Clinical trials: Central Nervous Injury
Spinal Cord Injuries
Repetitive Acute Intermittent Hypoxia for Spinal Cord Repair
Our goal is to enhance repeated exposure to acute intermittent hypoxia (rAIH)/training-induced aftereffects on upper and lower limb function recovery in humans with chronic spinal cord injury (SCI).
- Trial name
- NCT03433599
- Testing
- Repeated exposure to acute Intermittent Hypoxia (rAIH), Normal Room Air, Upper-limb Training by Research Staff
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Vision Disorder, Stroke
Visual Impairment and Functional Visual Performance Following Acquired Brain Injury: A Cross-Sectional Study
This cross-sectional observational study aims to characterize acquired visual impairment in adults with acquired brain injury and to examine the relationship between objectively identified visual impairment and self-reported…
- Conditions
- Vision Disorder, Stroke, Brain Injuries
- Trial name
- NCT07858708
- Where
- Czechia
- Volunteers
- 108 people
- Sponsor
- Charles University, Czech Republic
Spinal Cord Injury, Acute
Quality Control of a Strengthening Protocol in Subjects With Spinal Cord Injury
The aim of the master's thesis is to evaluate the clinic-internal strengthening concept of the Swiss Paraplegic Centre (SPZ). The SPZ is a rehabilitation clinic for spinal cord injured people.
- Trial name
- MKraft_Erstr (NCT03707704)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Brain Injuries, Intracranial Pressure Increase
Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Patients
The purpose of this clinical research project is to employ Mespere LifeSciences NeurOs Cerebral Oximetry system, equipped with noninvasive sensors approved by the FDA, to monitor and investigate the correlation within a cohort of…
- Conditions
- Brain Injuries, Intracranial Pressure Increase, Monitoring
- Trial name
- Mespere ICP (NCT06511804)
- Testing
- Intracranial Pressure Noninvasive Monitoring
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Louisville
Brain Injuries, Traumatic
Evaluating the Effectiveness of Treatment for Metacognition in Moderate and Severe Traumatic Brain Injury
Metacognition, in-the-moment awareness of performance while engaging in cognitive tasks, is negatively affected by traumatic brain injury (TBI).
- Trial name
- NCT03169647
- Testing
- Listening-based intervention
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Kessler Foundation
Minor Head Injury
Outcome of Patients With Mild Head Injury and Presence of an Acute Traumatic Abnormality on CT Scan of Head
Background: Patients with mild blunt traumatic brain injury (TBI) are frequently transferred to Level 1 trauma centers (L1TC) if they have any positive finding of any acute intracranial injury identified on a CT scan of the head.
- Trial name
- NCT04143347
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Massachusetts General Hospital
Neurologic Diseases, Arthropathy of Knee
Experience of Use and Biopsychosocial Effects of Robotic and Virtual Reality Devices in Neuromotor Rehabilitation
The implementation of virtual reality (VR) and robotic devices in neuromotor rehabilitation has so far provided promising evidence in terms of efficacy throughout different clinical populations.
- Conditions
- Neurologic Diseases, Arthropathy of Knee, Arthropathy of Hip
- Trial name
- NCT05399043
- Testing
- Multidisciplinary Conventional Neuromotor Rehabilitation, Technology-based Rehabilitation
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Spinal Cord Injuries
Heated Vest for Persons With Spinal Cord Injury
Persons with higher levels of spinal cord injury (above the 2nd thoracic vertebrae; tetraplegia) are unable to maintain normal core body temperature (Tcore) when exposed to cool environments.
- Trial name
- NCT03662308
- Testing
- Heated Vest, Non-Heated Vest
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Ventilator Associated Pneumonia, Morality
Endotracheal Tube Cuff Pressure Measurement
The effect of endotracheal cuff pressure measurement technique for preventing ventilatory associated pneumonia.
- Conditions
- Ventilator Associated Pneumonia, Morality, Trauma, Brain, Endotracheal Aspiration
- Trial name
- NCT04397952
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bagcilar Training and Research Hospital
Head Injury, Sport Injury
Dynamic Vision Testing and Concussion Management Dream Team 65
The purpose of this study is to determine the value of including dynamic vision testing into California State University, Northridge (CSUN) Athletics' established concussion protocol.
- Conditions
- Head Injury, Sport Injury, Concussion, Brain
- Trial name
- NCT05326555
- Testing
- Dynamic Vision Testing (Bertec Vision Advantage System) and Balance Error Scoring System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Stroke, Joint Replacement Surgery
SG Healthcare and Assistive Robotics Programme (SHARP) - Proof of Concept Study
Robots are commonly used in many settings to help with transportation needs, reduce human injuries, and assisting clinicians during surgeries.
