Clinical trials: Central Nervous Injury
Intracerebral Hemorrhage
Short-term And Longer-term Cognitive Impact Of Neurochecks
The proposed research plan seeks to understand the impact of sleep disruption in the Neurological Intensive Care Unit (ICU) on older patients with acute brain injury (ABI).
- Trial name
- NCT06219889
- Testing
- Frequency of neurochecks
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Military Family, Brain Injuries, Traumatic
Effects of PSTon Mental Health Outcomes in Caregivers of Post-9/11 Combat Veterans With a Traumatic Brain Injury
The primary aim of this study is to assess the efficacy of PST for positively impacting distressed military family caregiver's depression and burden levels (secondary outcomes), ultimately enhancing their mental health quality of…
- Trial name
- NCT03211884
- Testing
- Problem-Solving Thearpy
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Spinal Cord Injury, Acute, Professional-Patient Relations
Effectiveness of Psycho-emotional Support in Acute Spinal Cord Injury. ESPELMA Project
The purposes of the ESPELMA project are twofold: 1) To increase acute spinal cord injury patients' satisfaction with treatment while hospitalization and 2) To increase mastery among rehabilitation professionals with regard to the…
- Conditions
- Spinal Cord Injury, Acute, Professional-Patient Relations, Sensitivity Training Groups, Patient Non-Compliance
- Trial name
- ESPELMA (NCT01889940)
- Testing
- Training for professionals (Spinal Cord Injury Unit staff).
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Neurological Diseases, Ischemic Stroke
Establishment of Clinical Basis for Hematopoietic Growth Factors Therapy in Brain Injury
The purpose of our study is to determine the safety and efficacy of the combination of erythropoietin (EPO) and granulocyte-colony stimulating factors (G-CSF) in patients with neurological diseases.
- Conditions
- Neurological Diseases, Ischemic Stroke, Hemorrhagic Stroke, Cerebral Palsy
- Trial name
- NCT02018406
- Testing
- Combination injection of EPO and G-CSF, Injection of normal saline
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Acute Brain Injury
Impact of Continuous Monitoring of PtC02 on Ventilatory Weaning in Neuro-injured Patients
The investigators propose to study the value of non invasive continuous transcutaneous PtC02 monitoring for ventilatory withdrawal guidance in neuro-injured patients and to predict the risk of extubation failure in this category…
- Trial name
- CO2MBAWA (NCT04819984)
- Testing
- TCM5 device (Radiometer) for PtC02 continuous measurement
- Volunteers
- 98 people
- Sponsor
- Centre Hospitalier St Anne
Central Sensitisation, Fibromyalgia
The Nociceptive Flexion Reflex as a Diagnostic Tool of Central Sensitization
This experimental study will investigate whether the decreased NFR threshold and increased NFR temporal summation, which are frequently observed in chronic pain patients, are only symptomatic manifestations that occur in the…
- Conditions
- Central Sensitisation, Fibromyalgia, Neck Pain, Low Back Pain
- Trial name
- NFR-CS (NCT05321550)
- Where
- Belgium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Ghent
Pain, Brain Injuries
Validity and Reliability Study of the Pain Indicator Behavior Scale-Brain Damage (ESCID-DC)
A multicentre observational study to validate the adaptation of the Pain Indicator Behavior Scale (ESCID) for patients with acquired Brain Damage (ESCID-DC), as a measuring instrument.
- Conditions
- Pain, Brain Injuries, Behavior
- Trial name
- ESCID-DC (NCT04898491)
- Testing
- Pain assessment using a behavioral scale
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Candelas Lopez Lopez
Stroke, Traumatic Brain Injury
Validation of the FOUR Coma Scale in Russia.
The purpose of this study is to examine the validity of the Russian version of the FOUR Full Outline of UnResponsiveness (hereafter FOUR) scale in adult ICU patients with an acute cerebral insufficiency clinic (hereinafter…
- Conditions
- Stroke, Traumatic Brain Injury, Subarachnoid Hemorrhage
- Trial name
- FOUR-RUS (NCT04018989)
- Where
- 3 sites in Russia
- Volunteers
- 260 people
- Sponsor
- Russian Federation of Anesthesiologists and Reanimatologists
Normal Physiology, fMRI
The Effect of Transcranial Magnetic Stimulation on Learning With Reward in Healthy Humans
Background: Two areas on the surface of the brain, the dorsolateral prefrontal cortex (DLPFC) and motor cortex (MC), play a key role during learning.
