Clinical trials: Central Nervous Injury
Spinal Cord Injury
Oral Colecalciferol Treatment in Spinal Cord Lesion
Low vitamin D is frequently seen in patients with spinal cord injury (SCI) in acute and chronic periods. Among its causes are insufficient sun exposure, limited oral intake, obesity, the effect of the drugs used on the absorption…
- Trial name
- NCT04400747
- Testing
- Vitamin D3
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Hypotension, Brain Injuries
Correlation Between Circulating Biomarkers of Organs Damage and Intraoperative Hypotension Management
Intraoperative hypotension (defined as mean arterial pressure below 65 mmHg) is associated with increased organs dysfunction and mortality.
- Conditions
- Hypotension, Brain Injuries, Renal Failure, Endothelial Dysfunction
- Trial name
- NCT03527758
- Testing
- Flo TracIQ with HPI software
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Catania
Spinal Cord Injuries, Neuropathic Pain
Evaluation of Initiation Time on the Efficacy of Gabapentin in Treating Neuropathic Pain in SCI
Neuropathic pain is a common complaint in those with spinal cord injury (SCI) that has a significant negative effect on quality of life. Efficacy of various treatments, however, remains controversial.
- Trial name
- NCT04256603
- Testing
- Gabapentin, No gabapentin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- MetroHealth Medical Center
Brain Injuries, Minimally Conscious State
Effects of Whole-body Vibration Exercise in Brain Injury Patients With Minimally Conscious State
The purpose of this study is to investigate the effect of the whole body vibration exercise on cortical activity and consciousness Level in brain injury patients with minimally conscious state.
- Trial name
- NCT03389113
- Testing
- Whole body vibration, Exersice
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Samsung Medical Center
Cerebral Palsy, Traumatic Brain Injury
Hybrid Approach to Pediatric Rehabilitation
Children and youth recovering from acquired injuries typically receive therapy via in-patient or outpatient rehabilitation (OPR).
- Conditions
- Cerebral Palsy, Traumatic Brain Injury, Orthopedic Disorder
- Trial name
- NCT06547762
- Testing
- Hybrid approach (in-person and remote) to pediatric rehabilitation: A look beyond the COVID-19 crisis
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Traumatic Brain Injury
CONcussion Treatment After Combat Trauma (CONTACT)
This study compares the effects of Individualized Scheduled Telephone Support (ISTS) and Usual Care (UC) for service members with Mild Traumatic Brain Injury (mTBI). A total of 400 service members will participate in this study.
- Trial name
- CONTACT (NCT01387490)
- Testing
- Individualized Scheduled Telephone Support (ISTS), Usual Care (UC)
- Where
- 4 sites in United States
- Volunteers
- 366 people
- Sponsor
- INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Traumatic Brain Injury
Early Propranolol After Traumatic Brain Injury: Phase II
The primary objective of this study is to determine in patients with traumatic brain injury (TBI) the safe dosing of propranolol.
- Trial name
- EPAT: Phase II (NCT01202110)
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cedars-Sinai Medical Center
Brain Injuries, Traumatic
INTRuST Structured Assessment For Evaluation of TBI (SAFE-TBI)
The current study will evaluate the initial reliability and validity of a new instrument, the INTRuST Structured Assessment for Evaluation of TBI (SAFE-TBI), in three samples of Operation Enduring Freedom/Operation Iraqi…
- Trial name
- SAFE-TBI (NCT01554891)
- Where
- 6 sites in United States
- Volunteers
- 305 people
- Sponsor
- INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Spinal Cord Injury
Medico-legality of Acute Spinal Cord Injuries
1. Describe different medico-legal aspects of TSI (mode of trauma, cause and Pattern of spinal injuries). 2. Assess the outcome of TSI in studied cases. 3.
- Trial name
- NCT06717503
- Testing
- data collection
- Volunteers
- 120 people
- Sponsor
- Assiut University
Traumatic Brain Injury, TBI
Field Triage of Older Adults Who Experience Traumatic Brain Injury
Our overall goal in this proposed study is to describe the current prehospital trauma triage process for older adult (age≥55) patients with suspected Traumatic Brain Injury (TBI), to identify the effect of certain medications…
- Trial name
- NCT01884103
- Volunteers
- 4,533 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Spinal Cord Injuries
Umbilical Cord Blood Mononuclear Cell Transplant to Treat Chronic Spinal Cord Injury
The purpose of this study is to investigate the feasibility, safety, efficacy and optimal dose of umbilical cord blood mononuclear cell transplant in the treatment of chronic spinal cord injuries.
