Clinical trials: Central Nervous Injury
Traumatic Brain Injury, Orthopedic Injury
Epigenetic Effects on Traumatic Brain Injury Recovery
Methylation of the brain-derived neurotrophic factor (BDNF) gene is involved in both the biological encoding of childhood adversity and neuroplasticity following traumatic brain injury (TBI).
- Trial name
- EETR (NCT04186429)
- Where
- United States
- Volunteers
- 401 people
- Sponsor
- University of Pittsburgh
Brain Injuries, Acute
Acustocerebrography (ACG) in Severe Brain Injury
The study will enable the clinical applicability of the multiple-spectral-sonography for detection of severe brain injury in ICU patients.
- Trial name
- ACG-BrainICU (NCT03635736)
- Testing
- multiple-spectral-sonography as acustocerebrography (ACG)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Rostock
Chronic Pain, Post Stroke Pain
Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain
Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but current technology is unable to reliably achieve long-term pain symptom relief.
- Conditions
- Chronic Pain, Post Stroke Pain, Phantom Limb Pain, Spinal Cord Injuries
- Trial name
- NCT03029884
- Testing
- Open-Loop DBS, Closed-Loop DBS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Prasad Shirvalkar, MD, PhD
Muscle Weakness, Late Effect of Burn
Effect of In-Patient Exercise Training on Length of Hospitalization in Burned Patients
This study will measure efficacy of early in-patient exercise as an adjunct to current Standard of Care (SOC) for 96 patients in a multi-centre trial.
- Conditions
- Muscle Weakness, Late Effect of Burn, Muscle; Fatigue, Heart, Burn Rehabilitation
- Trial name
- MP-10 (NCT02739464)
- Testing
- Exercise + SOC PT/OT, SOC PT/OT
- Where
- 4 sites in United States
- Volunteers
- 77 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Spinal Cord Injury, Neurogenic Bowel
Use of Prokinetics During Inpatient Bowel Care for SCI Patients
Bowel care (BC) is a time-consuming and cumbersome activity of daily living for most individuals with SCI. Previous studies have reported that the average time to complete a BC routine is 45 minutes; 10-20% of SCI individuals…
- Trial name
- NCT02370433
- Testing
- Intravenous Neostigmine and Glycopyrrolate, Transdermal Neostigmine and Glycopyrrolate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries, Psychological Distress
A Guided Online ACT Intervention Combined With Psychoeducation for People With Spinal Cord Injury
The purpose of this preliminary study is to examine the effects of a guided online acceptance and commitment therapy (ACT) intervention combined with psychoeducation on people with spinal cord injury (SCI) who experience…
- Trial name
- NCT04670406
- Testing
- acceptance and commitment therapy (ACT) combined with psychoeducation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Alabama at Birmingham
End-stage Kidney Disease, Brain Damage
Interaction Research on Cognitive Impairment and Emotional Disorder in End-stage Renal Disease
End stage renal disease (ESRD) is the last stage (stage 5) of chronic kidney disease (CKD). Abnormalities of cognitive function and high levels of depression or anxiety incidence are characteristic of hemodialysis patients.
- Trial name
- NCT03191409
- Where
- 2 sites in China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Traumatic Brain Injury
Anosognosia Evaluation After Cranocerebral Trauma Moderate to Severe
This study is conducted over 18 months. The main objective of this study is to test and compare the relevance and reliability of different tools for measuring the anosognosia.
- Trial name
- ANOSOGNOSIA (NCT02333006)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Convergence Insufficiency, Traumatic Brain Injury
Eye Recovery Automation for Post Injury Dysfunction (iRAPID)
This study will test a portable virtual reality (VR) system with integrated eye tracking called Virtual Eye Rotation Vision Exercises (VERVE). The proposed VERVE platform will deliver vergence therapy in an automated manner.
