Therapy with ReHandyBot and RehabCoach
- Volunteers
- 30 people
- Sponsor
- Swiss Federal Institute of Technology
Spinal Cord Injuries
Reliability and Validity of the ISNCSCI in Patients With Non-traumatic Spinal Cord Lesions
Aim of the study is to assess the psychometric properties of the International Standards for Neurological Classification of Spinal Cord Injury in subjects with non traumatic lesions.
- Trial name
- NCT04949763
- Testing
- rehabilitation
- Volunteers
- 140 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Urinary Tract Infection
Efficacy of Micro-Patterned Foley Catheter to Reduce Catheter-Associated Urinary Tract Infection
The purpose of this study is to determine if the study Foley catheter with its patterned external surface can delay the time to the onset of urinary tract infection in spinal cord injury patients who are dependent on a Foley…
- Trial name
- NCT02198833
- Testing
- Urine Culture, Foley Catheter Tip Culture, Scanning Electron Microscopy
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Baylor College of Medicine
All Cause Mortality, Cardiovascular Diseases
Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality
The goal of this clinical trial is to test two advices on alcohol drinking in more than 10.000 Spanish adult drinkers (men of 50 or more years and women of 55 or more years).
- Conditions
- All Cause Mortality, Cardiovascular Diseases, Invasive Cancer, Liver Cirrhosis
- Trial name
- UNATI (NCT06338215)
- Testing
- Moderate Alcohol Drinking Pattern, Abstention
- Where
- Spain
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Cervical Spinal Cord Injury
Linking Brain to Behaviour Research in SCI
Introduction In recent years, client-centred and task-oriented training have emerged as important methods in rehabilitation including the rehabilitation of persons with spinal cord injury (SCI).
- Trial name
- NCT01963026
- Testing
- ToCUEST featuring a 'variable practice' approach., ToCUEST featuring a 'constant practice' approach.
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Adelante, Centre of Expertise in Rehabilitation and Audiology
Spinal Cord Injuries, Cardiometabolic Diseases
High Intensity Interval Exercise SCI
This study will determine if the implementation of a home-based telehealth high intensity interval exercise-training (HIIT)program can significantly improve cardiometabolic health and physical function in a cohort of individuals…
- Trial name
- NCT04940598
- Testing
- high intensity interval exercise, No-exercise control group
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Alabama at Birmingham
Spinal Cord Injury
Development of Low Cost Devices to Increase Access to Treadmill Training
The goals of this Model System Program are to expand upon and advance the findings and outcomes of previous and current Model Systems clinical research, to continue to develop and study the effectiveness of innovative treatment…
- Trial name
- NCT02560506
- Testing
- Elastic assisted treadmill walking
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Treatment of Spinal Cord Injury Using Autologous Concentrated Growth Factors
Spinal cord injury (SCI) is a severe disorder of the central nervous system, and effective clinical management remains a significant global challenge.
- Trial name
- NCT07253233
- Testing
- Concentrated Growth Factors (CGF)
- Volunteers
- 10 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Spinal Cord Injury
Improve Dynamic Lateral Balance of Humans With SCI
This study is to test whether pelvis perturbation training paired with transcutaneous spinal direct current stimulation (tsDCS) will be effective in improving dynamic balance and locomotor function in humans with SCI.
- Trial name
- NCT02991248
- Testing
- robotic training, spinal cord electrical stimulation, treadmill
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Shirley Ryan AbilityLab
Traumatic Brain Injury, TBI
Methylphenidate for Attention Problems After Pediatric TBI
Traumatic Brain Injury (TBI) - methylphenidate treatment
- Conditions
- Traumatic Brain Injury, TBI, ADHD
- Trial name
- NCT01933217
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Spinal Cord Injury, Safety
Efficacy of iPSC-Derived Motor Neuron Cells (XS228) in Subacute Spinal Cord Injury: A Phase II Randomized Controlled Trial
Purpose: This clinical trial is studying an investigational cell therapy called XS228-a lab-made stem cell product designed to help repair damaged nerves in the spinal cord.
- Conditions
- Spinal Cord Injury, Safety, Efficacy, Clinical Trial
- Trial name
- NCT06974968
- Testing
- Allogeneic Human Induced Pluripotent Stem Cell (iPSC)-Derived Motor Neuron Progenitor Cells
- Where
- China
- Volunteers
- 60 people
- Sponsor
- XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.
Ischemic Heart Disease, Cardiac Arrest
Registry of Multicenter Brain-Heart Comorbidity in China
This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program.
- Conditions
- Ischemic Heart Disease, Cardiac Arrest, Atrial Fibrillation, Heart Failure
- Trial name
- BHC-C (NCT05961748)
- Testing
- Multi-disciplinary assessment
- Where
- 14 sites in China
- Volunteers
- 100,000 people
- Sponsor
- Beijing Tiantan Hospital
Traumatic Brain Injury
Improving Well-Being After TBI Through Structured Volunteer Activity
The purpose of this project is to determine if participating in volunteer activity improves the psychological well-being of individuals with traumatic brain injury (TBI).
- Trial name
- NCT01728350
- Testing
- HOPE - Helping Others through Purpose and Engagement
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Craig Hospital
Drug/Agent Toxicity by Tissue/Organ, Leukemia
Growth Factor to Prevent Oral Mucositis in Patients With Hematologic Cancer
RATIONALE: Keratinocyte growth factor may prevent symptoms of mucositis in patients receiving radiation therapy and chemotherapy.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004132
- Testing
- filgrastim, palifermin, cyclophosphamide
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
TBI Traumatic Brain Injury, Enteral Nutrition Therapy
Effect of Enteral Formula (Commercial vs. Homemade) on Muscle Mass in Trauma Brain Injury
This randomized controlled clinical trial aims to determine whether there are differences in muscle mass (MM) in patients with traumatic brain injury who receive enteral nutrition based on polymeric formulas (homemade formula…
- Conditions
- TBI Traumatic Brain Injury, Enteral Nutrition Therapy, Critical Illness
- Trial name
- NCT06949163
- Testing
- Homemade formula, Commercial formula
- Where
- Mexico
- Volunteers
- 39 people
- Sponsor
- Hospital General "Dr. Miguel Silva" de Morelia
Cognition Disorder, Functional Brain Imaging
fMRI and NIRS Imaging for Traumatic Brain Injury
Background: The amount of blood flowing in brain areas goes up when those areas are being used for activities, such as movement or seeing.
- Trial name
- NCT01668758
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Cervical Spinal Cord Injury, Spine Injury
Study of Human Central Nervous System (CNS) Stem Cell Transplantation in Cervical Spinal Cord Injury
This study will evaluate the safety and efficacy of human central nervous system stem cell transplantation into patients with traumatic injury in the cervical region of the spinal cord.
- Conditions
- Cervical Spinal Cord Injury, Spine Injury, Cervical Spine Injury
- Trial name
- NCT02163876
- Testing
- HuCNS-SC cells
- Where
- 14 sites in United States, Canada
- Volunteers
- 31 people
- Sponsor
- StemCells, Inc.
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