- Trial name
- NCT01354483
- Testing
- Umbilical Cord Blood Mononuclear Cell, Methylprednisolone, Lithium Carbonate Tablet
- Where
- China
- Volunteers
- 20 people
- Sponsor
- China Spinal Cord Injury Network
Cardiovascular Diseases, Cancer
Phase I Human Analytics (HALO) Study
Discover, optimize, standardize, and validate clinical-trial measures and biomarkers used to diagnose and differentiate cardiovascular, oncologic, neurologic, and other diseases and disorders.
- Conditions
- Cardiovascular Diseases, Cancer, Dementia, Traumatic Brain Injury
- Trial name
- HALO (NCT05423860)
- Testing
- no interventions will be performed (observational)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- HALO Diagnostics
Spinal Metastases
Surgical Spinal Decompression of Metastatic Spinal Cord Compression, Minimal Access Versus Open Surgery
The investigators wish to evaluate the effect of minimal access spinal surgery compared to traditional open surgery spinal surgery in patients with metastatic spinal cord compression.
- Trial name
- NCT01865942
- Testing
- open surgery, Minimal access surgery
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mild Traumatic Brain Injury, Concussion
Advancement of Vestibular Intervention Via Portable Electrical Stimulator (VIPES)
The goal is to assess the potential benefit of stochastic galvanic vestibular stimulation (sGVS) in improving patient performance with respect to balance, gait, and/or overall vestibular function for individuals with known…
- Trial name
- NCT07466589
- Testing
- Stochastic Galvanic Vestibular Stimulation (sGVS)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Vivonics, Inc.
Spinal Cord Injury, Ambulation Difficulty
Exoskeleton and Spinal Cord Stimulation for SCI
The overall aim of this project is to assess the effect of combining transcutaneous lumbosacral stimulation (TLS) during Exoskeleton Assisted Walking (EAW) compared to EAW alone without stimulation on walking recovery.
- Conditions
- Spinal Cord Injury, Ambulation Difficulty, Muscle Spasticity
- Trial name
- NCT03096197
- Testing
- Exoskeleton-Assisted Walking, Transcutaneous Lumbosacral Stimulation (TLS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Kessler Foundation
Traumatic Brain Injury (TBI) Patients
Correlation and Rapid Analysis of Neurological Injury Using Markers
Each year, approximately 69 million people worldwide suffer from traumatic brain injuries (TBI), representing a significant burden on public health, society, and the economy.
- Trial name
- NCT06834659
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università Vita-Salute San Raffaele
Mild Traumatic Brain Injury, Post Concussion Syndrome
Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline
The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain.
- Trial name
- NCT07044596
- Testing
- Functional near-infrared spectroscopy (fNIRS), V1 stimulation electrodes, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Ictus, Severe Acquired Brain Injury
Personality Traits as a Variable in the Recovery of Patients With Acquired Brain Injury
This study aims to evaluate the potential effects of premorbid personality on the short- and long-term global cognitive recovery in patients with severe acquired brain injury (sABI) or stroke.
- Conditions
- Ictus, Severe Acquired Brain Injury, sABI
- Trial name
- NCT07119827
- Testing
- Motor, cognitive and psychological assessment
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Universita di Verona
Acquired Brain Injury
The Reliability of Heart Rate Variability Among Patients With Brain Injury as Measured by POLAR RC810XE Compared to HOLTER
Following a brain injury (BI) in addition to all other systems, there can be a failure in the control of the autonomic system activity. Heart rate (HR) has its own normal variability.
- Trial name
- NCT01451242
- Testing
- no intervention is made
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Brain Injuries, Traumatic, Neuropsychology
The Role of Hyperbaric Oxygen and Neuropsychological Therapy in Cognitive Function Following Traumatic Brain Injury
Traumatic brain injury (TBI) caused by accidents is a very important public health problem in Taiwan. There are many people with brain damage and cognitive dysfunction caused by traumatic brain injury every year.
- Trial name
- NCT03900182
- Testing
- Hyperbaric Oxygen Therapy
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hung-Chen Wang
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