Clinical trials: Central Nervous Injury
Brain Injury, Concussion
Safety Study for Adolescents With Concussion
The purpose of the study was to determine if administration of an exercise stress test within the first ten days after a sports related concussion would delay or otherwise interfere with recovery.
- Trial name
- NCT02714192
- Testing
- Exercise stress test (BCTT)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University at Buffalo
Brain Injuries
Group Based Treatment for Persons With Social Communication Difficulties
A large proportion of patients with ABI have cognitive deficits that affect the way they communicate. Cognitive difficulties with attention, memory, executive functions and so on affect social communication.
- Trial name
- NCT03636399
- Testing
- Standard GIST, Intensive GIST
- Where
- Norway
- Volunteers
- 49 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Focus: Healthy Adults Without Brain Injury
Normative Datasets for Assessments Planned for Mild Traumatic Brain Injury (NORMAL)
The purpose of the research study is to collect information about brain function and structure among active duty military personnel or civilians who are healthy.
- Trial name
- NORMAL (NCT01925963)
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Lindell Weaver
Traumatic Brain Injury
The Research for New Clinical Diagnostic Strategy of Specific Biomarkers for Traumatic Brain Injury
Traumatic brain injury (TBI) is the most common type of nerve injury and it severely endangers the public health. It is necessary to accurately measure the early neurological function of brain injury for monitoring its prognosis…
- Trial name
- NCT03976492
- Testing
- diagnostic of specific biomarkers
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Baiyun Liu
Hypoxic-Ischemic Encephalopathy, Brain Injury
Prospective Research in Infants With Mild Encephalopathy
A multicenter observational pilot study will be conducted to determine the natural history of infants with early diagnosis (≤ 6 hrs of age) of mild neonatal encephalopathy (NE) who are not qualified for therapeutic hypothermia.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Brain Injury, Neonatal Seizure
- Trial name
- PRIME (NCT01747863)
- Testing
- Neurologic examination
- Where
- 7 sites in United States, Canada and 2 more
- Volunteers
- 63 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Brain Damage, Postoperative
Evaluation of Neuronal Damage in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy With Biomarkers
Robotic assisted laparoscopic surgery has become an alternative to open or laparoscopic technique in various surgical fields. Robot assisted laparoscopic surgery is preferred by surgeons and patients due to easy accessibility…
- Conditions
- Brain Damage, Postoperative, Surgery-Complications
- Trial name
- NCT05692804
- Testing
- Mini Mental State Examination(MMSE),Montreal Cognitive Assessment ( MoCA),S100B ( protein S100 subunit beta) ,GFAP ( glial fibrillary acidic protein ),NSE ( neuron-specific enolase )
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Acquired Brain Injury, Subarachnoid Hemorrhage
Cohort Study on the Effects of Aging in Acquired Brain Injury Patients
A prospective cohort study (questionnaires), with an embedded case control study (neuropsychological assessments) in which the data is gathered within a timeframe of 3 years.
- Conditions
- Acquired Brain Injury, Subarachnoid Hemorrhage, Traumatic Brain Injury, Cerebrovascular Accident
- Trial name
- BRAINReADAPT (NCT05499806)
- Where
- 2 sites in Netherlands
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Spinal Cord Injuries, Physical Inactivity
An Online Rehabilitation Programme for People with SCI
The goal of this feasibility study is to explore the feasibility and effectiveness of a 12-week online rehabilitation programme in people with Spinal Cord Injury during the transition from hospital to home.
- Conditions
- Spinal Cord Injuries, Physical Inactivity, Spinal Cord Injury, Acute
- Trial name
- NCT06583538
- Testing
- Giraffe Healthcare
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Glasgow Caledonian University
Delirium
Hip Fracture Surgery in Elderly Patients
The objective of this study is to evaluate the incidence of Post-Operative Delirium (POD), diagnosed with the Confusion Assessment Method (CAM), in elderly patients undergoing hip fracture surgery under general anaesthesia with…
- Trial name
- HIPELD (NCT01199276)
- Testing
- Xenon, Sevoflurane
- Where
- 13 sites in Belgium, France and 4 more
- Volunteers
- 256 people
- Sponsor
- Air Liquide Santé International
Spinal Cord Injuries, Urinary Diversion
Efficacy and Safety of a Continent Cutaneous Urinary Diversion in Spinal Cord Injury Patients
Continent Cutaneous Urinary Deviation (CUD), using the Mitrofanoff, Yang-Monti or Casale principle, is offered to patients with neurological diseases who are unable to perform intermittent catheterisation through the native…
- Conditions
- Spinal Cord Injuries, Urinary Diversion, Neurogenic Bladder
- Trial name
- ELESDUCCBM (NCT04936217)
- Testing
- Data collection, Interview using a validated questionnaire
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Post-Traumatic Seizure Disorder, Head Injuries
Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures
OBJECTIVES: I. Determine whether treating head injured patients with valproate sodium will reduce the risk of developing seizures as a result of the head injury. II.