- Conditions
- Stroke, Joint Replacement Surgery, Acquired Brain Injury, Spinal Cord Injuries
- Trial name
- SHARPCARE (NCT04315389)
- Testing
- (1) Mobile Assistant Balance Robot, (2) Transfer Assistive Cobot
- Where
- Singapore
- Volunteers
- 52 people
- Sponsor
- Tan Tock Seng Hospital
Spinal Cord Injuries
Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury
Early detection of response to therapeutic intervention is vital, as it will enable early termination of intervention in non-responding patients, prevent unnecessary financial burden, and allow for early changes to the…
- Trial name
- NCT03854214
- Testing
- Functional Electric Stimulation cycling, Passive cycling
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Stroke, Spinal Cord Injuries (Complete and Incomplete)
Exoskeleton-assisted Neurorehabilitation
Objective assesment of the feasibility of integrating the Ekso Bionics - Ekso NR device into outpatient care Objective assesment of quality of life, functionality and clinical symptomps of patients with stroke, cerebellar ataxia…
- Conditions
- Stroke, Spinal Cord Injuries (Complete and Incomplete), Cerebellar Ataxia, Spastic Paraplegia
- Trial name
- NCT07352085
- Testing
- Gait training with exoskeleton
- Where
- Hungary
- Volunteers
- 5 people
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Traumatic Brain Injury
Respiratory Treatment of Patients With Moderate and Severe Traumatic Brain Injury
Intracranial pressure (ICP) in patients with traumatic brain injury (TBI) is influenced by several factors of which one is arterial CO2 tension.
- Trial name
- NCT01955785
- Testing
- pressure controlled ventilator, Pressure Regulated Volume Controlled Ventilator
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- Norwegian University of Science and Technology
Traumatic Brain Injury (TBI)
Targeted Evaluation, Action, & Monitoring of Traumatic Brain Injury
TEAM-TBI (Targeted Evaluation, Action, and Monitoring of Traumatic Brain Injury) is a research study that brings together TBI patients, advanced evaluation methods, and experts in a multi-faceted study to address the…
- Trial name
- TEAM-TBI (NCT02657135)
- Testing
- Cognitive/Neuropsychological Testing, Vestibular/Ocular-Motor Testing, Cervical (Neck) Evaluation
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury
Transcranial Direct Current Stimulation (tDCS) and Motor Training for Traumatic Brain Injury (TBI) Survivors
The aim of this study is to compare the effect of transcranial direct current stimulation and functional upper extremity task training to functional upper extremity task training alone.
- Trial name
- NCT01749735
- Testing
- Transcranial Direct Current Stimulation, Armeo training
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Spaulding Rehabilitation Hospital
Brain Injuries, Cerebral Palsy
Magnesium Sulfate to Prevent Brain Injury in Premature Infants
Premature infants are at risk for acute brain injuries and long-term developmental problems such as cerebral palsy (CP). Research suggests that high levels of magnesium at and around the time of birth may decrease the risk of…
- Trial name
- NCT00065949
- Testing
- magnesium sulfate
- Where
- United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Tuberculosis, Tuberculous Meningitis
Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)
The investigators will conduct a randomized, double blind, placebo controlled trial of adjunctive dexamethasone in the initial (6-8 weeks) treatment of tuberculous meningitis in Vietnamese adults.
- Conditions
- Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury, HIV
- Trial name
- NCT03092817
- Testing
- Dexamethasone
- Where
- 6 sites in Indonesia, Vietnam
- Volunteers
- 520 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Bladder and Bowel Dysfunction, SCI - Spinal Cord Injury
SCS Therapy for Patients With Bladder and Bowel Dysfunction After SCI
This clinical trial aims to evaluate the safety and efficacy of spinal cord stimulation (SCS) in treating patients with urinary and bowel dysfunction after spinal cord injury (SCI).
- Trial name
- SCSBBD (NCT07511244)
- Testing
- Spinal Cord Stimulation and Evaluation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Traumatic Brain Injury
Rehabilitation Research and Training Center for Traumatic Brain Injury Interventions--Teen Online Problem Solving Study
This study will evaluate the effectiveness of an Internet-based psychosocial treatment in improving problem-solving, communication skills, stress management strategies, and coping among teens who have had a traumatic brain injury…
- Trial name
- RRTC--TOPS (NCT01042899)
- Testing
- Teen Online Problem Solving (TOPS), Teen Online Problem Solving--Teen Only (TOPS-TO), Internet Resources Comparison (IRC)
- Where
- 5 sites in United States
- Volunteers
- 153 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
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