Clinical trials: Central Nervous Injury
Irritable Mood, Aggression
Utility of Amantadine Hydrochloride in the Treatment of Post-traumatic Irritability
The purpose of this study is to determine if amantadine hydrochloride given 100 mg in the morning and at noon is safe and effective in the treatment of mood and behavior changes (i.e.
- Conditions
- Irritable Mood, Aggression, Traumatic Brain Injury
- Trial name
- NCT00627250
- Testing
- Amantadine
- Volunteers
- 76 people
- Sponsor
- Wake Forest University Health Sciences
Traumatic Brain Injury
Internet-Based Treatment for Children With Traumatic Brain Injuries & Their Families: Counselor Assisted Problem Solving
This study will evaluate the effectiveness of an Internet-based psychosocial treatment in improving problem-solving, communication skills, stress management strategies, and coping among children who have had a traumatic brain…
- Trial name
- CAPS (NCT00409448)
- Testing
- Counselor-assisted problem solving (CAPS), Internet-resource comparison (IRC)
- Where
- 5 sites in United States
- Volunteers
- 132 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Traumatic Brain Injury
Neurofeedback-enhanced Mindfulness Meditation in Traumatic Brain Injury
Spaulding Rehabilitation Hospital is conducting a research study evaluating the effectiveness of the brain-training product, MUSE, an EEG-guided neurofeedback device designed to assist in cultivating a relaxed, attentive state of…
- Trial name
- NCT02615535
- Testing
- EEG neurofeedback-assisted meditation, Non-EEG feedback-assisted meditation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Spaulding Rehabilitation Hospital
Motor Disorders, Gait Disorders, Neurologic
Adherence to Long-term Exoskeleton Rehabilitation to Treat Lower Limb Weakness and / or Deficiencies in Adult Population
In 2019, approximately 2.4 billion people worldwide required rehabilitation for various health pathologies, a 63% increase since 1990.
- Conditions
- Motor Disorders, Gait Disorders, Neurologic, Neurodegenerative Diseases, Spinal Cord Injuries
- Trial name
- ALERT (NCT06538974)
- Testing
- Hands-free exoskeleton
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Wandercraft
TBI (Traumatic Brain Injury)
ENGAGE-TBI Feasibility Study
This study will first evaluate the feasibility of delivering the ENGAGE-TBI intervention in a community setting with adults with TBI.
- Trial name
- NCT07549997
- Testing
- Social intervention study for TBI survivors
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Brain Injury, Chronic
Investigating the Role of the Premotor Cortex in Higher Cognitive Functions
This project aims at understanding better the role of the frontal lobe of the brain in our capacity to perceive visual information consciously, and also, in our capacity to perceive others' actions.
- Trial name
- NCT00842413
- Where
- France
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Injury, Hyponatremia
Pharmacokinetics and Clinical Response of Tolvaptan in Neurocritical Care Patients
To assess the pharmacokinetic profile of tolvaptan in critically ill acute brain injury patients and to secondarily evaluate the clinical response and safety of tolvaptan in acute brain injured patients
- Trial name
- NCT02215148
- Testing
- Tolvaptan
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of North Carolina, Chapel Hill
Traumatic Brain Injury, Coma
Optimized Therapy in Severe Traumatic Brain Injured Patients
Severe traumatic brain injury is associated with life-threatening and incapacitating secondary injury. Contemporary therapeutic interventions are aimed at preventing and treating secondary damage.
- Trial name
- NCT02130674
- Testing
- Dipeptiven
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Posttraumatic Stress Disorder, Traumatic Brain Injury
Cognitive REmediation After Trauma Exposure Trial = CREATE Trial
This study will evaluate the efficacy of methylphenidate and galantamine in the treatment of persistent cognitive symptoms associated with posttraumatic stress disorder (PTSD) and/or traumatic brain injury (TBI).
- Trial name
- CREATE (NCT01416948)
- Testing
- Methylphenidate Hydrochloride 20 mg, Galantamine 12 mg
- Where
- 7 sites in United States
- Volunteers
- 32 people
- Sponsor
- INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Sars-CoV2, Severe Neurologic Injury
COVID-19 Brain Injury
A prospective cohort minimal risk study to determine the impact of the COVID-19 crisis on outcomes of neurologically injured ICU patients.