- Conditions
- Convergence Insufficiency, Traumatic Brain Injury, Concussion, Mild
- Trial name
- iRAPID (NCT06105892)
- Testing
- Virtual Eye Rotation Vision Exercise (VERVE)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New Jersey Institute of Technology
Consciousness Disorders, Brain Injury
Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness
Prolonged disorders of consciousness (pDOC) are defined as DOC lasting >1 year post injury for patients with Traumatic Brain Injury (TBI) and >3 months post injury for patients with non-TBI and at present there are limited…
- Conditions
- Consciousness Disorders, Brain Injury, Altered Level of Consciousness
- Trial name
- NCT06930716
- Testing
- Transcutaneous vagus nerve stimulation (taVNS), Physical therapy using Hocoma, Standard of Care
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Brain Injury
Impact of Continuous Monitoring of PtC02 on Ventilatory Weaning in Neuro-injured Patients
The investigators propose to study the value of non invasive continuous transcutaneous PtC02 monitoring for ventilatory withdrawal guidance in neuro-injured patients and to predict the risk of extubation failure in this category…
- Trial name
- CO2MBAWA (NCT04819984)
- Testing
- TCM5 device (Radiometer) for PtC02 continuous measurement
- Volunteers
- 98 people
- Sponsor
- Centre Hospitalier St Anne
Spinal Cord Injuries, Muscle Pareses
A Novel Combined Neuromodulation Therapy to Enhance Balance and Neuroplasticity
Many people with partial damages in their spinal cord (iSCI) have physical impairments such as muscle paralysis in legs which make standing balance difficult.
- Conditions
- Spinal Cord Injuries, Muscle Pareses, Fall
- Trial name
- NCT05940636
- Testing
- Activity-based rehabilitation+electrical stimulation
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University Health Network, Toronto
Traumatic Brain Injury, CVA (Cerebrovascular Accident)
The Brain Injury Neurorehabilitation Project
The primary objective of The Brain Injury Neurorehabilitation Project is a systematic effort to generate cutting edge research in brain injury and cognitive rehabilitation that will advance neurorehabilitation research.
- Trial name
- NCT06556316
- Testing
- Cognitive Intervention with the Categorization Program, Social Cognitive Communication Program, Non-Invasive Brain Stimulation with tDCS
- Where
- Cyprus
- Volunteers
- 200 people
- Sponsor
- University of Cyprus
Brain Concussion
Control Study of Nautilus BrainPulse for the Detection of Concussion
To use the Nautilus BrainPulse to compare and contrast the signal patterns from this cohort's signal patterns with those of concussed high school athletes.
- Trial name
- NCT02350699
- Testing
- Nautilus BrainPulse
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Cerebral Stroke, Traumatic Brain Injury
Telerehabilitation Early After CNS Injury
The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI).
- Conditions
- Cerebral Stroke, Traumatic Brain Injury, Spinal Cord Injuries
- Trial name
- NCT06069999
- Testing
- HandyMotion Treatment Program
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- TRCare, Inc.
Concussion, Brain
A Wrist-Worn Nerve Stimulator for Remediating Persistent Post-Concussive Symptoms in Adolescents
The goal of this study is to test a wearable nerve stimulator in adolescents with persistent post-concussive symptoms. The main questions it aims to answer is whether the device will reduce clinical symptom burden, reduce…
- Trial name
- NCT05685121
- Testing
- Apollo Neuro
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of South Carolina
Brain Injuries, Traumatic, Sleep Initiation and Maintenance Disorders
The Feasibility of Home-Based Measurement of Circadian Timing for Veterans With TBI and Insomnia
Veterans with traumatic brain injury (TBI) frequently experience insomnia, which is linked with delayed TBI recovery, more severe functional impairment, and exacerbation of disabling TBI after-effects such as depression, chronic…
- Trial name
- Home DLMO (NCT05665764)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury, Acute
Transcutaneous Tibial Nerve Stimulation in Acute Spinal Cord Injury
Most patients with spinal cord injury (SCI) develop neurogenic lower urinary tract dysfunction (NLUTD), one of the most devastating sequelae of SCI which ultimately can lead to renal failure.
- Trial name
- TASCI (NCT03965299)
- Testing
- VERUM TTNS
- Where
- 4 sites in Switzerland
- Volunteers
- 114 people
- Sponsor
- University of Zurich
Mild Traumatic Brain Injury, Concussion, Mild
Return to Work After Mild Traumatic Brain Injury
Background: Patients with mild traumatic brain injury can to some extend experience long-term physical, cognitive, social and behavioral deficits, which have serious implications for employment trajectories and financial…
- Trial name
- NCT03214432
- Where
- Denmark
- Volunteers
- 38,372 people
- Sponsor
- University of Copenhagen
Traumatic Brain Injury, Blast Injuries
Long-Term Effects of Repetitive, Low-Level Blast Exposure on Special Operations Forces Service Members
This is a pilot study to identify biomarkers that individually, and in combination, demonstrate the greatest sensitivity to repetitive, low-level blast exposure (RLLBE) neurotrauma in Special Operations Forces (SOF) personnel.
- Trial name
- ReBlast (NCT05183087)
- Testing
- 3T Connectome MRI, 7 Tesla MRI, TSPO PET
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
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