Clinical trials: Central Nervous Injury
Spinal Cord Injury, Spina Bifida
Virtual Reality Based Testing of Power Wheelchair Driving Skills
The purpose of this research study is to examine whether computer based or virtual reality based driving assessments are as useful as real-world power wheelchair driving tests in measuring driving performance and whether they may…
- Conditions
- Spinal Cord Injury, Spina Bifida, Spinal Cord Disease
- Trial name
- NCT00951509
- Testing
- Power Mobility Road Test (PMRT)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- US Department of Veterans Affairs
Traumatic Brain Injury, Alexithymia
Training to Reconnect With Emotional Awareness Therapy
To decrease emotional self-awareness deficits and improve emotional self-regulation, particularly anxiety, anger, depression, and positive affect, through the treatment of alexithymia.
- Trial name
- TREAT (NCT03414463)
- Testing
- TREAT
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Indiana University
Tumor, Cerebral Ventricle, Tumor, Cerebellar
Post Market Clinical Follow-Up Study on the Performance and Safety of Lyoplant®
Retrospective, single center, single arm PMCF study on the performance and safety of Lyoplant® used for the replacement and extension of connective tissue structures in neurosurgery.
- Conditions
- Tumor, Cerebral Ventricle, Tumor, Cerebellar, Aneurysm Cerebral, Trauma, Brain
- Trial name
- LYOPLACE (NCT05441618)
- Testing
- Lyoplant®
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Aesculap AG
Stroke, Quality of Life
EMG Analysis in ABI: Motor Imagery and Action
This study focuses on electromyographic analysis of upper limb muscle activation in stroke survivors during Motor Imagery (MI) and Action Observation (AO) rehabilitation techniques.
- Conditions
- Stroke, Quality of Life, Mirror Movement
- Trial name
- NCT06230718
- Testing
- Motor Imagery (MI), Action Observation (AO)
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- University of Salamanca
Osteoporosis, Spinal Cord Injuries
Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI
The objective of the proposed work is to determine whether administration for 12 months of romosozumab followed by 12 months of denosumab will maintain bone mass at the knee in subjects with subacute SCI compared to 24 months of…
- Trial name
- NCT05101018
- Testing
- Romosozumab, Denosumab
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Centreal Neurological Condition, Acquired Brain Injury (Including Stroke)
Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities
Spasticity is an umbrella term for impairments of muscle tone and control in people with damage to the brain and spinal cord. It is highly prevalent and results in pain, stiffness, and contribute to difficulties in activities of…
- Conditions
- Centreal Neurological Condition, Acquired Brain Injury (Including Stroke), Multiple Sclerosis, Spinal Cord Injury
- Trial name
- ICE (NCT07303582)
- Testing
- Cryoneurolysis, Botulinum toxin
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Oxford University Hospitals NHS Trust
Brain Injury, Intracranial Hypertension
Automated Chest Physiotherapy to Improve Outcomes in Neuro
Following current standard-of-care, subjects data (brain pressure) will be recorded for 1 hour and include 10-minutes of data during which the subject recieves chest physiotherapy (CPT).
- Trial name
- ACTION-ICP (NCT00571623)
- Testing
- Chest Physiotherapy
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Neurological Conditions, Brain Diseases
NEO-REEDUC - Mixed Reality for Motor Rehabilitation: a Prospective, Multicenter, Controlled, Randomized, Open Study.
This study aims to assess the effectiveness of a motor rehabilitation protocol that includes mixed reality activities, compared to conventional rehabilitation, on postural stability in children and adult patients with…
- Conditions
- Neurological Conditions, Brain Diseases, Cerebral Palsy, Parkinson Disease (PD)
- Trial name
- NCT07063810
- Testing
- Mixed Reality Rehabilitation
- Where
- 5 sites in France
- Volunteers
- 76 people
- Sponsor
- Slb Pharma
Central Sympathetic Nervous System Diseases
Role of Sympathetic Activation in Ischemia Reperfusion Injury
This study is designed to assess the effect of forearm ischemia-reperfusion injury on sympathetic nerve activity. To determine whether reduced sympathetic responsiveness is a contributor to the protective effects of remote…
- Trial name
- NCT04479813
- Testing
- Moxonidine 0.2 MG
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Royal Perth Hospital
Concussion, Brain, Sports-related Concussion
Ecological Test Standardization for Concussion Assessment in Football Players
Concussion is a major concern in the sports world. It represents an immediate and transient alteration of neurological functions due to a direct or indirect trauma, with or without loss of consciousness.