- Conditions
- Sars-CoV2, Severe Neurologic Injury, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT04496076
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Pittsburgh
Cognitive Impairment, Cognitive Decline
Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy
Randomized, placebo-controlled, double-blinded, parallel group clinical trial to investigate if 6 months of oral lithium tablets (S-lithium 0,5-1,0 mmol/l) will prevent cognitive decline after brain radiotherapy in pediatric…
- Conditions
- Cognitive Impairment, Cognitive Decline, Radiotherapy Side Effect, Radiotherapy; Complications
- Trial name
- LiBRA (NCT06051240)
- Testing
- Lithium
- Where
- 2 sites in Sweden
- Volunteers
- 84 people
- Sponsor
- Region Stockholm
Spinal Cord Injury
Acupuncture for Treatment of Acute Spinal Cord Injury: an Exploratory/Developmental Study
Specific Aim: to implement and evaluate a research protocol for demonstrating the efficacy of Acupuncture Therapy to improve neurological recovery after incomplete SCI compared to a control protocol.
- Trial name
- NCT00432289
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Craig Hospital
TBI (Traumatic Brain Injury)
The Development of a Virtual Reality Program to Improve Attention in Individuals With TBI
The purpose of this research is to investigate the effectiveness of a technique designed to improve divided attention and set-shifting impairments in persons with a traumatic brain injury (TBI).
- Trial name
- NCT03605017
- Testing
- Virtual Reality Executive Function Training (VREFT)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Kessler Foundation
Healthy, Concussion (Diagnosis)
Reliability of the SOT Over Clinical Administration Time Intervals of Concussion Assessment
The goal of this study has two parts. First, it examines whether performing multiple Sensory Organization Tests (SOT) on the SMART Balance Master, using two different testing orders, leads to different levels of practice…
- Conditions
- Healthy, Concussion (Diagnosis), Balance Assessment
- Trial name
- NCT07024368
- Testing
- Reliability of the Sensory Organization Test on the SMART Balance Master across multiple administrations
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Hyung Rock Lee
Persian Gulf Syndrome
Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)
The purpose of this study is to perform a randomized double-blind, placebo-controlled, 12 week study of the effects of carnosine on cognitive, psychometric, autonomic, and muscle strength outcomes in 100 GWI subjects.
- Trial name
- NCT00810368
- Testing
- Carnosine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Georgetown University
Acquired Brain Injury, Fatigue
e-COGRAT: A Blended eHealth Intervention for Fatigue Following Acquired Brain Injury
Fatigue is a common, persistent consequence of acquired brain injury (ABI). Research into treatments that may alleviate post-ABI fatigue is been limited.
- Trial name
- NCT05863897
- Testing
- e-COGRAT (a blended eHealth intervention)
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Universiteit Leiden
Alcohol Dependence
Treatment Strategy for Alcohol Use Disorders in Veterans With TBI
The purpose of this research study is to understand the effectiveness of valproate (a common mood stabilizer) to further reduce alcohol misuse when given in addition to attending an alcohol rehabilitation program as well as the…
- Trial name
- AUD (NCT01342549)
- Testing
- Valproate, Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- VA Office of Research and Development
Stroke (CVA) or TIA, Headache, Migraine
Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache
Post stroke headache occurs in approximately 10-23% of all stroke patients. Its onset is shortly after experiencing a stroke, or stroke like event, and persists for at least three months.
- Conditions
- Stroke (CVA) or TIA, Headache, Migraine, Botulinum Toxins, Type A, Cerebral Venous Sinus Thrombosis
- Trial name
- NCT04580238
- Testing
- Botox 200 UNT Injection, Non Botox based Standard of Care Treatments for Headache/Migraine
- Where
- Canada
- Sponsor
- University of Alberta
Traumatic Brain Injury
Deep Brain Stimulation for Traumatic Brain Injury
The study will evaluate the benefit of Deep Brain Stimulation for subjects with severe disability due to Traumatic Brain Injury.
- Trial name
- NCT01277952
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ali Rezai, MD
Mild Cognitive Impairment, Dementia
COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE
This retrospective study is a more extensive, confirmatory analysis of the cognitive and functional outcomes initially seen in 2 groups of MCI/dementia patients in Springfield, MA and compares specialized dementia care and a…
- Conditions
- Mild Cognitive Impairment, Dementia, Hypoxia, Hyperhomocysteinemia
- Trial name
- NCT02860338
- Volunteers
- 900 people
- Sponsor
- Clionsky Neuro Systems Inc.
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