Clinical trials: Central Nervous Injury
Severe Brain Trauma
Brain Densitometric Assessment With Axial Computerized Tomography After Severe Brain Trauma.
Processing the Digital Imaging and COmmunications in Medicine (DICOM) of tomographic using Mannheim Lung Analyzing software (MALUNA®) , to obtain volumetrical and densitometric data of brain tissue after patients with severe…
- Trial name
- NCT01990963
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Università degli Studi dell'Insubria
Trauma, Brain, Neuroinflammation
Imaging Lymphatic/Cerebrospinal Fluid (CSF) Drainage From the Head and Neck in Persons With Traumatic Brain Injury: Demonstration of Feasibility and Evaluation of Manual Therapy to Improve Drainage and Facilitate Cognitive Recovery
The purpose of this study is to determine whether a course of daily manual lymphatic drainage over the course of 5 days can improve lymphatic drainage function and cognitive outcomes and to determine whether single sessions of…
- Trial name
- NCT05129514
- Testing
- Manual Lymphatic Drainage (MLD)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Health Science Center, Houston
Traumatic Brain Injury, Severe Traumatic Brain Injury
Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II
After severe traumatic brain injury, adequate blood flow to the brain is essential for recovery. This depends on arterial blood pressure, yet intensive care units apply fixed targets to all patients - treating every brain and…
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Intracranial Pressure, Cerebral Perfusion Pressure
- Trial name
- Cogitate II (NCT07287358)
- Testing
- Optimal cerebral perfusion pressure
- Where
- 4 sites in Netherlands
- Volunteers
- 62 people
- Sponsor
- Maastricht University Medical Center
Traumatic Brain Injury
Effect of Recombinant Erythropoietin on Numbers of Circulating Endothelial Progenitor Cells in People With Persistent Symptoms During the Subacute Period After Traumatic Brain Injury
Background: Traumatic brain injury (TBI) injures blood vessels in the brain. Endothelial progenitor cells (EPCs) help the body form new blood vessels.
- Trial name
- NCT02226848
- Testing
- Erythropoeitin
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Brain Injuries, Stroke
Financial Coaching for Adults Living With Acquired Brain Injury
This pilot study will utilize a longitudinal concurrent mixed-methods research design that gathers and analyzes qualitative and quantitative data overtime about a new 10-session financial coaching program the investigators have…
- Trial name
- NCT06401655
- Testing
- Financial Coaching for People living with Acquired Brain Injury (FC-ABI)
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Brain Injury, Venous Thrombosis
The Use of Low Molecular Weight Heparin in Traumatic Brain Injury
To study the safety and efficacy of early administration of Low Molecular Weight Heparin to patients with traumatic brain injury.
- Trial name
- NCT00170378
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Hennepin Healthcare Research Institute
Eye-tracking
EYE-TRAC Advance: Technology Verification (ETA-TV) Cohort 2
This is a prospective multi-center cohort feasibility and exploratory study.
- Trial name
- ETA-TV (NCT02877732)
- Testing
- EYE-SYNC eye-tracking, SCAT-3 subtests, DEM
- Where
- 4 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Stanford University
Spinal Cord Injuries, Anxiety Disorders
UK Prevalence of Mental Health After SCI
Mental health decline after Spinal Cord Injury (SCI) is commonly reported but minimally investigated in the United Kingdom. The current study aims to explore the prevalence and impact of mental health challenges after SCI to…
- Conditions
- Spinal Cord Injuries, Anxiety Disorders, Depression, PTSD
- Trial name
- NCT06618404
- Testing
- No intervention - cross-sectional cohort analysis
- Where
- United Kingdom
- Volunteers
- 318 people
- Sponsor
- University of Reading
Traumatic Brain Injury
Efficacy of Stellate Ganglion Block in Traumatic Brain Injury Patients
The goal of this or clinical trial is to explore efficacy of stellate ganglion block on dysphagia and activities of daily living in Traumatic Brain Injury Patients.
- Trial name
- NCT06319638
- Testing
- Rehabilitation therapy, Stellate ganglion block, Lidocaine Hydrochloride
- Volunteers
- 100 people
- Sponsor
- Copka Sonpashan
Acquired Brain Injury (Including Stroke)
Stimulus Equivalence Learning in Acquired Brain Injury.