- Conditions
- Concussion, Brain, Sports-related Concussion, Football Players, Traumatic Brain Injury, Mild
- Trial name
- COMOFOOT (NCT07431320)
- Testing
- Ecological Dual-Task Cognitive Assessment, Visuospatial Working Memory Ecological Test
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape
Spinal Cord Injuries
Task-oriented Arm/Hand Skill Rehabilitation and Therapy Dose Dimensions in Subacute Spinal Cord Injury Rehabilitation
The study is a multicenter longitudinal observational study. The therapy content and the therapy dosage of arm/skill training for patients with cervical spinal cord injury (SCI) will be observed for the primary objective.
- Trial name
- NCT05452707
- Testing
- Observation and questionnaire of active therapy
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 47 people
- Sponsor
- Hasselt University
Spinal Cord Injury
Study on Functional Electrical Stimulation (FES) Cycling Following Spinal Cord Injury
This research is being done to study the effect of Functional Electrical Stimulation (FES) cycling on factors in blood and spinal cord in people with spinal cord injury (SCI).
- Trial name
- CURE-SCI (NCT01217047)
- Testing
- FES Cycling, Cycling without FES, Lumbar puncture
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Brain Injuries
Dexmedetomidine on Brain Injury Patients
The aim of the study is to check whether dexmedetomidine has neuroprotective properties in brain injury patients. The enrolled 60 patients will be divided into two groups; Group 1(n=30): are the patients who will receive…
- Trial name
- NCT06661980
- Testing
- Dexmedetomidine Injectable Solution
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour University
Spinal Cord Injuries (SCI), Spinal Cord Disease
Enhancing Rehabilitation Participation in Patients With SCI/D Using Motivational Interviewing
The purpose of this multi-site clinical trial is to see whether people with spinal cord injury or disorder (SCI/D) demonstrate higher level of participation in rehabilitation sessions and other outcomes when their therapists are…
- Trial name
- NCT07364773
- Testing
- Motivational Interviewing
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Shirley Ryan AbilityLab
Brain Injuries
Low Serum Ficolin-3 Levels on Admission Are Associated With Poor Outcomes After Severe Traumatic Brain Injury
The current study was designed to investigate the change of serum ficolin-3 levels and assess the prognostic predictive effect of serum ficolin-3 levels in the patients with severe traumatic brain injury.
- Trial name
- NCT02510573
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Sanmen People's Hospital
Stroke
Visualization of Cerebral Arteries Using Contrast-Enhanced Transcranial Ultrasound in Stroke Patients
The purpose of this study is to find out more about the usefulness of ultrasound in combination with a contrast solution to look for blood vessel blockage or occlusion in the brains of stroke patients.
- Trial name
- NCT00282841
- Testing
- ultrasound
- Where
- 2 sites in United States
- Volunteers
- 61 people
- Sponsor
- University of California, San Diego
Traumatic Brain Injury, Posttraumatic Stress Disorder
Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD
The primary objective of this study is to evaluate the efficacy of Cognitively Augmented Behavioral Activation (CABA), a new hybrid treatment for Veterans diagnosed with comorbid mild Traumatic Brain Injury (mTBI) and…
- Trial name
- CABA (NCT02391402)
- Testing
- Cognitively Augmented Behavioral Activation, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Glenohumeral Subluxation, Stroke
Electrotherapeutic Interventions for Glenohumeral Subluxation After Stroke
The aim of this single-blind randomized controlled trial is to compare the effects of two therapies-neuromuscular electrical stimulation (NMES) and electromyographic (EMG) biofeedback-in stroke patients with shoulder…
- Trial name
- NCT07423455
- Testing
- Neuromuscular electrical stimulation, Electromyographic (EMG) biofeedback, Conventional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Şahide Eda ARTUÇ
Spinal Cord Injuries
Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI
Spinal cord injury (SCI) can make it hard for the body to self-regulate some of its automatic functions like blood pressure, breathing, and heart rate.
- Trial name
- NCT06313515
- Testing
- Transcutaneous Spinal Cord Stimulation, Arm-crank bike exercise
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Washington
Obstructive Sleep Apnea, Spinal Cord Injuries
Overnight Upper Airway Infiltration in Spinal Cord Injury
Obstructive Sleep Apnea (OSA), a common disorder resulting from repetitive pharyngeal collapse during sleep, is multifactorial. Usually, OSA is considered primarily a problem of upper airway anatomy, with the craniofacial…
- Trial name
- OUI-SCI (NCT05391308)
- Testing
- Pre-polysomnography mesurement, Polysomnography measure, Post-polysomnography measurements
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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