- Trial name
- NCT01260740
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cerebrospinal Fluid Leak
Evaluate the Safety and Efficacy of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery
The objective of the study is to clinically assess the safety and effectiveness of LIQOSEAL® as a means of reducing intra- as well as post-operative CSF leakage in patients undergoing elective cranial intradural surgery with a…
- Trial name
- ENCASE-II (NCT04086550)
- Testing
- LIQOSEAL, DuraSeal, Adherus
- Where
- 17 sites in United States, Austria and 5 more
- Volunteers
- 228 people
- Sponsor
- Polyganics BV
Traumatic Brain Injury, Intracranial Hypertension
Effect of Ketamine (Ketalar) on Intracranial Pressure
Objectives: Ketamine is an effective, short-acting anesthetic drug, which does not decrease blood pressure. It is widely stated that Ketamine increases intracranial pressure (ICP), which prevents its use in many emergency…
- Trial name
- NCT00437814
- Testing
- Ketamine, effect on intracranial pressure
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rambam Health Care Campus
Coronary Heart Disease, Stroke
Examining the Long-Term Risks of Oophorectomy
At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.
- Conditions
- Coronary Heart Disease, Stroke, Breast Cancer, Ovarian Cancer
- Trial name
- NCT00655447
- Where
- United States
- Volunteers
- 32,175 people, healthy volunteers welcome
- Sponsor
- Parker, William H., M.D.
Traumatic Brain Injury
Functional Near-Infrared Spectroscopy (fNIRS) Assessing Neural Activity During Virtual Reality Walking Intervention
The purpose of this study is to evaluate the safety and feasibility of using a portable neuroimaging device called functional near-infrared spectroscopy (fNIRS) to successfully analyze fNIRS data in individuals with chronic TBI…
- Trial name
- fNIRS (NCT06276894)
- Testing
- Motek C-Mill™ treadmill, training session with and without VR wearing the fNIRS cap
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Craig Hospital
Traumatic Brain Injury
Aerobic Exercise After Traumatic Brain Injury
The purpose of this study is to examine the effects of individualized aerobic exercise regimen on recovery after traumatic brain injury (TBI).Investigators will determine if exercise facilitates recovery by facilitating…
- Trial name
- AER-TBI1 (NCT05786729)
- Testing
- Aerobic Exercise (AER), Rehabilitation
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Centre for Neuro Skills
Gulf War Syndrome, Adult Growth Hormone Deficiency
Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT)
The goal of the GWIT Study is to assess whether growth hormone replacement therapy is a safe and effective treatment for veterans with Gulf War Illness (GWI) and adult growth hormone deficiency (AGHD).
- Trial name
- GWIT (NCT05355272)
- Testing
- Recombinant human growth hormone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Traumatic Brain Injury
Prospective Analysis of the Use of N-Acetylcysteine and Vitamins in the Treatment of TBI in Geriatric Patients
This study will evaluate the administration of N-Acetyl-cysteine in combination with multi-vitamins/minerals in geriatric population (>60 years of age) who have experienced a traumatic brain injury.
- Trial name
- NCT04291066
- Testing
- N-Acetyl cysteine
- Where
- 2 sites in United States
- Volunteers
- 92 people
- Sponsor
- HonorHealth Research Institute
Intracranial Hemorrhage, Traumatic, Embolism and Thrombosis
Traumatic Intracranial Hemorrhage in Users of Oral Antithrombotic Drugs
Oral antithrombotic medications (OAM) are used for the prevention and treatment of thrombotic disorders. Among hemorrhagic complications of OAMs, intracranial hemorrhage (ICH) may have particularly devastating consequences with…
- Conditions
- Intracranial Hemorrhage, Traumatic, Embolism and Thrombosis, Hematoma, Subdural, Intracranial
- Trial name
- NCT02996851
- Volunteers
- 6,279 people
- Sponsor
- St. Olavs Hospital
Concussion, Professional TOP14 Rugby Players
Blood Biomarkers for the Management of Concussion in Professional Rugby Players
In the past 20 years, the incidence of concussion in direct contact sports has significantly increased. The incidence of concussion in rugby players ranges between 8 to 17 episodes / 1000 playing hours.
- Trial name
- RUGBYPROS100B (NCT02930395)
- Testing
- serum S100B assay
- Where
- France
- Volunteers
- 560 people
- Sponsor
- University Hospital, Clermont-Ferrand
Spinal Cord Injuries
FES-assisted Gait Intervention in People with Spinal Cord Injury - Pilot Study
A spinal cord injury (SCI) disrupts the communication within the nervous system, leading to limitations in sensorimotor activities such as walking.
- Trial name
- NCT05908175
- Testing
- FES-assisted gait training
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Stichting Reade
Traumatic Brain Injury
Assessing the Accuracy and the Impact of Standard-practice Ventricular Drainage on Intracranial Pressure Measurements Following Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of death following injury in civilian populations and is a major cause of death and disability in combat casualties.
- Trial name
- Dual ICP (NCT02911675)
- Testing
- EVD/IVC and the IPM/Camino
- Sponsor
- University of Maryland, Baltimore
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.