- Trial name
- NCT00004817
- Testing
- phenytoin, valproate sodium
- Volunteers
- 385 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Spinal Cord Injuries, Tetraplegia
Influence of Upper Extremity Vibration on Spasticity and Function in Persons With Tetraplegia
Vibration therapy is a possible alternative to drug-based treatments for spasticity following SCI. Research indicates that it may provide temporary relief from spasticity, but many interventions under investigation are not…
- Trial name
- NCT04020770
- Testing
- Vibrating ball
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shepherd Center, Atlanta GA
Virtual Rehabilitation, CP (Cerebral Palsy)
Virtual Rehabilitation Innovations for Motivation
Children and young people with movement difficulties such as Cerebral Palsy (CP) and Acquired Brain Injury (ABI) report that traditional therapies are highly repetitive and labourious.
- Conditions
- Virtual Rehabilitation, CP (Cerebral Palsy), Brain Injuries, Young Adult
- Trial name
- VR4REHAB-MOT (NCT04430673)
- Testing
- Home-School based VR system trial
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Brain Injuries, Pulmonary Embolism
Improving the Stewardship of Diagnostic Imaging Resources in Alberta Emergency Departments
Utilization of diagnostic imaging in the Emergency Department has increased dramatically over the past two decades, driven by an increased availability of advanced imaging, legal pressures to exclude serious diagnoses in low-risk…
- Trial name
- NCT02410941
- Testing
- Clinical decision support
- Where
- 16 sites in Canada
- Volunteers
- 52,058 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Spinal Cord Injury
STIMO: Epidural Electrical Simulation (EES) With Robot-assisted Rehabilitation in Patients With Spinal Cord Injury.
STIMO is a First-in-Man (FIM) study to confirm the safety and feasibility of a closed-loop Epidural Electrical Stimulation (EES) in combination with overground robot assisted rehabilitation training for patients with chronic…
- Trial name
- STIMO (NCT02936453)
- Testing
- Device implantation
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Jocelyne Bloch
Stroke, Spinal Cord Injury
ERIGO® Life- Control of Cardiovascular Parameters Via Verticalization and Simultaneous Mobilization
Early verticalization and stepping with the equipment of Hocoma ERIGO during monitoring of vital parameters. The device is already CE marked and, for the purposes of the study, will be used in accordance with the intended use…
- Trial name
- ERIGO®LIFE (NCT02268266)
- Testing
- Erigo
- Where
- 2 sites in Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Traumatic Brain Injury, Epilepsy
Preventing Epilepsy After Traumatic Brain Injury With Topiramate
Our hypothesis is that topiramate will reduce acute seizures after traumatic brain injury and will help prevent the development of epilepsy after traumatic brain injury.
- Trial name
- PEPTO (NCT00598923)
- Testing
- topiramate, phenytoin
- Volunteers
- 6 people
- Sponsor
- University of Pennsylvania
Brain Injury, Post Traumatic Stress Disorder
Innovative Multimodal and Attention Training to Improve Emotion Communication in Veterans With TBI and PTSD
Poor emotion recognition has been associated with poor quality of interpersonal relationships, loss of employment, behavioral problems, reduced social reintegration, social isolation and even suicide.
- Trial name
- NCT05478759
- Testing
- Multimodal affect recognition training, Attention Training, Brain Health Workshop
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Evaluation of Consciousness Impairment in Severe TBI and Full-cycle Neuroregulation Based on Multimodal Imaging
The goal of this observational study is to learn about in Evaluation of consciousness impairment in severe TBI and full-cycle neuroregulation based on multimodal imaging.
- Trial name
- NCT06469827
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
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