Stimulus Equivalence Learning (SEL) is a form of learning in which stimuli (such as words, pictures, or sounds) become linked to one another in memory, even though this specific connection has not been directly taught.
- Trial name
- NCT07345481
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Klimmendaal Revalidatiespecialisten
Brain Injuries
Examining the Experiences of Brain Injury Patients in Medical Trials
Historically, participation in clinical trials has been skewed towards certain groups. However, research on the factors that influence participation, both positive and negative, is limited.
- Trial name
- NCT05690919
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Traumatic Brain Injury
Osmotic Therapy for Treatment of Intracranial Hypertension for Traumatic Brain Injury
Osmotic therapy is a mainstay in the treatment of intracranial hypertension after traumatic brain injury.This study proposes to compare two hypertonic saline agents in patients with traumatic brain injury.
- Trial name
- NCT01215019
- Testing
- Mannitol, NaCl
- Where
- United States
- Sponsor
- Indiana University
Heart Arrest, Hypothermia
Histones and Free-plasma DNA After Cardiac Arrest
To evaluate the significance of free-plasma deoxyribonucleic acid (DNA) and plasma histones in cardiac arrest patients.
- Conditions
- Heart Arrest, Hypothermia, Post Cardiac Arrest Syndrome
- Trial name
- NCT02733146
- Testing
- cardiac arrest
- Where
- Denmark
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
SCI - Spinal Cord Injury
Nutrition and Pain Study
The purpose of this research is to assess the effectiveness of a nutrition intervention on diet quality in managing pain in individuals with spinal cord injury (SCI).
- Trial name
- NCT07179588
- Testing
- Nutrition Education Program, Nutrition Counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Critical Illness, Sepsis
Cerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis
Sepsis related cerebral dysfunction was underestimated in critical illness setting, and inflammatory response of brain could not be monitored directly and cerebral oximetry offered information of cerebral dysfunction.
- Conditions
- Critical Illness, Sepsis, Cerebral Injury
- Trial name
- NCT03523169
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
TBI (Traumatic Brain Injury), Stroke
Cognitive Profile of Patients at the Sagol Center for Hyperbaric Medicine and Research
In the investigator's institute there is ongoing treatment of different patients with cognitive deficits using Hyperbaric oxygen therapy (HBOT).
- Conditions
- TBI (Traumatic Brain Injury), Stroke, Fibromyalgia, Aging
- Trial name
- NCT04287283
- Testing
- Hyperbaric Oxygen
- Where
- Israel
- Volunteers
- 2,500 people
- Sponsor
- Assaf-Harofeh Medical Center
Pressure Ulcer, Bedsore
Quantification of the Pressure Threshold Related to Tissue Injury in Bedriden Paraplegics
The aim of this study is to correlate the intensity and the duration of a mechanical strain, applied over the skin of a bedridden paraplegics, with the microvascularization parameters (oxygen saturation, blood flow and blood…
- Conditions
- Pressure Ulcer, Bedsore, Spinal Cord Injury, Paraplegia
- Trial name
- NCT02412046
- Testing
- Muscle biopsy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Brain Injuries, Acquired Brain Injury
Human-Animal Interaction to Promote Recovery Following Pediatric Brain Injury
This study evaluates the addition of therapy dogs in inpatient physical and occupational therapy. Data will be collected across 10 PT and 10 OT sessions, half of which will incorporate a therapy dog.
- Conditions
- Brain Injuries, Acquired Brain Injury, Traumatic Brain Injury
- Trial name
- AAT (NCT04016961)
- Testing
- AAT - Dog, TAU - No Dog
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Mild Traumatic Brain Injury (mTBI)
Implementation of Biomarker-Based Care for mTBI - IMPACTS-BRAINI Study
This study aims to evaluate the real-world applicability and clinical added value of a new management pathway for patients presenting to the emergency department (ER) with mild traumatic brain injury (mTBI).
- Trial name
- IMPACTS-BRAINI (NCT07311486)
- Testing
- GFAP and UCH-L1
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Hospital Universitario 12 de Octubre
Traumatic Brain Injury, Children
Intranasal Dexmedetomidine Sedation for Pediatric CT Imaging
This study has the objective to determine if intranasal dexmedetomidine, a sedative, is suitable for pediatric sedation in children undergoing tomographic scans.
- Trial name
- NCT01900405
- Testing
- Dexmedetomidine
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
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